Whole and Refined Grain Intakes Are Related to Inflammatory Protein Concentrations in Human Plasma
Open accessAbstract
Inflammation may play a role in the pathogenesis of cardiovascular disease and type 2 diabetes, and it has been suggested that the protective effects of whole-grain consumption could be mediated by an effect on inflammation, although few studies have examined the relationships between grain intakes and inflammatory protein concentrations. Our objectives in this study were to examine the associations of whole grain and refined grain intake with plasminogen activator inhibitor type 1 (PAI-1), C-reactive protein (CRP), and fibrinogen plasma concentrations. Cross-sectional data from the Insulin Resistance Atherosclerosis Study were used to perform multiple regression analyses using dietary information on whole and refined grain intakes from a FFQ and clinical measures of plasma inflammatory protein concentrations in participants free of type 2 diabetes. After adjustment for demographic, lifestyle, and dietary variables, whole-grain intake was inversely related to log PAI-1 (beta = -0.102; SEM = 0.038; P = 0.0077) and log CRP (beta = -0.102; SEM = 0.048; P = 0.0340). Adding insulin sensitivity, waist circumference, and 2-h postload glucose to the model attenuated both associations to nonsignificance. Refined grain was positively related to log PAI-1 in the multivariate model (beta = 0.076; SEM = 0.034; P = 0.0251) and the relationship remained unchanged by additional adjustment for metabolic variables. Fibrinogen concentrations were not related to whole or refined grain intake. In summary, whole grain intake was inversely related to PAI-1 and CRP plasma concentrations, but these relationships were attenuated by the addition of metabolic variables to the model. Refined grain intake was positively independently related to plasma PAI-1 concentrations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The postprandial inflammatory response is probably important in generating insulin resistance and atherosclerosis.
“Although the postprandial inflammatory response has been known for several years (154) , it is only recently that its probable importance in the generation of insulin resistance and atherosclerosis has been appreciated (155 -157) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [156]
Cites
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works
Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens
Clauss, A. (2009) · Acta Haematologica · doi:10.1159/000205234 · Cited by 3,239 · see citing works
Danesh, J., Wheeler, J. G., Hirschfield, G. M., Eda, S., Eiriksdottir, G., Rumley, A., Lowe, G. D. O., Pepys, M. B., & Gudnason, V. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032804 · Cited by 2,953 · see citing works
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · see citing works
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes
Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.812 · Cited by 1,493 · see citing works
Plasma Fibrinogen Level and the Risk of Major Cardiovascular Diseases and Nonvascular Mortality
Danesh, J., Lewington, S., Thompson, S. G., Lowe, G. D. O., Collins, R., Kostis, J. B., Wilson, A. C., Folsom, A. R., Wu, K., Benderly, M., et al. (2005) · JAMA · doi:10.1001/jama.294.14.1799 · Cited by 1,120 · see citing works
Festa, A., D’Agostino, R., Tracy, R. P., & Haffner, S. M. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1131 · Cited by 1,057 · see citing works
Self-citationDiabetes Mellitus: Report of a WHO Study Group.
