The gut-bone axis: how bacterial metabolites bridge the distance

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549

Regulatory T Cells and Immune Tolerance

Sakaguchi, S., Yamaguchi, T., Nomura, T., & Ono, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.009 · Cited by 5,475

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838

Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752

The impact of the gut microbiota on human health: an integrative view

Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283

Short chain fatty acids in human large intestine, portal, hepatic and venous blood

Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119

Next-generation probiotics and engineered BEVs for precision therapeutics in osteoporosis

Wei, J., Ding, W., Song, K., Zhang, Y., Luo, Q., & Qi, C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1581971 · Cited by 30

The gut–bone axis in osteoporosis: a multifaceted interaction with implications for bone health

Gu, C., Du, H., Li, N., Zhou, Y., Li, S., Sun, Y., Han, Y., Xu, X., & Li, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1569152 · Cited by 32

Isovaleric acid ameliorates ovariectomy‐induced osteoporosis by inhibiting osteoclast differentiation

Cho, K. M., Kim, Y. S., Lee, M., Lee, H. Y., & Bae, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16482 · Cited by 29

Piezoelectric Microvibration Mitigates Estrogen Loss-Induced Osteoporosis and Promotes Piezo1, MicroRNA-29a, and Wnt3a Signaling in Osteoblasts

Wu, R., Lian, W., Chen, Y., Ko, J., Wang, S.-Y., Jahr, H., & Wang, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179476 · Cited by 30

A review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies

Zhou, D., Song, C., Mei, Y., Cheng, K., Liu, F., Cai, W., Gao, S., Wang, Z., & Liu, Z. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03869-4 · Cited by 30

Plasma high-resolution metabolomics identifies linoleic acid and linked metabolic pathways associated with bone mineral density

Bellissimo, M. P., Ziegler, T. R., Jones, D. P., Liu, K., Fernandes, J., Roberts, J. L., Weitzmann, M. N., Pacifici, R., & Alvarez, J. A. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.05.041 · Cited by 29

Dietary Resistant Starch From Potato Regulates Bone Mass by Modulating Gut Microbiota and Concomitant Short-Chain Fatty Acids Production in Meat Ducks

Zhang, H., Qin, S., Zhu, Y., Zhang, X., Du, P., Huang, Y., Michiels, J., Zeng, Q., & Chen, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.860086 · Cited by 29

Integrated Fecal Microbiome and Metabolomics Reveals a Novel Potential Biomarker for Predicting Tibial Dyschondroplasia in Chickens

Huang, S., Zhang, C., Xu, T., Shaukat, A., He, Y., Chen, P., Lin, L., Yue, K., Cao, Q., & Tong, X. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.887207 · Cited by 28

A review of mathematical modeling of bone remodeling from a systems biology perspective

Cook, C. V., Lighty, A. M., Smith, B. J., & Ford Versypt, A. N. (2024) · Frontiers in Systems Biology · doi:10.3389/fsysb.2024.1368555 · Cited by 25

Polysaccharides to postbiotics: Nurturing bone health via modulating “gut-immune axis”

Yadav, S., Sapra, L., & Srivastava, R. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134655 · Cited by 29

Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders

Wang, Y., Gao, X., Lv, J., Zeng, Y. H., Li, Q., Wang, L., Zhang, Y., Gao, W., & Wang, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.827575 · Cited by 26

Protective Effects of the Postbiotic Lactobacillus plantarum MD35 on Bone Loss in an Ovariectomized Mice Model

Myeong, J.-Y., Jung, H.-Y., Chae, H.-S., Cho, H. H., Kim, D., Jang, Y.-J., & Park, J.-I. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10065-7 · Cited by 26

Microbiome mediation of animal life histories via metabolites and insulin‐like signalling

Warne, R. W., & Dallas, J. W. (2022) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12833 · Cited by 24

The Pathology and Physiology of Ileostomy

Ma, H., Li, X., Yang, H., Qiu, Y., & Xiao, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.842198 · Cited by 29

The Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis

Guo, M., He, S., Song, W., Mai, J., Yuan, X., Huang, Y., Xi, H., Sun, G., Chen, Y., Du, B., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05813-4 · Cited by 25

