Obesity-induced inflammatory changes in adipose tissue

Obesity is associated with macrophage accumulation in adipose tissue

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

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Neuroendocrine factors in the regulation of inflammation: Excessive adiposity and calorie restriction

Fontana, L. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.005 · Cited by 81

Well-being and immune response: a multi-system perspective

Lasselin, J., Alvarez‐Salas, E., & Grigoleit, J. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.05.003 · Cited by 91

Obesity, Lutein Metabolism, and Age-Related Macular Degeneration: A Web of Connections

Johnson, E. J. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00105.x · Cited by 82

Obesity-induced chronic inflammation in high fat diet challenged C57BL/6J mice is associated with acceleration of age-dependent renal amyloidosis

van der Heijden, R. A., Bijzet, J., Meijers, W. C., Yakala, G. K., Kleemann, R., Nguyen, T. Q., de Boer, R. A., Schalkwijk, C. G., Hazenberg, B. P. C., Tietge, U. J. F., et al. (2015) · Scientific Reports · doi:10.1038/srep16474 · Cited by 83

Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway

Salaffi, F., Giacobazzi, G., & Carlo, M. D. (2018) · Pain Research and Management · doi:10.1155/2018/8564215 · Cited by 82

Hypothalamic integration of immune function and metabolism

Guijarro, A. I., Laviano, A., & Meguid, M. M. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53022-5 · Cited by 84

The effects of exercise modalities on adiposity in obese rats

Speretta, G. F. F., Rosante, M. C., Duarte, F. O., Leite, R. D., Lino, A. D. D. S., Andre, R. A., Silvestre, J. G., Selistre-de-Araújo, H. S., & Duarte, A. C. G. D. O. (2012) · Clinics · doi:10.6061/clinics/2012(12)19 · Cited by 83

The Effect of Very-Low-Calorie Diet on mRNA Expression of Inflammation-Related Genes in Subcutaneous Adipose Tissue and Peripheral Monocytes of Obese Patients with Type 2 Diabetes Mellitus

Mráz, M., Lacinová, Z., Drápalová, J., Haluzíková, D., Hořínek, A., Matoulek, M., Trachta, P., Kaválková, P., Svacina, S., & Haluzı́k, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1858 · Cited by 85

Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab

Gisondi, P., Lora, V., Bonauguri, C., Russo, A., Lippi, G., & Girolomoni, G. (2012) · British Journal of Dermatology · doi:10.1111/bjd.12118 · Cited by 83

Ghrelin receptor regulates adipose tissue inflammation in aging

Lin, L., Lee, J. H., Buras, E. D., Yu, K., Wang, R., Smith, C. W., Wu, H., Sheikh‐Hamad, D., & Sun, Y. (2016) · Aging · doi:10.18632/aging.100888 · Cited by 82

Dietary cocoa reduces metabolic endotoxemia and adipose tissue inflammation in high-fat fed mice

Gu, Y., Yu, S., Park, J. Y., Harvatine, K. J., & Lambert, J. D. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.12.004 · Cited by 83

Obesity-associated inflammation triggers an autophagy–lysosomal response in adipocytes and causes degradation of perilipin 1

Ju, L., Han, J., Zhang, X., Deng, Y., Han, Y., Wang, C., Li, X., Chen, S., Alimujiang, M., Li, X., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1393-8 · Cited by 81

Paradoxical Hyperadiponectinemia is Associated With the Metabolically Healthy Obese (MHO) Phenotype in African Americans

Doumatey (2012) · Journal of Endocrinology and Metabolism · doi:10.4021/jem95w · Cited by 82

Association between insulin resistance and c-reactive protein among Peruvian adults

Gelaye, B., Revilla, L., López, T., Suárez, L. A., Sánchez, S. E., Hevner, K., Fitzpatrick, A. L., & Williams, M. A. (2010) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-2-30 · Cited by 81

Nutrition, metabolic factors and cancer risk

Dossus, L., & Kaaks, R. (2008) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.08.003 · Cited by 82

Long‐term Successful Weight Loss Improves Vascular Endothelial Function in Severely Obese Individuals

