Obesity-induced inflammatory changes in adipose tissue

Obesity is associated with macrophage accumulation in adipose tissue

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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A central role for JNK in obesity and insulin resistance

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Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

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Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

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PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

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Mechanisms of Insulin Resistance in Humans and Possible Links With Inflammation

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Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties

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Macrophage recruitment in obese adipose tissue

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The metabolic consequences of childhood obesity

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Role of resistin in obesity, insulin resistance and Type II diabetes

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Live strong and prosper: the importance of skeletal muscle strength for healthy ageing

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The inflammatory consequences of psychologic stress: Relationship to insulin resistance, obesity, atherosclerosis and diabetes mellitus, type II

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Interleukin-6 depletion selectively improves hepatic insulin action in obesity.

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Macrophages, Chronic Inflammation, and Insulin Resistance

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Obesity and chronic kidney disease

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Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation

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Adipocyte-Macrophage Cross-Talk in Obesity

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Pathogenesis and management issues for non-alcoholic fatty liver disease

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Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function

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Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

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Obesity and dyslipidemia

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Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes

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The role of cadmium in obesity and diabetes

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Association Between Elevated Liver Enzymes and C-Reactive Protein

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Adherence to the Mediterranean Diet and Inflammatory Markers

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What is lipotoxicity?

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Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases

Tilg, H., & Moschen, A. R. (2008) · Clinical Science · doi:10.1042/cs20070196 · Cited by 252

Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in Primary Cultures of Newly Differentiated Human Adipocytes

Chung, S., LaPoint, K., Martinez, K., Kennedy, A. J., Sandberg, M. B., & McIntosh, M. (2006) · Endocrinology · doi:10.1210/en.2006-0536 · Cited by 254

SPARC and tumor growth: Where the seed meets the soil?

Framson, P. E., & Sage, E. H. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20091 · Cited by 250

Nutrition and reproduction in women

The ESHRE Capri Workshop Group (2006) · Human Reproduction Update · doi:10.1093/humupd/dmk003 · Cited by 247

Adipose tissues as an ancestral immune organ: Site‐specific change in obesity

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Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes

Han, C. Y., Kargi, A. Y., Omer, M., Chan, C. K., Wabitsch, M., O’Brien, K. D., Wight, T. N., & Chait, A. (2009) · Diabetes · doi:10.2337/db09-0925 · Cited by 250

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

Chaurasia, B., Kaddai, V., Lancaster, G. I., Henstridge, D. C., Sriram, S., Galam, D. L. A., Gopalan, V., Prakash, B., Velan, S. S., Bulchand, S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.002 · Cited by 247

Visceral adiposity, insulin resistance and cancer risk

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Obstructive sleep apnea and the metabolic syndrome: The road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment

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Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages

Mullen, A., Loscher, C. E., & Roche, H. M. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.02.008 · Cited by 245

Unfavorable cardiovascular risk profiles in untreated and treated psoriasis patients

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Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation

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High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice

Cao, J., Gregoire, B. R., & Gao, H. (2009) · Bone · doi:10.1016/j.bone.2009.02.017 · Cited by 235

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

Koliwad, S. K., Streeper, R. S., Monetti, M., Cornelissen, I., Chan, L. C., Terayama, K., Naylor, S. G., Rao, M., Hubbard, B. K., & Farese, R. V. (2010) · Journal of Clinical Investigation · doi:10.1172/jci36066 · Cited by 236

Characterization of the Human Visceral Adipose Tissue Secretome

Álvarez‐Llamas, G., Szalowska, E., de Vries, M. P., Weening, D., Landman, K., Hoek, A., Wolffenbuttel, B. H. R., Roelofsen, H., & Vonk, R. J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600265-mcp200 · Cited by 236

The diversity of sex steroid action: regulation of metabolism by estrogen signaling

Faulds, M. H., Zhao, C., Dahlman-Wright, K., & Gustafsson, J.-Å. (2012) · Journal of Endocrinology · doi:10.1530/joe-11-0044 · Cited by 230

The G/G Genotype of a Resistin Single-Nucleotide Polymorphism at −420 Increases Type 2 Diabetes Mellitus Susceptibility by Inducing Promoter Activity through Specific Binding of Sp1/3

Osawa, H., Yamada, K., Onuma, H., Murakami, A., Ochi, M., Kawata, H., Nishimiya, T., Niiya, T., Shimizu, I., Nishida, W., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/424761 · Cited by 228

Metabolic Syndrome: Focus on Dyslipidemia

Ginsberg, H. N., Zhang, Y., & Hernández‐Ono, A. (2006) · Obesity · doi:10.1038/oby.2006.281 · Cited by 228

Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-α

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On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?

