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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Open accessAbstract
Insulin resistance arises from the inability of insulin to act normally in regulating nutrient metabolism in peripheral tissues. Increasing evidence from human population studies and animal research has established correlative as well as causative links between chronic inflammation and insulin resistance. However, the underlying molecular pathways are largely unknown. In this report, we show that many inflammation and macrophage-specific genes are dramatically upregulated in white adipose tissue (WAT) in mouse models of genetic and high-fat diet-induced obesity (DIO). The upregulation is progressively increased in WAT of mice with DIO and precedes a dramatic increase in circulating-insulin level. Upon treatment with rosiglitazone, an insulin-sensitizing drug, these macrophage-originated genes are downregulated. Histologically, there is evidence of significant infiltration of macrophages, but not neutrophils and lymphocytes, into WAT of obese mice, with signs of adipocyte lipolysis and formation of multinucleate giant cells. These data suggest that macrophages in WAT play an active role in morbid obesity and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance. We propose that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue.
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“Chronic, sterile, low-grade inflammation is associated with both obesity and aging and is thought to be a major contributing factor for the development of insulin resistance (Fig. 1) (14,52).”
From Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity (2015) · cites this paper as [52]
In the citing paper
“Because the SASP includes macrophage attractant proteins such as MCP-1, it is possible that senescent cells in adipose tissue could be a driver of the macrophage infiltration that has been proposed to play an important role in adipose tissue inflammation leading to insulin resistance in obesity (12,52).”
From Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity (2015) · cites this paper as [52]
In the citing paper
“Vitamin D also suppresses TNF-a expression in monocytes/macrophages (734) and down-regulates the expression of TLR2 and TLR4 in human monocytes (735 -737) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [734]
In the citing paper
“In 2003, the novel discovery that adipose tissue from obese mice and humans is infiltrated with macrophages provided a major mechanistic advance into understanding how obesity propagates inflammation (101, 102).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [102]
In the citing paper
“In addition, macrophages were responsible for the majority of Tnfa expression in adipose tissue and contributed significantly to Il6 and Ikbkb expression (101, 102).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [102]
In the citing paper
“Supporting this hypothesis, large clusters of macrophage-related inflammatory genes were identified as significantly altered in obese AT (5).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“these reports also fueled the publication of numerous additional papers, thus firmly establishing the phenomenon of a macrophage-orchestrated inflammatory response co-existing with obesity-induced insulin resistance.”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“In 2003, two independent articles in the JCI highlighted the infiltration of macrophages into expanding AT as an important physiological phenomenon (5,6).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“In particular, increased expression levels of MCP-1, CXCL14, MIP-1α, MCP-2, MCP-3, and RANTES can be observed in AT of mice with genetic or DIO (5,16,18).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“Rodent studies revealed increased levels of macrophage markers present in AT of leptin-deficient, leptin receptor-deficient and diet-induced obese (DIO) mouse models (5).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [5]
In the citing paper
“Excess body adiposity has been associated with activation of macrophages and associated inflammation in a variety of peripheral tissues including WAT, liver, skeletal muscle and the vasculature and eventually is accompanied by increased circulating plasma levels of pro-inflammatory cytokines (193, 207).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [207]
In the citing paper
“Visceral adipose tissue has an increased number of adipose resident macrophages.”