(1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-4-597_2 · Cited by 1,030 · see citing works
Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction
Packard, R. R. S., & Libby, P. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097360 · Cited by 925 · see citing works
Dietary Patterns and Risk for Type 2 Diabetes Mellitus in U.S. Men
van Dam, R. M., Rimm, E. B., Willett, W. C., Stampfer, M. J., & Hu, F. B. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-3-200202050-00008 · Cited by 801 · see citing works
Macy, E. M., Hayes, T. E., & Tracy, R. P. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.1.52 · Cited by 797 · see citing works
Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women
Hu, F. B., Meigs, J. B., Li, T. Y., Rifai, N., & Manson, J. E. (2004) · Diabetes · doi:10.2337/diabetes.53.3.693 · Cited by 788 · see citing works
Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study
Liu, S., Stampfer, M. J., Hu, F. B., Giovannucci, E., Rimm, E., Manson, J. E., Hennekens, C. H., & Willett, W. C. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.412 · Cited by 774 · see citing works
Jacobs, D. R., Meyer, K. A., Kushi, L. H., & Folsom, A. R. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.248 · Cited by 636 · see citing works
Why whole grains are protective: biological mechanisms
Slavin, J. L. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2002221 · Cited by 614 · see citing works
Dietary Patterns and the Risk of Coronary Heart Disease in Women
Fung, T. T., Willett, W. C., Stampfer, M. J., Manson, J. E., & Hu, F. B. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.15.1857 · Cited by 549 · see citing works
Steffen, L. M., Jacobs, D. R., Stevens, J., Shahar, E., Carithers, T., & Folsom, A. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.383 · Cited by 538 · see citing works
Whole grain intake and cardiovascular disease: A meta-analysis
Mellen, P. B., Walsh, T. F., & Herrington, D. M. (2008) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.12.008 · Cited by 515 · see citing works
Whole-grain intake and the risk of type 2 diabetes: a prospective study in men
Fung, T. T., Hu, F. B., Pereira, M. A., Liu, S., Stampfer, M. J., Colditz, G. A., & Willett, W. C. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.535 · Cited by 497 · see citing works
The Insulin Resistance Atherosclerosis Study (IRAS)
Wagenknecht, L. E., Mayer, E. J., Rewers, M., Haffner, S. M., Selby, J. V., Borok, G. M., Henkin, L. F., Howard, G., Savage, P. J., Saad, M. F., et al. (1995) · Annals of Epidemiology · doi:10.1016/1047-2797(95)00062-3 · Cited by 493 · see citing works
Self-citationA prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women
Liu, S., Manson, J. E., Stampfer, M. J., Hu, F. B., Giovannucci, E. L., Colditz, G. A., Hennekens, C. H., & Willett, W. C. (2000) · American Journal of Public Health · doi:10.2105/ajph.90.9.1409 · Cited by 480 · see citing works
Dietary pattern, inflammation, and incidence of type 2 diabetes in women
Schulze, M. B., Hoffmann, K., Manson, J. E., Willett, W. C., Meigs, J. B., Weikert, C., Heidemann, C., Colditz, G. A., & Hu, F. B. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.675 · Cited by 462 · see citing works
Dietary pattern, inflammation, and incidence of type 2 diabetes in women
Schulze, M. B., Hoffmann, K., Manson, J. E., Willett, W. C., Meigs, J. B., Weikert, C., Heidemann, C., Colditz, G. A., & Hu, F. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.675 · Cited by 457 · see citing works
Danesh, J., Lewington, S., Thompson, S. G., Lowe, G. D. O., & Collins, R. (2005) · UCL Discovery (University College London) · Cited by 324 · see citing works
Whole-grain intake and insulin sensitivity: the Insulin Resistance Atherosclerosis Study
Liese, A. D., Roach, A. K., Sparks, K. C., Marquart, L. F., D'Agostino, R. B., & Mayer‐Davis, E. J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.5.965 · Cited by 309 · see citing works
Self-citationValidity and Reproducibility of a Food Frequency Interview in a Multi-Cultural Epidemiologic Study
Mayer-Davis, E. J., Vitolins, M. Z., Carmichael, S. L., Hemphill, S., Tsaroucha, G., Rushing, J., & Levin, S. (1999) · Annals of Epidemiology · doi:10.1016/s1047-2797(98)00070-2 · Cited by 300 · see citing works
Insulin resistance, inflammation, and the prediabetic state
Haffner, S. M. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00612-x · Cited by 268 · see citing works
Self-citationWhole-Grain, Bran, and Cereal Fiber Intakes and Markers of Systemic Inflammation in Diabetic Women
Qi, L., van Dam, R. M., Liu, S., Franz, M., Mantzoros, C., & Hu, F. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1903 · Cited by 261 · see citing works
Verma, S., Devaraj, S., & Jialal, I. (2006) · PubMed · Cited by 251 · see citing works
Beard, J. C., Bergman, R. N., Ward, W. K., & Porte, D. (1986) · Diabetes · doi:10.2337/diab.35.3.362 · Cited by 247 · see citing works
Jensen, M. K., Koh-Banerjee, P., FRANZ, M. M., Sampson, L., Grønbæk, M., & Rimm, E. B. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.275 · Cited by 226 · see citing works
Dietary Factors That Promote or Retard Inflammation
Basu, A., Devaraj, S., & Jialal, I. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000214295.86079.d1 · Cited by 222 · see citing works
Andersson, A., Tengblad, S., Karlström, B., Kamal-Eldin, A., Landberg, R., Basu, S., Åman, P., & Vessby, B. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.6.1401 · Cited by 221 · see citing works
Do atherosclerosis and type 2 diabetes share a common inflammatory basis?