Roohi, E., Jaafari, N., & Hashemian, F. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02100-7 · Cited by 256

Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity

Hardy, O. T., Perugini, R. A., Nicoloro, S. M. C., Gallagher-Dorval, K. A., Puri, V., Straubhaar, J., & Czech, M. (2010) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.05.013 · Cited by 229

Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters

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Curcumin inhibits NF-κB activation and reduces the severity of experimental steatohepatitis in mice

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Depressive symptoms and metabolic syndrome: is inflammation the underlying link?

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Obesity, pregnancy, inflammation, and vascular function

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Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic Overactivity

Canale, M. P., di Villahermosa, S. M., Martino, G., Rovella, V., Noce, A., LORENZO, A. D., & Daniele, N. D. (2013) · International Journal of Endocrinology · doi:10.1155/2013/865965 · Cited by 224

Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice

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Regulatory dendritic cells: there is more than just immune activation

Schmidt, S. V., Niño‐Castro, A., & Schultze, J. L. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00274 · Cited by 224

Overexpression of Glucose-6-Phosphate Dehydrogenase Is Associated with Lipid Dysregulation and Insulin Resistance in Obesity

Park, J., Rho, H. K., Kim, K. H., Choe, S. S., Lee, Y. S., & Kim, J. B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5146-5157.2005 · Cited by 212

Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys

Kavanagh, K., Jones, K. L., Sawyer, J., Kelley, K., Carr, J. J., Wagner, J. D., & Rudel, L. L. (2007) · Obesity · doi:10.1038/oby.2007.200 · Cited by 208

Human Primary Adipocytes Exhibit Immune Cell Function: Adipocytes Prime Inflammation Independent of Macrophages

Meijer, K., de Vries, M., Al-Lahham, S., Bruinenberg, M., Weening, D., Dijkstra, M., Kloosterhuis, N., van der Lei, R. J., van der Want, H., Kroesen, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017154 · Cited by 211

A Unique Role of Monocyte Chemoattractant Protein 1 among Chemokines in Adipose Tissue of Obese Subjects

Dahlman, I. A., Kaaman, M., Olsson, T., Tan, G. D., Bickerton, A. S. T., Wåhlén, K., Andersson, J. S. O., Nordström, E. A., Blomqvist, L., Sjögren, A., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0369 · Cited by 207

Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system

Hattori, N. (2009) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.12.001 · Cited by 205

Ghrelin Improves Endothelial Function in Patients With Metabolic Syndrome

Tesauro, M., Schinzari, F., Iantorno, M., Rizza, S., Melina, D., Lauro, D., & Cardillo, C. (2005) · Circulation · doi:10.1161/circulationaha.105.553883 · Cited by 205

The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders

Szymczak-Pajor, I., Drzewoski, J., & Śliwińska, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186644 · Cited by 214

Beyond insulin resistance

Maher, J. J., León, P., & Ryan, J. C. (2008) · Hepatology · doi:10.1002/hep.22399 · Cited by 208

Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance

Newton, J. L., Jones, D. E. J., Henderson, E. J., Kane, L., Wilton, K., Burt, A. D., & Day, C. (2008) · Gut · doi:10.1136/gut.2007.139303 · Cited by 204

Truncal fat mass as a contributor to inflammation in end-stage renal disease

Axelsson, J., Qureshi, A. R., Suliman, M. E., Honda, H., Pecoits‐Filho, R., Heimbürger, O., Lindholm, B., Cederholm, T., & Stenvinkel, P. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1222 · Cited by 199

Central Resistin Overexposure Induces Insulin Resistance Through Toll-Like Receptor 4