From The Vasculature in Prediabetes (2018) · cites this paper as [82]
In the citing paper
“Although some molecules secreted by WAT, such as leptin and adiponectin, are synthesized by mature adipocytes [8], the non-adipose SVF, comprising infiltrated macrophages among other cellular types, is a source of inflammation-related molecules that may exert a local action on adipose tissue biology, particularly within the enlarged WAT [9-11].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [9]
Citations
Cites
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,366
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,158
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Items 701–800 of 1,151
Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages
Kranendonk, M. E. G., Visseren, F. L. J., van Balkom, B. W. M., Hoen, E. N. M. N., van Herwaarden, J. A., de Jager, W., Schipper, H. S., Brenkman, A. B., Verhaar, M. C., Wauben, M. H. M., et al. (2013) · Obesity · doi:10.1002/oby.20679 · Cited by 221
Nakajima, T. E., Yamada, Y., Hamano, T., Furuta, K., Matsuda, T., Fujita, S., Kato, K., Hamaguchi, T., & Shimada, Y. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01518.x · Cited by 227
A decade of progress in adipose tissue macrophage biology
Hill, A. A., Bolus, W. R., & Hasty, A. H. (2014) · Immunological Reviews · doi:10.1111/imr.12216 · Cited by 227
Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling
Shi, H., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403886200 · Cited by 223
Wellen, K. E., Fucho, R., Gregor, M. F., Furuhashi, M., Morgan, C., Lindstad, T., Vaillancourt, E., Gorgun, C. Z., Saatcioglu, F., & Hotamisligil, G. S. (2007) · Cell · doi:10.1016/j.cell.2007.02.049 · Cited by 222
Obesity, pregnancy, inflammation, and vascular function
Denison, F. C., Roberts, K. A., Barr, S. M., & Norman, J. E. (2010) · Reproduction · doi:10.1530/rep-10-0074 · Cited by 221
Ji, Y., Sun, S., Xu, A., Bhargava, P., Yang, L., Lam, K. S. L., Gao, B., Lee, C., Kersten, S., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.350066 · Cited by 221
Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice
Ma, Y., Gao, M., & Liu, D. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1526-9 · Cited by 221
Lipid signaling in adipose tissue: Connecting inflammation & metabolism
Masoodi, M., Kuda, O., Rossmeisl, M., Flachs, P., & Kopecký, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.023 · Cited by 229
PPARγ in human and mouse physiology
Heikkinen, S., Auwerx, J. H., & Argmann, C. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.03.006 · Cited by 224
‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue
Pérez, L. M., Pareja‐Galeano, H., Sanchis‐Gomar, F., Emanuele, E., Lucia, A., & Gálvez, B. G. (2016) · The Journal of Physiology · doi:10.1113/jp271691 · Cited by 215
Maternal Obesity, Inflammation, and Developmental Programming
Segovia, S. A., Vickers, M. H., Gray, C. L., & Reynolds, C. M. (2014) · BioMed Research International · doi:10.1155/2014/418975 · Cited by 233
Chung, S. J., Kim, D., Park, M. J., Kim, Y. S., Kim, J., Jung, H. C., & Song, I. S. (2008) · Gut · doi:10.1136/gut.2007.147090 · Cited by 223
The role of declining adaptive homeostasis in ageing
Pomatto, L. C. D., & Davies, K. J. A. (2017) · The Journal of Physiology · doi:10.1113/jp275072 · Cited by 231
Vitamin D and obesity: current perspectives and future directions
Pourshahidi, L. K. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114001578 · Cited by 224
TNFα up‐regulates apelin expression in human and mouse adipose tissue
Daviaud, D., Boucher, J., Gesta, S., Dray, C., Guigné, C., Quilliot, D., Ayav, A., Ziegler, O., Carpéné, C., Saulnier‐Blache, J. S., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5243fje · Cited by 219
Zheng, H., Wang, J., Wei, X., Chang, L., & Liu, S. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143085 · Cited by 220
Morris, D. L., Cho, K. W., DelProposto, J. L., Oatmen, K. E., Geletka, L. M., Martinez-Santibanez, G., Singer, K., & Lumeng, C. N. (2013) · Diabetes · doi:10.2337/db12-1404 · Cited by 217
From chronic overnutrition to insulin resistance: The role of fat-storing capacity and inflammation
Lionetti, L., Mollica, M. P., Lombardi, A., Cavaliere, G., Gifuni, G., & Barletta, A. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.10.010 · Cited by 223
