Obesity-induced inflammatory changes in adipose tissue

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomázy, V. A., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81575-5 · Cited by 1,815

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690

Type 2 diabetes: principles of pathogenesis and therapy

Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662

n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases

Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529

The Metabolic Syndrome: Time for a Critical Appraisal

Kahn, R., Buse, J. B., Ferrannini, E., & Stern, M. P. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2289 · Cited by 2,400

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292

Recent advances in the relationship between obesity, inflammation, and insulin resistance.

Bastard, J., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., & Fève, B. (2006) · PubMed · Cited by 2,090

Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529

Graves' Ophthalmopathy

Bahn, R. S. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0905750 · Cited by 1,552

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335 · Cited by 1,497

The Many Faces of PPARγ

Lehrke, M., & Lazar, M. A. (2005) · Cell · doi:10.1016/j.cell.2005.11.026 · Cited by 1,472

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Weisberg, S. P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335c1 · Cited by 1,425

Genetics of gene expression and its effect on disease

Emilsson, V., Thorleifsson, G., Zhang, B., Leonardson, A. S., Zink, F., Zhu, J., Carlson, S., Helgason, A., Walters, G. B., Gunnarsdottir, S., et al. (2008) · Nature · doi:10.1038/nature06758 · Cited by 1,296

Immune system to brain signaling: Neuropsychopharmacological implications

Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195

Early Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?

Hanson, M. A., & Gluckman, P. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00029.2013 · Cited by 1,188

Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss

Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164

Disordered lipid metabolism and the pathogenesis of insulin resistance.

Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00024.2006 · Cited by 1,107

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098

Human epicardial adipose tissue: A review

Sacks, H. S., & Fain, J. N. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.03.019 · Cited by 986

Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes & Development · doi:10.1101/gad.1424806 · Cited by 952

Gut microorganisms, mammalian metabolism and personalized health care

Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1152 · Cited by 945

Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

Kamei, N., Tobe, K., Suzuki, R., Ohsugi, M., Watanabe, T., Kubota, N., Ohtsuka-Kowatari, N., Kumagai, K., Sakamoto, K. Q., Kobayashi, M., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601284200 · Cited by 916

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

DeFronzo, R. A. (2010) · Diabetologia · doi:10.1007/s00125-010-1684-1 · Cited by 908

Adiponectin as an anti-inflammatory factor

Ouchi, N., & Walsh, K. X. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 910

Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training

Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 966

CSF-1 regulation of the wandering macrophage: complexity in action

Pixley, F. J., & Stanley, E. R. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.09.016 · Cited by 807

Obesity and neuroinflammation: A pathway to cognitive impairment

Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 834

Effects of obesity on bone metabolism

Cao, J. (2011) · Journal of Orthopaedic Surgery and Research · doi:10.1186/1749-799x-6-30 · Cited by 798

Adipocytokines and the Metabolic Complications of Obesity

Rasouli, N., & Kern, P. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1613 · Cited by 751

Angiogenesis modulates adipogenesis and obesity

Cao, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32239 · Cited by 736

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

Vincent, H. K., & Taylor, A. G. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803177 · Cited by 752

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology · doi:10.1038/ni.2865 · Cited by 727

Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

Fujisaka, S., Usui, I., Bukhari, A., Ikutani, M., Oya, T., Kanatani, Y., Tsuneyama, K., Nagai, Y., Takatsu, K., Urakaze, M., et al. (2009) · Diabetes · doi:10.2337/db08-1475 · Cited by 731

Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta

Challier, J. C., Basu, S., Bintein, T., Minium, J., Hotmire, K., Catalano, P. M., & Hauguel-de Mouzon, S. (2008) · Placenta · doi:10.1016/j.placenta.2007.12.010 · Cited by 712

Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

Bhatti, J. S., Sehrawat, A., Mishra, J., Sidhu, I. S., Navik, U., Khullar, N., Kumar, S., Bhatti, G. K., & Reddy, P. H. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.019 · Cited by 753

T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance

Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.165100 · Cited by 692

Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease

Baker, A. R., da Silva, N. F., Quinn, D. W., Harte, A. L., Pagano, D., Bonser, R. S., Kumar, S., & McTernan, P. G. (2006) · Cardiovascular Diabetology · doi:10.1186/1475-2840-5-1 · Cited by 646

The association between chronic pain and obesity

Okifuji, A., & Hare, B. (2015) · Journal of Pain Research · doi:10.2147/jpr.s55598 · Cited by 597

