The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Triiodothyronine and Thyroxine in Hyperthyroidism COMPARISON OF THE ACUTE CHANGES DURING THERAPY WITH ANTITHYROID AGENTS
Open accessAbstract
In 66 untreated patients with hyperthyroidism, serum triiodothyronine (T(3)) and thyroxine (T(4)) concentrations were measured by immunoassay. The mean T(3) level was 478+/-28 ng/100 ml (all values mean+/-SEM) and the T(4) was 20.6+/-0.6 mug/100 ml. The serum T(4)/T(3) ratio by weight was 48+/-2 as opposed to a value of 71+/-3 in euthyroid adults. There was a significant inverse correlation of the T(4)/T(3) ratios with serum T(3) (r=0.77; P<0.01) but not with serum T(4)(r=0.21). These results suggested that relative overproduction of T(3) is consistently present in patients with hyperthyroidism. To examine the acute effects of various antithyroid agents on serum T(3) and T(4) concentrations, iodide, propylthiouracil (PTU), and methylmercaptoimidazole (MMI) were given alone to mine patients, and serial T(3) and T(4) measurements were made. There was an acute decrease in serum T(3) over the first 5 days in the three iodide and three PTU-treated patients which was greater than that seen in the MMI group. This suggested that PTU and MMI had different effects on T(3) production. To compare the effects of PTU and MMI under conditions in which thyroidal hormone release was minimized, these drugs were given in combination with iodide. The mean daily dosage of PTU was 827 (n=11) and of MMI was 88 (n=8). In the PTU+iodide group, the initial serum T(3) concentration was 586+/-61 ng/100 ml and decreased significantly to 326+/-41 on day 1 and to 248+/-21 on days 2 and 3, respectively, and did not change further on days 4 and 5. In the MMI + iodide group, basal serum T(3) was 645+/-90 ng/100 ml and decreased to 568+/-81, 452+/-73, and 344+/-51 on days 1, 2, and 3, respectively, and did not change thereafter. While the initial T(3) concentrations in serum were not different in the PTU and MMI groups, the T(3) concentrations in the PTU patients were significantly lower on days 1 and 2 and during the apparent plateau period on days 3-5. Serum T(4) concentrations decreased gradually in both groups, from 23.9+/-2.0 mug/100 ml, initially, to 17.5+/-1.6 on day 5 in the PTU group and from 22.0+/-2.6 to 14.6+/-2.0 in the MMI-treated patients. The T(4) values were not significantly different at any time. These changes resulted in increases in the serum T(4)/T(3) ratios in both groups, but these ratios were substantially higher in the patients treated with PTU + iodide. The initial serum T(4)/T(3) ratio was 43+/-3 and increased to 74+/-7 and 88+/-7 on days 1 and 2 in the PTU group, reaching a plateau value of 91+/-7 during days 3-5. Comparable values for MMI-treated patients were 35+/-2, 42+/-3, 52+/-6, and 54+/-3 during the plateau period. Previous investigations have shown that PTU inhibits T(4) deiodination in hyperthyroid patients and decreases T(3) production from T(4) in animals. The greater acute decrease in serum T(3) and the higher serum T(4)/T(3) ratios in the PTU-treated patients seems best explained by an inhibition of peripheral T(3) production by this agent. This conclusion is further supported by a direct relationship between the T(4)/T(3) ratio on days 3-5 and the dose of PTU administered. These results further suggest that both thyroidal and extrathyroidal pathways contribute substantially to the apparent overproduction of T(3) in hyperthyroidism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A number of therapeutic measures are specifically intended to decrease T 4 -to-T 3 conversion, such as the preferential use of PTU over MMI (229,230), glucocorticoid therapy (231), and the use of b-adrenergic blocking agents such as propranolol, with selective ability to inhibit type 1 deiodinase (232).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [229]
In the citing paper
“For example, an early article comparing acute changes in thyroid hormone level after initiation of PTU or MMI found that T 3 levels dropped by approximately 45% in the first 24 hours of PTU therapy compared to an approximately 10%-15% decrease after starting MMI (229).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [229]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine
Oppenheimer, J. H., Schwartz, H. L., & Surks, M. I. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107063 · Cited by 258
Simultaneous Measurement of Thyroxine and Triiodothyronine Peripheral Turnover Kinetics in Man
Nicoloff, J. T., LOW, J. C., Dussault, J. H., & Fisher, D. A. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106835 · Cited by 217
Direct immunoassay of triiodothyronine in human serum
Larsen, P. R. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107000 · Cited by 205
Self-citationQuantitation of extrathyroidal conversion of l-thyroxine to 3,5,3′-triiodo-l-thyronine in the rat
Schwartz, H. L., Surks, M. I., & Oppenheimer, J. H. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106584 · Cited by 173
Wartofsky, L., Ransii, B. J., & Ingbar, S. H. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106225 · Cited by 141
Immunoassay of Thyroxine in Unextracted Human Serum
Larsen, P. R., DOCKALOVA, J., Sipula, D., & WU, F. M. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-2-177 · Cited by 139
Self-citationTriiodothyronine: Review of recent studies of its physiology and pathophysiology in man
Larsen, P. R. (1972) · Metabolism · doi:10.1016/0026-0495(72)90038-8 · Cited by 137
Self-citationStanley, M. M. (1949) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-9-10-941 · Cited by 112
The effect of stable iodide on thyroid secretion in man.