Nagy, L., Szántó, A., Szatmári, I., & Széles, L. (2012) · Physiological Reviews · doi:10.1152/physrev.00004.2011 · Cited by 218
Yao‐Borengasser, A., Varma, V., Bodles, A. M., Rasouli, N., Phanavanh, B., Lee, M., Starks, T., Kern, L. M., Spencer, H. J., Rashidi, A. A., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0816 · Cited by 216
Seo, M.-J., Lee, Y., Hwang, J., Kim, K., & Lee, B.-Y. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.06.005 · Cited by 224
Visceral and Subcutaneous Fat Quality and Cardiometabolic Risk
Rosenquist, K. J., Pedley, A., Massaro, J. M., Therkelsen, K. E., Murabito, J. M., Hoffmann, U., & Fox, C. S. (2013) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2012.11.021 · Cited by 223
The Immune System as a Sensor of the Metabolic State
Odegaard, J. I., & Chawla, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.001 · Cited by 219
Steatohepatitis Induced by Intragastric Overfeeding in Mice *
Deng, Q.-G., She, H., Cheng, J. H., French, S. W., Koop, D. R., Xiong, S., & Tsukamoto, H. (2005) · Hepatology · doi:10.1002/hep.20877 · Cited by 218
Telenga, E. D., Tideman, S. W., Kerstjens, H. A. M., ten Hacken, N. H. T., Timens, W., Postma, D. S., & van den Berge, M. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02855.x · Cited by 242
Zhang, Y., Mei, H., Chang, X., Chen, F., Zhu, Y., & Han, X. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw040 · Cited by 222
Meex, R. C. R., Blaak, E. E., & van Loon, L. J. C. (2019) · Obesity Reviews · doi:10.1111/obr.12862 · Cited by 224
Trayhurn, P., Drevon, C. A., & Eckel, J. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2010.535835 · Cited by 214
Ehrenborg, E., & Krook, A. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001560 · Cited by 222
Clarke, J. R., Lyra e Silva, N. M., Figueiredo, C. P., Frozza, R. L., Ledo, J. H., Beckman, D., Katashima, C. K., Razolli, D., Carvalho, B. M., Frazão, R., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404183 · Cited by 214
Regulation of Adipogenesis by Lymphatic Fluid Stasis
Zampell, J. C., Aschen, S. Z., Weitman, E. S., Yan, A., Elhadad, S., Brot, M. D., & Mehrara, B. J. (2012) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3182450b2d · Cited by 215
Gao, D., Madi, M., Ding, C., Fok, M., Steele, T., Ford, C. T., Hunter, L., & Chen, B. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00430.2013 · Cited by 216
Macrophage TNF-α contributes to insulin resistance and hepatic steatosis in diet-induced obesity
De Taeye, B. M., Novitskaya, T., McGuinness, O. P., Gleaves, L., Medda, M., Covington, J. W., & Vaughan, D. E. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00194.2007 · Cited by 208
Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome
Martínez‐Fernández, L., Laiglesia, L. M., Huerta, A. E., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.07.003 · Cited by 218
Gauthier, M., O’Brien, E. L., Bigornia, S., Mott, M. M., Cacicedo, J. M., Xu, X. J., Gokce, N., Apovian, C. M., & Ruderman, N. B. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.127 · Cited by 212
Li, Y., Zhang, Y., Dorweiler, B., Cui, D., Wang, T., Woo, C. W., Brunkan, C. S., Wolberger, C., Imai, S., & Tabas, I. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805866200 · Cited by 212
Macrophage function in obesity-induced inflammation and insulin resistance
Lauterbach, M., & Wunderlich, F. T. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1955-5 · Cited by 216
Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism
Schéele, C., & Wolfrum, C. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz007 · Cited by 224
Recent advances in obesity-induced inflammation and insulin resistance
Tateya, S., Kim, F., & Tamori, Y. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00093 · Cited by 211
Natural killer T cells in adipose tissue prevent insulin resistance
Schipper, H. S., Rakhshandehroo, M., van de Graaf, S. F. J., Venken, K., Koppen, A., Stienstra, R., Prop, S., Meerding, J., Hamers, N., Besra, G. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62739 · Cited by 210
Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised
Salvioli, S., Monti, D., Lanzarini, C., Conte, M., Pirazzini, C., Bacalini, M. G., Garagnani, P., Giuliani, C., Fontanesi, E., Ostan, R., et al. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219531 · Cited by 209
Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?
