Cited by 346Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

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Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

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Peiris, A N, Mueller, R A, Smith, G A, Struve, M F, Kissebah, A H·1986·Journal of Clinical Investigation

DOI 10.1172/jci112758PMC PMC423938

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Abstract

The effects of obesity and body fat distribution on splanchnic insulin metabolism and the relationship to peripheral insulin sensitivity were assessed in 6 nonobese and 16 obese premenopausal women. When compared with the nonobese women, obese women had significantly greater prehepatic production and portal vein levels of insulin both basally and following glucose stimulation. This increase correlated with the degree of adiposity but not with waist-to-hip girth ratio (WHR). WHR, however, correlated inversely with the hepatic extraction fraction and directly with the posthepatic delivery of insulin. The latter correlated with the degree of peripheral insulinemia. The decline in hepatic insulin extraction with increasing WHR also correlated with the accompanying diminution in peripheral insulin sensitivity. Increasing adiposity is thus associated with insulin hypersecretion. The pronounced hyperinsulinemia of upper body fat localization, however, is due to an additional defect in hepatic insulin extraction. This defect is closely allied with the decline in peripheral insulin sensitivity.

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Authors: Peiris, A. N., Mueller, R. A., Smith, G. A., Struve, M. F., & Kissebah, A. H.
Affiliations: Froedtert Hospital (US)
ORCID: Peiris, A N
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1986-12-01
Volume: 78
Issue: 6
Pages: 1648-1657
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci112758
PMC: PMC423938
OpenAlex: W2163235578
Cited by: 346
References: 49
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 7 · 2012: 8
FWCI: 9.67
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Yale University
National Institutes of Health (RR00058)
National Heart, Lung, and Blood Institute (HL32060)
National Center for Research Resources (RR00058)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: obesity, body fat distribution, waist-to-hip ratio, hepatic insulin extraction, insulin hypersecretion, peripheral insulin sensitivity, premenopausal women
MeSH terms: Adipose Tissue, Adult, C-Peptide, Female, Glucose, Humans, Insulin, Kinetics, Liver, Obesity, Viscera

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Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

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