DeGroot, L. J., & Greer, M. A. (1956) · PubMed · Cited by 63
THE EFFECT OF IODIDE ON THE RELEASE OF THYROID HORMONE IN HYPERTHYROIDISM*
GOLDSMITH, R. E., & Eisele, M. L. (1956) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-16-1-130 · Cited by 49
Research works printed but not linked: 1
- Ingbar, S. H., and K. A. Woeber. 1968. The thyroid gland. In Textbook of Endocrinology. R. H. Williams, editor. W. B. Saunders Company, Philadelphia. 4th edition. 214.
Cited by
Sorted by citations
Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938
“For example, an early article comparing acute changes in thyroid hormone level after initiation of PTU or MMI found that T3 levels dropped by approximately 45% in the first 24 hours of PTU therapy compared to an approximately 10%–15% decrease after starting MMI (229).”
BackgroundBianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Self-citationDeiodinases: implications of the local control of thyroid hormone action
Bianco, A. C., & Kim, B. W. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29812 · Cited by 845
Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans
Luiza Maia, A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25083 · Cited by 360
Thyroid-Pituitary Interaction: Feedback Regulation of Thyrotropin Secretion by Thyroid Hormones
Bleich, H. L., Moore, M. J., & Larsen, P. R. (1982) · New England Journal of Medicine · doi:10.1056/nejm198201073060107 · Cited by 357
Self-citationThe sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism
Docter, R., Krenning, E. P., de Jong, M., & Hennemann, G. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02401.x · Cited by 345
Cooper, D. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411223112106 · Cited by 323
Paradigms of dynamic control of thyroid hormone signaling
Bianco, A. C., Dumitrescu, A., Gereben, B., Ribeiro, M. O., Fonseca, T. L., Fernandes, G. W., & Bocco, B. M. L. C. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00275 · Cited by 293
Deiodinases and their intricate role in thyroid hormone homeostasis
Luongo, C., Dentice, M., & Salvatore, D. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0218-2 · Cited by 332
Satoh, T., Isozaki, O., Suzuki, A., Wakino, S., Iburi, T., Tsuboi, K., Kanamoto, N., Otani, H., Furukawa, Y., Teramukai, S., et al. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0336 · Cited by 262
Experimental alcohol-induced hepatic necrosis: suppression by propylthiouracil.
Israel, Y., Kalant, H., Orrego, H., Khanna, J. M., Videla, L. A., & Phillips, J. M. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.3.1137 · Cited by 237
Type 1 iodothyronine deiodinase in human physiology and disease
Maia, A. L., Goemann, I. M., Meyer, E. L. D. S., & Wajner, S. M. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0481 · Cited by 229
Gereben, B., Zeöld, A., Dentice, M., Salvatore, D., & Bianco, A. C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7396-0 · Cited by 207
Berry, M. J., Kieffer, J. D., Harney, J. W., & Larsen, P. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98657-6 · Cited by 202
Self-citationType 2 iodothyronine deiodinase is highly expressed in human thyroid.
