The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
Open accessAbstract
Glucagon-like peptide-1 (GLP-1) released from the gut functions as an incretin that stimulates insulin secretion.GLP-1 is also a brain neuropeptide that controls feeding and drinking behavior and gastric emptying and elicits neuroendocrine responses including development of conditioned taste aversion.Although GLP-1 receptor (GLP-1R) agonists are under development for the treatment of diabetes, GLP-1 administration may increase blood pressure and heart rate in vivo.We report here that centrally and peripherally administered GLP-1R agonists dose-dependently increased blood pressure and heart rate.GLP-1R activation induced c-fos expression in the adrenal medulla and neurons in autonomic control sites in the rat brain, including medullary catecholamine neurons providing input to sympathetic preganglionic neurons.Furthermore, GLP-1R agonists rapidly activated tyrosine hydroxylase transcription in brainstem catecholamine neurons.These findings suggest that the central GLP-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo.
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“Peripheral and central GLP-1 agonists induce c-fos expression, suggesting they activate the adrenal medulla and autonomic regulatory neurons in the rat brain (53).”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [53]
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“GLP-1 receptor agonists have dose-dependent chronotropic and pressor responses in rodents (5, 53)”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [53]
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“In addition to regulating glycemia, there is evidence that the neuropeptide GLP-1, administered peripherally or centrally, inhibits vagal activity in animals and humans (19, 50, 51) and increases sympathetic activity in rats (52, 53).”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [53]
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Cites
A role for glucagon-like peptide-1 in the central regulation of feeding
Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659
Self-citationDirect hypothalamo-autonomic connections
Saper, C. B., Loewy, A. D., Swanson, L. W., & Cowan, W. M. (1976) · Brain Research · doi:10.1016/0006-8993(76)90738-1 · Cited by 1,199
Self-citationSawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150
Göke, R., Fehmann, H. C., Linn, T., Schmidt, H., Krause, M., Eng, J., & Göke, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36565-2 · Cited by 837
Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
Elias, C. F., Lee, C., Kelly, J., Aschkenasi, C. J., Ahima, R. S., Couceyro, P. R., Kuhar, M. J., Saper, C. B., & Elmquist, J. K. (1998) · Neuron · doi:10.1016/s0896-6273(00)80656-x · Cited by 809
Self-citationEricsson, A. B., Kovacs, K., & Sawchenko, P. E. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00897.1994 · Cited by 679
Larsen, P. J., Tang-Christensen, M., Holst, J. J., & Ørskov, C. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00434-4 · Cited by 663
Drucker, D. J. (1998) · Diabetes · doi:10.2337/diab.47.2.159 · Cited by 598
Self-citationStrack, A. M., Sawyer, W. B., Hughes, J., Platt, K. B., & Loewy, A. D. (1989) · Brain Research · doi:10.1016/0006-8993(89)90098-x · Cited by 591
Ross, C. A., Ruggiero, D. A., JOH, T. H., Park, D. H., & Reis, D. J. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902280204 · Cited by 545
Ericsson, A., Liu, C., Hart, R. P., & Sawchenko, P. E. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903610410 · Cited by 471
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers
Edwards, C. M. B., Stanley, S. A., Davis, R. P., Brynes, A. E., Frost, G. S., Seal, L., Ghatei, M. A., & Bloom, S. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.1.e155 · Cited by 468
Young, A. A., Gedulin, B. R., Bhavsar, S., Bodkin, N., Jodka, C., Hansen, B., & Denaro, M. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1026 · Cited by 440
Circuits and mechanisms governing hypothalamic responses to stress: a tale of two paradigms
Sawchenko, P. E., Li, H.-Y., & Ericsson, A. B. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62131-7 · Cited by 353
Neurochemical organization of the hypothalamic projection to the spinal cord in the rat
Cechetto, D. F., & Saper, C. B. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902720410 · Cited by 346
Self-citationToft-Nielsen, M.-B., Madsbad, S., & Holst, J. J. (1999) · Diabetes Care · doi:10.2337/diacare.22.7.1137 · Cited by 339
Elmquist, J. K., Scammell, T. E., Jacobson, C. D., & Saper, C. B. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960715)371:1 · Cited by 335
Self-citationJin, S.-L. C., Han, V. K. M., Simmons, J. G., Towle, A. C., Lauder, J. M., & Lund, P. K. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902710405 · Cited by 332
Larsen, P. J., Tang‐Christensen, M., & Jessop, D. S. (1997) · Endocrinology · doi:10.1210/endo.138.10.5270 · Cited by 317
Kovacs, K., & Sawchenko, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00262.1996 · Cited by 310
Orskov, C., Poulsen, S. S., Moller, M., & Holst, J. J. (1996) · Diabetes · doi:10.2337/diabetes.45.6.832 · Cited by 303
Chan, R. K. W., & Sawchenko, P. E. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903480309 · Cited by 301
Ørskov, C., Poulsen, S. S., Mørten, M., & Holst, J. J. (1996) · Diabetes · doi:10.2337/diab.45.6.832 · Cited by 300
