Epithelial barrier repair and prevention of allergy

The basics of epithelial-mesenchymal transition

Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196

Atopic Dermatitis

Williams, H. C., Leung, D. Y. M., Thestrup‐Pedersen, K., & David, T. J. (2000) · Cited by 4,597

Atopic Dermatitis: Global Epidemiology and Risk Factors

Nutten, S. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000370220 · Cited by 3,124

The human skin microbiome

Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806

Food Allergy

Burks, A. W., James, J. M., & Eigenmann, P. (1951) · Cited by 2,573

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C. J., Sharpe, A. H., Caput, D., Crum, C. P., et al. (1999) · Nature · doi:10.1038/19539 · Cited by 2,264

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

Moffatt, M. F., Gut, I. G., Démenais, F., Strachan, D. P., Bouzigon, E., Heath, S. C., von Mutius, E., Farrall, M., Lathrop, M. G., & Cookson, W. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906312 · Cited by 2,043

Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis

Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960

Disordered Microbial Communities in Asthmatic Airways

Hilty, M., Burke, C. M., Pedro, H., Cárdenas, P., Bush, A., Bossley, C. J., Davies, J. C., Ervine, A., Poulter, L. W., Pachter, L. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008578 · Cited by 1,874

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

Woodruff, P. G., Modrek, B., Choy, D. F., Jia, G., Abbas, A. R., Ellwanger, A., Arron, J. R., Koth, L. L., & Fahy, J. V. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0392oc · Cited by 1,832

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

Kong, H. H., Oh, J., Deming, C., Conlan, S., Grice, E. A., Beatson, M. A., Nomicos, E., Polley, E. C., Komarow, H. D., Program, N. C. S., et al. (2012) · Genome Research · doi:10.1101/gr.131029.111 · Cited by 1,808

Atopic Dermatitis

Bieber, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmra074081 · Cited by 1,780

The cornified envelope: a model of cell death in the skin

Candi, E., Schmidt, R., & Melino, G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1619 · Cited by 1,776

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus

Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3161 · Cited by 1,606

Atopic dermatitis

Weidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0001-z · Cited by 1,549

Claudin-based tight junctions are crucial for the mammalian epidermal barrier

Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

Beck, L. A., Thaçi, D., Hamilton, J. D., Graham, N. M. H., Bieber, T. R. M., Rocklin, R. E., Ming, J. E., Ren, H., Kao, R., Simpson, E. L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314768 · Cited by 1,435

New insights into atopic dermatitis

Leung, D. Y. M., Boguniewicz, M., Howell, M. D., Nomura, I., & Hamid, Q. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21060 · Cited by 1,435

Efficacy of a New Tonic Containing Urea, Lactate, Polidocanol, and Glycyrrhiza inflata Root Extract in the Treatment of a Dry, Itchy, and Subclinically Inflamed Scalp

Schweiger, D., Baufeld, C., Drescher, P., Oltrogge, B., Höpfner, S., Mess, A., Lüttke, J., Rippke, F., Filbry, A. W., & Max, H. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000348473 · Cited by 1,349

Filaggrin Mutations Associated with Skin and Allergic Diseases

Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217

Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

Nakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4680 · Cited by 1,095

Cytokine modulation of atopic dermatitis filaggrin skin expression

Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084

Disease-associated functions of IL-33: the new kid in the IL-1 family

Liew, F. Y., Pitman, N. I., & McInnes, I. B. (2010) · Nature reviews. Immunology · doi:10.1038/nri2692 · Cited by 1,020

Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis

Gittler, J. K., Shemer, A., Suárez-Fariñas, M., Fuentes-Duculan, J., Gulewicz, K. J., Wang, C. Q. F., Mitsui, H., Cardinale, I., de Guzman Strong, C., Krueger, J. G., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.012 · Cited by 981

Notch1 functions as a tumor suppressor in mouse skin

Nicolas, M., Wolfer, A., Raj, K., Kummer, J. A., Mill, P., van Noort, M., Hui, C., Clevers, H. C., Dotto, G. P., & Radtke, F. (2003) · Nature Genetics · doi:10.1038/ng1099 · Cited by 969

Moisturization and skin barrier function

Rawlings, A. V., & Harding, C. R. (2004) · Dermatologic Therapy · doi:10.1111/j.1396-0296.2004.04s1005.x · Cited by 924 · cited 1×

IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

Wolk, K., Witte, E., Wallace, E., Döcke, W., Kunz, S., Asadullah, K., Volk, H., Sterry, W., & Sabat, R. (2006) · European Journal of Immunology · doi:10.1002/eji.200535503 · Cited by 911

Filaggrin in the frontline: role in skin barrier function and disease

Sandilands, A., Sutherland, C. D., Irvine, A. D., & McLean, W. H. I. (2009) · Journal of Cell Science · doi:10.1242/jcs.033969 · Cited by 886

Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis

Blanchard, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26679 · Cited by 871

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

Rangarajan, A., Talora, C., Okuyama, R., Nicolas, M., Mammucari, C., Oh, H., Aster, J. C., Krishna, S., METZGER, D., Chambon, P., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3427 · Cited by 867

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

Naik, S., Bouladoux, N., Linehan, J. L., Han, S.-J., Harrison, O. J., Wilhelm, C., Conlan, S., Himmelfarb, S., Byrd, A. L., Deming, C., et al. (2015) · Nature · doi:10.1038/nature14052 · Cited by 820

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

Nograles, K. E., Zaba, L. C., Guttman‐Yassky, E., Fuentes‐Duculan, J., Suárez‐Fariñas, M., Cardinale, I. R., Khatcherian, A., Gonzalez, J., Pierson, K. C., White, T. R., et al. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08769.x · Cited by 816

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z.-R., Hooper, L. V., Schmidt, R. R., von Aulock, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2062 · Cited by 781