Bigornia, S., Mott, M. M., Hess, D. T., Apovian, C. M., McDonnell, M. E., Duess, M., Kluge, M. A., Fiscale, A. J., Vita, J. A., & Gokce, N. (2010) · Obesity · doi:10.1038/oby.2009.482 · Cited by 80

Adipocyte Size and Liability to Cell Death

Monteiro, R., de Castro, P. M. S. T., Calhau, C., & Azevedo, I. (2006) · Obesity Surgery · doi:10.1381/096089206777346600 · Cited by 79

Obesity enhanced respiratory health effects of ambient air pollution in Chinese children: the Seven Northeastern Cities study

Dong, G., Qian, Z. M., Liu, M.-M., Wang, D., Ren, W.-H., Fu, Q., Wang, J., Simckes, M. S., Ferguson, T. F., & Trevathan, E. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.125 · Cited by 81

N-3 Polyunsaturated Fatty Acids and Inflammation in Obesity: Local Effect and Systemic Benefit

Wang, Y., & Huang, F. (2015) · BioMed Research International · doi:10.1155/2015/581469 · Cited by 89

Central Resistin/TLR4 Impairs Adiponectin Signaling, Contributing to Insulin and FGF21 Resistance

Benomar, Y., Amine, H., Crépin, D., Al Rifai, S., Riffault, L., Gertler, A., & Taouis, M. (2016) · Diabetes · doi:10.2337/db15-1029 · Cited by 76

Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis

Anthony, S., Guarnieri, A., Gozdiff, A., Helsley, R. N., Owens, A. P., & Tranter, M. (2019) · Clinical Science · doi:10.1042/cs20190578 · Cited by 82

Proliferative and Non-Proliferative Lesions of the Rat and Mouse Soft Tissue, Skeletal Muscle and Mesothelium

Greaves, P., Chouinard, L., Ernst, H., Mecklenburg, L., Pruimboom‐Brees, I., Rinke, M., Rittinghausen, S., Thibault, S., von Erichsen, J., & Yoshida, T. (2013) · Journal of Toxicologic Pathology · doi:10.1293/tox.26.1s · Cited by 80

Role of the Electrophilic Lipid Peroxidation Product 4-Hydroxynonenal in the Development and Maintenance of Obesity in Mice

Singh, S. P., Niemczyk, M., Saini, D., Awasthi, S., Zimniak, L., & Zimniak, P. (2008) · Biochemistry · doi:10.1021/bi702124u · Cited by 82

Serum resistin level among healthy subjects: relationship to anthropometric and metabolic parameters

Chen, C., Li, T., Li, C.-I., Liu, C.-S., Wang, H.-J., & Lin, C. (2005) · Metabolism · doi:10.1016/j.metabol.2004.10.015 · Cited by 80

The potential interactions between polyunsaturated fatty acids and colonic inflammatory processes

Mills, S., Windsor, A. C. J., & Knight, S. C. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02851.x · Cited by 81

Fatigue symptoms relate to systemic inflammation in patients with type 2 diabetes

Lasselin, J., Layé, S., Dexpert, S., Aubert, A., Gonzalez, C., Gin, H., & Capuron, L. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.03.003 · Cited by 77

Inflammation mediates the association between visceral adiposity and obstructive sleep apnea in adolescents

Gaines, J., Vgontzas, A. N., Fernández‐Mendoza, J., Calhoun, S. L., He, F., Liao, D., Sawyer, M. D., & Bixler, E. O. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2016 · Cited by 78

Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity

Sears, B., & Ricordi, C. (2010) · Journal of Obesity · doi:10.1155/2011/431985 · Cited by 82

Metabolic syndrome, activity of the hypothalamic-pituitary-adrenal axis and inflammatory mediators in depressive disorder.