Salvatore, D., Tu, H., Harney, J. W., & Larsen, P. R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118880 · Cited by 196
Self-citationThe classic pathways of thyroid hormone metabolism
van der Spek, A. H., Fliers, E., & Boelen, A. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.025 · Cited by 194
Geffner, D. L., Azukizawa, M., & Hershman, J. M. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107925 · Cited by 192
Methimazole Treatment of 262 Cats With Hyperthyroidism
Peterson, M. E., Kintzer, P. P., & Hurvitz, A. I. (1988) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1988.tb02812.x · Cited by 176
Neonatal Thyroid Function after Propylthiouracil Therapy for Maternal Graves' Disease
Cheron, R. G., Kaplan, M. M., Larsen, P. R., Selenkow, H. A., & Crigler, J. F. (1981) · New England Journal of Medicine · doi:10.1056/nejm198102263040907 · Cited by 160
Self-citationThyroid Physiology and Diagnostic Evaluation of Patients with Thyroid Disorders
Salvatore, D., Davies, T. F., Schlumberger, M.-J., HAY, I. D., & Larsen, P. R. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00011-0 · Cited by 156
Self-citationKlieverik, L. P., Coomans, C. P., Endert, E., Sauerwein, H. P., Havekes, L. M., Voshol, P. J., Rensen, P. C. N., Romijn, J. A., Kalsbeek, A., & Fliers, E. (2009) · Endocrinology · doi:10.1210/en.2009-0297 · Cited by 154
Thyroidal and Peripheral Production of Thyroid Hormones
Schimmel, M., & UTIGER, R. D. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-6-760 · Cited by 152
Review of Antithyroid Drug Use During Pregnancy and Report of a Case of Aplasia Cutis
Mandel, S. J., Brent, G. A., & Larsen, P. R. (1994) · Thyroid · doi:10.1089/thy.1994.4.129 · Cited by 150
Self-citationThyroid Storm: A Japanese Perspective
Akamizu, T. (2017) · Thyroid · doi:10.1089/thy.2017.0243 · Cited by 145
Reduction in extrathyroidal triiodothyronine production by propylthiouracil in man.
Saberi, M., Sterling, F. H., & Utiger, R. D. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107924 · Cited by 138
Barbero, P., Valdéz, R., Rodriguez, H. A., Tiscornia, C., Mansilla, E., Allons, A., Coll, S., & Liascovich, R. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32497 · Cited by 128
Antithyroid drug therapy: 70 years later
Burch, H. B., & Cooper, D. S. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0678 · Cited by 125
Borst, G. C., EIL, C., & BURMAN, K. D. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-3-366 · Cited by 122
The Role of Selenium in Thyroid Hormone Action*
Berry, M. J., & Larsen, P. R. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-2-207 · Cited by 119
Self-citationCloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase
Mandel, S. J., Berry, M. J., Kieffer, J. D., Harney, J. W., Warne, R. L., & Larsen, P. R. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400883 · Cited by 114
Self-citationThe Influence of β-Adrenoceptor Blocking Agents on Plasma Thyroxine and Triiodothyronine
Wiersinga, W. M., & TOUBER, J. L. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-2-293 · Cited by 113
Emiliano, A. B., Governale, L. A., Parks, M. A., & Cooper, D. S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2752 · Cited by 110
Physiological role and regulation of iodothyronine deiodinases: A 2011 update
Marsili, A., Zavacki, A. M., Harney, J. W., & Larsen, P. R. (2011) · Journal of Endocrinological Investigation · doi:10.1007/bf03347465 · Cited by 103
Self-citationWiersinga, W. M., & CHOPRA, I. J. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(82)84024-x · Cited by 100
Thyroid Hormones in Alcoholic Liver Disease
Israel, Y., Walfish, P. G., Orrego, H., Blake, J. E., & Kalant, H. (1979) · Gastroenterology · doi:10.1016/s0016-5085(79)80137-7 · Cited by 94
Clinical Pharmacokinetics of Antithyroid Drugs
