Cited by 683Lipid metabolism and biosynthesisAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

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Influence of body fat distribution on free fatty acid metabolism in obesity.

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Jensen, M D, Haymond, M W, Rizza, R A, Cryer, P E, Miles, J M·1989·Journal of Clinical Investigation

DOI 10.1172/jci113997PMC PMC303803

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Abstract

UNLABELLED: In order to determine whether differences in body fat distribution result in specific abnormalities of free fatty acid (FFA) metabolism, palmitate turnover, a measure of systemic adipose tissue lipolysis, was measured in 10 women with upper body obesity, 9 women with lower body obesity, and 8 nonobese women under overnight postabsorptive (basal), epinephrine stimulated and insulin suppressed conditions. RESULTS: Upper body obese women had greater (P less than 0.005) basal palmitate turnover than lower body obese or nonobese women (2.8 +/- 0.2 vs. 2.1 +/- 0.2 vs. 1.8 +/- 0.2 mumol.kg lean body mass (LBM)-1.min-1, respectively), but a reduced (P less than 0.05) net lipolytic response to epinephrine (59 +/- 7 vs. 79 +/- 5 vs. 81 +/- 7 mumol palmitate/kg LBM, respectively). Both types of obesity were associated with impaired suppression of FFA turnover in response to euglycemic hyperinsulinemia compared to nonobese women (P less than 0.005). These specific differences in FFA metabolism may reflect adipocyte heterogeneity, which may in turn affect the metabolic aberrations associated with different types of obesity. These findings emphasize the need to characterize obese subjects before studies.

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Authors: Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M.
Affiliations: Mayo Clinic (US)
Washington University in St. Louis (US)
ORCID: Jensen, M D
Haymond, M W
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1989-04-01
Volume: 83
Issue: 4
Pages: 1168-1173
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci113997
PMC: PMC303803
OpenAlex: W2087710728
Cited by: 683
References: 38
Citations by year: 2026: 7 · 2025: 5 · 2024: 21 · 2023: 15 · 2022: 23 · 2021: 22 · 2020: 22 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 23 · 2015: 24 · 2014: 27 · 2013: 32 · 2012: 24
FWCI: 5.49
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Mayo Foundation for Medical Education and Research
National Institute of Diabetes and Digestive and Kidney Diseases (DK 26989, DK 29953, DK-38029)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: body fat distribution, upper body obesity, lower body obesity, free fatty acid metabolism, adipose tissue lipolysis, hyperinsulinemic-euglycemic clamp, adipocyte heterogeneity
MeSH terms: Adipose Tissue, Adult, Blood Glucose, Body Composition, Epinephrine, Fatty Acids, Nonesterified, Female, Humans, Infusions, Intravenous, Insulin, Kinetics, Obesity, Palmitates, Triglycerides

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Influence of body fat distribution on free fatty acid metabolism in obesity.

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