Tight junction defects in patients with atopic dermatitis

Benedetto, A. D., Rafaels, N. M., McGirt, L. Y., Ivanov, A. I., Georas, S. N., Cheadle, C., Berger, A. E., Zhang, K., Vidyasagar, S., Yoshida, T., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.018 · Cited by 750

Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes

Nomura, I., Goleva, E., Howell, M. D., Hamid, Q., Ong, P. Y., Hall, C. F., Darst, M. A., Gao, B., Boguniewicz, M., Travers, J. B., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3262 · Cited by 729

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., McLean, W. H. I., Brown, S. J., Chen, Z., Chen, Y., & Williams, H. C. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.08.005 · Cited by 722

Asthma

Holgate, S. T., Wenzel, S. E., Postma, D. S., Weiss, S. T., Renz, H. E., & Sly, P. D. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.25 · Cited by 685

Type 2 cytokines: mechanisms and therapeutic strategies

Wynn, T. A. (2015) · Nature reviews. Immunology · doi:10.1038/nri3831 · Cited by 683

Food allergy: immune mechanisms, diagnosis and immunotherapy

Yu, W., Hussey, D. M., & Nadeau, K. C. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.111 · Cited by 676

TH2, allergy and group 2 innate lymphoid cells

Licona-Limón, P., Kim, L. K., Palm, N. W., & Flavell, R. A. (2013) · Nature Immunology · doi:10.1038/ni.2617 · Cited by 675

The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

Brunner, P. M., Guttman‐Yassky, E., & Leung, D. Y. M. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.01.011 · Cited by 662

Epidermal differentiation: the bare essentials.

Fuchs, E. V. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.2807 · Cited by 649

Application of moisturizer to neonates prevents development of atopic dermatitis

Horimukai, K., Morita, K., Narita, M., Kondo, M., Kitazawa, H., Nozaki, M., Shigematsu, Y., Yoshida, K., Niizeki, H., Motomura, K.-I., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.07.060 · Cited by 607

Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis

Byrd, A. L., Deming, C., Cassidy, S. K. B., Harrison, O. J., Ng, W.-I., Conlan, S., Program, N. C. S., Belkaid, Y., Segre, J. A., & Kong, H. H. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal4651 · Cited by 607

Therapeutic opportunities of the IL-22–IL-22R1 system

Sabat, R., Ouyang, W., & Wolk, K. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4176 · Cited by 588

A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes

Scharschmidt, T. C., Vasquez, K. S., Truong, H.-A., Gearty, S. V., Pauli, M. L., Nosbaum, A., Gratz, I. K., Otto, M., Moon, J. J., Liese, J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.016 · Cited by 586

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

Bønnelykke, K., Abou‐Sleiman, P. M., Nielsen, K. R., Kreiner‐Møller, E., Mercader, J. M., Belgrave, D. C. M., den Dekker, H. T., Husby, A., Sevelsted, A., Tellez, G. F., et al. (2013) · Nature Genetics · doi:10.1038/ng.2830 · Cited by 582

Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial

Thaçi, D., Simpson, E. L., Beck, L. A., Bieber, T. R. M., Blauvelt, A., Papp, K. A., Soong, W., Worm, M., Szepietowski, J. C., Sofen, H. L., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00388-8 · Cited by 573

Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.

Yuspa, S. H., Kilkenny, A., Steinert, P. M., & Roop, D. R. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.3.1207 · Cited by 572

Staphylococcal and Streptococcal Superantigen Exotoxins

Spaulding, A. R., Salgado‐Pabón, W., Kohler, P. L., Horswill, A. R., Leung, D. Y. M., & Schlievert, P. M. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00104-12 · Cited by 566

Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis

Kobayashi, T., Glatz, M., Horiuchi, K., Kawasaki, H., Akiyama, H., Kaplan, D. H., Kong, H. H., Amagai, M., & Nagao, K. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.014 · Cited by 566

Sensing the outside world: TSLP regulates barrier immunity

Ziegler, S. F., & Artis, D. (2010) · Nature Immunology · doi:10.1038/ni.1852 · Cited by 563

Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6

Kim, B. E., Leung, D. Y. M., Boguniewicz, M., & Howell, M. D. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.11.006 · Cited by 538

Intestinal barrier: An interface between health and disease

Farhadi, A., Banan, A., Fields, J. Z., & Keshavarzian, A. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03032.x · Cited by 532

The airway microbiome in patients with severe asthma: Associations with disease features and severity

Huang, Y. J., Nariya, S., Harris, J. M., Lynch, S. V., Choy, D. F., Arron, J. R., & Boushey, H. A. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.044 · Cited by 530

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

Briot, A., Deraison, C., Lacroix, M., Bonnart, C., Robin, A., Besson, C., Dubus, P., & Hovnanian, A. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082242 · Cited by 504 · cited 18×

p63 regulates proliferation and differentiation of developmentally mature keratinocytesPreprint

Truong, A. B., Kretz, M., Ridky, T. W., Kimmel, R. A., & Khavari, P. A. (2006) · Genes & Development · doi:10.1101/gad.1463206 · Cited by 489

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

Janssens, M., van Smeden, J., Gooris, G. S., Bras, W., Portale, G., Caspers, P. J., Vreeken, R. J., Hankemeier, T., Kezic, S., Wolterbeek, R., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p030338 · Cited by 488

Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches

Leung, D. Y. M., & Guttman‐Yassky, E. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.08.008 · Cited by 486

Characterization of a Common Susceptibility Locus for Asthma-Related Traits

Laitinen, T., Polvi, A., Rydman, P. S., Vendelin, J., Pulkkinen, V., Salmikangas, P., Mäkelä, S., Rehn, M., Pirskanen, A., Rautanen, A., et al. (2004) · Science · doi:10.1126/science.1090010 · Cited by 485

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis

Suárez-Fariñas, M., Dhingra, N., Gittler, J., Shemer, A., Cardinale, I., de Guzman Strong, C., Krueger, J. G., & Guttman-Yassky, E. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.046 · Cited by 483

Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis

Hamilton, J. D., Suárez‐Fariñas, M., Dhingra, N., Cardinale, I. R., Li, X., Kostić, A., Ming, J. E., Radin, A. R., Krueger, J. G., Graham, N. M. H., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.013 · Cited by 472

Non-lesional Atopic Dermatitis Skin Is Characterized by Broad Terminal Differentiation Defects and Variable Immune Abnormalities

Suárez‐Fariñas, M., Tintle, S. J., Shemer, A., Chiricozzi, A., Nograles, K. E., Cardinale, I. R., Duan, S., Bowcock, A. M., Krueger, J. G., & Guttman‐Yassky, E. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.1124 · Cited by 469

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

Fallon, P. G., Sasaki, T., Sandilands, A., Campbell, L., Saunders, S. P., Mangan, N. E., Callanan, J. J., Kawasaki, H., Shiohama, A., Kubo, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.358 · Cited by 468

Update on risk factors for food allergy

Lack, G. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.02.036 · Cited by 460

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

Linehan, J. L., Harrison, O. J., Han, S.-J., Byrd, A. L., Vujkovic-Cvijin, I., Villarino, A. V., Sen, S. K., Shaik, J., Smelkinson, M., Tamoutounour, S., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.033 · Cited by 456

IL-13 involvement in eosinophilic esophagitis: Transcriptome analysis and reversibility with glucocorticoids

Blanchard, C., Mingler, M. K., Vicario, M., Abonia, J. P., Wu, Y., Lu, T. X., Collins, M. H., Putnam, P. E., Wells, S. I., & Rothenberg, M. E. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.10.024 · Cited by 454

Canonical notch signaling functions as a commitment switch in the epidermal lineagePreprint

Blanpain, C., Lowry, W. E., Pasolli, H. A., & Fuchs, E. V. (2006) · Genes & Development · doi:10.1101/gad.1477606 · Cited by 444

The atopic march

Hill, D. A., & Spergel, J. M. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.10.037 · Cited by 436

The multifunctional role of filaggrin in allergic skin disease

McAleer, M. A., & Irvine, A. D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.668 · Cited by 426

The sentinel role of the airway epithelium in asthma pathogenesis

Holgate, S. T. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01030.x · Cited by 419

Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis

Thyssen, J. P., & Kežić, S. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.06.014 · Cited by 411

The immunogenetics of asthma and eczema: a new focus on the epithelium

Cookson, W. (2004) · Nature reviews. Immunology · doi:10.1038/nri1500 · Cited by 390

Food allergy

Renz, H. E., Allen, K. J., Sicherer, S. H., Sampson, H. A., Lack, G., Beyer, K., & Oettgen, H. C. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.98 · Cited by 388

Role of lipids in the formation and maintenance of the cutaneous permeability barrier

Feingold, K. R., & Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.007 · Cited by 383

Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression

Nakatsuji, T., Chen, T. H., Two, A. M., Chun, K., Narala, S., Geha, R. S., Hata, T. R., & Gallo, R. L. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.127 · Cited by 379

The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation

Eckert, R. L., Crish, J. F., & Robinson, N. A. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.2.397 · Cited by 375

Changes in the Ceramide Profile of Atopic Dermatitis Patients

Ishikawa, J., Narita, H., Kondo, N., Hotta, M., Takagi, Y., Masukawa, Y., Kitahara, T., Takema, Y., Koyano, S., Yamazaki, S., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.161 · Cited by 372

Dissecting the formation, structure and barrier function of the stratum corneum

Matsui, T., & Amagai, M. (2015) · International Immunology · doi:10.1093/intimm/dxv013 · Cited by 368

Does atopic dermatitis cause food allergy? A systematic review

Tsakok, T., Marrs, T., Mohsin, M., Baron, S., du Toit, G., Till, S., & Flohr, C. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.049 · Cited by 368

Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients

van Smeden, J., & Bouwstra, J. A. (2016) · Current Problems in Dermatology · doi:10.1159/000441540 · Cited by 366

The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma

Goleva, E., Jackson, L. P., Harris, J. K., Robertson, C. E., Sutherland, E. R., Hall, C. F., Good, J. T., Gelfand, E. W., Martin, R. J., & Leung, D. Y. M. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201304-0775oc · Cited by 363

Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year

Kennedy, E. A., Connolly, J., Hourihane, J. O., Fallon, P. G., McLean, W. H. I., Murray, D. M., Jo, J., Segre, J. A., Kong, H. H., & Irvine, A. D. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.07.029 · Cited by 359

Calcium regulation of keratinocyte differentiation

Bikle, D. D., Xie, Z., & Tu, C. (2012) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.12.34 · Cited by 345

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

Brough, H. A., Liu, A. H., Sicherer, S., Makinson, K., Douiri, A., Brown, S. J., Stephens, A. C., Irwin McLean, W. H., Turcanu, V., Wood, R. A., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.007 · Cited by 345

Cytokine Milieu of Atopic Dermatitis Skin Subverts the Innate Immune Response to Vaccinia Virus

Howell, M. D., Gallo, R. L., Boguniewicz, M., Jones, J. F., Wong, C., Streib, J. E., & Leung, D. Y. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.006 · Cited by 336

Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment

Durack, J., Lynch, S. V., Nariya, S., Bhakta, N. R., Beigelman, A., Castro, M., Dyer, A.-M., Israel, E., Kraft, M., Martin, R. J., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.08.055 · Cited by 327

Sustained Serine Proteases Activity by Prolonged Increase in pH Leads to Degradation of Lipid Processing Enzymes and Profound Alterations of Barrier Function and Stratum Corneum Integrity

Hachem, J. P., Man, M.-Q., Crumrine, D. A., Uchida, Y., Brown, B. E., Rogiers, V., Roseeuw, D. I., Feingold, K. R., & Elias, P. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23838.x · Cited by 314

