The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Obesity-induced inflammatory changes in adipose tissue
Open accessAbstract
Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.
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“Adipose tissue is known to accumulate and activate macrophages and lymphocytes which secrete inflammatory factors (186, 187).”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [187]
In the citing paper
“Chronic inflammation with increased circulating levels of cytokines is also characteristic of obesity (162, 186, 187).”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [187]
In the citing paper
“Ageing is also associated with increased concentrations of TNF-a (178,179) , CRP (180) and IL-1ra (176,181) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [179]
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Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Self-citationDiet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL
Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomázy, V. A., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81575-5 · Cited by 1,815
Cited by
Sorted by citations
Items 1,001–1,001 of 1,001
Greaves, P. (2012) · Histopathology of Preclinical Toxicity Studies · doi:10.1016/b978-0-444-53856-7.00002-6 · Cited by 5
Metadata
- Authors
- Wellen, K. E., & Hotamisligil, G. S.
- Affiliations
- Harvard University (US)
- ORCID
- Wellen, Kathryn E.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-12-15
- Volume
- 112
- Issue
- 12
- Pages
- 1785-1788
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC297006
- OpenAlex
- W2007194743
- Cited by
- 1,823
- References
- 19
- Citations by year
- 2026: 18 · 2025: 30 · 2024: 53 · 2023: 36 · 2022: 65 · 2021: 47 · 2020: 69 · 2019: 64 · 2018: 84 · 2017: 89 · 2016: 99 · 2015: 95 · 2014: 98 · 2013: 140 · 2012: 112
- FWCI
- 46.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, adipose tissue inflammation, macrophage infiltration, low-grade inflammation, adipose tissue macrophages
- MeSH terms
- Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Biological Evolution, Humans, Inflammation, Macrophages, Models, Biological, Obesity, Transcription, Genetic
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