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The gut-bone axis: how bacterial metabolites bridge the distance
Open accessAbstract
The gut microbiome is a key regulator of bone health that affects postnatal skeletal development and skeletal involution. Alterations in microbiota composition and host responses to the microbiota contribute to pathological bone loss, while changes in microbiota composition that prevent, or reverse, bone loss may be achieved by nutritional supplements with prebiotics and probiotics. One mechanism whereby microbes influence organs of the body is through the production of metabolites that diffuse from the gut into the systemic circulation. Recently, short-chain fatty acids (SCFAs), which are generated by fermentation of complex carbohydrates, have emerged as key regulatory metabolites produced by the gut microbiota. This Review will focus on the effects of SCFAs on the musculoskeletal system and discuss the mechanisms whereby SCFAs regulate bone cells.
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“Beyond their influence on the GI tract, SCFAs have emerged as potent regulators of osteoclast activity and bone metabolism [31].”
From Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics (2023) · cites this paper as [31]
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From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
Regulatory T Cells and Immune Tolerance
Sakaguchi, S., Yamaguchi, T., Nomura, T., & Ono, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.009 · Cited by 5,475
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis
Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., Junt, T., Nicod, L. P., Harris, N. L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3444 · Cited by 2,862
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
Gibson, G. R., Probert, H. M., Loo, J. V., Rastall, R. A., & Roberfroid, M. B. (2004) · Nutrition Research Reviews · doi:10.1079/nrr200479 · Cited by 2,539
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368
Chang, P. V., Hao, L., Offermanns, S., & Medzhitov, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322269111 · Cited by 2,175
Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003 · cited 1×
“In addition, efficient intestinal barrier function can be restored upon supplementation of butyrate to the diet (85).”
BackgroundCox, L. M., Yamanishi, S., Sohn, J., Alekseyenko, A. V., Leung, J. M., Cho, I., Kim, S. G., Li, H., Gao, Z., Mahana, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.052 · Cited by 1,859
Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716
NFAT proteins: key regulators of T-cell development and function
Macián, F. (2005) · Nature reviews. Immunology · doi:10.1038/nri1632 · Cited by 1,624
Antibiotics in early life alter the murine colonic microbiome and adiposity
Cho, I., Yamanishi, S., Cox, L., Methé, B. A., Zavadil, J., Li, K., Gao, Z., Mahana, D., Raju, K., Teitler, I., et al. (2012) · Nature · doi:10.1038/nature11400 · Cited by 1,613
Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558
Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7734 · Cited by 1,439
Regulation of bone mass by Wnt signaling
Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407
Regulation of immune cell function by short‐chain fatty acids
Corrêa‐Oliveira, R., Fachi, J. L., Vieira, A., Sato, F. T., & Vinolo, M. A. R. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.17 · Cited by 1,346
Reichardt, N., Duncan, S. H., Young, P., Belenguer, Á., Leitch, E. C. M., Scott, K. P., Flint, H. J., & Louis, P. (2014) · The ISME Journal · doi:10.1038/ismej.2014.14 · Cited by 1,327
Feng, X., & McDonald, J. M. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130203 · Cited by 1,272 · cited 1×
“Skeletal involution is determined by the process of bone remodeling, which involves the continuous removal of packets of old bone by the resorptive action of osteoclasts, and their replacement by new bone formed by osteoblasts (1, 2).”