The inflammation highway: metabolism accelerates inflammatory traffic in obesity

Johnson, A. R., Justin Milner, J., & Makowski, L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01151.x · Cited by 603

Metabolic Syndrome, Aging and Involvement of Oxidative Stress

Bonomini, F., Rodella, L. F., & Rezzani, R. (2015) · Aging and Disease · doi:10.14336/ad.2014.0305 · Cited by 599

MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

Xie, H., Lim, B., & Lodish, H. F. (2009) · Diabetes · doi:10.2337/db08-1299 · Cited by 586

Macrophage Infiltration into Omental Versus Subcutaneous Fat across Different Populations: Effect of Regional Adiposity and the Comorbidities of Obesity

Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1811 · Cited by 574

Acute phase proteins in ruminants

Ceciliani, F., Cerón, J. M. C., Eckersall, P. D., & Sauerwein, H. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.04.004 · Cited by 579

Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents

Di Pino, A., & DeFronzo, R. A. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00141 · Cited by 535

Adipokines as novel biomarkers and regulators of the metabolic syndrome

Deng, Y., & Scherer, P. E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05875.x · Cited by 578

Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production

Zeyda, M., Farmer, D., Todoric, J., Aszmann, O. C., Speiser, M., Györi, G., Zlabinger, G. J., & Stulnig, T. M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803632 · Cited by 575

Obesity and Asthma

Beuther, D. A., Weiss, S. T., & Sutherland, E. R. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200602-231pp · Cited by 557

Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity

Bays, H. E., González-Campoy, J. M., Bray, G. A., Kitabchi, A. E., Bergman, D. A., Schorr, A. B., Rodbard, H. W., & Henry, R. R. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.343 · Cited by 543

Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation

Rocha, V. Z., Folco, E. J. E., Sukhova, G. K., Shimizu, K., Gotsman, I., Vernon, A. H., & Libby, P. (2008) · Circulation Research · doi:10.1161/circresaha.108.177105 · Cited by 540

Normal fasting plasma glucose levels and type 2 diabetes in young men

Tirosh, A., Shai, I., Tekes-Manova, D., Israeli, E., Pereg, D., Shochat, T., Kochba, I., & Rudich, A. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050080 · Cited by 508

Insulin Resistance, Obesity and Lipotoxicity

Yazıcı, D., & Sezer, H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_12 · Cited by 525

Can probiotics modulate human disease by impacting intestinal barrier function?

Bron, P. A., Kleerebezem, M., Brummer, R.-J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004037 · Cited by 499

The Hyperglycemia-induced Inflammatory Response in Adipocytes

Lin, Y., Berg, A. H., Iyengar, P., Lam, T. K. T., Giacca, A., Combs, T. P., Rajala, M. W., Du, X., Rollman, B., Li, W., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411863200 · Cited by 507

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

Elgazar-Carmon, V., Rudich, A., Hadad, N., & Lévy, R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800132-jlr200 · Cited by 510

Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?

Ohira, H., Tsutsui, W., & Fujioka, Y. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17006 · Cited by 492

Peroxisome Proliferator-Activated Receptor γ and Adipose Tissue—Understanding Obesity-Related Changes in Regulation of Lipid and Glucose Metabolism

Sharma, A. M., & Staels, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1268 · Cited by 483

Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression

Jernås, M., Palming, J., Sjöholm, K., Jennische, E., Svensson, P.-A., Gabrielsson, B. G., Levin, M., Sjögren, A., Rudemo, M., Lystig, T. C., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5678fje · Cited by 454

The Potential of Adipose Stem Cells in Regenerative Medicine

Lindroos, B., Suuronen, R., & Miettinen, S. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9193-7 · Cited by 443

Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels

Nishimura, S., Manabe, I., Nagasaki, M., Hosoya, Y., Yamashita, H., Fujita, H., Ohsugi, M., Tobe, K., Kadowaki, T., Nagai, R., et al. (2007) · Diabetes · doi:10.2337/db06-1749 · Cited by 440

Hyperuricemia as a Mediator of the Proinflammatory Endocrine Imbalance in the Adipose Tissue in a Murine Model of the Metabolic Syndrome

Baldwin, W., McRae, S., Marek, G. W., Wymer, D. C., Pannu, V., Baylis, C., Johnson, R. J., & Sautin, Y. Y. (2011) · Diabetes · doi:10.2337/db10-0916 · Cited by 442

Stress hormones: physiological stress and regulation of metabolism

Kyrou, I., & Tsigos, C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.08.007 · Cited by 469

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Ligthart, S., Vaez, A., Võsa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.09.009 · Cited by 421

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

Titos, E., Rius, B., González-Périz, A., López-Vicario, C., Morán-Salvador, E., Martínez-Clemente, M., Arroyo, V., & Clària, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100225 · Cited by 412

Versatile functions for IL-6 in metabolism and cancer

Mauer, J., Denson, J. L., & Brüning, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.008 · Cited by 415

Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.

