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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Open accessAbstract
Insulin resistance arises from the inability of insulin to act normally in regulating nutrient metabolism in peripheral tissues. Increasing evidence from human population studies and animal research has established correlative as well as causative links between chronic inflammation and insulin resistance. However, the underlying molecular pathways are largely unknown. In this report, we show that many inflammation and macrophage-specific genes are dramatically upregulated in white adipose tissue (WAT) in mouse models of genetic and high-fat diet-induced obesity (DIO). The upregulation is progressively increased in WAT of mice with DIO and precedes a dramatic increase in circulating-insulin level. Upon treatment with rosiglitazone, an insulin-sensitizing drug, these macrophage-originated genes are downregulated. Histologically, there is evidence of significant infiltration of macrophages, but not neutrophils and lymphocytes, into WAT of obese mice, with signs of adipocyte lipolysis and formation of multinucleate giant cells. These data suggest that macrophages in WAT play an active role in morbid obesity and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance. We propose that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue.
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In the citing paper
“Chronic, sterile, low-grade inflammation is associated with both obesity and aging and is thought to be a major contributing factor for the development of insulin resistance (Fig. 1) (14,52).”
From Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity (2015) · cites this paper as [52]
In the citing paper
“Because the SASP includes macrophage attractant proteins such as MCP-1, it is possible that senescent cells in adipose tissue could be a driver of the macrophage infiltration that has been proposed to play an important role in adipose tissue inflammation leading to insulin resistance in obesity (12,52).”
From Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity (2015) · cites this paper as [52]
In the citing paper
“Vitamin D also suppresses TNF-a expression in monocytes/macrophages (734) and down-regulates the expression of TLR2 and TLR4 in human monocytes (735 -737) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [734]
In the citing paper
“In 2003, the novel discovery that adipose tissue from obese mice and humans is infiltrated with macrophages provided a major mechanistic advance into understanding how obesity propagates inflammation (101, 102).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [102]
In the citing paper
“In addition, macrophages were responsible for the majority of Tnfa expression in adipose tissue and contributed significantly to Il6 and Ikbkb expression (101, 102).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [102]
In the citing paper
“Supporting this hypothesis, large clusters of macrophage-related inflammatory genes were identified as significantly altered in obese AT (5).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“these reports also fueled the publication of numerous additional papers, thus firmly establishing the phenomenon of a macrophage-orchestrated inflammatory response co-existing with obesity-induced insulin resistance.”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“In 2003, two independent articles in the JCI highlighted the infiltration of macrophages into expanding AT as an important physiological phenomenon (5,6).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“In particular, increased expression levels of MCP-1, CXCL14, MIP-1α, MCP-2, MCP-3, and RANTES can be observed in AT of mice with genetic or DIO (5,16,18).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“Rodent studies revealed increased levels of macrophage markers present in AT of leptin-deficient, leptin receptor-deficient and diet-induced obese (DIO) mouse models (5).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“Excess body adiposity has been associated with activation of macrophages and associated inflammation in a variety of peripheral tissues including WAT, liver, skeletal muscle and the vasculature and eventually is accompanied by increased circulating plasma levels of pro-inflammatory cytokines (193, 207).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [207]
In the citing paper
“Visceral adipose tissue has an increased number of adipose resident macrophages.”
