Cited by 405Gut microbiota and healthBone Metabolism and DiseasesBone health and osteoporosis research

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The gut-bone axis: how bacterial metabolites bridge the distance

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Zaiss, Mario M., Jones, Rheinallt M., Schett, Georg, Pacifici, Roberto·2019·Journal of Clinical Investigation

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Abstract

The gut microbiome is a key regulator of bone health that affects postnatal skeletal development and skeletal involution. Alterations in microbiota composition and host responses to the microbiota contribute to pathological bone loss, while changes in microbiota composition that prevent, or reverse, bone loss may be achieved by nutritional supplements with prebiotics and probiotics. One mechanism whereby microbes influence organs of the body is through the production of metabolites that diffuse from the gut into the systemic circulation. Recently, short-chain fatty acids (SCFAs), which are generated by fermentation of complex carbohydrates, have emerged as key regulatory metabolites produced by the gut microbiota. This Review will focus on the effects of SCFAs on the musculoskeletal system and discuss the mechanisms whereby SCFAs regulate bone cells.

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Authors: Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Emory University (US)
Corresponding author: Pacifici, Roberto
ORCID: Zaiss, Mario M.
Jones, Rheinallt M.
Schett, Georg
Pacifici, Roberto
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2019-07-15
Volume: 129
Issue: 8
Pages: 3018-3028
ISSN: 0021-9738 (ISSN-L)
1558-8238
DOI: 10.1172/jci128521
PMC: PMC6668676
OpenAlex: W2957498904
Cited by: 403
References: 168
Citations by year: 2026: 83 · 2025: 65 · 2024: 69 · 2023: 63 · 2022: 45 · 2021: 48 · 2020: 24 · 2019: 5
FWCI: 2.69
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Emory University
Georgia Clinical and Translational Science Alliance
Johannes und Frieda Marohn-Stiftung
Deutsche Forschungsgemeinschaft (CRC‐1181, FOR2886, DFG – FOR 2886 “PANDORA”, DFG-FOR2886, FOR2886 - PANDORA, DFG–CRC1181)
Else Kröner-Fresenius-Stiftung
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119229, R01DK108842, R01DK112946, R01DK098391)
National Center for Research Resources (S10RR028009)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: gut-bone axis, gut microbiota, bone health, short-chain fatty acids, bacterial metabolites, bone loss, postnatal skeletal development, prebiotics, probiotics, bone cells, musculoskeletal system
MeSH terms: Gastrointestinal Microbiome, Animals, Bone Diseases, Metabolic, Fatty Acids, Volatile, Humans, Probiotics, Prebiotics

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The gut-bone axis: how bacterial metabolites bridge the distance

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