Zabolotny, J. M., Kim, Y.-B., Welsh, L. A., Kershaw, E. E., Neel, B. G., & Kahn, B. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800061200 · Cited by 404

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

Kawasaki, N., Asada, R., Saito, A., Kanemoto, S., & Imaizumi, K. (2012) · Scientific Reports · doi:10.1038/srep00799 · Cited by 420

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice

Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., Heywood, E. B., Jones, K. L., Kawamori, R., Cassis, L. A., Tschöp, M. H., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31986 · Cited by 401

Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

Brestoff, J. R., Wilen, C. B., Moley, J. R., Li, Y., Zou, W., Malvin, N. P., Rowen, M. N., Saunders, B. T., Ma, H., Mack, M. R., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.008 · Cited by 399

Secretory factors from human adipose tissue and their functional role

Hauner, H. (2005) · Proceedings of the Nutrition Society · doi:10.1079/pns2005428 · Cited by 391

Elevated endotoxin levels in non-alcoholic fatty liver disease

Harte, A. L., da Silva, N. F., Creely, S. J., McGee, K. C., Billyard, T., Elabd, E. M. Y., Tripathi, G., Ashour, E., Abdalla, M. S., Sharada, H. M., et al. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-15 · Cited by 406

Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects

Apovian, C. M., Bigornia, S., Mott, M. M., Meyers, M. R., Ulloor, J., Gagua, M., McDonnell, M. E., Hess, D. T., Joseph, L., & Gokce, N. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.170316 · Cited by 392

Immunometabolism: From basic mechanisms to translation

Makowski, L., Chaib, M., & Rathmell, J. C. (2020) · Immunological Reviews · doi:10.1111/imr.12858 · Cited by 386

The metabolic syndrome: time for a critical appraisal

Kahn, R., Buse, J. B., Ferrannini, E., & Stern, M. P. (2005) · Diabetologia · doi:10.1007/s00125-005-1876-2 · Cited by 384

Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections

Hodgson, K., Morris, J. L., Bridson, T. L., Govan, B., Rush, C. M., & Ketheesan, N. (2014) · Immunology · doi:10.1111/imm.12394 · Cited by 375

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

Li, A. C., & Glass, C. K. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400010-jlr200 · Cited by 357

Inflammation in End-Stage Renal Disease-What Have We Learned in 10 Years?

Carrero, J. J., & Stenvinkel, P. (2010) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2010.00784.x · Cited by 359

Inflammation, Abdominal Obesity, and Smoking as Predictors of Hypertension

NISKANEN, L. K., Laaksonen, D. E., Nyyssönen, K., Punnonen, K. R. A., Valkonen, V.-P., Fuentes, R. M., Tuomainen, T., Salonen, R. M., & Salonen, J. T. (2004) · Hypertension · doi:10.1161/01.hyp.0000146691.51307.84 · Cited by 351

Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression

Park, J., Euhus, D., & Scherer, P. E. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0030 · Cited by 361

Body Mass and Glucocorticoid Response in Asthma

Sutherland, E. R., Goleva, E., Strand, M. J., Beuther, D. A., & Leung, D. Y. M. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-076oc · Cited by 355

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

Bakker, W., Eringa, E. C., Sipkema, P., & van Hinsbergh, V. W. M. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0685-6 · Cited by 359

Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

Yamauchi, T., & Kadowaki, T. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.233 · Cited by 347

From excess adiposity to insulin resistance: The role of free fatty acids

Capurso, C., & Capurso, A. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.05.003 · Cited by 337

Central effects of estradiol in the regulation of food intake, body weight, and adiposity

Brown, L. M., & Clegg, D. J. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.005 · Cited by 331

Endocrine Functions of Adipose Tissue

Waki, H., & Tontonoz, P. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.2.010506.091859 · Cited by 348

Analysis of Association between Vitamin D Deficiency and Insulin Resistance

Szymczak-Pajor, I., & Śliwińska, A. (2019) · Nutrients · doi:10.3390/nu11040794 · Cited by 350

Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat

Davis, J. E., Gabler, N. K., Walker‐Daniels, J., & Spurlock, M. E. (2008) · Obesity · doi:10.1038/oby.2008.210 · Cited by 334

Metabolic effects of obesity: A review

Singla, P. (2010) · World Journal of Diabetes · doi:10.4239/wjd.v1.i3.76 · Cited by 341

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

Ilan, Y., Maron, R., Tukpah, A.-M. C., Maioli, T. U., Murugaiyan, G., Yang, K., Wu, H. Y., & Weiner, H. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908771107 · Cited by 327

Adipokines and the Peripheral and Neural Control of Energy Balance

Ahima, R. S., & Lazar, M. A. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0529 · Cited by 324

Cytokine Research in Depression: Principles, Challenges, and Open Questions

Himmerich, H., Patsalos, O., Lichtblau, N., Ibrahim, M. A. A., & Dalton, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00030 · Cited by 313

Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids

Todoric, J., Löffler, M. G., Huber, J., Bilban, M., Reimers, M., Kadl, A., Zeyda, M., Waldhäusl, W., & Stulnig, T. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0300-x · Cited by 318

Angiogenic Role of LYVE-1–Positive Macrophages in Adipose Tissue

Cho, C.-H., Jun Koh, Y., Han, J., Sung, H.-K., Jong Lee, H., Morisada, T., Schwendener, R. A., Brekken, R. A., Kang, G., Oike, Y., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000259564.92792.93 · Cited by 309

Dysregulated metabolism contributes to oncogenesis

Hirschey, M. D., DeBerardinis, R. J., Diehl, A. M., Drew, J. E., Frezza, C., Green, M. F., Jones, L. W., Ko, Y. H., Le, A., Lea, M. A., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.10.002 · Cited by 316

Macrophage-secreted factors induce adipocyte inflammation and insulin resistance

Permana, P. A., Menge, C., & Reaven, P. D. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.012 · Cited by 307

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

Satoh, T., Kidoya, H., Naito, H., Yamamoto, M., Takemura, N., Nakagawa, K., Yoshioka, Y., Morii, E., Takakura, N., Takeuchi, O., et al. (2013) · Nature · doi:10.1038/nature11930 · Cited by 311

Chemerin enhances insulin signaling and potentiates insulin‐stimulated glucose uptake in 3T3‐L1 adipocytes

Takahashi, M., Takahashi, Y., Takahashi, K. P., Zolotaryov, F. N., Hong, K. S., Kitazawa, R., Iida, K., Okimura, Y., Kaji, H., Kitazawa, S., et al. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.01.023 · Cited by 296

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

Keiran, N., Ceperuelo‐Mallafré, V., Calvo, E., Hernández‐Álvarez, M. I., Ejarque, M., Núñez‐Roa, C., Horrillo, D., Maymó‐Masip, E., Rodríguez, M. M., Fradera, R., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0372-7 · Cited by 307

Feeding Our Immune System: Impact on Metabolism

Wolowczuk, I., Verwaerde, C., Viltart, O., Delanoye, A., Delacre, M., Pot, B., & Grangette, C. (2008) · Clinical and Developmental Immunology · doi:10.1155/2008/639803 · Cited by 307

Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue

Wu, D., Ren, Z., Pae, M., Guo, W., Cui, X., Merrill, A. H., & Meydani, S. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4829 · Cited by 293

[New trends in macrophages, inflammation and adipose tissue].

Rico-Rosillo, M. G., & Vega-Robledo, G. B. (2012) · PubMed · Cited by 2

Review article: Is obesity an inflammatory illness? Role of low‐grade inflammation and macrophage infiltration in human white adipose tissue

Cancello, R., & Clément, K. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01004.x · Cited by 418

Papel do tecido adiposo e dos macrófagos no estado de inflamação crónica associada à obesidade: implicações clínicas.

Ramalho, R., & Guimarães, C. (2008) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 5

Le tissu adipeux

Dalmas, É., Tordjman, J., Guerre-Millo, M., & Clément, K. (2011) · médecine/sciences · doi:10.1051/medsci/20112711016 · Cited by 17

Adipose Tissue Inflammation in Obesity

Poitou, C., Dalmas, É., & Clément, K. (2012) · Springer eBooks · doi:10.1007/978-2-8178-0343-2_20 · Cited by 2