From The Vasculature in Prediabetes (2018) · cites this paper as [82]
In the citing paper
“Although some molecules secreted by WAT, such as leptin and adiponectin, are synthesized by mature adipocytes [8], the non-adipose SVF, comprising infiltrated macrophages among other cellular types, is a source of inflammation-related molecules that may exert a local action on adipose tissue biology, particularly within the enlarged WAT [9-11].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [9]
Citations
Cites
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,366
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,158
Cited by
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Items 901–1,000 of 1,152
Obesity, Metabolic Syndrome, and Type 2 Diabetes: Inflammatory Basis of Glucose Metabolic Disorders
Pradhan, A. D. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00354.x · Cited by 179
Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
Zhao, Y., Zhao, M., Jiang, S., Wu, J., Liu, J., Yuan, X., Shen, D., Zhang, J., Zhou, N., He, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14450-6 · Cited by 181
Tsatsoulis, A., Mantzaris, M. D., Bellou, S., & Andrikoula, M. (2013) · Metabolism · doi:10.1016/j.metabol.2012.11.004 · Cited by 174
The link between abdominal obesity and the metabolic syndrome
Phillips, L. K., & Prins, J. B. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0029-7 · Cited by 178
Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations
Parker, R., Kim, S.-J., & Gao, B. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.116 · Cited by 175
Ott, B., Skurk, T., Hastreiter, L., Lagkouvardos, I., Fischer, S., Büttner, J., Kellerer, T., Clavel, T., Rychlik, M., Haller, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12109-9 · Cited by 170
Barrea, L., Marzullo, P., Muscogiuri, G., Di Somma, C., Scacchi, M., Orio, F., Aimaretti, G., Colao, A., & Savastano, S. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422418000136 · Cited by 171
Conjugated Linoleic Acid Induces Human Adipocyte Delipidation
Brown, J. M., Sandberg, M. B., Chung, S., Fabiyi, O., Morrison, R. F., Mandrup, S., & McIntosh, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401766200 · Cited by 173
de Sousa, B. R., Parreira, R. C., Fonseca, E. A., Amaya, M. J., Tonelli, F. M. P., Lacerda, S. M. D. S. N., Lalwani, P. J., Santos, A. K., Gomes, K. N., Ulrich, H., et al. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22402 · Cited by 175
Pejnovic, N. N., Pantic, J. M., Jovanović, I., Radosavljevic, G. D., Milovanović, M., Nikolić, I., Zdravkovic, N. S., Djukić, A., Arsenijević, N., & Lukić, M. L. (2013) · Diabetes · doi:10.2337/db12-0222 · Cited by 172
Septembre‐Malaterre, A., Stanislas, G., Quessary, E. D., & Gonthier, M. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.147 · Cited by 172
Reduced oxidative capacity in macrophages results in systemic insulin resistance
Jung, S.-B., Choi, M. J., Ryu, D., Yi, H., Lee, S. E., Chang, J. Y., Chung, H. K., Kim, Y. K., Kang, S., Lee, J. H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03998-z · Cited by 174
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Lin, N., & Simon, M. C. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84426 · Cited by 170
Gruen, M. L., Hao, M., Piston, D. W., & Hasty, A. H. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00062.2007 · Cited by 183
The insulin resistance syndrome: physiological considerations
Kashyap, S. R., & DeFronzo, R. A. (2007) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2007.001 · Cited by 178
Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus
Guilherme, A., Henriques, F. D. S., Bedard, A. H., & Czech, M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0165-y · Cited by 179
Physical Activity and Cancer Prevention: Pathways and Targets for Intervention
Rogers, C. J., Colbert, L. H., Greiner, J. W., Perkins, S. N., & Hursting, S. D. (2008) · Sports Medicine · doi:10.2165/00007256-200838040-00002 · Cited by 170
Biomedical applications of Aloe vera
Gao, Y., Kuok, K. I., Jin, Y., & Wang, R. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1496320 · Cited by 170