Zhou, M.-S., Wang, A., & Yu, H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-12 · Cited by 217
Cohen, P., & Spiegelman, B. M. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-10-0749 · Cited by 217
White adipocyte dysfunction and obesity-associated pathologies in humans
Hagberg, C. E., & Spalding, K. L. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00680-1 · Cited by 236
Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys
Kavanagh, K., Jones, K. L., Sawyer, J., Kelley, K., Carr, J. J., Wagner, J. D., & Rudel, L. L. (2007) · Obesity · doi:10.1038/oby.2007.200 · Cited by 208
Eduardo Fuentes, Q., Fuentes, F., Vilahur, G., Badimón, L., & Palomo, I. F. (2013) · Mediators of Inflammation · doi:10.1155/2013/136584 · Cited by 212
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
Bartelt, A., Widenmaier, S. B., Schlein, C., Johann, K., Gonçalves, R. L. S., Eguchi, K., Fischer, A. W., Parlakgül, G., Snyder, N., Nguyen, T. B., et al. (2018) · Nature Medicine · doi:10.1038/nm.4481 · Cited by 212
Islet inflammation in type 2 diabetes
Böni‐Schnetzler, M., & Meier, D. T. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00745-4 · Cited by 225
Abdominal Obesity and the Risk of Barrett's Esophagus
El‐Serag, H. B., Kvapil, P., Hacken, J. B., & Kramer, J. R. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00251.x · Cited by 208
Meijer, K., de Vries, M., Al-Lahham, S., Bruinenberg, M., Weening, D., Dijkstra, M., Kloosterhuis, N., van der Lei, R. J., van der Want, H., Kroesen, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017154 · Cited by 211
Dahlman, I. A., Kaaman, M., Olsson, T., Tan, G. D., Bickerton, A. S. T., Wåhlén, K., Andersson, J. S. O., Nordström, E. A., Blomqvist, L., Sjögren, A., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0369 · Cited by 207
Self-citationAdipose tissue and adipocyte dysregulation
Lafontan, M. (2013) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.08.002 · Cited by 218
Innate immunity, insulin resistance and type 2 diabetes
Fernández‐Real, J. M., & Pickup, J. C. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.10.004 · Cited by 206
Bellia, A., Garcovich, C., D’Adamo, M., Lombardo, M., Tesauro, M., Donadel, G., Gentileschi, P., Lauro, D., Federici, M., Lauro, R., et al. (2013) · Internal and Emergency Medicine · doi:10.1007/s11739-011-0559-x · Cited by 206
Hattori, N. (2009) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.12.001 · Cited by 205
Free fatty acids and skeletal muscle insulin resistance
Kraegen, E. W., & Cooney, G. J. (2008) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000319118.44995.9a · Cited by 210
Vázquez, L. A., Pazos, F., de Berrazueta, J. R., Fernández-Escalante, C., García‐Unzueta, M. T., Freijanes, J., & Amado, J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032059 · Cited by 205
Stubbins, R. E., Najjar, K., Holcomb, V. B., Hong, J., & Núñez, N. P. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01488.x · Cited by 204
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism
Takahashi, H., Alves, C. R. R., Stanford, K. I., Middelbeek, R. J. W., Nigro, P., Ryan, R. E., Xue, R., Sakaguchi, M., Lynes, M. D., So, K., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0030-7 · Cited by 204
Adipose tissue and the immune system.