BackgroundKato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086
Calcium signalling in lymphocyte activation and disease
Feske, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2152 · Cited by 1,043
Sodium butyrate inhibits histone deacetylation in cultured cells
Candido, E. (1978) · Cell · doi:10.1016/0092-8674(78)90305-7 · Cited by 1,036
Links between diet, gut microbiota composition and gut metabolism
Flint, H. J., Duncan, S. H., Scott, K. P., & Louis, P. (2015) · Proceedings of the Nutrition Society · doi:10.1017/s0029665114001463 · Cited by 1,020
Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine
Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.-H., May, C., Wilck, N., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.007 · Cited by 927
The role of microbial amino acid metabolism in host metabolism
Neis, E., Dejong, C., & Rensen, S. (2015) · Nutrients · doi:10.3390/nu7042930 · Cited by 920
LeBlanc, J. G., Chain, F., Martín, R., Bermúdez‐Humarán, L. G., Courau, S., & Langella, P. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0691-z · Cited by 912
Regulation of osteoblastogenesis and bone mass by Wnt10b
Bennett, C. N., Longo, K. A., Hahn, W. S., Suva, L. J., Lane, T. F., Hankenson, K. D., & MacDougald, O. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408742102 · Cited by 898
The gut microbiota regulates bone mass in mice
Sjögren, K., Engdahl, C., Henning, P., Lerner, U. H., Tremaroli, V., Lagerquist, M. K., Bäckhed, F., & Ohlsson, C. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1588 · Cited by 822
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
Lucas, S., Omata, Y., Hofmann, J., Böttcher, M., Iljazovic, A., Sarter, K., Albrecht, O., Schulz, O., Krishnacoumar, B., Krönke, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02490-4 · Cited by 815
Self-citationLouis, P., Young, P., Holtrop, G., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02066.x · Cited by 798
Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4466 · Cited by 789
n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells
Riggs, M. G., WHITTAKER, R. G., Neumann, J. R., & Ingram, V. M. (1977) · Nature · doi:10.1038/268462a0 · Cited by 777
Understanding the effects of diet on bacterial metabolism in the large intestine
Louis, P., Scott, K. P., Duncan, S. H., & Flint, H. J. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03322.x · Cited by 775
Gut microbiota induce IGF-1 and promote bone formation and growth
Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., Sartor, B. R., Aliprantis, A. O., & Charles, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607235113 · Cited by 750
Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
Jilka, R. L. (2007) · Bone · doi:10.1016/j.bone.2007.03.017 · Cited by 736
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children
Blanton, L. V., Charbonneau, M. R., Salih, T., Barratt, M. J., Venkatesh, S., Ilkaveya, O., Subramanian, S., Manary, M. J., Trehan, I., Jorgensen, J. M., et al. (2016) · Science · doi:10.1126/science.aad3311 · Cited by 735 · cited 1×
“More-over, animal studies have revealed that BMD is altered by the ablation of the gut microbiome, as it occurs in mice raised in germ-free (GF) conditions (7–9), and in mice treated with antibiotics (10–12).”
BackgroundTranscriptional Mechanisms Underlying Lymphocyte Tolerance
Macián, F., Garcia-Cozar, F. J., Im, S., Horton, H. F., Byrne, M. C., & Rao, A. (2002) · Cell · doi:10.1016/s0092-8674(02)00767-5 · Cited by 687
Mariño, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., et al. (2017) · Nature Immunology · doi:10.1038/ni.3713 · Cited by 686
Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics
Li, J.-Y., Chassaing, B., Tyagi, A. M., Vaccaro, C., Luo, T., Adams, J., Darby, T. M., Weitzmann, M. N., Mulle, J. G., Gewirtz, A. T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86062 · Cited by 643
Self-citationWaldecker, M., Kautenburger, T., Daumann, H., Busch, C., & Schrenk, D. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.08.002 · Cited by 615 · cited 1×
“In addition, SCFAs inhibit histone deacetylases (HDACs) and stimulate histone acetyl-transferase (53, 56, 77, 78) (Figure 1).”