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

Kottyan, L. C., Davis, B. P., Sherrill, J. D., Liu, K., Rochman, M., Kaufman, K. M., Weirauch, M. T., Vaughn, S. E., Lázaro, S., Rupert, A., et al. (2014) · Nature Genetics · doi:10.1038/ng.3033 · Cited by 309

Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis

Jensen, J.-M., Fölster-Holst, R., Baranowsky, A., Schunck, M., Winoto-Morbach, S., Neumann, C., Schütze, S., & Proksch, E. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22621.x · Cited by 309

Thematic Review Series: Skin Lipids. Antimicrobial lipids at the skin surface

Drake, D. R., Brogden, K. A., Dawson, D. V., & Wertz, P. W. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r700016-jlr200 · Cited by 305

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis

Noti, M., Kim, B., Siracusa, M. C., Rak, G. D., Kubo, M., Moghaddam, A. E., Sattentau, Q. J., Comeau, M. R., Spergel, J. M., & Artis, D. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.01.021 · Cited by 302

Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood

Roduit, C., Frei, R., Depner, M., Karvonen, A. M., Renz, H., Braun-Fahrländer, C., Schmausser-Hechfellner, E., Pekkanen, J., Riedler, J., Dalphin, J.-C., et al. (2017) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2017.0556 · Cited by 302

Mechanisms of food allergy

Sampson, H. A., O’Mahony, L., Burks, A. W., Plaut, M., Lack, G., & Akdiş, C. A. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.11.005 · Cited by 299

Coordinate Interaction between IL-13 and Epithelial Differentiation Cluster Genes in Eosinophilic Esophagitis

Blanchard, C., Stucke, E. M., Burwinkel, K., Caldwell, J. M., Collins, M. H., Ahrens, A., Buckmeier, B. K., Jameson, S. C., Greenberg, A. B., Kaul, A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903069 · Cited by 297

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

Kezic, S., O’Regan, G. M., Yau, N., Sandilands, A., Chen, H., Campbell, L. E., Kroboth, K., Watson, R., Rowland, M., Irwin McLean, W. H., et al. (2011) · Allergy · doi:10.1111/j.1398-9995.2010.02540.x · Cited by 295

Epidermal Notch signalling: differentiation, cancer and adhesion

Watt, F. M., Estrach, S., & Ambler, C. A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.010 · Cited by 294

Research Techniques Made Simple: Transepidermal Water Loss Measurement as a Research Tool

Alexander, H., Brown, S., Danby, S. G., & Flohr, C. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.09.001 · Cited by 291

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

Scharschmidt, T. C., Man, M., Hatano, Y., Crumrine, D. A., Gunathilake, R., Sundberg, J. P., Silva, K. A., Mauro, T. M., Hupe, M., Cho, S., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.06.046 · Cited by 287

The altered landscape of the human skin microbiome in patients with primary immunodeficienciesPreprint

Oh, J., Freeman, A. F., Program, N. C. S., Park, M., Sokolic, R. A., Candotti, F., Holland, S. M., Segre, J. A., & Kong, H. H. (2013) · Genome Research · doi:10.1101/gr.159467.113 · Cited by 286

The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines

Han, H., Roan, F., & Ziegler, S. F. (2017) · Immunological Reviews · doi:10.1111/imr.12546 · Cited by 285

Lipid abnormalities in atopic skin are driven by type 2 cytokines

Berdyshev, E., Goleva, E., Bronova, I., Dyjack, N., Rios, C., Jung, J., Taylor, P., Jeong, M., Hall, C. F., Richers, B. N., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.98006 · Cited by 283

Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin

Cho, S. H., Strickland, I., Boguniewicz, M., & Leung, D. Y. M. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.117455 · Cited by 282

Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

Kežić, S., O’Regan, G. M., Lutter, R., Jakaša, I., Koster, E. S., Saunders, S. P., Caspers, P. J., Kemperman, P. M. J. H., Puppels, G. J., Sandilands, A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.989 · Cited by 276

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

van Smeden, J., Janssens, M., Kaye, E., Caspers, P. J., Lavrijsen, A. P. M., Vreeken, R. J., & Bouwstra, J. A. (2013) · Experimental Dermatology · doi:10.1111/exd.12293 · Cited by 274

Decreased Levels of Sphingosine, a Natural Antimicrobial Agent, may be Associated with Vulnerability of the Stratum Corneum from Patients with Atopic Dermatitis to Colonization by Staphylococcus aureus

Arikawa, J., Ishibashi, M., Kawashima, M., Takagi, Y., Ichikawa, Y., & Imokawa, G. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01846.x · Cited by 268

Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis

Guttman-Yassky, E., Suárez-Fariñas, M., Chiricozzi, A., Nograles, K. E., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Lin, P., Bergman, R., Bowcock, A. M., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.031 · Cited by 268

Molecular Diagnosis of Eosinophilic Esophagitis by Gene Expression Profiling

Wen, T., Stucke, E. M., Grotjan, T. M., Kemme, K. A., Abonia, J. P., Putnam, P. E., Franciosi, J. P., Garza, J. M., Kaul, A., King, E. C., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.046 · Cited by 255

Asthmatic Bronchial Epithelium Is More Susceptible to Oxidant-Induced Apoptosis

Bucchieri, F., Puddicombe, S. M., Lordan, J. L., Richter, A., Buchanan, D., Wilson, S. J., Ward, J., Zummo, G., Howarth, P. H., Djukanović, R., et al. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.27.2.4699 · Cited by 251

Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy

Meylan, P., Lang, C., Mermoud, S., Johannsen, A., Norrenberg, S., Hohl, D., Vial, Y., Prod’hom, G., Greub, G., Kypriotou, M., et al. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.07.834 · Cited by 251

Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling

Nakajima, S., Igyártó, B. Z., Honda, T., Egawa, G., Otsuka, A., Hara‐Chikuma, M., Watanabe, N., Ziegler, S. F., Tomura, M., Inaba, K., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.01.063 · Cited by 244

Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides

Kihara, A. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.04.001 · Cited by 244

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus

Miajlović, H., Fallon, P. G., Irvine, A. D., & Foster, T. J. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.015 · Cited by 242

GWAS identifies four novel eosinophilic esophagitis loci

Abou‐Sleiman, P. M., Wang, M., Cianferoni, A., Aceves, S. S., Gonsalves, N. P., Nadeau, K. C., Bredenoord, A. J., Furuta, G. T., Spergel, J. M., & Hakonarson, H. H. (2014) · Nature Communications · doi:10.1038/ncomms6593 · Cited by 241

TNF-α Downregulates Filaggrin and Loricrin through c-Jun N-terminal Kinase: Role for TNF-α Antagonists to Improve Skin Barrier

Kim, B. E., Howell, M. D., Guttman, E., Gilleaudeau, P. M., Cardinale, I. R., Boguniewicz, M., Krueger, J. G., & Leung, D. Y. M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.24 · Cited by 239

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin

Pellerin, L., Henry, J., Hsu, C.-Y., Balica, S., Jean-Decoster, C., Méchin, M.-C., Hansmann, B., Rodriguez, E., Weindinger, S., Schmitt, A.-M., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1566 · Cited by 239

Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis

Elias, P. M., & Wakefield, J. S. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.048 · Cited by 238

p63 induces key target genes required for epidermal morphogenesis

Koster, M. I., Dai, D., Marinari, B., Sano, Y., Costanzo, A., Karin, M., & Roop, D. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611376104 · Cited by 234

Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

Gruber, R. W., Elias, P. M., Crumrine, D. A., Lin, T.-K., Brandner, J. M., Hachem, J. P., Presland, R. B., Fleckman, P. H., Janecke, A., Sandilands, A., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.01.053 · Cited by 234

Th2 Cytokines Act on S100/A11 to Downregulate Keratinocyte Differentiation

Howell, M. D., Fairchild, H. R., Kim, B. E., Bin, L., Boguniewicz, M., Redzic, J. S., Hansen, K. C., & Leung, D. Y. M. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.74 · Cited by 224

Skin exposure promotes a Th2-dependent sensitization to peanut allergens

Tordesillas, L., Goswami, R., Benedé, S., Grishina, G. T., Dunkin, D., Järvinen, K. M., Maleki, S. J., Sampson, H. A., & Berin, M. C. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75660 · Cited by 221

Relationship of Epidermal Growth Factor Receptors to Goblet Cell Production in Human Bronchi

Takeyama, K., Fahy, J. V., & Nadel, J. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.2.2001038 · Cited by 220

Skin Diseases Associated with the Depletion of Stratum Corneum Lipids and Stratum Corneum Lipid Substitution Therapy

Sahle, F. F., Gebre‐Mariam, T., Dobner, B., Wohlrab, J., & Neubert, R. H. H. (2014) · Skin Pharmacology and Physiology · doi:10.1159/000360009 · Cited by 216

Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect

Brown, S., Kroboth, K., Sandilands, A., Campbell, L., Pöhler, E., Kežić, S., Cordell, H. J., McLean, W. H. I., & Irvine, A. D. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.342 · Cited by 213

Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype

Pain, M., Bermúdez, O. M., Lacoste, P., Royer, P., Botturi, K., Tissot, A., Brouard, S., Eickelberg, O., & Magnan, A. (2014) · European Respiratory Review · doi:10.1183/09059180.00004413 · Cited by 212

Serine Protease Signaling of Epidermal Permeability Barrier Homeostasis

Hachem, J. P., Houben, E., Crumrine, D. A., Man, M.-Q., Schürer, N., Roelandt, T., Choi, E. H., Uchida, Y., Brown, B. E., Feingold, K. R., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700351 · Cited by 210

Thematic Review Series: Skin Lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology

Schmuth, M., Jiang, Y. J., Dubrac, S., Elias, P. M., & Feingold, K. R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800001-jlr200 · Cited by 204

Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study

Tran, M. M., Lefebvre, D. L., Dharma, C., Dai, D., Lou, W. Y. W., Subbarao, P., Becker, A. B., Mandhane, P. J., Turvey, S. E., Sears, M. R., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.08.024 · Cited by 198

Wnt–Notch signalling crosstalk in development and disease

Collu, G. M., Hidalgo‐Sastre, A., & Brennan, K. R. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1644-x · Cited by 197

Barrier dysfunction in the skin allergy

Egawa, G., & Kabashima, K. (2017) · Allergology International · doi:10.1016/j.alit.2017.10.002 · Cited by 196

12R-lipoxygenase deficiency disrupts epidermal barrier function

Epp, N., Fürstenberger, G., Müller, K., de Juanes, S., Leitges, M., Haußer, I., Thieme, F., Liebisch, G., Schmitz, G., & Krieg, P. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612116 · Cited by 194

IL-4 Regulates Skin Homeostasis and the Predisposition toward Allergic Skin Inflammation

Sehra, S., Yao, Y., Howell, M. D., Nguyen, E., Kansas, G. S., Leung, D. Y. M., Travers, J. B., & Kaplan, M. H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901860 · Cited by 193

Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

Kagalwalla, A. F., Akhtar, N., Woodruff, S. A., Rea, B. A., Masterson, J. C., Mukkada, V. A., Parashette, K. R., Du, J., Fillon, S., Protheroe, C. A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.03.005 · Cited by 193

Skin Barrier and Immune Dysregulation in Atopic Dermatitis: An Evolving Story with Important Clinical Implications

Czarnowicki, T., Krueger, J. G., & Guttman‐Yassky, E. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.03.006 · Cited by 184

The role of sphingolipid metabolism in cutaneous permeabilitybarrier formation

Breiden, B., & Sandhoff, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.08.010 · Cited by 181

