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VPS34 complexes from a structural perspective

Ohashi, Yohei, Tremel, Shirley, Williams, Roger L.·2019·Journal of Lipid Research

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  1. Miller, 2010, Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34, Science., 327, 1638, 10.1126/science.1184429 · DOI
  2. Rostislavleva, 2015, Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes, Science., 350, aac7365, 10.1126/science.aac7365 · DOI · Paper page
  3. Baskaran, 2014, Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex, eLife., 3, e05115, 10.7554/eLife.05115 · DOI
  4. Stjepanovic, 2017, Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex, Mol. Cell. Oncol., 4, e1367873, 10.1080/23723556.2017.1367873 · DOI
  5. Stjepanovic, 2017, Vps34 kinase domain dynamics regulate the autophagic PI 3-kinase complex, Mol. Cell., 67, 528, 10.1016/j.molcel.2017.07.003 · DOI
  6. Russell, 2013, ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase, Nat. Cell Biol., 15, 741, 10.1038/ncb2757 · DOI · Paper page
  7. Yan, 2009, hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells, Biochem. J., 417, 747, 10.1042/BJ20081865 · DOI · Paper page
  8. Itakura, 2008, Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG, Mol. Biol. Cell., 19, 5360, 10.1091/mbc.e08-01-0080 · DOI · Paper page
  9. Thoresen, 2010, A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic, Exp. Cell Res., 316, 3368, 10.1016/j.yexcr.2010.07.008 · DOI
  10. Munson, 2015, mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival, EMBO J., 34, 2272, 10.15252/embj.201590992 · DOI
  11. Kim, 2013, Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy, Cell., 152, 290, 10.1016/j.cell.2012.12.016 · DOI
  12. Xu, 2016, PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity, EMBO J., 35, 496, 10.15252/embj.201592864 · DOI
  13. Ohashi, 2016, Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex, Autophagy., 12, 2129, 10.1080/15548627.2016.1226736 · DOI
  14. Ma, 2017, Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3–C1 and -C2, Cell Res., 27, 989, 10.1038/cr.2017.94 · DOI
  15. Furuya, 2010, Negative regulation of Vps34 by Cdk mediated phosphorylation, Mol. Cell., 38, 500, 10.1016/j.molcel.2010.05.009 · DOI
  16. Jiang, 2017, VPS34 stimulation of p62 phosphorylation for cancer progression, Oncogene., 36, 6850, 10.1038/onc.2017.295 · DOI
  17. Liu, 2018, Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation, J. Cell Biol., 217, 347, 10.1083/jcb.201705116 · DOI
  18. Shain, 2015, Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway, Nat. Genet., 47, 1194, 10.1038/ng.3382 · DOI
  19. Sanborn, 2015, Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination, Proc. Natl. Acad. Sci. USA., 112, 10995, 10.1073/pnas.1508074112 · DOI
  20. Song, 2014, Identification of genomic alterations in oesophageal squamous cell cancer, Nature., 509, 91, 10.1038/nature13176 · DOI
  21. Su, 2017, VPS34 acetylation controls its lipid kinase activity and the initiation of canonical and non-canonical autophagy, Mol. Cell., 67, 907, 10.1016/j.molcel.2017.07.024 · DOI
  22. Bilanges, 2017, Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism, Nat. Commun., 8, 1804, 10.1038/s41467-017-01969-4 · DOI
  23. Mohan, 2016, VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation, Oncotarget., 7, 52239, 10.18632/oncotarget.10469 · DOI
  24. Mathew, 2009, Autophagy suppresses tumorigenesis through elimination of p62, Cell., 137, 1062, 10.1016/j.cell.2009.03.048 · DOI
  25. Morselli, 2009, Anti- and pro-tumor functions of autophagy, Biochim. Biophys. Acta., 1793, 1524, 10.1016/j.bbamcr.2009.01.006 · DOI
  26. Choi, 2012, Autophagy and cancer, Exp. Mol. Med., 44, 109, 10.3858/emm.2012.44.2.033 · DOI
  27. Walker, 2000, Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine, Mol. Cell., 6, 909, 10.1016/S1097-2765(05)00089-4 · DOI
