Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions

Conlon, Donna M.; Schneider, Carolin V.; Ko, Yi-An; Rodrigues, Amrith; Guo, Kathy; Hand, Nicholas J.; Rader, Daniel J.

doi:10.1172/jci144334

Cited by 24

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions

Conlon, Donna M., Schneider, Carolin V., Ko, Yi-An, Rodrigues, Amrith, Guo, Kathy, Hand, Nicholas J., Rader, Daniel J.·2022·Journal of Clinical Investigation

DOI 10.1172/jci144334PMC PMC8920325

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Hepatocyte sortilin modulates very low density lipoprotein (VLDL) secretion.
“In addition to facilitating PCSK9 secretion, hepatocyte sortilin has been shown to modulate very low density lipoprotein (VLDL) secretion;66–70”
From EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis (2025) · cites this paper as [68]

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Genomewide Association Analysis of Coronary Artery Disease
Samani, N. J., Erdmann, J., Hall, A. S., Hengstenberg, C., Mangino, M., Mayer, B., Dixon, R. J., Meitinger, T., Braund, P., Wichmann, H.-E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072366 · Cited by 2,044
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
Musunuru, K., Strong, A., Frank-Kamenetsky, M., Lee, N. E., Ahfeldt, T., Sachs, K. V., Li, X., Li, H., Kuperwasser, N., Ruda, V. M., et al. (2010) · Nature · doi:10.1038/nature09266 · Cited by 1,140
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Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism
Strong, A., Ding, Q., Edmondson, A. C., Millar, J. S., Sachs, K. V., Li, X., Kumaravel, A., Wang, M. Y., Ai, D., Guo, L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63563 · Cited by 222
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Macrophage Sortilin Promotes LDL Uptake, Foam Cell Formation, and Atherosclerosis
Patel, K. M., Strong, A., Tohyama, J., Jin, X., Morales, C. R., Billheimer, J., Millar, J., Kruth, H., & Rader, D. J. (2015) · Circulation Research · doi:10.1161/circresaha.116.305811 · Cited by 194
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Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control
Pan, M., Maitin, V., Parathath, S., Andreo, U., Lin, S. X., Germain, C. S., Yao, Z., Maxfield, F. R., Williams, K. J., & Fisher, E. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707460104 · Cited by 128

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Sorted by citations

EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis
Ma, F., Longo, M., Meroni, M., Bhattacharya, D., Paolini, E., Mughal, S., Hussain, S., Anand, S. K., Gupta, N., Zhu, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.01.020 · Cited by 29

Authors: Conlon, D. M., Schneider, C. V., Ko, Y.-A., Rodrigues, A., Guo, K., Hand, N. J., & Rader, D. J.
ORCID: Conlon, Donna M.
Schneider, Carolin V.
Ko, Yi-An
Hand, Nicholas J.
Rader, Daniel J.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2022-03-15
Volume: 132
Issue: 6
ISSN: 1558-8238
DOI: 10.1172/jci144334
PMC: PMC8920325
Cited by: 24
References: 5
Language: en
Licence: creativecommons.org/licenses/by/4.0/ (vor)
Funders: National Heart, Lung, and Blood Institute (R01 HL109489,F32 HL134564)

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Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions

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