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Cited by 574

The DOI matches its OpenAlex record; 3 of the 3 references it cites were found in a registry or an index.

Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

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Craig E Daniels, Mark C. Wilkes, Maryanne Edens, Theodore J. Kottom, Stephen J. Murphy, ANDREW HAR LIMPER, Edward B. Leof·2004·Journal of Clinical Investigation
DOI 10.1172/jci19603
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Abstract

Idiopathic pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Prior efforts to treat idiopathic pulmonary fibrosis that focused on anti-inflammatory therapy have not proven to be effective. Recent insight suggests that the pathogenesis is mediated through foci of dysregulated fibroblasts driven by profibrotic cytokine signaling. TGF-beta and PDGF are 2 of the most potent of these cytokines. In the current study, we investigated the role of TGF-beta-induced fibrosis mediated by activation of the Abelson (Abl) tyrosine kinase. Our data indicate that fibroblasts respond to TGF-beta by stimulating c-Abl kinase activity independently of Smad2/3 phosphorylation or PDGFR activation. Moreover, inhibition of c-Abl by imatinib prevented TGF-beta-induced ECM gene expression, morphologic transformation, and cell proliferation independently of any effect on Smad signaling. Further, using a mouse model of bleomycin-induced pulmonary fibrosis, we found a significant inhibition of lung fibrosis by imatinib. Thus, Abl family members represent common targets for the modulation of profibrotic cytokine signaling.

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Metadata

Authors
Daniels, C. E., Wilkes, M. C., Edens, M., Kottom, T. J., Murphy, S. J., LIMPER, A. H., & Leof, E. B.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2004-11-01
Volume
114
Issue
9
Pages
1308-1316
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci19603
OpenAlex
W1977445008
Cited by
574
References
3
FWCI
23.42
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis. https://app.cochat.ai/papers/10.1172/jci19603
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Daniels, C. E., Wilkes, M. C., Edens, M., Kottom, T. J., Murphy, S. J., LIMPER, A. H., & Leof, E. B. (2004). Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis. Journal of Clinical Investigation. https://doi.org/10.1172/jci19603

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.