Benomar, Y., Gertler, A., De Lacy, P., Crépin, D., Ould Hamouda, H., Riffault, L., & Taouis, M. (2013) · Diabetes · doi:10.2337/db12-0237 · Cited by 177

Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome

Paniagua, J. A. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i19.483 · Cited by 197

A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling

Kennedy, D. J., Kuchibhotla, S., Westfall, K. M., Silverstein, R. L., Morton, R. E., & Febbraio, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq360 · Cited by 211

Oxidative Stress and Inflammation Are Associated with Adiposity in Moderate to Severe CKD

Ramos, L. F., Shintani, A., Ikizler, T. A., & Himmelfarb, J. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007030355 · Cited by 197

PTP1B: A simple enzyme for a complex world

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Role of C-Reactive Protein in Diabetic Inflammation

Stanimirović, J., Radovanović, J., Banjac, K., Obradovic, M. M., Essack, M., Zafirovic, S. S., Gluvic, Z. M., Gojobori, T., & Isenović, E. R. (2022) · Mediators of Inflammation · doi:10.1155/2022/3706508 · Cited by 219

Thrombospondin-1 Is an Adipokine Associated With Obesity, Adipose Inflammation, and Insulin Resistance

Varma, V., Yao-Borengasser, A., Bodles, A. M., Rasouli, N., Phanavanh, B., Nolen, G. T., Kern, E. M., Nagarajan, R., Spencer, H. J., Lee, M.-J., et al. (2008) · Diabetes · doi:10.2337/db07-0840 · Cited by 194

N ε -(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance

Gaens, K. H. J., Goossens, G. H., Niessen, P., van Greevenbroek, M. M. J., Kallen, C., Niessen, H. W. M., Rensen, S. S., Buurman, W. A., Greve, J. W. M., Blaak, E. E., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302281 · Cited by 196

Non-alcoholic steatohepatitis: From cell biology to clinical practice

Cortez‐Pinto, H., de Moura, M. C., & Day, C. P. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.09.002 · Cited by 194

Sex Differences in the Relationship between C-Reactive Protein and Body Fat

Khera, A., Vega, G. L., Das, S. R., Ayers, C. R., McGuire, D. K., Grundy, S. M., & de Lemos, J. A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2406 · Cited by 190

Vitamin D and adipose tissue—more than storage

Mutt, S. J., Hyppönen, E., Saarnio, J., Järvelin, M., & Herzig, K. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00228 · Cited by 197

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response

Winnay, J. N., Boucher, J., Mori, M. A., Ueki, K., & Kahn, C. R. (2010) · Nature Medicine · doi:10.1038/nm.2121 · Cited by 195

Spironolactone Improves Glucose and Lipid Metabolism by Ameliorating Hepatic Steatosis and Inflammation and Suppressing Enhanced Gluconeogenesis Induced by High-Fat and High-Fructose Diet

Wada, T., Kenmochi, H., Miyashita, Y., Sasaki, M., Ojima, M., Sasahara, M., Koya, D., Tsuneki, H., & Sasaoka, T. (2010) · Endocrinology · doi:10.1210/en.2009-0869 · Cited by 189

Immunosenescence and Immunogenetics of Human Longevity

Ostan, R., Bucci, L., Capri, M., Salvioli, S., Scurti, M., Pini, E., Monti, D., & Franceschi, C. (2008) · NeuroImmunoModulation · doi:10.1159/000156466 · Cited by 189

Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation

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Molecular Mechanisms for the Vicious Cycle between Insulin Resistance and the Inflammatory Response in Obesity

Szukiewicz, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129818 · Cited by 216

NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes

Han, C. Y., Umemoto, T., Omer, M., Den Hartigh, L. J., Chiba, T., LeBoeuf, R., Buller, C. L., Sweet, I. R., Pennathur, S., Abel, E. D., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.304998 · Cited by 187

Metabolic syndrome pathophysiology: The role of adipose tissue

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Leptin Increases the Expression of the Iron Regulatory Hormone Hepcidin in HuH7 Human Hepatoma Cells

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Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America

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Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention

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