Increased collagen content in insulin-resistant skeletal muscle
Berria, R., Wang, L., Richardson, D. K., Finlayson, J., Belfort, R., Pratipanawatr, T., De Filippis, E. A., Kashyap, S., & Mandarino, L. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00202.2005 · Cited by 171
Ye, J., & Keller, J. N. (2010) · Aging · doi:10.18632/aging.100155 · Cited by 175
Local proliferation initiates macrophage accumulation in adipose tissue during obesity
Zheng, C., Yang, Q., Cao, J., Xie, N., Liu, K., Shou, P., Qian, F., Wang, Y., & Shi, Y. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.54 · Cited by 177
Self-citationNon-alcoholic fatty liver disease: A sign of systemic disease
Reccia, I., Jayant, K., Akladios, C. Y., Virdis, F., Pai, M., Habib, N., & Spalding, D. R. C. (2017) · Metabolism · doi:10.1016/j.metabol.2017.04.011 · Cited by 171
Insulin Resistance and Cancer: In Search for a Causal Link
CHIEFARI, E. D., Mirabelli, M., Vignera, S. L., Tanyolaç, S., FOTI, D. P., Aversa, A., & Brunetti, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011137 · Cited by 180
Insulin Resistance in Equids: Possible Role in Laminitis
Treiber, K. H., Kronfeld, D. S., & Geor, R. J. (2006) · Journal of Nutrition · doi:10.1093/jn/136.7.2094s · Cited by 170
Lou, M., Luo, P., Ru, T., Peng, Y., Yu, S., Huang, W., & He, L. (2015) · BMC Endocrine Disorders · doi:10.1186/s12902-015-0002-9 · Cited by 175
Xia, S., Sha, H., Liu, Y., Ji, Y., Ostrand‐Rosenberg, S., & Qi, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237123 · Cited by 169
‘Metabolically healthy obesity’: Origins and implications
Denis, G. V., & Obin, M. S. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.10.004 · Cited by 176
Claycombe, K., Harkins, J. M., Chung, Y.-J., Penner, K. M., Pestka, J. J., North, C. M., & Moustaïd‐Moussa, N. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2673 · Cited by 169
Hasegawa, Y., Saito, T., Ogihara, T., Ishigaki, Y., Yamada, T., Imai, J., Uno, K., Gao, J., Kaneko, K., Shimosawa, T., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.054346 · Cited by 169
Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
Trim, W. V., Turner, J. E., & Thompson, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00169 · Cited by 178
Xiao, S., Liu, C., Chen, M., Zou, J., Zhang, Z., Cui, X., Jiang, S., Shang, E., Qian, D., & Duan, J. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10174-w · Cited by 167
The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications
Herder, C., Dalmas, É., Böni‐Schnetzler, M., & Donath, M. Y. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.08.001 · Cited by 176
Wnt10b Inhibits Obesity in ob/ob and Agouti Mice
Hahn, W. S., Longo, K. A., Dolinsky, V. W., Gerin, I., Kang, S., Bennett, C. N., Chiang, S.-H., Prestwich, T. C., Gress, C., Burant, C., et al. (2007) · Diabetes · doi:10.2337/db06-1339 · Cited by 172
Pop-Busui, R., Lu, J., Brooks, M. M., Albert, S., Althouse, A. D., Escobedo, J., Green, J., Palumbo, P., Perkins, B. A., Whitehouse, F., et al. (2013) · Diabetes Care · doi:10.2337/dc13-0012 · Cited by 167
Expression of macrophage‐selective markers in human and rodent adipocytes
Khazen, W., Mbika, J., Tomkiewicz, C., Benelli, C., Chany, C., Achour, A., & Forest, C. D. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.032 · Cited by 175
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders
Fukuda, D., Aïkawa, E., Świrski, F. K., Novobrantseva, T. I., Koteliansky, V., Görgün, C. Z., Chudnovskiy, A., Yamazaki, H., Croce, K., Weissleder, R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116889109 · Cited by 171
Alisi, A., Carpino, G., de Oliveira, F. L., Panera, N., Nobili, V., & Gaudio, E. (2017) · Mediators of Inflammation · doi:10.1155/2017/8162421 · Cited by 172
Dobrian, A. D., Ma, Q., Lindsay, J. W., Leone, K. A., Ma, K., Coben, J., Galkina, E. V., & Nadler, J. L. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00463.2010 · Cited by 166
State of the union between metabolism and the immune system in type 2 diabetes
Nikolajczyk, B. S., Jagannathan‐Bogdan, M., Shin, H., & Gyurko, R. (2011) · Genes and Immunity · doi:10.1038/gene.2011.14 · Cited by 168