BackgroundScholz-Ahrens, K. E., Ade, P., Marten, B., Weber, P., Timm, W., Asil, Y., Glüer, C.-C., & Schrezenmeir, J. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.3.838s · Cited by 591
Tyagi, A. M., Yu, M., Darby, T. M., Vaccaro, C., Li, J., Owens, J. A., Hsu, E., Adams, J., Weitzmann, M. N., Jones, R. M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.013 · Cited by 589
Self-citationIn vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche
Fujisaki, J., Wu, J. W., Carlson, A. L., Silberstein, L., Putheti, P., Larocca, R. A., Gao, W., Saito, T. I., Celso, C. L., Tsuyuzaki, H., et al. (2011) · Nature · doi:10.1038/nature10160 · Cited by 570
Fellows, R., Denizot, J., Stellato, C., Cuomo, A., Jain, P., Stoyanova, E., Balázsi, S., Hajnády, Z., Liebert, A., Kazakevych, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02651-5 · Cited by 568
Feedback control of AHR signalling regulates intestinal immunity
Schiering, C., Wincent, E., Metidji, A., Iseppon, A., Li, Y., Potocnik, A. J., Omenetti, S., Henderson, C. J., Wolf, C. R., Nebert, D. W., et al. (2017) · Nature · doi:10.1038/nature21080 · Cited by 543
Abrams, S. A., Griffin, I. J., Hawthorne, K. M., Liang, L. K., Gunn, S., Darlington, G., & Ellis, K. J. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.2.471 · Cited by 534
Probiotic L. reuteri Treatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse Model
Britton, R. A., Irwin, R., Quach, D., Schaefer, L., Zhang, J., Lee, T., Parameswaran, N., & McCabe, L. R. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24636 · Cited by 499
High Bone Mass in Mice Expressing a Mutant LRP5 Gene
Babij, P., Zhao, W., Small, C. G., Kharode, Y. P., Yaworsky, P. J., Bouxsein, M., Reddy, P. S., Bodine, P. V. N., Robinson, J. A., Bhat, B. M., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.960 · Cited by 496
Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora
Miller, T. L., & Wolin, M. J. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.5.1589-1592.1996 · Cited by 481
Parfitt, A. M. (2002) · Bone · doi:10.1016/s8756-3282(01)00642-1 · Cited by 462
Yan, F., & Polk, D. B. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834baa4d · Cited by 447
The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation
Zaiss, M. M., Rapin, A., Lebon, L., Dubey, L. K., Mosconi, I., Sarter, K., Piersigilli, A., Menin, L., Walker, A. W., Rougemont, J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.012 · Cited by 437
Self-citationThe effect of short-chain fatty acids on human monocyte-derived dendritic cells
Nastasi, C., Candela, M., Bonefeld, C. M., Geisler, C., Hansen, M., Krejsgaard, T., Biagi, E., Andersen, M. H., Brigidi, P., Ødum, N., et al. (2015) · Scientific Reports · doi:10.1038/srep16148 · Cited by 414
Jones, R. M., Luo, L., Ardita, C., Richardson, A. N., Kwon, Y. M., Mercante, J. W., Alam, A. M., Gates, C. L., Wu, H., Swanson, P. A., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.224 · Cited by 409
Self-citationAlmeida, M., Li, H., Bellido, T., Manolagas, S. C., & Kousteni, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502168200 · Cited by 403
Treg cells suppress osteoclast formation: A new link between the immune system and bone
Zaiss, M. M., Axmann, R., Zwerina, J., Polzer, K., Gückel, E., Skapenko, A., Schulze‐Koops, H., Horwood, N., Cope, A. P., & Schett, G. A. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23138 · Cited by 402
Self-citationA novel SCFA receptor, the microbiota, and blood pressure regulation
Pluznick, J. (2014) · Gut Microbes · doi:10.4161/gmic.27492 · Cited by 374
Nagpal, R., Wang, S., Ahmadi, S., Hayes, J., Gagliano, J., Subashchandrabose, S., Kitzman, D. W., Becton, T., Read, R., & Yadav, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-30114-4 · Cited by 366
Pomare, E. W., Branch, W. J., & Cummings, J. H. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111847 · Cited by 356
Bourriaud, C., Robins, R. J., Martin, L., Kozlowski, F., Tenailleau, E., Cherbut, C., & Michel, C. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02605.x · Cited by 345