Martinac, M., Pehar, D., Karlović, D., Babic, D. D., Marčinko, D., & Jakovljević, M. (2014) · PubMed · Cited by 83

Novel Connections Between the Neuroendocrine and Immune Systems: The Ghrelin Immunoregulatory Network

Taub, D. D. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)77014-5 · Cited by 80

Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet

Shen, H., Huang, S.-Y., Kung, C.-W., Chen, S., Chen, Y., Cheng, P., Lam, K., & Lee, Y. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.02.001 · Cited by 78

Obesity is associated with activated and insulin resistant immune cells

Viardot, A., Heilbronn, L. K., Samocha‐Bonet, D., Mackay, F., Campbell, L. V., & Samaras, K. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2302 · Cited by 77

Micronutrient deficiency and cognitive and physical performance in Indian children

Swaminathan, S., Edward, B., & Kurpad, A. V. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.14 · Cited by 77

Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes

Faßhauer, M., Klein, J. C., Kralisch, S., Klier, M., Lössner, U., Blüher, M., & Paschke, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.090 · Cited by 77

The Effects of Weight Loss and Gastric Banding on the Innate and Adaptive Immune System in Type 2 Diabetes and Prediabetes

Viardot, A., Lord, R. V., & Samaras, K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2371 · Cited by 79

Leptin in the regulation of the immunometabolism of adipose tissue-macrophages

Monteiro, L. D. B., Pereira, J. A. D. S., Palhinha, L., & Moraes‐Vieira, P. M. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr1218-478r · Cited by 80

c-MAF–dependent perivascular macrophages regulate diet-induced metabolic syndrome

Silva, H. M., Kitoko, J. Z., Queiroz, C. P., Kroehling, L., Matheis, F., Yang, K. L., Reis, B. S., Ren‐Fielding, C. J., Littman, D. R., Bozza, M. T., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abg7506 · Cited by 75

Stress and Diabetes Mellitus: Pathogenetic Mechanisms and Clinical Outcome

Ingrosso, D. M. F., Primavera, M., Samvelyan, S., Tagi, V. M., & Chiarelli, F. (2022) · Hormone Research in Paediatrics · doi:10.1159/000522431 · Cited by 86

Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets

Lohmann, C., Schäfer, N., von Lukowicz, T., Stein, M., Borén, J., Rütti, S., Wahli, W., Donath, M. Y., Lüscher, T. F., & Matter, C. M. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.05.004 · Cited by 80

In vitro evidence that hyperglycemia stimulates tumor necrosis factor-α release in obese women with polycystic ovary syndrome

González, F., Rote, N. S., Minium, J., & Kirwan, J. P. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06579 · Cited by 76

Characterization of the human visceral adipose tissue secretome

Álvarez‐Llamas, G., Szalowska, E., de Vries, M. P., Weening, D., Landman, K., Hoek, A., Wolffenbuttel, B. H. R., Roelofsen, H., & Vonk, R. J. (2007) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 75

Fatty acid and non-alcoholic fatty liver disease: Meta-analyses of case-control and randomized controlled trials

Guo, X., Yang, B., Tang, J., & Li, D. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.01.003 · Cited by 79

Diet‐induced obesity alters immune cell infiltration and expression of inflammatory cytokine genes in mouse ovarian and peri‐ovarian adipose depot tissues

Nteeba, J., Ortinau, L. C., Perfield, J. W., & Keating, A. F. (2013) · Molecular Reproduction and Development · doi:10.1002/mrd.22231 · Cited by 74

Adiposopathy: why do adiposity and obesity cause metabolic disease?

Bays, H. E., & Ballantyne, C. M. (2006) · Future Lipidology · doi:10.2217/17460875.1.4.389 · Cited by 75

Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells

Anfossi, G., Russo, I., Doronzo, G., Pomero, A., & Trovati, M. (2010) · Mediators of Inflammation · doi:10.1155/2010/174341 · Cited by 76

Adipose tissue changes in obesity

Coppack, S. W. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331049 · Cited by 74

Long noncoding RNA MALAT1 regulates generation of reactive oxygen species and the insulin responses in male mice

Chen, J., Ke, S., Zhong, L., Wu, J., Tseng, A. M., Morpurgo, B., Golovko, A., Wang, G., Cai, J. J., Ma, X., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.03.019 · Cited by 79

Oral Glutamine Supplementation Reduces Obesity, Pro-Inflammatory Markers, and Improves Insulin Sensitivity in DIO Wistar Rats and Reduces Waist Circumference in Overweight and Obese Humans