Kampmann, J. P., & Hansen, J. (1981) · Clinical Pharmacokinetics · doi:10.2165/00003088-198106060-00001 · Cited by 91
Laurberg, P., Vestergaard, H., Nielsen, S., Christensen, S. E., Seefeldt, T., Helleberg, K., & Pedersen, K. M. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0178 · Cited by 90
Triiodothyronine, Thyroxine, and Iodine in Purified Thyroglobulin from Patients with Graves' Disease
Izumi, M., & Larsen, P. R. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108734 · Cited by 86
Self-citationLoPresti, J. S., Eigen, A., Kaptein, E., Anderson, K. P., Spencer, C. A., & Nicoloff, J. T. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114343 · Cited by 80
OKAMURA, K., IKENOUE, H., Shiroozu, A., Sato, K., Yoshinari, M., & Fujishima, M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-4-719 · Cited by 78
COOPER, D. S., SAXE, V. C., MESKELL, M., MALOOF, F., & RIDGWAY, E. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-101 · Cited by 76
Kim, B. W., Daniels, G. H., Harrison, B. J., Price, A., Harney, J. W., Larsen, P. R., & Weetman, A. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020921 · Cited by 72
Self-citationComparison of Sodium Ipodate (Oragrafin) and Propylthiouracil in Early Treatment of Hyperthyroidism*
Wu, S.-Y., Shyh, T.-P., CHOPRA, I. J., Solomon, D. H., Huang, H.-W., & Chu, P.-C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-3-630 · Cited by 72
Toyoda, N., Harney, J. W., Berry, M. J., & Larsen, P. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31995-6 · Cited by 59
Self-citationZhang, C.-Y., Kim, S., Harney, J. W., & Larsen, P. R. (1998) · Endocrinology · doi:10.1210/endo.139.3.5849 · Cited by 72
Self-citationROTI, E., ROBUSCHI, G., GARDINI, E., MONTERMINI, M., SALVI, M., MANFREDI, A., GNUDI, A., & BRAVERMAN, L. E. (1988) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1988.tb01217.x · Cited by 57
Bruinstroop, E., van der Spek, A. H., & Boelen, A. (2023) · European Thyroid Journal · doi:10.1530/etj-22-0211 · Cited by 54
Non‐Selective and Selective β‐1‐Adrenoceptor Blocking Agents in the Treatment of Hyperthyroidism
Nilsson, O. R., Karlberg, B. E., Kågedal, B., Tegler, L., & Almqvist, S. (1979) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1979.tb13463.x · Cited by 47
Comparison of Propylthiouracil vs Methimazole for Thyroid Storm in Critically Ill Patients
Lee, S. Y., Modzelewski, K. L., Law, A. C., Walkey, A. J., Pearce, E. N., & Bosch, N. A. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.8655 · Cited by 46
The thyroid hormone nuclear receptors and the Wnt/β-catenin pathway: An intriguing liaison
Skah, S., Uchuya-Castillo, J., Sirakov, M., & Plateroti, M. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.01.003 · Cited by 47
Carbimazole therapy of feline hyperthyroidism
Mooney, C. T., Thoday, K. L., & Doxey, D. L. (1992) · Journal of Small Animal Practice · doi:10.1111/j.1748-5827.1992.tb01122.x · Cited by 45
Thyroid Physiology and Diagnostic Evaluation of Patients With Thyroid Disorders
Salvatore, D., Davies, T. F., Schlumberger, M.-J., HAY, I. D., & Larsen, P. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00011-3 · Cited by 44
Self-citationTakata, K., Amino, N., Kubota, S., Sasaki, I., Nishihara, E., Kudo, T., Ito, M., Fukata, S., & Miyauchi, A. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03745.x · Cited by 42
Sharp, B. M., REED, A. W., Tamagna, E. I., Geffner, D. L., & Hershman, J. M. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-3-622 · Cited by 41
Vickers, A. E. M., Heale, J., Sinclair, J. R., Morris, S., Rowe, J., & Fisher, R. L. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.01.029 · Cited by 34
Davies, T. F., Laurberg, P., & Bahn, R. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00012-5 · Cited by 32
Clinical Review and Update on the Management of Thyroid Storm.