Pradhan, A. (2002) · European Heart Journal · doi:10.1053/euhj.2001.3052 · Cited by 214 · see citing works
Lutsey, P. L., Jacobs, D. R., Kori, S., Mayer‐Davis, E. J., Shea, S., Steffen, L. M., Szklo, M., & Tracy, R. P. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507700715 · Cited by 213 · see citing works
Plasminogen activator inhibitor-1, adipose tissue and insulin resistance
Alessi, M.-C., Poggi, M., & Juhan-Vague, I. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32814e6d29 · Cited by 212 · see citing works
Scirica, B. M., & Morrow, D. A. (2006) · Circulation · doi:10.1161/circulationaha.105.611350 · Cited by 187 · see citing works
Hemostatic Markers of Endothelial Dysfunction and Risk of Incident Type 2 Diabetes
Meigs, J. B., O’Donnell, C. J., Tofler, G. H., Benjamin, E. J., Fox, C. S., Lipinska, I., Nathan, D. M., SULLIVAN, L. M., D’Agostino, R. B., & Wilson, P. W. F. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1041 · Cited by 184 · see citing works
Whole grain foods for the prevention of type 2 diabetes mellitus
Priebe, M. G., van Binsbergen, J., de Vos, R., & Vonk, R. J. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006061.pub2 · Cited by 142 · see citing works
Anti-inflammatory effects of insulin
Dandona, P., Chaudhuri, A., Mohanty, P., & Ghanim, H. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3281e38774 · Cited by 124 · see citing works
Food Intake Patterns Associated With Incident Type 2 Diabetes
Liese, A. D., Weis, K. E., Schulz, M., & Tooze, J. A. (2008) · Diabetes Care · doi:10.2337/dc08-1325 · Cited by 119 · see citing works
Self-citationCereal grains, legumes, and weight management: a comprehensive review of the scientific evidence
Williams, P., Grafenauer, S., & O’Shea, J. E. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00022.x · Cited by 117 · see citing works
Fibrinogen - marker or mediator of vascular disease?
Reinhart, W. H. (2003) · Vascular Medicine · doi:10.1191/1358863x03vm494ra · Cited by 110 · see citing works
Qi, L., & Hu, F. B. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328011c6e0 · Cited by 98 · see citing works
Liese, A. D., Schulz, M., Moore, C. G., & Mayer‐Davis, E. J. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041279 · Cited by 62 · see citing works
Self-citationDeclerck, P. J., & Collen, D. (1990) · Thrombosis Research · doi:10.1016/0049-3848(90)90373-k · Cited by 50 · see citing works
Kohl, A., Gögebakan, Ö., Möhlig, M., Osterhoff, M. A., Isken, F., Pfeiffer, A. F. H., & Weickert, M. O. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.03.002 · Cited by 29 · see citing works
Turpeinen, A. M., Juntunen, K. S., Mutanen, M. L., & Mykkänen, H. M. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600975 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Aune, D., Keum, N., Giovannucci, E., Fadnes, L. T., Boffetta, P., Greenwood, D. C., Tonstad, S., Vatten, L. J., Riboli, E., & Norat, T. (2016) · BMJ · doi:10.1136/bmj.i2716 · Cited by 1,013 · see citing works
Aune, D., Norat, T., Romundstad, P., & Vatten, L. J. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-013-9852-5 · Cited by 539 · see citing works
Neuenschwander, M., Ballon, A., Weber, K. S., Norat, T., Aune, D., Schwingshackl, L., & Schlesinger, S. (2019) · BMJ · doi:10.1136/bmj.l2368 · Cited by 513 · see citing works
Inflammation and type 2 diabetes
Calle, M. C., & Fernández, M. L. (2012) · Diabetes & Metabolism · doi:10.1016/j.diabet.2011.11.006 · Cited by 492 · see citing works