Abboud, K. Y., Reis, S. K., Martelli, M. E., Zordão, O. P., Tannihão, F., de Souza, A. Z. Z., Assalin, H. B., Guadagnini, D., Rocha, G. Z., Saad, M. J. A., et al. (2019) · Nutrients · doi:10.3390/nu11030536 · Cited by 74

Dissecting folliculitis (dissecting cellulitis) of the scalp: a 66‐patient case series and proposal of classification

Lee, C., Chen, W., Hsu, C., Weng, T., Lee, J. Y., & Yang, C. (2018) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.13649 · Cited by 73

Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack

Oates, J. R., McKell, M. C., Moreno‐Fernandez, M. E., Damen, M. S. M. A., Deepe, G. S., Qualls, J. E., & Divanovic, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02893 · Cited by 78

Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19

Shin, J., Toyoda, S., Nishitani, S., Fukuhara, A., Kita, S., Otsuki, M., & Shimomura, I. (2021) · Diabetes · doi:10.2337/db20-1094 · Cited by 73

Antioxidant Supplementation Lowers Exercise‐Induced Oxidative Stress in Young Overweight Adults

Vincent, H. K., Bourguignon, C. M., Vincent, K. R., WELTMAN, A. L., Bryant, M., & Taylor, A. G. (2006) · Obesity · doi:10.1038/oby.2006.261 · Cited by 73

Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease

Chen, G., Ni, Y., Nagata, N., Xu, L., & Ota, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091379 · Cited by 75

Perivascular Adipose Tissue Angiotensin II Type 1 Receptor Promotes Vascular Inflammation and Aneurysm Formation

Sakaue, T., Suzuki, J., Hamaguchi, M., Suehiro, C., Tanino, A., Nagao, T., Uetani, T., Aono, J., Nakaoka, H., Kurata, M., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09512 · Cited by 73

Senescent T Cells Predict the Development of Hyperglycemia in Humans

Lee, Y., Kim, S. R., Han, D. H., Yu, H. T., Han, Y. D., Kim, J. H., Kim, S. H., Lee, C. J., Min, B., Kim, D.-H., et al. (2018) · Diabetes · doi:10.2337/db17-1218 · Cited by 73

Blockade of AT1 Receptor Improves Adipocyte Differentiation in Atherosclerotic and Diabetic Models

Tomono, Y., Iwai, M., Inaba, S., Mogi, M., & Horiuchi, M. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2007.50 · Cited by 72

Adipokines and the Immune System: An Adipocentric View

MacLaren, R., Cui, W., & Cianflone, K. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-78952-1_1 · Cited by 73

Changes in Fat Mass Correlate With Changes in Soluble sCD163, a Marker of Mature Macrophages, in Patients With CKD

Axelsson, J., Møller, H. J., Witasp, A., Qureshi, A. R., Carrero, J. J., Heimbürger, O., Barany, P. F., Alvestrand, A., Lindholm, B., Moestrup, S. K., et al. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2006.08.022 · Cited by 72

CNS-targets in control of energy and glucose homeostasis

Kleinridders, A., Könner, A. C., & Brüning, J. C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.10.006 · Cited by 74

A mathematical model for the effect of obesity on cancer growth and on the immune system response

Ku-Carrillo, R. A., Delgadillo‐Alemán, S. E., & Chen‐Charpentier, B. M. (2015) · Applied Mathematical Modelling · doi:10.1016/j.apm.2015.12.018 · Cited by 70

Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism

Rong, B., Tianyu, X., Tiantian, Z., Feng, R., Huang, H., Wu, Q., & Sun, C. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.020 · Cited by 73

The Role of cGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention

Gong, J., Gao, X., Ge, S., Li, H., Wang, R., & Zhao, L. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.84890 · Cited by 73

Review article: lymphatic system and associated adipose tissue in the development of inflammatory bowel disease

von der Weid, P. Y., & Rainey, K. J. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04407.x · Cited by 70

Role of Obesity in Asthma Control, the Obesity-Asthma Phenotype

Novosad, S., Khan, S., Wolfe, B. M., & Khan, A. (2013) · Journal of Allergy · doi:10.1155/2013/538642 · Cited by 77

Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice

Um, J., Rim, H.-K., Kim, S., Kim, H., & Hong, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029524 · Cited by 71