Probiotics Protect Mice from Ovariectomy-Induced Cortical Bone Loss
Ohlsson, C., Engdahl, C., Fåk, F., Andersson, A., Windahl, S. H., Farman, H. H., Movérare-Skrtic, S., Islander, U., & Sjögren, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092368 · Cited by 339
Nilsson, A. G., Sundh, D., Bäckhed, F., & Lorentzon, M. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12805 · Cited by 323
A Crisis in the Treatment of Osteoporosis
Khosla, S., & Shane, E. J. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2888 · Cited by 318
Gut microbiota-derived propionate reduces cancer cell proliferation in the liver
Bindels, L. B., Porporato, P. E., Dewulf, E. M., Verrax, J., Neyrinck, A. M., Martin, J. C., Scott, K. P., Calderón, P. B., Féron, O., Muccioli, G. G., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.409 · Cited by 317
Tahara, Y., Yamazaki, M., Sukigara, H., Motohashi, H., Sasaki, H., Miyakawa, H., Haraguchi, A., Ikeda, Y., Fukuda, S., & Shibata, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-19836-7 · Cited by 317
Blaser, M. J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci78366 · Cited by 303
SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor
Vinolo, M. A. R., Ferguson, G. J., Kulkarni, S., Damoulakis, G., Anderson, K. E., Bohlooly‐Y, M., Stephens, L., Hawkins, P. T., & Curi, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021205 · Cited by 300
The 2015 Dietary Guidelines Advisory Committee Scientific Report: Development and Major Conclusions
Millen, B. E., Abrams, S. A., Adams-Campbell, L. L., Anderson, C. A. M., Brenna, J. T., Campbell, W. W., Clinton, S. K., Hu, F. B., Nelson, M. E., Neuhouser, M. L., et al. (2016) · Advances in Nutrition · doi:10.3945/an.116.012120 · Cited by 298
Wnt signaling and osteoblastogenesis
Bodine, P. V. N., & Komm, B. S. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9002-4 · Cited by 295
Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation
Bennett, C. N., Ouyang, H., Li, Y., Zeng, Q., Gerin, I., Sousa, K. M., Lane, T. F., Krishnan, V., Hankenson, K. D., & MacDougald, O. A. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070810 · Cited by 285
McCabe, L. R., Irwin, R., Schaefer, L., & Britton, R. A. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24340 · Cited by 285
Siavoshian, S., Segain, J.-P., Kornprobst, M., Bonnet, C., Cherbut, C., Galmiche, J.-P., & Blottière, H. M. (2000) · Gut · doi:10.1136/gut.46.4.507 · Cited by 277
Liu, Y., Yang, R., Liu, X., Zhou, Y., Qu, C., Kikuiri, T., Wang, S., Zandi, E., Du, J., Ambudkar, I. S., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.03.005 · Cited by 265
Parathyroid hormone: a double-edged sword for bone metabolism
Qin, L., Raggatt, L. J., & Partridge, N. C. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.01.006 · Cited by 264
Yuille, S., Reichardt, N., Panda, S., Dunbar, H., & Mulder, I. E. (2018) · PLOS ONE · doi:10.1371/journal.pone.0201073 · Cited by 257
Parathyroid hormone (PTH)–induced bone gain is blunted in SOST overexpressing and deficient mice
Krämer, I., Loots, G. G., Studer, A., Keller, H., & Kneissel, M. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090730 · Cited by 247
Diet, Gut Microbiome, and Bone Health
Weaver, C. M. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0257-0 · Cited by 246
Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome
McCabe, L. R., Britton, R. A., & Parameswaran, N. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0292-x · Cited by 242
Diversity analysis of gut microbiota in osteoporosis and osteopenia patients
Wang, J., Wang, Y., Gao, W., Wang, B., Zhao, H., Zeng, Y. H., Ji, Y., & Hao, D. (2017) · PeerJ · doi:10.7717/peerj.3450 · Cited by 241
Molecular analysis of the effect of short-chain fatty acids on intestinal cell proliferation
Blottière, H. M., Buecher, B., Galmiche, J.-P., & Cherbut, C. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2002215 · Cited by 239