Cho, S. S., Qi, L., Fahey Jr, G. C., & Klurfeld, D. M. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.067629 · Cited by 421 · see citing works
Nutrition and Cardiovascular Health
Casas, R. M., Castro‐Barquero, S., Estruch, R., & Sacanella, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123988 · Cited by 344 · see citing works
Petroski, W., & Minich, D. M. (2020) · Nutrients · doi:10.3390/nu12102929 · Cited by 336 · see citing works
Vitaglione, P., Mennella, I., Ferracane, R., Rivellese, A. A., Giacco, R., Ercolini, D., Gibbons, S. M., Storia, A. L., Gilbert, J. A., Jonnalagadda, S. S., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.088120 · Cited by 325 · see citing works
Vanegas, S. M., Meydani, M., Barnett, J. B., Goldin, B., Kane, A., Rasmussen, H., Brown, C., Vangay, P., Knights, D., Jonnalagadda, S., et al. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.146928 · Cited by 277 · see citing works
Jonnalagadda, S. S., Harnack, L., Liu, R. H., McKeown, N. M., Seal, C. J., Liu, S., & Fahey, G. C., Jr. (2011) · Journal of Nutrition · doi:10.3945/jn.110.132944 · Cited by 268 · see citing works
Aune, D. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz042 · Cited by 215 · see citing works
Azadbakht, L., Surkan, P. J., Esmaillzadeh, A., & Willett, W. C. (2011) · Journal of Nutrition · doi:10.3945/jn.110.136739 · Cited by 182 · see citing works
Buyken, A. E., Goletzke, J., Joslowski, G., Felbick, A., Cheng, G., Herder, C., & Brand-Miller, J. C. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.074252 · Cited by 180 · see citing works
de Mello, V. D., Schwab, U., Kolehmainen, M., Köenig, W., Siloaho, M., Poutanen, K. S., Mykkänen, H. M., & Uusitupa, M. I. J. (2011) · Diabetologia · doi:10.1007/s00125-011-2285-3 · Cited by 176 · see citing works
Germinated grains: a superior whole grain functional food?
Nelson, K., Stojanovska, L., Vasiljevic, T., & Mathai, M. L. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0351 · Cited by 167 · see citing works
Haghighatdoost, F., Bellissimo, N., Totosy de Zepetnek, J. O., & Rouhani, M. H. (2017) · Public Health Nutrition · doi:10.1017/s1368980017001768 · Cited by 153 · see citing works
Effects of Whole Grains on Coronary Heart Disease Risk
Harris, K. A., & Kris‐Etherton, P. M. (2010) · Current Atherosclerosis Reports · doi:10.1007/s11883-010-0136-1 · Cited by 134 · see citing works
KONES, R. J. (2010) · Drug Design Development and Therapy · doi:10.2147/dddt.s10812 · Cited by 111 · see citing works
Mitigation of Inflammation with Foods
Wu, X., & Schauss, A. G. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3007008 · Cited by 103 · see citing works
González-Campoy, J. M., Jeor, S. T. S., CASTORINO, K. N., Ebrahim, A., Hurley, D., Jovanovič, L., Mechanick, J. I., Petak, S. M., Yu, Y., Harris, K. A., et al. (2013) · Endocrine Practice · doi:10.4158/ep13155.esgl · Cited by 101 · see citing works
González-Campoy, J. M., CASTORINO, K. N., Ebrahim, A., Hurley, D., Jovanovič, L., Mechanick, J. I., Petak, S. M., Yu, Y., Jeor, S. T. S., Harris, K. A., et al. (2013) · Endocrine Practice · doi:10.4158/ep13155.gl · Cited by 101 · see citing works
Ampatzoglou, A., Atwal, K., Maidens, C. M., Williams, C. L., Ross, A. B., Thielecke, F., Jonnalagadda, S. S., Kennedy, O. B., & Yaqoob, P. (2014) · Journal of Nutrition · doi:10.3945/jn.114.202176 · Cited by 95 · see citing works
Does wheat make us fat and sick?