Clinical features of Parkinson disease when onset of diabetes came first
Cereda, E., Barichella, M., Cassani, E., Caccialanza, R., & Pezzoli, G. (2012) · Neurology · doi:10.1212/wnl.0b013e3182553cc9 · Cited by 166
Obesity-Related Upregulation of Monocyte Chemotactic Factors in Adipocytes
Jiao, P., Chen, Q., Shah, S., Du, J., Bo, T., Tzameli, I., Yan, W., & Xu, H. (2008) · Diabetes · doi:10.2337/db07-1344 · Cited by 171
Self-citationPresence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes
Roche, R., Hoareau, L., Bès-Houtmann, S., Gonthier, M., Laborde, C., Baron, J.-F., Haffaf, Y., Césari, M., & Festy, F. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0127-4 · Cited by 174
Vila, I. K., Badin, P.-M., Marques, M.-A., Monbrun, L., Lefort, C., Mir, L., Louche, K., Bourlier, V., Roussel, B., Gui, P., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.062 · Cited by 165
Hontecillas, R., O’Shea, M., Einerhand, A. W. C., DiGuardo, M. A., & Bassaganya-Riera, J. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10719770 · Cited by 168
The immune system's involvement in obesity-driven type 2 diabetes
Shu, C. J., Benoist, C. O., & Mathis, D. J. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.12.001 · Cited by 170
Obesity, Neuroinflammation, and Reproductive Function
Lainez, N. M., & Coss, D. (2019) · Endocrinology · doi:10.1210/en.2019-00487 · Cited by 180
Obesity and post‐operative complications in patients undergoing non‐bariatric surgery
Doyle, S. L., Lysaght, J., & Reynolds, J. V. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00700.x · Cited by 168
Inflammation arising from obesity reduces taste bud abundance and inhibits renewal
Kaufman, A., Choo, E., Koh, A., & Dando, R. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2001959 · Cited by 169
Origins, Biology, and Diseases of Tissue Macrophages
Cox, N., Pokrovskii, M. V., Vicario, R., & Geissmann, F. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-111748 · Cited by 171
Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms
Naz, R., Saqib, F., Awadallah, S. M., Wahid, M., Latif, M. F., Iqbal, I., & Mubarak, M. S. (2023) · Molecules · doi:10.3390/molecules28103996 · Cited by 178
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114521003962 · Cited by 164
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Pathophysiology of NASH: perspectives for a targeted treatment
Marra, F., & Lotersztajn, S. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990344 · Cited by 163
Morton, N. M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.024 · Cited by 169
COX‐2‐mediated Inflammation in Fat Is Crucial for Obesity‐linked Insulin Resistance and Fatty Liver
Hsieh, P., Jin, J., Chiang, C., Chan, P., Chen, C., & Shih, K. (2009) · Obesity · doi:10.1038/oby.2008.674 · Cited by 163
Wang, B., & Trayhurn, P. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0055-8 · Cited by 163
Microarray profiling of gene expression in human adipocytes in response to anthocyanins
Tsuda, T., Ueno, Y., Yoshikawa, T., Kojo, H., & Osawa, T. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.042 · Cited by 165
Ectopic fat accumulation and metabolic syndrome
Rasouli, N., Molavi, B., Elbein, S. C., & Kern, P. A. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00590.x · Cited by 169
Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion
Han, C. Y., Subramanian, S., Chan, C. K., Omer, M., Chiba, T., Wight, T. N., & Chait, A. (2007) · Diabetes · doi:10.2337/db07-0218 · Cited by 164
Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients
Sh, T., Sanctis, J. B. D., Briceño, L., Hernandez, N., & Finol, H. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1810419 · Cited by 163
Namgaladze, D., & Brüne, B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.002 · Cited by 169
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges
Silva, H. M., Báfica, A. L. B., Rodrigues-Luiz, G. F., Chi, J., Santos, P. D. A., Reis, B. S., van Konijnenburg, D. P. H., Crane, A., Arifa, R. D. D. N., Martin, P. K., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181049 · Cited by 168
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