Serine Protease Activity and Residual LEKTI Expression Determine Phenotype in Netherton Syndrome

Hachem, J. P., Wågberg, F., Schmuth, M., Crumrine, D. A., Lissens, W., Jayakumar, A., Houben, E., Mauro, T. M., Leonardsson, G., Brattsand, M., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700288 · Cited by 180

Preferential Binding of Staphylococcus aureus to Skin Sites of Th2-Mediated Inflammation in a Murine Model

Cho, S. H., Strickland, I., Tomkinson, A., Fehringer, A. P., Gelfand, E. W., & Leung, D. Y. M. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01331.x · Cited by 178

Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects

Margolis, D. J., Gupta, J., Apter, A. J., Ganguly, T., Hoffstad, O., Papadopoulos, M., Rebbeck, T. R., & Mitra, N. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.015 · Cited by 175

Goblet Cell and Mucin Gene Abnormalities in Asthma*

Fahy, J. V. (2002) · CHEST Journal · doi:10.1378/chest.122.6_suppl.320s · Cited by 175

Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing

Sherrill, J. D., KC, K., Blanchard, C., Stucke, E. M., Kemme, K. A., Collins, M. H., Abonia, J. P., Putnam, P. E., Mukkada, V. A., Kaul, A., et al. (2014) · Genes and Immunity · doi:10.1038/gene.2014.27 · Cited by 170

Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes

Williams, M. R., Nakatsuji, T., Sanford, J. A., Vrbanac, A. F., & Gallo, R. L. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.10.008 · Cited by 170

Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation

Ohno, Y., Nakamichi, S., Ohkuni, A., Kamiyama, N., Naoe, A., Tsujimura, H., Yokose, U., Sugiura, K., Ishikawa, J., Akiyama, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503491112 · Cited by 168

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

Dumortier, A., Durham, A., Piazza, M., Vauclair, S., Koch, U., Ferrand, G., Ferrero, I., Demehri, S., Song, L. L., Farr, A. G., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009258 · Cited by 165

Cis -urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT 2A receptor

Walterscheid, J. P., Nghiem, D. X., Kazimi, N., Nutt, L. K., McConkey, D. J., Norval, M., & Ullrich, S. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603119103 · Cited by 163

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin via interleukin-18

Roth, W., Kumar, V., Beer, H., Richter, M., Wohlenberg, C., Reuter, U., Thiering, S., Staratschek‐Jox, A., Hofmann, A., Kreusch, F., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.116574 · Cited by 160

Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma

Lachowicz-Scroggins, M. E., Yuan, S., Kerr, S. C., Dunican, E. M., Yu, M. A., Carrington, S. D., & Fahy, J. V. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201603-0526le · Cited by 160

A randomized trial of a barrier lipid replacement strategy for the prevention of atopic dermatitis and allergic sensitization: the PEBBLES pilot study

Lowe, A. J., Su, J. C., Allen, K. J., Abramson, M. J., Cranswick, N., Robertson, C. F., Forster, D., Varigos, G., Hamilton, S., Kennedy, R., et al. (2018) · British Journal of Dermatology · doi:10.1111/bjd.15747 · Cited by 160

Recent advances in urocanic acid photochemistry, photobiology and photoimmunology

Gibbs, N. K., Tye, J., & Norval, M. (2008) · Photochemical & Photobiological Sciences · doi:10.1039/b717398a · Cited by 159

Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy

Hussain, M., Borcard, L., Walsh, K. P., Rodriguez, M. P., Mueller, C., Kim, B., Kubo, M., Artis, D., & Noti, M. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.02.035 · Cited by 158

Interleukin-13 Induces Goblet Cell Differentiation in Primary Cell Culture from Guinea Pig Tracheal Epithelium

Kondo, M., Tamaoki, J., Takeyama, K., Nakata, J., & Nagai, A. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4682 · Cited by 154

25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

Bikle, D. D., Chang, S., Crumrine, D. A., Elalieh, H. Z., Man, M., Choi, E. H., Dardenne, O., Xie, Z., Arnaud, R. S., Feingold, K. R., et al. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22424.x · Cited by 151

Multiple Roles of Notch Signaling in the Regulation of Epidermal Development

Moriyama, M., Durham, A., Moriyama, H., Hasegawa, K., Nishikawa, S., Radtke, F., & Osawa, M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.017 · Cited by 150

Knockdown of Filaggrin in a Three-Dimensional Reconstructed Human Epidermis Impairs Keratinocyte Differentiation

Pendaries, V., Malaisse, J., Pellerin, L., Lamer, M. L., Nachat, R., Kežić, S., Schmitt, A.-M., Paul, C. F., Poumay, Y., Serre, G., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.259 · Cited by 150

The Constitutive Capacity of Human Keratinocytes to Kill Staphylococcus aureus Is Dependent on β-Defensin 3

Kisich, K. O., Howell, M. D., Boguniewicz, M., Heizer, H. R., Watson, N. U., & Leung, D. Y. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700861 · Cited by 150

Peanut protein in household dust is related to household peanut consumption and is biologically active

Brough, H. A., Santos, A. F., Makinson, K., Penagos, M., Stephens, A. C., Douiri, A., Fox, A. T., Toit, G. D., Turcanu, V., & Lack, G. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.034 · Cited by 149

Barrier function of the nasal mucosa in health and type‐2 biased airway diseases

Zhang, N., Crombruggen, K. V., Gevaert, E., & Bachert, C. (2015) · Allergy · doi:10.1111/all.12809 · Cited by 146

Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis

Yoshida, K., Kubo, A., Fujita, H., Yokouchi, M., Ishii, K., Kawasaki, H., Nomura, T., Shimizu, H., Kouyama, K., Ebihara, T., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.08.001 · Cited by 145

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Cole, C., Kroboth, K., Schurch, N., Sandilands, A., Sherstnev, A., O’Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.04.021 · Cited by 142

Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition

Danso, M. O., Boiten, W. A., van Drongelen, V., Meijling, K. A. G., Gooris, G. S., Ghalbzouri, A. E., Absalah, S., Vreeken, R. J., Kežić, S., van Smeden, J., et al. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.05.005 · Cited by 140

PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

Hirabayashi, T., tatsuki, A., Kaneko, A., Senoo, Y., Shibata, A., Takama, H., Yokoyama, K., Nishito, Y., Ono, T., Taya, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms14609 · Cited by 137

Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human β-defensin-3

Kisich, K. O., Carspecken, C. W., Fiévé, S., Boguniewicz, M., & Leung, D. Y. M. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.022 · Cited by 136

Deficient Production of Hexadecenoic Acid in the Skin Is Associated in Part with the Vulnerability of Atopic Dermatitis Patients to Colonization by Staphylococcus aureus

Takigawa, H., Nakagawa, H., Kuzukawa, M., Mori, H., & Imokawa, G. (2005) · Dermatology · doi:10.1159/000087018 · Cited by 135

Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression

Lefort, K., & Dotto, G. P. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.04.017 · Cited by 135

Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization

Broccardo, C. J., Mahaffey, S. B., Schwarz, J., Wruck, L. M., David, G. L., Schlievert, P. M., Reisdorph, N. A., & Leung, D. Y. M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.033 · Cited by 132

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

Murthy, A., Shao, Y. W., Narala, S., Molyneux, S. D., Zúñiga‐Pflücker, J. C., & Khokha, R. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.005 · Cited by 129

Food allergy: Insights into etiology, prevention, and treatment provided by murine models

Oyoshi, M. K., Oettgen, H. C., Chatila, T. A., Geha, R. S., & Bryce, P. J. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.12.1045 · Cited by 127

Filaggrin Deficiency Leads to Impaired Lipid Profile and Altered Acidification Pathways in a 3D Skin Construct

Vávrová, K., Henkes, D., Strüver, K., Sochorová, M., Školová, B., Witting, M., Frieß, W., Schreml, S., Meier, R. J., Schäfer‐Korting, M., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.402 · Cited by 125

Identification of PCDH1 as a Novel Susceptibility Gene for Bronchial Hyperresponsiveness

Koppelman, G. H., Meyers, D. A., Howard, T. D., Zheng, S. L., Hawkins, G., Ampleford, E. J., Xu, J., Koning, H., Bruinenberg, M., Nolte, I. M., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1621oc · Cited by 124

The Epidermal Ca2+ Gradient: Measurement Using the Phasor Representation of Fluorescent Lifetime Imaging

Celli, A., Sánchez, S. A., Behne, M. J., Hazlett, T. L., Gratton, E., & Mauro, T. M. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.10.055 · Cited by 123

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Ohno, Y., Kamiyama, N., Nakamichi, S., & Kihara, A. (2017) · Nature Communications · doi:10.1038/ncomms14610 · Cited by 121

Minimally invasive skin tape strip RNA sequencing identifies novel characteristics of the type 2–high atopic dermatitis disease endotype

Dyjack, N. T., Goleva, E., Rios, C. L., Kim, B. E., Bin, L., Taylor, P. A., Bronchick, C., Hall, C. F., Richers, B. N., Seibold, M. A., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.10.046 · Cited by 121

Th2 Cytokines Increase Staphylococcus aureus Alpha Toxin–Induced Keratinocyte Death through the Signal Transducer and Activator of Transcription 6 (STAT6)

Brauweiler, A. M., Goleva, E., & Leung, D. Y. M. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.43 · Cited by 116

Interleukin-9 Induces Goblet Cell Hyperplasia during Repair of Human Airway Epithelia

Vermeer, P. D., Harson, R., Einwalter, L. A., Moninger, T., & Zabner, J. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4887 · Cited by 111

Epithelial origin of eosinophilic esophagitis

Rochman, M., Azouz, N. P., & Rothenberg, M. E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.05.008 · Cited by 111

Staphylococcal exotoxins are strong inducers of IL-22: A potential role in atopic dermatitis

Niebuhr, M., Scharonow, H., Gathmann, M., Mamerow, D., & Werfel, T. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.07.041 · Cited by 110

Thymic stromal lymphopoietin–mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis

Han, H., Thelen, T. D., Comeau, M. R., & Ziegler, S. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci77798 · Cited by 109

Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis

Benedetto, A. D., Slifka, M. K., Rafaels, N. M., Kuo, I., Georas, S. N., Boguniewicz, M., Hata, T. R., Schneider, L. C., Hanifin, J. M., Gallo, R. L., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.014 · Cited by 104

Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients

Loxham, M., & Davies, D. E. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.04.005 · Cited by 104

Epithelial Injury and Repair in Airways Diseases

Grainge, C., & Davies, D. E. (2013) · CHEST Journal · doi:10.1378/chest.12-1944 · Cited by 100

An Innate Bactericidal Oleic Acid Effective Against Skin Infection of Methicillin-Resistant Staphylococcus aureus: A Therapy Concordant with Evolutionary Medicine

Chen, C.-H., Wang, Y., Nakatsuji, T., Liu, Y.-T., Zouboulis, C. C., Gallo, R. L., Zhang, L., Hsieh, M.-F., & Huang, C.-M. (2011) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1011.11014 · Cited by 94

Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis

Rochman, M., Travers, J., Miracle, C. E., Bedard, M. C., Wen, T., Azouz, N. P., Caldwell, J. M., Kiran, K. C., Sherrill, J. D., Davis, B. P., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.11.042 · Cited by 90

Emerging role of Notch signaling in epidermal differentiation and skin cancer

Panelos, J., & Massi, D. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.21.9921 · Cited by 85

DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss‐of‐function variants

Ziyab, A. H., Karmaus, W., Holloway, J. W., Zhang, H., Ewart, S., & Arshad, S. H. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12000 · Cited by 84