Brouns, F. J. P. H., van Buul, V. J., & Shewry, P. R. (2013) · Journal of Cereal Science · doi:10.1016/j.jcs.2013.06.002 · Cited by 95 · see citing works
Baden, M. Y., Satija, A., Hu, F. B., & Huang, T. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy301 · Cited by 82 · see citing works
Infant Cereals: Current Status, Challenges, and Future Opportunities for Whole Grains
Klerks, M., Bernal, M. J., Román, S., Bodenstab, S., Gil, Á., & Sánchez-Siles, L. M. (2019) · Nutrients · doi:10.3390/nu11020473 · Cited by 80 · see citing works
Hajihashemi, P., Azadbakht, L., Hashemipor, M., Kelishadi, R., & Esmaillzadeh, A. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300582 · Cited by 66 · see citing works
Evaluation of the evidence between consumption of refined grains and health outcomes
Williams, P. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00452.x · Cited by 66 · see citing works
Effect of whole grains on markers of subclinical inflammation
Lefevre, M., & Jonnalagadda, S. S. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00487.x · Cited by 64 · see citing works
Ross, A. B., Godin, J., Minehira, K., & Kirwan, J. P. (2013) · International Journal of Endocrinology · doi:10.1155/2013/585876 · Cited by 64 · see citing works
Health effects of wheat lectins: A review
van Buul, V. J., & Brouns, F. J. P. H. (2014) · Journal of Cereal Science · doi:10.1016/j.jcs.2014.01.010 · Cited by 63 · see citing works
Whole grain diet reduces systemic inflammation
Xu, Y., Wan, Q., Feng, J., Du, L., Li, K., & Zhou, Y. (2018) · Medicine · doi:10.1097/md.0000000000012995 · Cited by 60 · see citing works
Perspective: Refined Grains and Health: Genuine Risk, or Guilt by Association?
Gaesser, G. A. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy104 · Cited by 60 · see citing works
Gu, Y., Manly, J. J., Mayeux, R. P., & Brickman, A. M. (2018) · Current Alzheimer Research · doi:10.2174/1567205015666180101145619 · Cited by 59 · see citing works
Kolehmainen, M., Ulven, S. M., Paananen, J., de Mello, V. D., Schwab, U., Carlberg, C., Myhrstad, M. C. W., Pihlajamäki, J., Dungner, E., Sjölin, E., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092783 · Cited by 55 · see citing works
Impact of whole cereals and processing on type 2 diabetes mellitus: a review
Wu, W., Qiu, J., Wang, A., & Li, Z. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1574708 · Cited by 54 · see citing works
Mann, K. D., Pearce, M. S., McKevith, B., Thielecke, F., & Seal, C. J. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000525 · Cited by 53 · see citing works
Bresciani, L., Scazzina, F., Leonardi, R., Dall’Aglio, E., Newell, M. L., Dall’Asta, M., Melegari, C., Ray, S., Brighenti, F., & Rio, D. D. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600238 · Cited by 52 · see citing works
Hajihashemi, P., & Haghighatdoost, F. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1490935 · Cited by 50 · see citing works
Price, R. K., Wallace, J. M. W., Hamill, L. L., Keaveney, E. M., Strain, J. J., Parker, M. J., & Welch, R. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007070 · Cited by 48 · see citing works
Whole grain intakes in the diets of Irish children and teenagers
Devlin, N. F. C., McNulty, B. A., Gibney, M. J., Thielecke, F., Smith, H., & Nugent, A. P. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512004989 · Cited by 41 · see citing works
Emerging science on whole grain intake and inflammation
Sang, S., Idehen, E., Zhao, Y., & Chu, Y. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz079 · Cited by 41 · see citing works
Langkamp‐Henken, B., Nieves, C., Culpepper, T., Radford, A., Girard, S., Hughes, C., Christman, M. C., Mai, V., Dahl, W. J., Boileau, T. W.-M., et al. (2012) · Journal of Nutrition · doi:10.3945/jn.112.164996 · Cited by 39 · see citing works