  28. Brunn, 1997, Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin, Science., 277, 99, 10.1126/science.277.5322.99 · DOI · Paper page
  29. Sarkaria, 1998, Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin, Cancer Res., 58, 4375
  30. Pasquier, 2016, Autophagy inhibitors, Cell. Mol. Life Sci., 73, 985, 10.1007/s00018-015-2104-y · DOI · Paper page
  31. Bago, 2014, Characterisation of VPS34-IN1, a selective inhibitor of Vps34 reveals that the phosphatidylinositol 3-phosphate binding SGK3 protein kinase is a downstream target of class III PI-3 kinase, Biochem. J., 463, 413, 10.1042/BJ20140889 · DOI · Paper page
  32. Dowdle, 2014, Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo, Nat. Cell Biol., 16, 1069, 10.1038/ncb3053 · DOI · Paper page
  33. Honda, 2015, Potent, selective, and orally bioavailable inhibitors of VPS34 provide chemical tools to modulate autophagy in vivo, ACS Med. Chem. Lett., 7, 72, 10.1021/acsmedchemlett.5b00335 · DOI
  34. Pasquier, 2015, Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors, J. Med. Chem., 58, 376, 10.1021/jm5013352 · DOI
  35. Young, 2016, Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy, Proc. Natl. Acad. Sci. USA., 113, 8224, 10.1073/pnas.1603650113 · DOI · Paper page
  36. Dyczynski, 2018, Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib, Cancer Lett., 435, 32, 10.1016/j.canlet.2018.07.028 · DOI
  37. Schlütermann, 2018, Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex, Urol. Oncol., 36, 160.e1, 10.1016/j.urolonc.2017.11.021 · DOI
  38. Nemazanyy, 2015, Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling, Nat. Commun., 6, 8283, 10.1038/ncomms9283 · DOI · Paper page
  39. Stack, 1994, Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities, J. Biol. Chem., 269, 31552, 10.1016/S0021-9258(18)31729-0 · DOI
  40. Herman, 1991, A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery, EMBO J., 10, 4049, 10.1002/j.1460-2075.1991.tb04981.x · DOI
  41. Nemazanyy, 2013, Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease, EMBO Mol. Med., 5, 870, 10.1002/emmm.201202057 · DOI · Paper page
  42. Gstrein, 2018, Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans, Nat. Neurosci., 21, 207, 10.1038/s41593-017-0053-5 · DOI
  43. Shull, 2012, Novel somatic mutations to PI3K pathway genes in metastatic melanoma, PLoS One., 7, e43369, 10.1371/journal.pone.0043369 · DOI
  44. Murray, 2002, Role of Rab5 in the recruitment of hVps34/p150 to the early endosome, Traffic., 3, 416, 10.1034/j.1600-0854.2002.30605.x · DOI · Paper page
  45. Murray, 2005, Analysis of hVps34/hVps15 interactions with Rab5 in vivo and in vitro, Methods Enzymol., 403, 789, 10.1016/S0076-6879(05)03068-5 · DOI
  46. Stoetzel, 2016, A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi, Nat. Commun., 7, 13586, 10.1038/ncomms13586 · DOI
  47. Wu, 2007, ird1 is a Vps15 homologue important for antibacterial immune responses in Drosophila, Cell. Microbiol., 9, 1073, 10.1111/j.1462-5822.2006.00853.x · DOI
  48. Rommens, 1995, Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21, Genomics., 28, 530, 10.1006/geno.1995.1185 · DOI
  49. Aita, 1999, Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21, Genomics., 59, 59, 10.1006/geno.1999.5851 · DOI
  50. Laddha, 2014, Mutational landscape of the essential autophagy gene BECN1 in human cancers, Mol. Cancer Res., 12, 485, 10.1158/1541-7786.MCR-13-0614 · DOI
  51. Egan, 2015, Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates, Mol. Cell., 59, 285, 10.1016/j.molcel.2015.05.031 · DOI · Paper page
  52. Pattingre, 2005, Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy, Cell., 122, 927, 10.1016/j.cell.2005.07.002 · DOI · Paper page
  53. Liang, 2006, Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG, Nat. Cell Biol., 8, 688, 10.1038/ncb1426 · DOI · Paper page