New Insights in Oxidant Biology in Asthma

ERZURUM, S. C. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201506-385mg · Cited by 82

Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci

Martin, L. J., He, H., Collins, M. H., Abonia, J. P., Myers, J. M. B., Eby, M. D., Johansson, H., Kottyan, L. C., Hershey, G. K. K., & Rothenberg, M. E. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.046 · Cited by 82

IL-33 promotes gastrointestinal allergy in a TSLP-independent manner

Han, H., Roan, F., Johnston, L. K., Smith, D. E., Bryce, P. J., & Ziegler, S. F. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.61 · Cited by 81

Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity

Wallace, L., Roberts-Thompson, L., & Reichelt, J. (2012) · Journal of Cell Science · doi:10.1242/jcs.097139 · Cited by 80

Staphylococcus aureus α-toxin modulates skin host response to viral infection

Bin, L., Kim, B. E., Brauweiler, A. M., Goleva, E., Streib, J. E., Ji, Y., Schlievert, P. M., & Leung, D. Y. M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.06.019 · Cited by 78

Infected atopic dermatitis lesions contain pharmacologic amounts of lipoteichoic acid

Travers, J. B., Kozman, A., Mousdicas, N., Saha, C., Landis, M. N., Al‐Hassani, M., Yao, W., Yao, Y., Hyatt, A.-M., Sheehan, M. P., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.052 · Cited by 78

Lipid abnormalities and lipid-based repair strategies in atopic dermatitis

Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.001 · Cited by 78

Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis

Cai, S. C. S., Chen, H., Koh, W., Common, J., Bever, H. P. V., McLean, W. H. I., Lane, E. B., Giam, Y. C., & Tang, M. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10541.x · Cited by 77

Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin–induced keratinocyte death

Brauweiler, A. M., Bin, L., Kim, B. E., Oyoshi, M. K., Geha, R. S., Goleva, E., & Leung, D. Y. M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.10.030 · Cited by 76

In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification

Pendaries, V., Lamer, M. L., Cau, L., Hansmann, B., Malaisse, J., Kežić, S., Serre, G., & Simon, M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.29 · Cited by 75

Beyond epithelial‐to‐mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma

Loffredo, L. F., Abdala‐Valencia, H., Anekalla, K. R., Cuervo‐Pardo, L., Gottardi, C. J., & Berdnikovs, S. (2017) · Allergy · doi:10.1111/all.13222 · Cited by 74

DAMP molecules S100A9 and S100A8 activated by IL ‐17A and house‐dust mites are increased in atopic dermatitis

Jin, S., Park, C. O., Shin, J. U., Noh, J. Y., Lee, Y. S., Lee, N. R., Kim, H. R., Noh, S., Lee, Y., Lee, J., et al. (2014) · Experimental Dermatology · doi:10.1111/exd.12563 · Cited by 72

Epidermal thymic stromal lymphopoietin predicts the development of atopic dermatitis during infancy

Kim, J., Kim, B. E., Lee, J., Han, Y., Jun, H.-Y., Kim, H., Choi, J., Leung, D. Y. M., & Ahn, K. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.12.1306 · Cited by 72

Uncommon Filaggrin Variants Are Associated with Persistent Atopic Dermatitis in African Americans

Margolis, D. J., Mitra, N., Gochnauer, H. R., Wubbenhorst, B. S., D'Andrea, K. P., Kraya, A., Hoffstad, O., Gupta, J., Kim, B., Yan, A. C., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.01.029 · Cited by 72

Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

Akdiş, C. A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00538-7 · Cited by 1,066

Type 2 immunity in the skin and lungs

Akdiş, C. A., Arkwright, P. D., Brüggen, M., Busse, W. W., Gadina, M., Guttman‐Yassky, E., Kabashima, K., Mitamura, Y., Vian, L., Wu, J., et al. (2020) · Allergy · doi:10.1111/all.14318 · Cited by 594

Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

Jiang, Y., Tsoi, L. C., Billi, A. C., Ward, N. L., Harms, P. W., Zeng, C., Maverakis, E., Kahlenberg, J. M., & Gudjonsson, J. E. (2020) · JCI Insight · doi:10.1172/jci.insight.142067 · Cited by 381

Update on the Pathogenesis and Therapy of Atopic Dermatitis

Li, H., Zhang, Z., Zhang, H., Guo, Y., & Yao, Z. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08880-3 · Cited by 277

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Breiteneder, H., Peng, Y., Agache, I. O., Diamant, Z., Eiwegger, T., Fokkens, W. J., Traidl‐Hoffmann, C., Nadeau, K. C., O’Hehir, R. E., O’Mahony, L., et al. (2020) · Allergy · doi:10.1111/all.14582 · Cited by 257

Cutaneous barrier dysfunction in allergic diseases

Leung, D. Y. M., Berdyshev, E., & Goleva, E. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.02.021 · Cited by 190

The Skin as a Route of Allergen Exposure: Part I. Immune Components and Mechanisms

Smith, A. R., Knaysi, G. A., Wilson, J. M., & Wiśniewski, J. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0674-5 · Cited by 38

Epithelial Barrier Dysfunction in Atopic Dermatitis, Allergic Contact Dermatitis, and Chronic Spontaneous Urticaria and its Therapeutic Implications

Lawrence, C. N., Kohli, H., & Brar, K. (2026) · Current Allergy and Asthma Reports · doi:10.1007/s11882-026-01275-4 · Cited by 2

The Role of Defective Epithelial Barriers in Allergic Lung Disease and Asthma Development

Noureddine, N., Chałubiński, M., & Wawrzyniak, P. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-220260 · Cited by 19

Epidermal Barrier Dysfunction in Atopic Dermatitis

Gomes, T. F., Calado, R., & Gonçalo, M. (2021) · Journal of the Portuguese Society of Dermatology and Venereology · doi:10.29021/spdv.79.3.1405 · Cited by 6