The interplay of estrogen, gut microbiome, and bone immunity in osteoporosis

Chen, M., Wang, J., Yang, Y., He, Y., & Li, L. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02538-9 · Cited by 28

Gut microbiota preserves bone mass through modulating the hyodeoxycholic acid–TGR5 axis

Zheng, X.-Q., Huang, J., Yuan, W.-Q., Wu, T., Wang, H., Liu, H., Zhang, Y.-D., He, J., Huang, C., & Song, C. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2593088 · Cited by 26

Low Ca diet leads to increased Ca retention by changing the gut flora and ileal pH value in laying hens

Jiang, S., Zou, X.-Y., Mao, M., Zhang, M., Tu, W., & Jin, M.-L. (2023) · Animal Nutrition · doi:10.1016/j.aninu.2023.02.006 · Cited by 24

Health Benefits of Dairy Products’ Consumption—Consumer Point of View

Jakubowska, D., Dąbrowska, A. Z., Staniewska, K., Kiełczewska, K., Przybyłowicz, K. E., Żulewska, J., & Łobacz, A. (2024) · Foods · doi:10.3390/foods13233925 · Cited by 23

Deciphering the gut microbiome’s metabolic code: pathways to bone health and novel therapeutic avenues

Hwang, D., Chong, E. G., Li, Y., Li, Y., & Roh, K. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1553655 · Cited by 29

Acidification of drinking water improved tibia mass of broilers through the alterations of intestinal barrier and microbiota

Zhang, H.-Y., Guo, Y., Wang, Z.-Y., Wang, Y.-S., Chen, B., Du, P.-F., Zhang, X.-L., Huang, Y.-Q., Li, P., Michiels, J., et al. (2022) · Animal bioscience · doi:10.5713/ab.21.0455 · Cited by 23

Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis

Zhou, R.-X., Zhang, Y., Cao, M., Liu, C.-H., Rui, Y., & Li, Y. (2023) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-023-01415-0 · Cited by 25

The genetically predicted causal relationship of inflammatory bowel disease with bone mineral density and osteoporosis: evidence from two-sample Mendelian randomization

Xu, D., Chen, Y., Gao, X. H., Xie, W., Wang, Y., Shen, J., Yang, G., & Xie, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148107 · Cited by 23

Does the gut microbiome influence disc health and disease? The interplay between dysbiosis, pathobionts, and disc inflammation: a pilot study

Rajasekaran, S., Vasudevan, G., Tangavel, C., Ramachandran, K., Nayagam, S. M., Muthurajan, R., Gopalakrishnan, C., Anand, K. S. S. V., Shetty, A. P., & Kanna, R. M. (2024) · The Spine Journal · doi:10.1016/j.spinee.2024.06.020 · Cited by 23

Associations between gut microbiota and osteoporosis or osteopenia in a cohort of Chinese Han youth

Lai, J., Gong, L., Liu, Y., Zhang, X., Liu, W., Han, M., Zhou, D., & Shi, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-71731-6 · Cited by 24

Gut microbiota and fecal metabolic signatures in rat models of disuse-induced osteoporosis

Qiao, X., Zhang, K., Li, X., Lv, Z., Wei, W., Zhou, R., Yan, L., Pan, Y., Yang, S., Sun, X., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1018897 · Cited by 22

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Foessl, I., Bassett, J. H. D., Bjørnerem, Å., Busse, B., Calado, Â., Chavassieux, P., Christou, M., Douni, E. K., Fiedler, I. A. K., Fonseca, J. E., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.720728 · Cited by 22

T cells heal bone fractures with help from the gut microbiome

Aurora, R., & Silva, M. J. (2023) · Journal of Clinical Investigation · doi:10.1172/jci167311 · Cited by 21

Gut–X Axis and Its Role in Poultry Bone Health: A Review

Yanan, L., Yue, T.-J., Ding, W., Xu, B., Li, J., & Huang, S. (2025) · Microorganisms · doi:10.3390/microorganisms13040757 · Cited by 22

Gut Microbiota Regulates Brain–Bone Axis to Influence Osteoporosis Pathogenesis and Treatment

Shi, H., Huang, L., Zhang, J. H., Shen, C., Zhang, N., Lv, C., Shao, L., Li, M., Sun, Z., Shi, L., et al. (2026) · Research · doi:10.34133/research.1178 · Cited by 21