Diet-regulated production of PDGFcc by macrophages controls energy storage
Cox, N., Crozet, L., Holtman, I. R., Loyher, P.-L., Lazarov, T., White, J. B., Mass, E., Stanley, E. R., Elemento, O., Glass, C. K., et al. (2021) · Science · doi:10.1126/science.abe9383 · Cited by 172
Inflammatory markers and bariatric surgery: a meta-analysis
Rao, S. R. (2012) · Inflammation Research · doi:10.1007/s00011-012-0473-3 · Cited by 162
Between brown and white: Novel aspects of adipocyte differentiation
Cinti, S. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.535557 · Cited by 169
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue
Goldberg, E. L., Shchukina, I., Asher, J. L., Sidorov, S., Artyomov, M. N., & Dixit, V. D. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0160-6 · Cited by 162
Obesity: A Review of Pathophysiology and Classification
Busebee, B. T., Ghusn, W., Cifuentes, L., & Acosta, A. J. (2023) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2023.05.026 · Cited by 192
Kiefer, F. W., Zeyda, M., Todoric, J., Huber, J., Geyeregger, R., Weichhart, T., Aszmann, O. C., Ludvik, B. H., Silberhumer, G. R., Prager, G., et al. (2007) · Endocrinology · doi:10.1210/en.2007-1312 · Cited by 161
Circulating oxidized LDL: a biomarker and a pathogenic factor
Ishigaki, Y., Oka, Y., & Katagiri, H. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832fa58d · Cited by 162
Beumer, W., Drexhage, R. C., de Wit, H., Versnel, M. A., Drexhage, H. A., & Cohen, D. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.001 · Cited by 162
Neuropsychiatric Comorbidity in Obesity: Role of Inflammatory Processes
Castanon, N., Lasselin, J., & Capuron, L. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00074 · Cited by 168
Louwen, F., Ritter, A., Kreis, N., & Yuan, J. (2018) · Obesity Reviews · doi:10.1111/obr.12679 · Cited by 163
Mechanisms of obesity and related pathology: linking immune responses to metabolic stress
Karalis, K. P., Giannogonas, P., Kodela, E., Koutmani, Y., Zoumakis, M., & Teli, T. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07304.x · Cited by 163
Gervois, P. P., Fruchart, J., & Staels, B. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0397 · Cited by 159
Bradley, R. L., Fisher, F. M., & Maratos–Flier, E. (2008) · Obesity · doi:10.1038/oby.2008.39 · Cited by 163
Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice
Kim, J. E., Lee, M., Nam, D. H., Song, H. K., Kang, Y. S., Lee, J. E., Kim, H. W., Joo, J., Hyun, Y. Y., Han, S. Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062068 · Cited by 160
Inflammation and adipose tissue macrophages in lipodystrophic mice
Herrero, L., Shapiro, H., Nayer, A., Lee, J., & Shoelson, S. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905310107 · Cited by 163
Energy metabolism and fertility—a balance preserved for female health
Torre, S. D., Benedusi, V., Fontana, R., & Maggi, A. C. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.203 · Cited by 162
Segovia, S. A., Vickers, M. H., Harrison, C. J., Patel, R., Gray, C. L., & Reynolds, C. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00001 · Cited by 160
Roles of Reactive Oxygen Species on Insulin Resistance in Adipose Tissue
Han, C. Y. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.4.272 · Cited by 159
Lee, S. G., Kim, B., Yang, Y., Pham, T. X., Park, Y., Manatou, J., Koo, S. I., Chun, O. K., & Lee, J. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.12.001 · Cited by 160
Woo, H.-M., Kang, J., Kawada, T., Yoo, H., Sung, M., & Yu, R. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.11.030 · Cited by 160
Liu, H.-Q., Qiu, Y. F., Mu, Y., Zhang, X.-J., Liu, L., Hou, X.-H., Zhang, L., Xu, X., Ji, A.-L., Cao, R., et al. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.07.004 · Cited by 165
Ko, H. J., Zhang, Z., Jung, D. Y., Jun, J. Y., Ma, Z., Jones, K. E., Chan, S. Y., & Kim, J. K. (2009) · Diabetes · doi:10.2337/db08-1361 · Cited by 160
Nisar, A., Jagtap, S., Vyavahare, S., Deshpande, M., Harsulkar, A., Ranjekar, P. K., & Prakash, O. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1177050 · Cited by 183