Pond, C. (2005) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.005 · Cited by 210
The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders
Szymczak-Pajor, I., Drzewoski, J., & Śliwińska, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186644 · Cited by 214
Adipose tissue inflammation and ectopic lipid accumulation [Review]
Suganami, T., Tanaka, M., & Ogawa, Y. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0271 · Cited by 207
Maher, J. J., León, P., & Ryan, J. C. (2008) · Hepatology · doi:10.1002/hep.22399 · Cited by 208
Pu, P., Gao, D.-M., Salim, M., Chen, J., Zhang, J., Zhou, X., Nai-jing, Z., Xie, J., & Jiang, H. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.11.026 · Cited by 203
Kornek, M., Lynch, M., Mehta, S. H., Lai, M., Exley, M. A., Afdhal, N. H., & Schuppan, D. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.031 · Cited by 210
Okamoto, Y., Folco, E. J. E., Minami, M., Wara, A. K., Feinberg, M. W., Sukhova, G. K., Colvin, R. A., Kihara, S., Funahashi, T., Luster, A. D., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.164988 · Cited by 208
Kawano, Y., Nakae, J., Watanabe, N., Kikuchi, T., Tateya, S., Tamori, Y., Kaneko, M., Abe, T., Onodera, M., & Itoh, H. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.009 · Cited by 207
Obesity I: Overview and molecular and biochemical mechanisms
Lustig, R. H., Collier, D., Kassotis, C., Roepke, T. A., Kim, M. J., Blanc, E., Barouki, R., Bansal, A., Cave, M. C., Chatterjee, S., et al. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115012 · Cited by 203
The Small Molecule Harmine Is an Antidiabetic Cell-Type-Specific Regulator of PPARγ Expression
Waki, H., Park, K. W., Mitro, N., Pei, L., Damoiseaux, R. D., Wilpitz, D. C., Reue, K., Sáez, E., & Tontonoz, P. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.010 · Cited by 204
Hypothalamic Inflammation in the Control of Metabolic Function
Valdearcos, M., Xu, A. W., & Koliwad, S. K. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071656 · Cited by 209
Insulin Resistance and Atherosclerosis
Razani, B., Chakravarthy, M. V., & Semenkovich, C. F. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.05.001 · Cited by 201
The endocrinology of food intake
Begg, D. P., & Woods, S. C. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.136 · Cited by 214
Malandrino, M. I., Fucho, R., Weber, M., Calderón‐Domínguez, M., Mir, J. F., Valcárcel-Jiménez, L., Escoté, X., Gómez‐Serrano, M., Peral, B., Salvadó, L., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2014 · Cited by 208
QUINN, L., STRAITBODEY, L., ANDERSON, B., ARGILES, J., & HAVEL, P. (2005) · Cell Biology International · doi:10.1016/j.cellbi.2005.02.005 · Cited by 199
Immunologic and endocrine functions of adipose tissue: implications for kidney disease
Zhu, Q., & Scherer, P. E. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.157 · Cited by 200
Influence of body weight on bone mass, architecture and turnover
Iwaniec, U. T., & Turner, R. T. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0089 · Cited by 199
Pachón-Peña, G., Yu, G., Tucker, A., Wu, X., Vendrell, J. J., Bunnell, B. A., & Gimble, J. M. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22408 · Cited by 199
The influence of perivascular adipose tissue on vascular homeostasis
Szasz, T., Bomfim, G. F., & Webb (2013) · Vascular Health and Risk Management · doi:10.2147/vhrm.s33760 · Cited by 205
Endocrinology of Adipose Tissue - An Update
Fischer‐Posovszky, P., Wabitsch, M., & Hochberg, Z. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-976539 · Cited by 202
Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress
Galili, O., Versari, D., Sattler, K., Olson, M. L., Mannheim, D., McConnell, J. P., Chade, A., Lerman, L. O., & Lerman, A. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00628.2006 · Cited by 198
Negrotto, L., Farez, M. F., & Correale, J. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2015.4807 · Cited by 198
Cardiovascular Disease Under the Influence of Excess Visceral Fat
Després, J. (2007) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0b013e318057d4c9 · Cited by 205
Saturated Fatty Acids in Obesity-Associated Inflammation