An update on the effects of food-derived active peptides on the intestinal microecology

Mu, J., Lin, Q., & Liang, Y. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2094889 · Cited by 21

Yogurt Benefits Bone Mineralization in Ovariectomized Rats with Concomitant Modulation of the Gut Microbiome

He, W., Xie, Z., Wittig, N. K., Zachariassen, L. F., Andersen, A., Andersen, H. J., Birkedal, H., Nielsen, D. S., Hansen, A. K., & Bertram, H. C. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200174 · Cited by 22

Metabolic crosstalk between stromal and malignant cells in the bone marrow niche

Tirado, H. A., Balasundaram, N., Laaouimir, L., Erdem, A., & van Gastel, N. (2023) · Bone Reports · doi:10.1016/j.bonr.2023.101669 · Cited by 25

Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone mass

Lawenius, L., Cowardin, C. A., Grahnemo, L., Scheffler, J. M., Horkeby, K., Engdahl, C., Wu, J., Vandenput, L., Koskela, A., Tuukkanen, J., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2236755 · Cited by 23

Blackcurrants shape gut microbiota profile and reduce risk of postmenopausal osteoporosis via the gut-bone axis: Evidence from a pilot randomized controlled trial

Nosal, B. M., Thornton, S., Mofrad, M. D., Sakaki, J. R., Mahoney, K. J., Macdonald, Z., Daddi, L., Tran, T. D. B., Weinstock, G. M., Zhou, Y., et al. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109701 · Cited by 24

Causal associations between gut microbiota with intervertebral disk degeneration, low back pain, and sciatica: a Mendelian randomization study

Fang, M., Liu, W., Wang, Z., Li, J., Hu, S., Li, Z., Chen, W., & Zhang, N. (2024) · European Spine Journal · doi:10.1007/s00586-024-08131-x · Cited by 20

Immune cells: the key mediator between the gut microbiota and osteoporosis

Ma, T., Zhang, T., Peng, C., Liu, K., Xiong, Y., Chen, K., Peng, N., Wei, Z., Kuang, J., & Ou, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1680021 · Cited by 22

Vitamin K in CKD Bone Disorders

Fusaro, M., Cianciolo, G., Evenepoel, P., Schurgers, L. J., & Plebani, M. (2021) · Calcified Tissue International · doi:10.1007/s00223-020-00792-2 · Cited by 20

Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis

Madel, M., Halper, J., Ibáñez, L., Claire, L., Rouleau, M., Boutin, A., Mahler, A., Pontier-Bres, R., Ciucci, T., Topi, M., et al. (2023) · eLife · doi:10.7554/elife.82037 · Cited by 21

Prebiotics Beyond the Gut: Omics Insights, Artificial Intelligence, and Clinical Trials in Organ-Specific Applications

Al-Adham, I. S. I., Agha, A. S. A. A., Al‐Akayleh, F., Al-Remawi, M. M., Jaber, N., Al-Manasur, M. A., & Collier, P. J. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10465-x · Cited by 19

Mild stimulatory effect of a probiotic mix on bone mass when treatment is initiated 1.5 weeks after ovariectomy in mice

Ohlsson, C., Lawenius, L., Andersson, A., Gustafsson, K., Wu, J., Lagerquist, M. K., Movérare‐Skrtic, S., Islander, U., & Sjögren, K. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00412.2020 · Cited by 18

Gut Microbiota Characteristics Are Associated With Severity of Acute Radiation-Induced Esophagitis

Lin, M.-Q., Wu, Y., Yang, J., Lin, H., Liu, L., Yu, Y., Yao, Q., & Li, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.883650 · Cited by 18

Early hematopoietic injury triggered by benzene characterized with inhibition of erythrocyte differentiation involving the mollicutes_RF39-derived citrulline

Zhang, L., Lin, H., Liu, Z., Jing, J., Wang, J., Zhang, W., & Gao, A. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135009 · Cited by 18

Altered Intestinal Microbiomes and Lipid Metabolism in Patients With Prolonged Disorders of Consciousness

Luo, B., Yu, J., He, F., He, F., Meng, F., Xu, C., Xu, C., Wen, X., 洪丽蓉, Gao, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.781148 · Cited by 18

Gut Microbiome - Should we treat the gut and not the bones?