  54. Zalckvar, 2009, Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL, Autophagy., 5, 720, 10.4161/auto.5.5.8625 · DOI
  55. Wei, 2013, EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance, Cell., 154, 1269, 10.1016/j.cell.2013.08.015 · DOI · Paper page
  56. Noda, 2012, Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy, J. Biol. Chem., 287, 16256, 10.1074/jbc.M112.348250 · DOI
  57. Huang, 2012, Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein, Cell Res., 22, 473, 10.1038/cr.2012.24 · DOI
  58. Matsunaga, 2010, Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L, J. Cell Biol., 190, 511, 10.1083/jcb.200911141 · DOI · Paper page
  59. Park, 2016, The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14, Autophagy., 12, 547, 10.1080/15548627.2016.1140293 · DOI · Paper page
  60. Wold, 2016, ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models, Mol. Neurodegener., 11, 76, 10.1186/s13024-016-0141-0 · DOI · Paper page
  61. Yuan, 2013, Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy, Autophagy., 9, 1983, 10.4161/auto.26058 · DOI
  62. Vanni, 2013, Amphipathic lipid packing sensor motifs: probing bilayer defects with hydrophobic residues, Biophys. J., 104, 575, 10.1016/j.bpj.2012.11.3837 · DOI
  63. Tan, 2016, PtdIns(4,5)P2 signaling regulates ATG14 and autophagy, Proc. Natl. Acad. Sci. USA., 113, 10896, 10.1073/pnas.1523145113 · DOI
  64. Perelman, 1997, Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus, Genomics., 41, 397, 10.1006/geno.1997.4623 · DOI
  65. Iida, 2000, Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation, Hum. Genet., 106, 277, 10.1007/s004390000245 · DOI
  66. Lee, 2011, UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila, Dev. Biol., 356, 588, 10.1016/j.ydbio.2011.06.024 · DOI
  67. He, 2015, Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers, Nat. Commun., 6, 7839, 10.1038/ncomms8839 · DOI
  68. Ionov, 2004, Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability, Oncogene., 23, 639, 10.1038/sj.onc.1207178 · DOI
  69. Kim, 2008, Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability, Hum. Pathol., 39, 1059, 10.1016/j.humpath.2007.11.013 · DOI
  70. Knævelsrud, 2010, UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy, Autophagy., 6, 863, 10.4161/auto.6.7.13033 · DOI
  71. Takáts, 2014, Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila, Mol. Biol. Cell., 25, 1338, 10.1091/mbc.e13-08-0449 · DOI
  72. He, 2013, PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex, Nat. Cell Biol., 15, 1206, 10.1038/ncb2848 · DOI
  73. Giannakis, 2016, Genomic correlates of immune-cell infiltrates in colorectal carcinoma, Cell Reports., 15, 857, 10.1016/j.celrep.2016.03.075 · DOI
  74. Bova, 2016, Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer, Cold Spring Harb. Mol. Case Stud., 2, a000752, 10.1101/mcs.a000752 · DOI
  75. Mouradov, 2014, Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer, Cancer Res., 74, 3238, 10.1158/0008-5472.CAN-14-0013 · DOI · Paper page
  76. Gui, 2011, Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder, Nat. Genet., 43, 875, 10.1038/ng.907 · DOI
  77. Kim, 2015, mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation, Mol. Cell., 57, 207, 10.1016/j.molcel.2014.11.013 · DOI
  78. Antonioli, 2014, AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics, Dev. Cell., 31, 734, 10.1016/j.devcel.2014.11.013 · DOI
  79. Zhong, 2014, Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels, J. Biol. Chem., 289, 26021, 10.1074/jbc.M114.561134 · DOI
  80. Araki, 2013, Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity, J. Cell Biol., 203, 299, 10.1083/jcb.201304123 · DOI · Paper page
  81. Ma, 2017, MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy, Autophagy., 13, 592, 10.1080/15548627.2016.1269988 · DOI · Paper page
