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Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis
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“Following internalization, the acidic environment of the endosome induces conformational changes in LDLR, allowing it to dissociate from LDL particles. LDLR is then recycled back to the hepatocyte surface, while LDL cholesterol is trafficked to lysosomes for degradation24–27.”
From ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver (2025) · cites this paper as [27]
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Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis
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Self-citationNeutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223
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Cited by
Sorted by citations
Hepatic inflammatory responses in liver fibrosis
Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803
Ma, J., Guillot, A., Yang, Z., Mackowiak, B., Hwang, S., Park, O., Peiffer, B. J., Ahmadi, A. R., Melo, L., Kusumanchi, P., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci157780 · Cited by 90
Self-citationRole of Neutrophils in the Pathogenesis of Nonalcoholic Steatohepatitis
Hwang, S., Yun, H., Moon, S., Cho, Y. E., & Gao, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.751802 · Cited by 84
Self-citationImmunopathogenic mechanisms and immunoregulatory therapies in MASLD
He, Y., Chen, Y., Qian, S., van Der Merwe, S., Dhar, D., Brenner, D. A., & Tacke, F. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01307-5 · Cited by 81
“Among these miRNAs, miR-223 is broadly recognized as a protective factor in MASLD via myeloid cell-to-hepatocyte communication by targeting several in fl amma-tory genes and oncogenes in hepatocytes to prevent MASH and MASLD-HCC [116, 117].”
Self-citationLee, J. S., O’Connell, E. M., Pacher, P., & Lohoff, F. W. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081758 · Cited by 31
Self-citation
Metadata
- Authors
- He, Y., Rodrigues, R. M., Wang, X., Seo, W., Ma, J., Hwang, S., Fu, Y., Trojnár, E., Mátyás, C., Zhao, S., Ren, R., Feng, D., Pacher, P., Kunos, G., & Gao, B.
- Venue
- Journal of Clinical Investigation
- Published
- 2021-02-01
- Volume
- 131
- Issue
- 3
- ISSN
- 0021-9738
- 1558-8238
- Cited by
- 165
- References
- 10
- Language
- en
- Funders
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health (N/A)
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