Regulation of Adipose Differentiation by Fructose and GluT5

Du, L., & Heaney, A. P. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1122 · Cited by 72

Visceral adiposity in gastrointestinal and hepatic carcinogenesis

Vongsuvanh, R., George, J., Qiao, L., & van der Poorten, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.038 · Cited by 72

Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes

Hajavi, J., Momtazi‐Borojeni, A. A., Johnston, T. P., Banach, M., Majeed, M. A., & Sahebkar, A. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26121 · Cited by 72

Novel agents for the treatment of type 2 diabetes

DeFronzo, R. A., Triplitt, C. L., Abdul-Ghani, M., & Cersosimo, E. (2014) · Diabetes Spectrum · doi:10.2337/diaspect.27.2.100 · Cited by 83

Insulin Resistance, Obesity, and Lipotoxicity

Yazıcı, D., Demir, S. Ç., & Sezer, H. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_14 · Cited by 85

Low Visceral Fat Content is Associated with Poor Prognosis in a Database of 507 Upper Gastrointestinal Cancers

Harada, K., Baba, Y., Ishimoto, T., Kosumi, K., Tokunaga, R., Izumi, D., Ida, S., Imamura, Y., Iwagami, S., Miyamoto, Y., et al. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4432-4 · Cited by 70

Shifts in Diet from High Fat to High Carbohydrate Improved Levels of Adipokines and Pro-inflammatory Cytokines in Mice Fed a High-fat Diet

Lee, I. S., Shin, G., & Choue, R. (2010) · Endocrine Journal · doi:10.1507/endocrj.k09e-046 · Cited by 70

Gastric bypass surgery improves psoriasis

Hossler, E. W., Maroon, M. S., & Mowad, C. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2010.01.001 · Cited by 70

Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation

Frühbeck, G., Catalán, V., Rodrı́guez, A., Ramírez, B., Becerril, S., Portincasa, P., & Gómez‐Ambrosi, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-02848-0 · Cited by 73

C-reactive protein and postmenopausal breast cancer risk: results from the E3N cohort study

Dossus, L., Jiménez-Corona, A., Romieu, I., Boutron‐Ruault, M., Boutten, A., Dupré, T., Fagherazzi, G., Clavel‐Chapelon, F., & Mesrine, S. (2014) · Cancer Causes & Control · doi:10.1007/s10552-014-0355-9 · Cited by 69

The Emerging Role of Adipocytokines as Inflammatory Mediators in Inflammatory Bowel Disease

Κarmiris, K., Κoutroubakis, I. E., & Kouroumalis, E. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000178915.54264.8f · Cited by 69

Differential effects of high-fat-diet rich in lard oil or soybean oil on osteopontin expression and inflammation of adipose tissue in diet-induced obese rats

Wang, X., Cheng, M., Zhao, M., Ge, A., Guo, F., Zhang, M., Yang, Y., Liu, L., & Yang, N. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0428-z · Cited by 70

Adipose tissue inflammation and liver pathology in human obesity

Tordjman, J., Guerre-Millo, M., & Clément, K. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)74601-9 · Cited by 71

RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted), Inflammation, Obesity, and the Metabolic Syndrome

Matter, C. M., & Handschin, C. (2007) · Circulation · doi:10.1161/circulationaha.106.685230 · Cited by 69

Adipocytokines and obesity-linked disorders.

Ouchi, N., Ohashi, K., Shibata, R., & Murohara, T. (2012) · PubMed Central · doi:10.18999/nagjms.74.1-2.19 · Cited by 67

Ectopic fat: the true culprit linking obesity and cardiovascular disease?