Jeyaraman, M., Nallakumarasamy, A., & Jain, V. K. (2023) · Journal of Clinical Orthopaedics and Trauma · doi:10.1016/j.jcot.2023.102149 · Cited by 18

The probiotic Lactiplantibacillus plantarum attenuates ovariectomy-induced osteoporosis through osteoimmunological signaling

Tsai, W.-H., Lin, W., Chou, C., & Yang, L.-C. (2023) · Food & Function · doi:10.1039/d3fo00681f · Cited by 18

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Fisher, L., Fisher, A., & Smith, P. N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103253 · Cited by 18

The Potential Value of Probiotics after Dental Implant Placement

Xu, J., Chen, C., Gan, S., Liao, Y., Fu, R., Hou, C., Yang, S., Zheng, Z., & Chen, W. (2023) · Microorganisms · doi:10.3390/microorganisms11071845 · Cited by 20

Prebiotics as modulators of colonic calcium and magnesium uptake

Stumpff, F., & Manneck, D. (2025) · Acta Physiologica · doi:10.1111/apha.14262 · Cited by 17

Intermittent fasting and bone health: a bone of contention?

Clayton, D. J., Varley, I., & Papageorgiou, M. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523000545 · Cited by 17

MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients

Heidt, C., Pons‐Kühnemann, J., Kämmerer, U., Marquardt, T., & Reuss-Borst, M. A. (2023) · Nutrients · doi:10.3390/nu15173719 · Cited by 17

Grape seed extract prevents oestrogen deficiency‐induced bone loss by modulating the gut microbiota and metabolites

Lu, L., Li, J., Liu, L., Wang, C., Xie, Y., Yu, X., & Tian, L. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.14485 · Cited by 17

Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice

Maeda, Y., Rabenow, M., Xiang, W., Schmid, E., Otterbein, N., Gimaev, I., Amend, L., Riedinger, L., Ehnes, L., Miyagawa, I., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116755 · Cited by 16

Gut microbiota and bone aging: Focusing on the gut-X axis modes

Zhang, Y.-W., Li, R.-Y., Wu, Y., Wang, P., Zhou, Q., & Su, J. (2026) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2026.101064 · Cited by 17

Genetically determined SCFA concentration modifies the association of dietary fiber intake with changes in bone mineral density during weight loss: The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial

Zhou, T., Sun, D., Li, X., Heianza, Y., LeBoff, M. S., Bray, G. A., Sacks, F. M., & Qi, L. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab037 · Cited by 15

Effects of intestinal microbes on rheumatic diseases: A bibliometric analysis

Huang, R., Zhang, M., Lu, Y., Xu, D., Liu, Y., Jin, M., Xian, S., Wang, S., Tong, X., Lu, J., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1074003 · Cited by 15

Post Hoc Analysis of a Randomized Controlled Trial on Fasting and Plant-Based Diet in Rheumatoid Arthritis (NutriFast): Nutritional Supply and Impact on Dietary Behavior

Hartmann, A. M., D'Urso, M., Dell’Oro, M., Koppold, D. A., Steckhan, N., Michalsen, A., Kandil, F. I., & Keßler, C. S. (2023) · Nutrients · doi:10.3390/nu15040851 · Cited by 16

Mitigating lead-induced osteoporosis: The role of butyrate in gut-bone axis restoration

Ge, Y., Jia, Z., Zhao, S., Zhang, W., Shi, X., Xie, R., Gong, Y., Sheng, J., Hof, R. V., Yang, J., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116943 · Cited by 15

Dietary fiber derived short-chain fatty acids as a critical driver of the gut–bone axis in animal bone health: A review

Zulfiqar, Z., Huang, S., & Shi, Y. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.05.002 · Cited by 17

Crosstalk Between Microbiome and Ferroptosis in Diseases: From Mechanism to Therapy

Ding, S., Lei, Y., Zhao, Z., Li, X., Lang, J., Zhang, J., Li, Y., Zhang, C., & Dai, D. (2025) · Comprehensive physiology · doi:10.1002/cph4.70042 · Cited by 15

Diallyl trisulfide ameliorates bone loss and alters specific gut microbiota and serum metabolites in natural aging mice