Zhou, H., Urso, C. J., & Jadeja, V. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s229691 · Cited by 211
Altintas, M. M., Azad, A., Nayer, B., Contreras, G., Zaias, J., Faul, C., Reiser, J., & Nayer, A. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m011338 · Cited by 198
Paniagua, J. A. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i19.483 · Cited by 197
Jiao, P., Ma, J., Feng, B., Zhang, H., Diehl, J. A., Eugene‐Chin, Y., Yan, W., & Xu, H. (2010) · Obesity · doi:10.1038/oby.2010.200 · Cited by 203
Self-citationLinscheid, P., Seboek, D., Zulewski, H., Keller, U. B., & Müller-Stich, B. P. (2005) · Endocrinology · doi:10.1210/en.2004-1424 · Cited by 197
Central regulation of stress-evoked peripheral immune responses
Chan, K. L., Poller, W. C., Swirski, F. K., & Russo, S. J. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00729-2 · Cited by 207
Matsuda, M., & Shimomura, I. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9271-7 · Cited by 205
O’Rourke, R. W., Metcalf, M. D., White, A. E., Madala, A., Winters, B. R., Maizlin, I. I., Jobe, B. A., Roberts, C. T., Slifka, M. K., & Marks, D. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.133 · Cited by 206
Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity
Wang, X., Cao, Q., Yu, L., Shi, H., Xue, B., & Shi, H. (2016) · JCI Insight · doi:10.1172/jci.insight.87748 · Cited by 202
Hussaarts, L., García‐Tardón, N., van Beek, L., Heemskerk, M. M., Haeberlein, S., van der Zon, G. C. M., Ozir‐Fazalalikhan, A., Berbée, J. F. P., van Dijk, K. W., van Harmelen, V., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-266239 · Cited by 198
Chan, K. L., Pillon, N. J., Sivaloganathan, D. M., Costford, S. R., Liu, Z., Théret, M., Chazaud, B., & Klip, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.646992 · Cited by 196
Lai, Z.-L., Tseng, C.-H., Ho, H. J., Cheung, C., Lin, J.-Y., Chen, Y., Cheng, F.-C., Hsu, Y., Lin, J., El-Omar, E. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33893-y · Cited by 192
Luci, C., Bourinet, M., Leclère, P. S., Anty, R., & Gual, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.597648 · Cited by 195
On phagocytes and macular degeneration
Guillonneau, X., Eandi, C. M., Paques, M., Sahel, J.-A., Sapieha, P., & Sennlaub, F. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.06.002 · Cited by 185
Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194
Varma, V., Yao-Borengasser, A., Bodles, A. M., Rasouli, N., Phanavanh, B., Nolen, G. T., Kern, E. M., Nagarajan, R., Spencer, H. J., Lee, M.-J., et al. (2008) · Diabetes · doi:10.2337/db07-0840 · Cited by 194
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes
Legrand-Poels, S., Esser, N., L’homme, L., Scheen, A., Paquot, N., & Piette, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.013 · Cited by 194
Metadata
- Authors
- Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., & Chen, H.
- Affiliations
- Takeda Oncology (United States) (US)
- Corresponding author
- Chen, Hong
- Venue
- Journal of Clinical Investigation
- Published
- 2003-12-15
- Volume
- 112
- Issue
- 12
- Pages
- 1821-1830
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC296998
- OpenAlex
- W2136024338
- Cited by
- 6,760
- References
- 62
- Citations by year
- 2026: 138 · 2025: 177 · 2024: 203 · 2023: 227 · 2022: 257 · 2021: 315 · 2020: 313 · 2019: 347 · 2018: 359 · 2017: 367 · 2016: 401 · 2015: 388 · 2014: 372 · 2013: 499 · 2012: 400
- FWCI
- 103.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, insulin resistance, chronic inflammation, white adipose tissue, macrophages, high-fat diet-induced obesity, rosiglitazone, adipocyte lipolysis, multinucleated giant cells, adipose tissue macrophage infiltration, inflammatory genes
- MeSH terms
- Rosiglitazone, Adipose Tissue, Animals, Body Weight, Cells, Cultured, Gene Expression Regulation, Immunohistochemistry, Inflammation, Insulin Resistance, Lymphocytes, Macrophages, Male, Mice, Inbred C57BL, Mice, Obese, Models, Biological, Neutrophils, Obesity, RNA, RNA, Messenger, Time Factors, Down-Regulation, Giant Cells, Up-Regulation, In Situ Hybridization, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Thiazolidinediones, Mice
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