Association of Systemic Chemokine Concentrations With Impaired Glucose Tolerance and Type 2 Diabetes
Herder, C., Haastert, B., Müller-Scholze, S., Köenig, W., Thorand, B., Holle, R., Wichmann, H. ‐., Scherbaum, W. A., Martin, S., & Kolb, H. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s11 · Cited by 159
Zhang, C., McFarlane, C., Lokireddy, S., Bonala, S., Ge, X., Masuda, S., Gluckman, P. D., Sharma, M., & Kambadur, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2079-7 · Cited by 158
Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis
Taleb, S., Lacasa, D., Bastard, J., Poitou, C., Cancello, R., Pelloux, V., Viguerie, N., Benis, A., Zucker, J., Bouillot, J., et al. (2005) · The FASEB Journal · doi:10.1096/fj.05-3673fje · Cited by 158
Lee, J. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0023-8 · Cited by 161
Liu, X., Zheng, P., Wang, X., Dai, G., Cheng, H., Zhang, Z., Hua, R., Niu, X., Shi, J., & An, Y. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt446 · Cited by 164
Alligier, M., Meugnier, E., Debard, C., Lambert-Porcheron, S., Chanséaume, E., Sothier, M., Loizon, E., Hssain, A. A., Brozek, J., Scoazec, J., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2314 · Cited by 164
Inducible Nitric Oxide Synthase Has Divergent Effects on Vascular and Metabolic Function in Obesity
Noronha, B., Li, J., Wheatcroft, S. B., Shah, A. M., & Kearney, M. T. (2005) · Diabetes · doi:10.2337/diabetes.54.4.1082 · Cited by 158
Chung, S., Brown, J. M., Provo, J. N., Hopkins, R. G., & McIntosh, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508159200 · Cited by 160
Dixit, V. D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108028 · Cited by 163
Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice
Zamarron, B. F., Mergian, T. A., Cho, K. W., Martinez-Santibañez, G., Luan, D., Singer, K., DelProposto, J. L., Geletka, L. M., Muir, L. A., & Lumeng, C. N.-K. (2016) · Diabetes · doi:10.2337/db16-0500 · Cited by 159
Kunz, H., Hart, C. R., Gries, K. J., Parvizi, M., LAURENTI, M. C., Man, C. D., Moore, N., Zhang, X., Ryan, Z., Polley, E. C., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00070.2021 · Cited by 170
Averill, M. M., Barnhart, S., Becker, L., Li, X., Heinecke, J. W., LeBoeuf, R. C., Hamerman, J. A., Sorg, C., Kerkhoff, C., & Bornfeldt, K. E. (2011) · Circulation · doi:10.1161/circulationaha.110.985523 · Cited by 155
Lymphocytes in obesity-related adipose tissue inflammation
Chatzigeorgiou, A., Karalis, K. P., Bornstein, S. R., & Chavakis, T. (2012) · Diabetologia · doi:10.1007/s00125-012-2607-0 · Cited by 163
The role of interleukin-18 in the metabolic syndrome
Trøseid, M., Seljeflot, I., & Arnesen, H. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-11 · Cited by 155
Metadata
- Authors
- Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., & Chen, H.
- Affiliations
- Takeda Oncology (United States) (US)
- Corresponding author
- Chen, Hong
- Venue
- Journal of Clinical Investigation
- Published
- 2003-12-15
- Volume
- 112
- Issue
- 12
- Pages
- 1821-1830
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC296998
- OpenAlex
- W2136024338
- Cited by
- 6,760
- References
- 62
- Citations by year
- 2026: 138 · 2025: 177 · 2024: 203 · 2023: 227 · 2022: 257 · 2021: 315 · 2020: 313 · 2019: 347 · 2018: 359 · 2017: 367 · 2016: 401 · 2015: 388 · 2014: 372 · 2013: 499 · 2012: 400
- FWCI
- 103.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, insulin resistance, chronic inflammation, white adipose tissue, macrophages, high-fat diet-induced obesity, rosiglitazone, adipocyte lipolysis, multinucleated giant cells, adipose tissue macrophage infiltration, inflammatory genes
- MeSH terms
- Rosiglitazone, Adipose Tissue, Animals, Body Weight, Cells, Cultured, Gene Expression Regulation, Immunohistochemistry, Inflammation, Insulin Resistance, Lymphocytes, Macrophages, Male, Mice, Inbred C57BL, Mice, Obese, Models, Biological, Neutrophils, Obesity, RNA, RNA, Messenger, Time Factors, Down-Regulation, Giant Cells, Up-Regulation, In Situ Hybridization, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Thiazolidinediones, Mice
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