  82. Yang, 2017, NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models, Autophagy., 13, 2028, 10.1080/15548627.2017.1379633 · DOI · Paper page
  83. Cianfanelli, 2015, Connecting autophagy: AMBRA1 and its network of regulation, Mol. Cell. Oncol., 2, e970059, 10.4161/23723548.2014.970059 · DOI
  84. Fimia, 2007, Ambra1 regulates autophagy and development of the nervous system, Nature., 447, 1121, 10.1038/nature05925 · DOI
  85. Matsunaga, 2009, Binding Rubicon to cross the Rubicon, Autophagy., 5, 876, 10.4161/auto.9098 · DOI
  86. Sun, 2010, Rubicon controls endosome maturation as a Rab7 effector, Proc. Natl. Acad. Sci. USA., 107, 19338, 10.1073/pnas.1010554107 · DOI · Paper page
  87. Tabata, 2010, Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain, Mol. Biol. Cell., 21, 4162, 10.1091/mbc.e10-06-0495 · DOI
  88. Cheng, 2017, Pacer mediates the function of class III PI3K and HOPS complexes in autophagosome maturation by engaging Stx17, Mol. Cell., 65, 1029, 10.1016/j.molcel.2017.02.010 · DOI
  89. Jiang, 2014, The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17, Mol. Biol. Cell., 25, 1327, 10.1091/mbc.e13-08-0447 · DOI · Paper page
  90. Hamasaki, 2013, Autophagosomes form at ER-mitochondria contact sites, Nature., 495, 389, 10.1038/nature11910 · DOI · Paper page
  91. Eisenberg-Lerner, 2012, PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk, Cell Death Differ., 19, 788, 10.1038/cdd.2011.149 · DOI
  92. Yang, 2013, Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy, Proc. Natl. Acad. Sci. USA., 110, 6841, 10.1073/pnas.1217692110 · DOI
  93. Hirsch, 2014, Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1, Cell. Signal., 26, 1258, 10.1016/j.cellsig.2014.02.009 · DOI
  94. Qian, 2017, Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy, Mol. Cell., 65, 917, 10.1016/j.molcel.2017.01.027 · DOI
  95. Li, 2017, CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation, Nat. Commun., 8, 1159, 10.1038/s41467-017-01272-2 · DOI
  96. Wei, 2015, The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation, eLife., 4, 05289, 10.7554/eLife.05289 · DOI
  97. Fogel, 2013, Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy, Mol. Cell. Biol., 33, 3675, 10.1128/MCB.00079-13 · DOI
  98. Maejima, 2013, Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2, Nat. Med., 19, 1478, 10.1038/nm.3322 · DOI · Paper page
  99. Shi, 2010, TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy, Sci. Signal., 3, ra42, 10.1126/scisignal.2000751 · DOI
  100. Wirawan, 2010, Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria, Cell Death Dis., 1, e18, 10.1038/cddis.2009.16 · DOI
  101. Zhang, 2016, AMPK regulates autophagy by phosphorylating BECN1 at threonine 388, Autophagy., 12, 1447, 10.1080/15548627.2016.1185576 · DOI
  102. Ashkenazi, 2017, Polyglutamine tracts regulate beclin 1-dependent autophagy, Nature., 545, 108, 10.1038/nature22078 · DOI · Paper page
  103. Sun, 2015, Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth, Nat. Commun., 6, 7215, 10.1038/ncomms8215 · DOI
  104. Xia, 2013, WASH inhibits autophagy through suppression of Beclin 1 ubiquitination, EMBO J., 32, 2685, 10.1038/emboj.2013.189 · DOI
  105. Oppermann, 2009, Large-scale proteomics analysis of the human kinome, Mol. Cell. Proteomics., 8, 1751, 10.1074/mcp.M800588-MCP200 · DOI
  106. Minard, 2016, mTORC1 is a major regulatory node in the FGF21 signaling network in adipocytes, Cell Reports., 17, 29, 10.1016/j.celrep.2016.08.086 · DOI

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Metadata

Authors
Ohashi, Y., Tremel, S., & Williams, R. L.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2019-02
Volume
60
Issue
2
Pages
229-241
ISSN
0022-2275
Cited by
147
References
15
Language
en
Funders
Medical Research Council (MC_U105184308)

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