Quality, Nutritional Properties, and Glycemic Index of Colored Whole Wheat Breads
Köksel, H., Çetiner, B., Shamanin, V. P., Tekin‐Cakmak, Z. H., Pototskaya, I. V., Kahraman, K., Sağdıç, O., & Morgounov, A. I. (2023) · Foods · doi:10.3390/foods12183376 · Cited by 37 · see citing works
Kim, Y., Keogh, J. B., & Clifton, P. M. (2017) · Nutrients · doi:10.3390/nu9040336 · Cited by 37 · see citing works
Sanjeevi, N., Lipsky, L. M., & Nansel, T. R. (2018) · Nutrients · doi:10.3390/nu10101552 · Cited by 37 · see citing works
Rouhani, M. H., Najafabadi, M. M., Surkan, P. J., Esmaillzadeh, A., Feizi, A., & Azadbakht, L. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.09.001 · Cited by 37 · see citing works
Saneei, P., Larijani, B. A., & Esmaillzadeh, A. (2016) · Public Health Nutrition · doi:10.1017/s1368980016002172 · Cited by 36 · see citing works
Giriwono, P. E., Shirakawa, H., Hokazono, H., Gotō, T., & Komai, M. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110374 · Cited by 35 · see citing works
Ampatzoglou, A., Williams, C. L., Atwal, K., Maidens, C. M., Ross, A. B., Thielecke, F., Jonnalagadda, S. S., Kennedy, O. B., & Yaqoob, P. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0836-y · Cited by 35 · see citing works
Nelson, K., Mathai, M. L., Ashton, J., Donkor, O. N., Vasiljevic, T., Mamilla, R., & Stojanovska, L. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.08.023 · Cited by 32 · see citing works
Calabriso, N., Massaro, M., Scoditti, E., Pasqualone, A., Laddomada, B., & Carluccio, M. A. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02109-y · Cited by 32 · see citing works
The associations between whole grain and refined grain intakes and serum C-reactive protein
Taskinen, R. E., Hantunen, S., Tuomainen, T., & Virtanen, J. K. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00996-1 · Cited by 30 · see citing works
Lappi, J., Kolehmainen, M., Mykkänen, H. M., & Poutanen, K. S. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.550388 · Cited by 30 · see citing works
Can Whole Grain Help in Weight Management?
Thielecke, F., & Jonnalagadda, S. S. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000243 · Cited by 30 · see citing works
Rice Bran Extract Reduces the Risk of Atherosclerosis in Post-Menopausal Vietnamese Women
Nhung, B. T., Tuyên, L. D., Vu Anh, L. I. N. H., Anh, N. D. V., Tran, N. T., Thuc, V. T. M., Yui, K., Ito, Y., NAKASHIMA, Y., & Yamamoto, S. (2016) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.62.295 · Cited by 28 · see citing works
Zamaratskaia, G., Omar, N. A. M., Brunius, C. F., Hallmans, G., Johansson, J., Andersson, S.-O., Larsson, A. O., Åman, P., & Landberg, R. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.01.007 · Cited by 28 · see citing works
Arabzadegan, N., Daneshzad, E., Fatahi, S., Moosavian, S. P., Surkan, P. J., & Azadbakht, L. (2019) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-019-00757-x · Cited by 28 · see citing works
Enzymatic polishing of cereal grains for improved nutrient retainment
Singh, A. P., Karmakar, S., Jacob, S., Bhattacharya, P., Kumar, S. P. J., & Banerjee, R. (2014) · Journal of Food Science and Technology · doi:10.1007/s13197-014-1405-8 · Cited by 27 · see citing works
Xue, K., Liu, Y., Iversen, K., Mazidi, M., Qu, Z., Dong, C., Jin, T., Hallmans, G., Åman, P., Johansson, A. S., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.608623 · Cited by 26 · see citing works
Zhang, W., Jiang, J., Li, X., He, Y., Chen, F., & Li, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.834258 · Cited by 25 · see citing works
Decreased GlycA after lifestyle intervention among obese, prediabetic adolescent Latinos
