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Cited by 1,017

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

Open access
Creager, M A, Cooke, J P, Mendelsohn, M E, Gallagher, S J, Coleman, S M, Loscalzo, J, Dzau, V J·1990·Journal of Clinical Investigation
DOI 10.1172/jci114688
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Abstract

The effect of hypercholesterolemia on vascular function was studied in humans. To eliminate the potential confounding effects of atherosclerosis, vascular reactivity was measured in the forearm resistance vessels of 11 normal subjects (serum LDL cholesterol = 111 +/- 7 mg/dl) and 13 patients with hypercholesterolemia (serum LDL cholesterol = 211 +/- 19 mg/dl, P less than 0.05). Each subject received intrabrachial artery infusions of methacholine, which releases endothelium-derived relaxant factor, and nitroprusside which directly stimulates guanylate cyclase in vascular smooth muscle. Maximal vasodilatory potential was determined during reactive hyperemia. Vasoconstrictive responsiveness was examined during intra-arterial phenylephrine infusion. Forearm blood flow was determined by venous occlusion plethysmography. Basal forearm blood flow in normal and hypercholesterolemic subjects was comparable. Similarly, reactive hyperemic blood flow did not differ between the two groups. In contrast, the maximal forearm blood flow response to methacholine in hypercholesterolemic subjects was less than that observed in normal subjects. In addition, the forearm blood flow response to nitroprusside was less in hypercholesterolemic subjects. There was no difference in the forearm vasoconstrictive response to phenylephrine in the two groups. Thus, the vasodilator responses to methacholine and nitroprusside were blunted in patients with hypercholesterolemia. We conclude that in humans with hypercholesterolemia, there is a decreased effect of nitrovasodilators, including endothelium-derived relaxing factor, on the vascular smooth muscle of resistance vessels.

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Metadata

Authors
Creager, M. A., Cooke, J. P., Mendelsohn, M. E., Gallagher, S. J., Coleman, S. M., Loscalzo, J., & Dzau, V. J.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1990-07-01
Volume
86
Issue
1
Pages
228-234
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci114688
OpenAlex
W2043595406
Cited by
1,017
References
1
FWCI
16.36
Type
journal article
Language
en
Open access
bronze

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