Almeida, R. D., Mccalmon, S., & Cabandugama, P. K. (2022) · PubMed Central · Cited by 31
Mandel, S. J., Larsen, P. R., & Davies, T. F. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00012-2 · Cited by 31
Self-citationThe hyperthyroidism due to trophoblastic hormone
HIGGINS, H. P., & Hershman, J. M. (1978) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(78)80041-3 · Cited by 28
Larsen, P. R. (1975) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31957-5 · Cited by 26
Self-citationThe efficiency and safety of methimazole and propylthiouracil in hyperthyroidism
Tan, S., Chen, L., Jin, L., & Fu, X. (2021) · Medicine · doi:10.1097/md.0000000000026707 · Cited by 25
Triiodothyronine Production in Graves' Hyperthyroidism
Woeber, K. A. (2006) · Thyroid · doi:10.1089/thy.2006.16.687 · Cited by 24
Gupta, K., Kaur, R., & Kaur, H. (2017) · International Journal of Applied and Basic Medical Research · doi:10.4103/2229-516x.198514 · Cited by 22
Combined Cardiac Surgery and Total Thyroidectomy
Matsuyama, K., Ueda, Y., Ogino, H., Sugita, T., Nishizawa, J., Matsubayashi, K., Yoshimura, S., Yoshioka, T., & Tokuda, Y. (1999) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.63.1004 · Cited by 22
Pathogenesis and Therapy of Neonatal Graves Disease
Fisher, D. A. (1976) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1976.02120030023003 · Cited by 22
Thyroid storm in pregnancy: a review
Vadini, V., Vasistha, P., Shalit, A., & Maraka, S. (2024) · Thyroid Research · doi:10.1186/s13044-024-00190-y · Cited by 21
Tan, T. T., Morat, P. B., NG, M. L., & Khalid, B. A. K. (1989) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1989.tb00270.x · Cited by 21
Regulation of thyroid hormone metabolism in rat liver fractions
Höffken, B., Ködding, R., Mühlen, A. V. Z., Hehrmann, T., Jüppner, H., & Hesch, R. D. (1978) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(78)90126-5 · Cited by 20
Britton, R. S., Koves, G., Orrego, H., Kalant, H., Phillips, M. J., Khanna, J. M., & Israel, Y. (1979) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(79)90017-6 · Cited by 19
Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism
Batistuzzo, A., Salas-Lucia, F., Gereben, B., Ribeiro, M. O., & Bianco, A. C. (2023) · Endocrinology · doi:10.1210/endocr/bqad155 · Cited by 18
Arteaga, E., LÓPEZ, J. M., Rodríguez, J. Á., MICHAUD, P., & de López, G. M. (1983) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1983.tb00040.x · Cited by 18
Thyroid Emergencies: A Narrative Review
Kruithoff, M., & Gigliotti, B. J. (2025) · Endocrine Practice · doi:10.1016/j.eprac.2025.06.010 · Cited by 17
Iodine and Myo-Inositol: A Novel Promising Combination for Iodine Deficiency
Barbaro, D., Orrù, B., & Unfer, V. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00457 · Cited by 17
Weetman, A., Shepherdley, C. A., Mansell, P., Ubhi, C., & Visser, T. J. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490443 · Cited by 17
Peripheral distribution and metabolism of the thyroid hormones: A primarily quantitative assessment
DiStefano, J. J., & Fisher, D. A. (1976) · Pharmacology & Therapeutics Part B General and Systematic Pharmacology · doi:10.1016/0306-039x(76)90007-6 · Cited by 16
T4 uptake into the perfused rat liver and liver T4 uptake in humans are inhibited by fructose
de Jong, M., Docter, R., Bernard, B. F., van der Heijden, J. T., van Toor, H., Krenning, E. P., & HENNEMANN, G. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.5.e768 · Cited by 16
Coma secondary to apathetic thyrotoxicosis.