Morelli, M., Gaggini, M., Daniele, G., Marraccini, P., Sicari, R., & Gastaldelli, A. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-04-0285 · Cited by 68

Expression of Selenoprotein Genes Is Affected by Obesity of Pigs Fed a High-Fat Diet

Zhao, H. Y., Li, K., Tang, J., Zhou, J., Wang, K., Xia, X., & Lei, X. G. (2015) · Journal of Nutrition · doi:10.3945/jn.115.211318 · Cited by 69

The interleukin-6 and noradrenaline mediated inflammation-stress feedback mechanism is dysregulated in metabolic syndrome: Effect of exercise

Martín-Cordero, L., García, J. J., Hinchado, M. D., & Ortega, E. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-42 · Cited by 67

Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: Gaps and open questions

Ruscica, M., Baragetti, A., Catapano, A. L., & Norata, G. D. (2016) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.12.005 · Cited by 67

A role for sphingolipids in the pathophysiology of obesity-induced inflammation

Bikman, B. T. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0917-5 · Cited by 67

Insulin signaling and life span

Avogaro, A., de Kreutzenberg, S. V., & Fadini, G. P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0721-8 · Cited by 66

Preadipocyte response and impairment of differentiation in an inflammatory environment

Poulain‐Godefroy, O., & Froguel, P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.053 · Cited by 67

Divergent Effects of Peroxisome Proliferator-activated Receptor γ Agonists and Tumor Necrosis Factor α on Adipocyte ApoE Expression

Yue, L., Rasouli, N., Ranganathan, G., Kern, P. A., & Mazzone, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408461200 · Cited by 67

An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: Role of IL-8 and noradrenaline

Bote, E., García, J. J., Hinchado, M. D., & Ortega, E. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.11.009 · Cited by 67

Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: a review

Zimmermann, M. B., & Herter‐Aeberli, I. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.202 · Cited by 67

A Novel Effect of Growth Hormone on Macrophage Modulates Macrophage-Dependent Adipocyte Differentiation

Lü, C., Pasupulati, A. K., Fan, Y., Sperling, M. A., & Menon, R. K. (2010) · Endocrinology · doi:10.1210/en.2009-1194 · Cited by 67

Phentermine, topiramate and their combination for the treatment of adiposopathy ('sick fat') and metabolic disease

Bays, H. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.125 · Cited by 66

Deletion of G-protein-coupled receptor 55 promotes obesity by reducing physical activity

Meadows, A. G., Lee, J. H., Wu, C., Wei, Q., Pradhan, G., Yafi, M., Lu, H.-C., & Sun, Y. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.209 · Cited by 68

Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1

Heo, M.-G., & Choung, S. (2018) · Food & Function · doi:10.1039/c8fo00986d · Cited by 67

Dyslipidemia in obese cats

Jordan, E. T., Kley, S., Le, N., Waldron, M. K., & Hoenig, M. E. (2008) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2008.05.008 · Cited by 69

Innate immune mechanisms linking non-esterified fatty acids and respiratory disease

Wood, L. G., Scott, H. A., Garg, M. L., & Gibson, P. G. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.10.001 · Cited by 67

Serum and urinary concentrations of calprotectin as markers of insulin resistance and type 2 diabetes

Ortega, F. J., Sabater, M., Moreno‐Navarrete, J. M., Pueyo, N., Botas, P., Delgado, E., Ricart, W., Frühbeck, G., & Fernández‐Real, J. M. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0374 · Cited by 68

Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity

Chen, Y., Wu, Z., Zhao, S., & Xiang, R. (2016) · Scientific Reports · doi:10.1038/srep27486 · Cited by 80

RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27

Puri, V., Virbasius, J. V., Guilherme, A., & Czech, M. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01786.x · Cited by 65

[New trends in macrophages, inflammation and adipose tissue].

Rico-Rosillo, M. G., & Vega-Robledo, G. B. (2012) · PubMed · Cited by 2

Review article: Is obesity an inflammatory illness? Role of low‐grade inflammation and macrophage infiltration in human white adipose tissue

Cancello, R., & Clément, K. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01004.x · Cited by 418

Papel do tecido adiposo e dos macrófagos no estado de inflamação crónica associada à obesidade: implicações clínicas.

Ramalho, R., & Guimarães, C. (2008) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 5

Le tissu adipeux

Dalmas, É., Tordjman, J., Guerre-Millo, M., & Clément, K. (2011) · médecine/sciences · doi:10.1051/medsci/20112711016 · Cited by 17

Adipose Tissue Inflammation in Obesity

Poitou, C., Dalmas, É., & Clément, K. (2012) · Springer eBooks · doi:10.1007/978-2-8178-0343-2_20 · Cited by 2