Jha, S., Wang, Z., Laucis, N. C., & Bhattacharyya, T. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2565 · Cited by 234
Reactive Oxygen Production Induced by the Gut Microbiota: Pharmacotherapeutic Implications
Jones, R. M., Mercante, J. W., & Neish, A. S. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712799828283 · Cited by 232
Self-citationLactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway
Jones, R. M., Desai, C., Darby, T. M., Luo, L., Wolfarth, A. A., Scharer, C. D., Ardita, C., Reedy, A. R., Keebaugh, E. S., & Neish, A. S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.042 · Cited by 231
Self-citationGuo, J., Liu, M., Yang, D., Bouxsein, M., Saito, H., Galvin, R. J. S., Kuhstoss, S. A., Thomas, C. C., Schipani, E., Baron, R., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.12.007 · Cited by 223
Hydrogen Sulfide Signaling in the Gastrointestinal Tract
Linden, D. R. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5312 · Cited by 222
Rahman, M. M., Kukita, A., Kukita, T., Shobuike, T., Nakamura, T., & Kohashi, O. (2003) · Blood · doi:10.1182/blood-2002-08-2622 · Cited by 216
Tang, Y., Chen, Y., Jiang, H., & Nie, D. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.117 · Cited by 207
Regulation of bone metabolism by Wnt signals
Kobayashi, Y., Uehara, S., Udagawa, N., & Takahashi, N. (2015) · The Journal of Biochemistry · doi:10.1093/jb/mvv124 · Cited by 206
T Lymphocytes Amplify the Anabolic Activity of Parathyroid Hormone through Wnt10b Signaling
Terauchi, M., Li, J., Bedi, B., Baek, K., Tawfeek, H. A. W., Galley, S. A., Gilbert, L. C., Nanes, M. S., Zayzafoon, M., Guldberg, R. E., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.07.010 · Cited by 195
Self-citationMicrobial regulation of host hydrogen sulfide bioavailability and metabolism
Shen, X., Carlström, M., Borniquel, S., Jädert, C., Kevil, C. G., & Lundberg, J. O. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.024 · Cited by 194
Lei, H., Schmidt‐Bleek, K., Dienelt, A., Reinke, P., & Volk, H. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00184 · Cited by 192
Mutuş, R., Kocabağlı, N., Alp, M., Acar, N., Eren, M., & Gezen, Ş. Ş. (2006) · Poultry Science · doi:10.1093/ps/85.9.1621 · Cited by 192
Inulin and oligofructose and mineral metabolism: the evidence from animal trials.
Scholz-Ahrens, K., & Schrezenmeir, J. (2007) · Journal of NutriLife · doi:10.1093/jn/137.11.2513s · Cited by 186
Kim, Y., Lee, C., Nah, S.-S., Mun, S. H., Yoo, B., & Moon, H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.042 · Cited by 180
Bözec, A., Zaiss, M. M., Kagwiria, R., Voll, R. E., Rauh, M., Chen, Z., Mueller-Schmucker, S. M., Kroczek, R. A., Heinzerling, L., Moser, M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007764 · Cited by 178
Self-citationWeaver, C. M., Martin, B. R., Nakatsu, C. H., Armstrong, A. P., Clavijo, A. P., McCabe, L. D., McCabe, G. P., Duignan, S., Schoterman, M. H. C., & van den Heuvel, E. G. H. M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2009777 · Cited by 173
Jafarnejad, S., Djafarian, K., Fazeli, M. R., Yekaninejad, M. S., Rostamian, A., & Keshavarz, S. A. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1318724 · Cited by 172
Gurav, A., Sivaprakasam, S., Bhutia, Y. D., Boettger, T., Singh, N., & Ganapathy, V. (2015) · Biochemical Journal · doi:10.1042/bj20150242 · Cited by 170
The Wnt antagonist secreted frizzled‐related protein‐1 controls osteoblast and osteocyte apoptosis
Bodine, P. V. N., Billiard, J., Moran, R. A., Ponce‐de‐Leon, H., McLarney, S., Mangine, A., Scrimo, M. J., Bhat, R. A., Stauffer, B., Green, J., et al. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20599 · Cited by 167
Stevens, J. R., Miranda‐Carboni, G. A., Singer, M. A., Brugger, S. M., Lyons, K. M., & Lane, T. F. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.118 · Cited by 166
Chonan, O., Matsumoto, K., & Watanuki, M. (1995) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.59.236 · Cited by 164
Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases
Lewiecki, E. M. (2013) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x13510479 · Cited by 164
Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis
Kelchtermans, H., Geboes, L., Mitera, T., Huskens, D., Leclercq, G., & Matthys, P. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.086066 · Cited by 164
Takimoto, T., Hatanaka, M., Hoshino, T., Takara, T., Tanaka, K., Shimizu, A., Morita, H., & Nakamura, T. (2018) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.18-006 · Cited by 158
Zhang, J., Motyl, K. J., Irwin, R., MacDougald, O. A., Britton, R. A., & McCabe, L. R. (2015) · Endocrinology · doi:10.1210/en.2015-1308 · Cited by 153
Alam, A. M., Leoni, G., Wentworth, C. C., Kwal, J., Wu, H., Ardita, C., Swanson, P. A., Lambeth, J. D., Jones, R. M., Nusrat, A., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.84 · Cited by 149
Self-citationModulation of Antimicrobial Host Defense Peptide Gene Expression by Free Fatty Acids
Sunkara, L. T., Jiang, W., & Zhang, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049558 · Cited by 140
Effects of short chain fatty acids on effector mechanisms of neutrophils
Vinolo, M. A. R., Hatanaka, E., Lambertucci, R. H., Newsholme, P., & Curi, R. (2008) · Cell Biochemistry and Function · doi:10.1002/cbf.1533 · Cited by 134
Straub, R. H., Cutolo, M., & Pacifici, R. (2015) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2015.04.014 · Cited by 132
Self-citationWnt signaling in bone and muscle
Rudnicki, M. A., & Williams, B. O. (2015) · Bone · doi:10.1016/j.bone.2015.02.009 · Cited by 132
Dietary Chicory Inulin Increases Whole-Body Bone Mineral Density in Growing Male Rats
Roberfroid, M. B., Cumps, J., & Devogelaer, J. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3599 · Cited by 130
Chiang, S.-S., & Pan, T.-M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2013716 · Cited by 128
Zaiss, M. M., Sarter, K., Hess, A., Engelke, K., Böhm, C., Nimmerjahn, F., Voll, R., Schett, G., & David, J. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27535 · Cited by 122
Self-citationFructooligosaccharide Consumption Enhances Femoral Bone Volume and Mineral Concentrations in Rats
Takahara, S., Morohashi, T., Sano, T., Ohta, A., Yamada, S., & Sasa, R. (2000) · Journal of Nutrition · doi:10.1093/jn/130.7.1792 · Cited by 122
Novince, C. M., Whittow, C. R., Aartun, J. D., Hathaway, J. D., Poulides, N., Chavez, M. B., Steinkamp, H. M., Kirkwood, K. A., Huang, E., Westwater, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06126-x · Cited by 121
Parathyroid Hormone Increases β-Catenin Levels through Smad3 in Mouse Osteoblastic Cells
Tobimatsu, T., Kaji, H., Sowa, H., Naito, J., Canaff, L., Hendy, G. N., Sugimoto, T., & Chihara, K. (2006) · Endocrinology · doi:10.1210/en.2005-1627 · Cited by 117
Messora, M. R., de Oliveira, L. F. F., Foureaux, R. D. C., Taba, M., Zangerônimo, M. G., Furlaneto, F. A. C., & Pereira, L. J. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.120644 · Cited by 116
Collins, F. L., Irwin, R., Bierhalter, H., Schepper, J. D., Britton, R. A., Parameswaran, N., & McCabe, L. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153180 · Cited by 112
Kim, D. S., Kwon, J.-E., Lee, S. H., Kim, E., Ryu, J., Jung, K., Choi, J., Park, M.-J., Moon, Y., Park, S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01525 · Cited by 111
Mediterranean diet and bone mineral density in two age groups of women
Rivas, A., Romero, A., Mariscal‐Arcas, M., Monteagudo, C., Feriche, B., Lorenzo, M. L., & Olea‐Serrano, F. (2012) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2012.718743 · Cited by 110
Sodium butyrate activates ERK to regulate differentiation of mesenchymal stem cells
Chen, T.-H., Chen, W., Hsu, K., Kuo, C., & Hung, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.057 · Cited by 110
Tu, M., Chen, H., Tung, Y., Kao, C.-C., Hu, F.-C., & Chen, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144231 · Cited by 110