Serri, O., Gagnon, R. M., Goulet, Y., & Somma, M. (1978) · PubMed Central · Cited by 15
Graves’ Disease Associated with Elevated Serum Thyroxine-Binding Globulin Concentrations*
YABU, Y., Amino, N., NAKATANI, K., Ichihara, K., AZUKIZAWA, M., & Miyai, K. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-2-325 · Cited by 15
Clinical Management of Patients with Hyperthyroidism
Cooper, D. S., & Ridgway, E. C. (1985) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30999-3 · Cited by 15
Prevention and management of hyperthyroid storm
DOBYNS, B. M. (1978) · World Journal of Surgery · doi:10.1007/bf01561498 · Cited by 13
Watanabe, N., Noh, J. Y., Akamizu, T., & Yamada, M. (2021) · Endocrine Journal · doi:10.1507/endocrj.ej21-0238 · Cited by 12
Low Dose Lithium‐Carbimazole in the Treatment of Thyrotoxicosis
Hedley, J., Turner, J. G., Brownlie, B. E. W., & Sadler, W. A. (1978) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1978.tb04852.x · Cited by 12
Peterson, C. M. (1994) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(22)00338-1 · Cited by 12
Atypical presentation of thyroid storm: a diagnostic dilemma
Banerjee, A., Bala, R., & Aggarwal, R. (2019) · BMJ Case Reports · doi:10.1136/bcr-2019-231090 · Cited by 10
Selenium, deiodinases and endocrine function
Bianco, A. C., & Larsen, P. R. (2007) · Springer eBooks · doi:10.1007/0-387-33827-6_19 · Cited by 9
Self-citationSaad, N. S., Repas, S. J., Floyd, K. T., Janssen, P. M. L., & Elnakish, M. T. (2017) · BioMed Research International · doi:10.1155/2017/6071031 · Cited by 9
THE EFFECT OF AMIODARONE ON THE CONTROL OF HYPERTHYROIDISM BY PROPYLTHIOURACIL
Rajatanavin, R., Chailurkit, L., Kongsuksai, A., TEERAVANINTHORN, U., & Himathongkam, T. (1990) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1990.tb00483.x · Cited by 9
Santini, F., Chiovato, L., Lapi, P., Lupetti, M., Dolfi, A., Bianchi, F., Bernardini, N., Bendinelli, G., Mammoli, C., Vitti, P., et al. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03532-c · Cited by 9
Effect of amiodarone on serum T4 and T3 levels in hyperthyroid patients treated with methimazole
Reeth, O. V., Decoster, C. G., & Unger, J. (1987) · European Journal of Clinical Pharmacology · doi:10.1007/bf00607567 · Cited by 8
McClung, M. R., & Greer, M. A. (1980) · Annual Review of Medicine · doi:10.1146/annurev.me.31.020180.002125 · Cited by 8
Wolmarans, D. W. (2017) · South African Family Practice · doi:10.4102/safp.v59i4.4723 · Cited by 7
The Medical Management of Graves’ Disease
Ross, D. S. (1995) · Endocrine Practice · doi:10.4158/ep.1.3.193 · Cited by 7
Graves’ disease: a new era of pathophysiology-guided therapeutics
Stan, M. N., & Toro-Tobón, D. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag010 · Cited by 6
Thyroid Emergencies: New Insight into Old Problems.
Pangtey, G. S., Baruah, U., Baruah, M. P., & Bhagat, S. (2017) · PubMed · Cited by 6
Heinen, E., Herrmann, J., Mosny, D., Moreno, F. S., Teschke, R., & Krüskemper, H. L. (1981) · Journal of Endocrinological Investigation · doi:10.1007/bf03349453 · Cited by 6
Three-compartmental analysis of effects of D-propranolol on thyroid hormone kinetics
van der Heijden, J. T., Krenning, E. P., van Toor, H., Hennemann, G., & Docter, R. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.1.e80 · Cited by 6
Management of Thyroid Disorders
McGuinness, M. E., & Talbert, R. L. (1994) · American Pharmacy · doi:10.1016/s0160-3450(15)30226-9 · Cited by 6
Reeth, O. V., & Unger, J. (1991) · Thyroid · doi:10.1089/thy.1991.1.301 · Cited by 6
Kampmann, J., & Hansen, M. J. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01289.x · Cited by 6
Bürgi, H., & Labhart, A. (1974) · Springer eBooks · doi:10.1007/978-3-642-96158-8_6 · Cited by 6
Metadata
- Authors
- Abuid, J., & Larsen, P. R.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1974-07-01
- Volume
- 54
- Issue
- 1
- Pages
- 201-208
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC301541
- OpenAlex
- W2081779848
- Cited by
- 156
- References
- 17
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 9 · 2016: 4 · 2015: 2 · 2014: 1 · 2012: 1
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- hyperthyroidism, triiodothyronine, thyroxine, T3/T4 ratio, antithyroid drugs, propylthiouracil, methimazole, iodide, thyroid hormone synthesis, thyroid hormone secretion
- MeSH terms
- Dose-Response Relationship, Drug, Humans, Hyperthyroidism, Iodine, Methimazole, Propylthiouracil, Antithyroid Agents, Thyroid Gland, Thyroxine, Triiodothyronine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
