The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Open accessAbstract
Interactions between endothelial cells (ECs) and perivascular mural cells (MCs) via signaling molecules or physical contacts are implicated both in vascular remodeling and maintenance of vascular integrity. However, it remains unclear how MCs regulate the morphogenic activity of ECs to form an organized vascular architecture, comprising distinct artery, vein, and capillary, from a simple mesh-like network. A clear elucidation of this question requires an experimental model system in which ECs are separated from MCs and yet form vascular structures. Here we report that injection of an antagonistic mAb against PDGFR-beta into murine neonates provides such an experimental system in the retina by completely blocking MC recruitment to developing vessels. While a vascular network was formed even in the absence of MCs, it was poorly remodeled and leaky. Using this vascular system ideal for direct assessment of the activities of MC-derived molecules, we show that addition of recombinant modified angiopoietin-1 restored a hierarchical vasculature, and also rescued retinal edema and hemorrhage in the complete absence of MCs. These observations demonstrate the potential of Ang1 as a new therapeutic modality for MC dropout in diseases such as diabetic retinopathies.
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Endothelial/Pericyte Interactions
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Bergers, G., & Song, S. (2005) · Neuro-Oncology · doi:10.1215/s1152851705000232 · Cited by 1,584
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation
Winkler, F., Kozin, S. V., Tong, R. T., Chae, S.-S., Booth, M. F., Garkavtsev, I., Xu, L., Hicklin, D. J., Fukumura, D., di Tomaso, E., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.10.011 · Cited by 1,170
Pericytes of the neurovascular unit: key functions and signaling pathways
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Metadata
- Authors
- Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S.-I.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-12-01
- Volume
- 110
- Issue
- 11
- Pages
- 1619-1628
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2068203209
- Cited by
- 277
- References
- 55
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S.-I. (2002). Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. Journal of Clinical Investigation. https://doi.org/10.1172/jci15621
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