Olson, M. L., Rentería-Mexia, A. M., Connelly, M. A., Vega‐López, S., Soltero, E. G., Konopken, Y. P., Williams, A. N., Castro, F. G., Keller, C. S., Yang, H., et al. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2018.09.011 · Cited by 22 · see citing works
Um, C. Y., Campbell, P. T., Carter, B. D., Wang, Y., Gapstur, S. M., & McCullough, M. L. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02032-2 · Cited by 22 · see citing works
Fu, T., Ye, S., Sun, Y., Dan, L., Wang, X., & Chen, J. (2022) · Nutrients · doi:10.3390/nu14194058 · Cited by 21 · see citing works
Santaren, I. D., Watkins, S. M., Liese, A. D., Wagenknecht, L. E., Rewers, M., Haffner, S. M., Lorenzo, C., Festa, A., Bazinet, R. P., & Hanley, A. J. (2017) · Journal of Lipid Research · doi:10.1194/jlr.p076836 · Cited by 21 · see citing works
Self-citationGrain Intake and Clinical Outcome in Stage III Colon Cancer: Results From CALGB 89803 (Alliance)
Brown, J. C., Zhang, S., Niedzwiecki, D., Saltz, L. B., Mayer, R. J., Mowat, R. B., Whittom, R., Hantel, A., Benson, A. B., Atienza, D. M., et al. (2018) · JNCI Cancer Spectrum · doi:10.1093/jncics/pky017 · Cited by 20 · see citing works
Flor‐Alemany, M., Marín‐Jiménez, N., Nestares, T., Borges‐Cosic, M., Aranda, P., & Aparicio, V. A. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.04.002 · Cited by 20 · see citing works
Inflammation, diet, and type 2 diabetes: a mini-review
Jafaripour, S., Sedighi, S., Jokar, M. H., Aghaei, M., & Moradzadeh, M. (2020) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2020.1750423 · Cited by 19 · see citing works
Zhao, R., Ghazzawi, N., Wu, J., Le, K., Li, C., Moghadasian, M. H., Siow, Y. L., Apea-Bah, F. B., Trust Beta, Yin, Z.-F., et al. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00005 · Cited by 18 · see citing works
Shahidi, F., Zhong, Y., & Chandrasekara, A. (2012) · Wiley eBooks · doi:10.1002/9781118229415.ch19 · Cited by 18 · see citing works
Refined grains consumption is associated with a greater odds of glioma
Mousavi, S. M., Rigi, S., Shayanfar, M., Mohammad-Shirazi, M., Sharifi, G., & Esmaillzadeh, A. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1758889 · Cited by 16 · see citing works
Rowicka, G., Klemarczyk, W., Ambroszkiewicz, J., Strucińska, M., Kawiak‐Jawor, E., Weker, H., & Chełchowska, M. (2023) · Antioxidants · doi:10.3390/antiox12030682 · Cited by 16 · see citing works
Yamini, S., & Trumbo, P. R. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw027 · Cited by 15 · see citing works
Ovarian failure and cancer treatment: incidence and interventions for premenopausal women.
Feldman, J. (1989) · PubMed · Cited by 15 · see citing works
Effect of Germination Processing on Bioactive Compounds of Cereals and Legumes
Hassan, S., Hussain, M. B., Waheed, M., Ahmad, K., Kassymov, S., Shariati, M. A., Akram, M., Mishra, A. P., & Egbuna, C. (2020) · Springer eBooks · doi:10.1007/978-3-030-42319-3_16 · Cited by 14 · see citing works
Sakhaei, R., Ramezani‐Jolfaie, N., Mohammadi, M., & Salehi‐Abargouei, A. (2018) · Nutrition · doi:10.1016/j.nut.2018.06.020 · Cited by 14 · see citing works
The Effect of Rye-Based Foods on Postprandial Plasma Insulin Concentration: The Rye Factor
Iversen, K., Jonsson, K., & Landberg, R. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.868938 · Cited by 13 · see citing works
Papanikolaou, Y., Slavin, J. L., Clemens, R., Brenna, J. T., Hayes, D., Gaesser, G. A., & Fulgoni, V. L. I. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa125 · Cited by 12 · see citing works
Samadi, M., Khosravy, T., Azadbakht, L., Rezaei, M., Mosafaghadir, M., Kamari, N., Bagheri, A., Pasdar, Y., Najafi, F., Hamze, B., et al. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2617 · Cited by 10 · see citing works
Mahabady, M., Zolfaghari, H., Samimi, M., Gilasi, H., Sharifi, N., & Aminianfar, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-80238-z · Cited by 9 · see citing works