Direct projections from the A5 catecholamine cell group to the intermediolateral cell column
Loewy, A. D., McKellar, S., & Saper, C. B. (1979) · Brain Research · doi:10.1016/0006-8993(79)90852-7 · Cited by 293
Self-citationRitter, S., Bugarith, K., & Dinh, T. T. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1097 · Cited by 257
Egan, J. M., Clocquet, A. R., & Elahi, D. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8337 · Cited by 254
Ventromedial Preoptic Prostaglandin E2 Activates Fever-Producing Autonomic Pathways
Scammell, T. E., Elmquist, J. K., Griffin, J. D., & Saper, C. B. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06246.1996 · Cited by 249
Self-citationDrucker, D. J. (1998) · Diabetes · doi:10.2337/diabetes.47.2.159 · Cited by 193
Self-citationSeeley, R. J., Blake, K., Rushing, P. A., Benoit, S. C., Eng, J., Woods, S. C., & D’Alessio, D. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01616.2000 · Cited by 169
Herman, J. P., Schäfer, M. K.-H., Watson, S. J., & Sherman, T. G. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-10-1447 · Cited by 136
Zhang, Y.-H., Lu, J., Elmquist, J. K., & Saper, C. B. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06578.2000 · Cited by 135
Self-citationThe entero-insular axis in type 2 diabetes - incretins as therapeutic agents
Creutzfeldt, W. (2001) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2001-18589 · Cited by 127
Casas, J. M. B., Rodrı́guez, R. E., Eng, J., & Blázquez, E. (1996) · Regulatory Peptides · doi:10.1016/s0167-0115(96)00113-9 · Cited by 115
Stornetta, R. L., Guyenet, P. G., & McCarty, R. C. (1987) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(87)90109-3 · Cited by 111
Ca2+ current and Ca2+ transients under action potential clamp in guinea pig ventricular myocytes
Arreola, J., Dirksen, R. T., Shieh, R., Williford, D. J., & Sheu, S. S. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.261.2.c393 · Cited by 107
Descending noradrenergic pathways involved in the A5 depressor response
Loewy, A. D., Marson, L., Parkinson, D., Perry, M. A., & Sawyer, W. B. (1986) · Brain Research · doi:10.1016/0006-8993(86)90168-x · Cited by 82
Chan, R. K. W., & Sawchenko, P. E. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00600-a · Cited by 78
Organization and evolution of the rat tyrosine hydroxylase gene
BROWN, E. R., Coker, G. T., & O’Malley, K. L. (1987) · Biochemistry · doi:10.1021/bi00390a046 · Cited by 73
Biochemical consequences of synaptic stimulation:
Zigmond, R. E. (1985) · Trends in Neurosciences · doi:10.1016/0166-2236(85)90028-1 · Cited by 67
Egan, J. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.3.1282 · Cited by 62
Bojanowska, E., & Stempniak, B. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00119-1 · Cited by 60
Concurrent reductions in blood pressure and metabolic rate during fasting in the unrestrained SHR
Williams, T. D., Chambers, J. B., May, O. L., Henderson, R. P., Rashotte, M. E., & Overton, J. M. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.1.r255 · Cited by 56
Self-citationBiguet, N. F., Rittenhouse, A. R., Mallet, J. J., & Zigmond, R. E. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90353-4 · Cited by 51
The CI Area of the Rostral Ventrolateral Medulla Oblongata
Reis, D. J., Ruggiero, D. A., & Morrison, S. F. (1989) · American Journal of Hypertension · doi:10.1093/ajh/2.12.363s · Cited by 48
Bachelard, H., Gardiner, S. M., & Bennett, T. (1990) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(90)90184-k · Cited by 35
Merchenthaler (1999) · doi:10.1002/(sici)1096-9861(19990111)403:2
Research works printed but not linked: 6
- Van Dijk, 1996, Am J Physiol, 271, R1096
- Thiele, 1997, Am J Physiol, 272, R726
- Rinaman, 1999, Am J Physiol, 277, R582
- Rinaman, 1999, Am J Physiol, 277, R1537
- Barragan, 1994, Am J Physiol, 266, E459
- Barragan, 1999, Am J Physiol, 277, E784
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Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
Self-citationThe Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
The biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210
Self-citationGlucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
Self-citationSaper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
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Metadata
- Authors
- Yamamoto, H., Lee, C. E., Marcus, J. N., Williams, T. D., Overton, J. M., Lopez, M. E., Hollenberg, A. N., Baggio, L., Saper, C. B., Drucker, D. J., & Elmquist, J. K.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Florida State University (US)
- University of Toronto (CA)
- Corresponding author
- Elmquist, Joel K.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2002-07-01
- Volume
- 110
- Issue
- 1
- Pages
- 43-52
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4252795044
- Cited by
- 429
- References
- 44
- Citations by year
- 2026: 11 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 14 · 2021: 19 · 2020: 16 · 2019: 15 · 2018: 13 · 2017: 18 · 2016: 21 · 2015: 25 · 2014: 30 · 2013: 32 · 2012: 30
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- glucagon-like peptide-1, GLP-1 receptor agonists, blood pressure, heart rate, autonomic regulation, sympathetic nervous system, catecholaminergic neurons, adrenal medulla, Fos expression, tyrosine hydroxylase, brainstem, cardiovascular response, incretins
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