Zhang, F., Xu, J., Hu, Y., Fang, J., Yang, M., Huang, K., Xu, W., & He, X. (2023) · Food & Function · doi:10.1039/d3fo01840g · Cited by 14

Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in mice with diabetes mellitus

Zhang, Y., Lu, M., Zhang, Y., Yuan, X., Zhou, M., Xu, X., Zhang, T., & Song, J. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15058 · Cited by 14

Cistanche deserticola improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acids

Yang, F., Liu, C., Lu, X., Liu, S., Zhang, Y., Yu, Y. H., & Long, Y. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105925 · Cited by 14

Effector memory CD4+T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance

Ono-Ohmachi, A., Yamada, S., Uno, S., Tamai, M., Soga, K., Nakamura, S., Udagawa, N., Nakamichi, Y., Koide, M., Morita, Y., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00434-2 · Cited by 15

Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review

Chen, Y., Xie, Y., & Yu, X. (2025) · Frontiers of Medicine · doi:10.1007/s11684-025-1129-3 · Cited by 16

Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity

Zhang, L., Liu, Z., Zhang, W., Wang, J., Kang, H., Jing, J., Lin, H., & Gao, A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2323227 · Cited by 14

Recent Progress of Oral Functional Nanomaterials for Intestinal Microbiota Regulation

Li, W., Zhan, M., Wen, Y., Chen, Y., Zhang, Z., Wang, S., Tian, D., & Tian, S. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16070921 · Cited by 14

Gut microbiome-targeted therapies and bone health across the lifespan: a scoping review

Mehta, M., Hodgson, E., Reimer, R. A., & Gabel, L. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2397459 · Cited by 13

The gut microbiota can be a potential regulator and treatment target of bone metastasis

Contino, K. F., Yadav, H., & Shiozawa, Y. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114916 · Cited by 14

Dynamic Alteration of the Gut Microbiota Associated with Obesity and Intestinal Inflammation in Ovariectomy C57BL/6 Mice

Zhao, H., Wang, Q., Hu, L., Xing, S., Gong, H., Liu, Z., Qin, P., Xu, J., Du, J., Ai, W., et al. (2022) · International Journal of Endocrinology · doi:10.1155/2022/6600158 · Cited by 13

Sequestration of Intestinal Acidic Toxins by Cationic Resin Attenuates Pancreatic Cancer Progression through Promoting Autophagic Flux for YAP Degradation

Zhao, G., Zhang, T., Liu, W. C., Edderkaoui, M., Hu, R., Li, J., Pandol, S. J., Fu, X., & Han, Y. (2022) · Cancers · doi:10.3390/cancers14061407 · Cited by 12

Emerging nanotherapeutic strategies targeting gut-X axis against diseases

Sun, A., Liu, H., Sun, M., Yang, W., Liu, J., Lin, Y., Shi, X., Sun, J. Y., & Liu, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115577 · Cited by 13

Lacticaseibacillus rhamnosus GG Improves Periodontal Bone Repair via Gut–Blood Axis in Hyperlipidemia

Huang, Y., Ge, R., Qian, J., Lu, J., Qiao, D., Chen, R., Jiang, H., Cui, D., Zhang, T., Wang, N., et al. (2024) · Journal of Dental Research · doi:10.1177/00220345231217402 · Cited by 13

The Improvement and Related Mechanism of Microecologics on the Sports Performance and Post-Exercise Recovery of Athletes: A Narrative Review

Yang, K., Chen, Y., Wang, M., Zhang, Y., Yuan, Y. J., Hou, H., & Mao, Y.-H. (2024) · Nutrients · doi:10.3390/nu16111602 · Cited by 14

Natural Products as Potential Bone Therapies

Wong, M., Poon, C. C., Zhou, L., & Xiao, H.-H. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_322 · Cited by 12

Mathematical Modeling of the Gut–Bone Axis and Implications of Butyrate Treatment on Osteoimmunology

Islam, M. A., Cook, C. V., Smith, B. J., & Versypt, A. N. F. (2021) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.1c02949 · Cited by 12

Supplemental effect of Pediococcus acidilactici CNCM I-4622 probiotic on the laying characteristics and calcium and phosphorus metabolism in laying hens

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