Nakamura, T., Kukita, T., Shobuike, T., Nagata, K., Wu, Z., Ogawa, K., Hotokebuchi, T., Kohashi, O., & Kukita, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5809 · Cited by 109
Grassi, F., Tyagi, A. M., Calvert, J. W., Gambari, L., Walker, L. D., Yu, M., Robinson, J. W., Li, J., Lisignoli, G., Vaccaro, C., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2757 · Cited by 108
Self-citationKim, S. C., Kim, D. H., Mogun, H., Eddings, W., Polinski, J. M., Franklin, J. M., & Solomon, D. H. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2832 · Cited by 105
Bedi, B., Li, J., Tawfeek, H. A. W., Baek, K., Adams, J., Vangara, S. S., Chang, M.-K., Kneissel, M., Weitzmann, M. N., & Pacifici, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120735109 · Cited by 104
Self-citationBrüssow, H., & Parkinson, S. J. (2014) · Nature Biotechnology · doi:10.1038/nbt.2845 · Cited by 97
HDAC3 and HDAC7 Have Opposite Effects on Osteoclast Differentiation
Pham, L., Kaiser, B., Romsa, A. M., Schwarz, T. M., Gopalakrishnan, R., Jensen, E. D., & Mansky, K. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.216853 · Cited by 92
Katono, T., Kawato, T., Tanabe, N., Suzuki, N., Iida, T., Morozumi, A., Ochiai, K., & Maeno, M. (2008) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2008.02.016 · Cited by 90
Cortical bone density of adult lacto-ovo-vegetarian and omnivorous women
Marsh, A. G., Sanchez, T., Mickelsen, O., Keiser, J. A., & Mayor, G. H. (1980) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)05128-2 · Cited by 88
Molecular analysis of short-chain fatty acids on intestinal cell proliferation
Blottière, H. (2003) · Medical Entomology and Zoology · Cited by 87
Wauquier, F., Philippe, C., Léotoing, L., Mercier, S., Davicco, M.-J., Lebecque, P., Guicheux, J., Pilet, P., Miot-Noirault, E., Poitout, V., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.429084 · Cited by 84
Ardita, C., Mercante, J. W., Kwon, Y. M., Luo, L., Houser, M. C., Powell, D. N., Jones, R. M., & Neish, A. S. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.01039-14 · Cited by 83
Self-citationInhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro
Cantley, M. D., Fairlie, D. P., Bartold, P. M., Rainsford, K. D., Le, G. T., Lucke, A. J., Holding, C. A., & Haynes, D. R. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22684 · Cited by 82
Matthews, G. M., Howarth, G. S., & Butler, R. N. (2012) · Chemotherapy · doi:10.1159/000335672 · Cited by 82
Slevin, M. M., Allsopp, P. J., Magee, P. J., Bonham, M. P., Naughton, V. R., Strain, J., Duffy, M. E., Wallace, J. M. W., & McSorley, E. M. (2014) · Journal of Nutrition · doi:10.3945/jn.113.188144 · Cited by 82
Agave Fructans: Their Effect on Mineral Absorption and Bone Mineral Content
García-Vieyra, M. I., Real, A. D., & López, M. G. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.0137 · Cited by 80
Narva, M., Collin, M., Lamberg-Allardt, C., Kärkkäinen, M., Poussa, T., Vapaatalo, H., & Korpela, R. (2004) · Annals of Nutrition and Metabolism · doi:10.1159/000080455 · Cited by 77
Commensal-Epithelial Signaling Mediated via Formyl Peptide Receptors
Wentworth, C. C., Jones, R. M., Kwon, Y. M., Nusrat, A., & Neish, A. S. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100529 · Cited by 73
Self-citationLi, J., Walker, L. D., Tyagi, A. M., Adams, J., Weitzmann, M. N., & Pacifici, R. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2044 · Cited by 72
Self-citationYu, M., D’Amelio, P., Tyagi, A. M., Vaccaro, C., Li, J., Hsu, E., Buondonno, I., Sassi, F., Adams, J., Weitzmann, M. N., et al. (2017) · EMBO Reports · doi:10.15252/embr.201744421 · Cited by 70
Self-citationEffects of short chain fatty acid, sodium butyrate, on osteoblastic cells and osteoclastic cells
Iwami, K., & Moriyama, T. (1993) · International Journal of Biochemistry · doi:10.1016/0020-711x(93)90522-g · Cited by 63
Lei, M., Hua, L., & Wang, D.-W. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0067 · Cited by 61
Bollrath, J., & Powrie, F. M. (2013) · Science · doi:10.1126/science.1242674 · Cited by 60
Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells
Säemann, M. D., Parolini, O., Böhmig, G. A., Kelemen, P., Krieger, P.-M., Neumüller, J., Knarr, K., Kammlander, W., Hörl, W. H., Diakos, C., et al. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.2.238 · Cited by 58
Effects of Doxycycline on Mechanical Properties of Bones in Rats with Ovariectomy-Induced Osteopenia
Pytlik, M., Folwarczna, J., & Janiec, W. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0097-x · Cited by 58
Peptidoglycan and lipopolysaccharide synergistically enhance bone resorption and osteoclastogenesis
Kishimoto, T., Kaneko, T., Ukai, T., Yokoyama, M., Ayon Haro, R., Yoshinaga, Y., Yoshimura, A., & Hara, Y. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2011.01452.x · Cited by 56
Association Analysis of WNT10B With Bone Mass and Structure Among Individuals of African Ancestry
Zmuda, J. M., Yerges, L. M., Kammerer, C. M., Cauley, J. A., Wang, X., Nestlerode, C. S., Wheeler, V. W., Patrick, A. L., Bunker, C. H., Moffett, S. P., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081106 · Cited by 47
Cherbuy, C., Andrieux, C., Honvo‐Houeto, E., Thomas, M., Ide, C., Druesne‐Pecollo, N., Chaumontet, C., Darcy‐Vrillon, B., & Duée, P. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03908.x · Cited by 43
A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo
Fehr, T. H., Lucas, C. L., Kurtz, J. M., Onoe, T., Zhao, G., Hogan, T., Vallot, C., Rao, A., & Sykes, M. (2009) · Blood · doi:10.1182/blood-2009-07-230680 · Cited by 43
Scholz-Ahrens, K. E., Delling, G., Stampa, B., Helfenstein, A., Hahne, H. ‐., Açil, Y., Timm, W., Barkmann, R., Hassenpflug, J., Schrezenmeir, J., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00627.2006 · Cited by 42
Astakhova, L., Ngara, M., Babich, O., Prosekov, A. Y., Asyakina, L. K., Dyshlyuk, L. S., Midtvedt, T., Zhou, X., Ernberg, I. T., & Matskova, L. V. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154102 · Cited by 35
Qiu, X., Gui, Y., Xu, Y., Li, D., & Wang, L. (2015) · BioScience Trends · doi:10.5582/bst.2015.01073 · Cited by 33
Peptidoglycan and lipopolysaccharide synergistically enhance bone resorption and osteoclastogenesis
岸本, 隆. (2012) · Institutional Repositories DataBase (IRDB) · Cited by 32
Acetate as a carbon source for lipid synthesis in cultured cells
Howard, B. V. (1977) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(77)90132-1 · Cited by 23
Pintado, J., Guyot, J., & Ampe, F. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.02058.x · Cited by 19
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Metadata
- Authors
- Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Emory University (US)
- Corresponding author
- Pacifici, Roberto
- Venue
- Journal of Clinical Investigation
- Published
- 2019-07-15
- Volume
- 129
- Issue
- 8
- Pages
- 3018-3028
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC6668676
- OpenAlex
- W2957498904
- Cited by
- 403
- References
- 168
- Citations by year
- 2026: 83 · 2025: 65 · 2024: 69 · 2023: 63 · 2022: 45 · 2021: 48 · 2020: 24 · 2019: 5
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Emory University
- Georgia Clinical and Translational Science Alliance
- Johannes und Frieda Marohn-Stiftung
- Deutsche Forschungsgemeinschaft (CRC‐1181, FOR2886, DFG – FOR 2886 “PANDORA”, DFG-FOR2886, FOR2886 - PANDORA, DFG–CRC1181)
- Else Kröner-Fresenius-Stiftung
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119229, R01DK108842, R01DK112946, R01DK098391)
- National Center for Research Resources (S10RR028009)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- gut-bone axis, gut microbiota, bone health, short-chain fatty acids, bacterial metabolites, bone loss, postnatal skeletal development, prebiotics, probiotics, bone cells, musculoskeletal system
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bone Diseases, Metabolic, Fatty Acids, Volatile, Humans, Probiotics, Prebiotics
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