Yashpal, S., Liese, A. D., Boucher, B. A., Wagenknecht, L. E., Haffner, S. M., Johnston, L., Bazinet, R. P., Rewers, M., Rotter, J. I., Watkins, S. M., et al. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521003561 · Cited by 9 · see citing works
Self-citationChen, Q.-Y., Keum, N., & Giovannucci, E. L. (2025) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaf098 · Cited by 8 · see citing works
Madardam, U., Veerasakul, S., Tamrin, S. B. M., & Mongkonkansai, J. (2022) · Roczniki Państwowego Zakładu Higieny · doi:10.32394/rpzh.2022.0210 · Cited by 8 · see citing works
Zhou, J., Sheng, J., Fan, Y., Zhu, X., & Wang, S. (2018) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2018.1515184 · Cited by 8 · see citing works
The Effect of Acai (Euterpe spp.) Fruit Pulp on Brain Health and Performance
Schauss, A. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-411462-3.00019-9 · Cited by 8 · see citing works
Dietary patterns in relation to glioma: a case–control study
Nemati, M., Shayanfar, M., Almasi, F., Mohammad-Shirazi, M., Sharifi, G., Aminianfar, A., & Esmaillzadeh, A. (2024) · Cancer & Metabolism · doi:10.1186/s40170-024-00336-4 · Cited by 7 · see citing works
Litbarg, N. O. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00040-2 · Cited by 7 · see citing works
Relationship between plasma fibrinogen and fiber intake in the EPIC-Norfolk cohort
de Freitas, R. N., Luben, R., Wareham, N. J., & Khaw, K. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.194 · Cited by 7 · see citing works
Berthy, F., Allès, B., Fezeu, L., Lairon, D., Pointereau, P., Touvier, M., Herçberg, S., Galan, P., Baudry, J., & Kesse‐Guyot, E. (2025) · International Journal of Epidemiology · doi:10.1093/ije/dyaf011 · Cited by 5 · see citing works
Flour bleaching: over a century of health risks and controversies
Hou, L., Li, S., Ou, Y., & Zhu, L. (2025) · Food, Nutrition and Health. · doi:10.1007/s44403-025-00028-x · Cited by 4 · see citing works
Whole grains and legumes consumption in association with neuromyelitis optica spectrum disorder odds
Rezaeimanesh, N., Ariyanfar, S., Sahraian, M. A., Moghadasi, A. N., Ghorbani, Z., & Jahromi, S. R. (2021) · Current Journal of Neurology · doi:10.18502/cjn.v20i3.7688 · Cited by 4 · see citing works
MicroRNA-mediated mechanisms in whole grain consumption for preventing type 2 diabetes mellitus
Qin, M., Chen, Z., Liu, X., & Ren, X. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104745 · Cited by 4 · see citing works
Zheng, X., Shang, J., Yue, Q., & Li, M. (2019) · Springer eBooks · doi:10.1007/978-981-13-6167-8_6 · Cited by 3 · see citing works
Nutrition and Chronic Conditions
Ojo, O. (2019) · MDPI eBooks · doi:10.3390/books978-3-03897-603-5 · Cited by 3 · see citing works
Calle, M. C. (2013) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2013/4248 · Cited by 3 · see citing works
Food and Health Forum meeting – nutritional approaches to cardiovascular health: workshop report
Mitchell, H. L., Gibbins, J. M., Griffin, B. A., Lovegrove, J. A., Stowell, J. D., & FOOT, E. A. (2012) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2012.01984.x · Cited by 2 · see citing works
Inflammatory Cytokines and type 2 diabetes
Jokar, M. H., Sedighi, S., Aghaei, M., Mohamadkhani, A., & Moradzadeh, M. (2020) · کومش · doi:10.29252/koomesh.22.3.396 · Cited by 2 · see citing works
Shivappa, N. (2014) · Scholar Commons (University of South Carolina) · Cited by 2 · see citing works
Zastosowanie diety śródziemnomorskiej w prewencji i leczeniu zespołu metabolicznego
Bawa, S., Gajewska, D., & Myszkowska-Ryciak, J. (2010) · Cited by 2 · see citing works
THA NUTRITIONAL VALUE OF GERMINATED SORGHUM
Abbas, S. F. (2024) · Humanitarian and Natural Sciences Journal · doi:10.53796/hnsj56/16 · Cited by 1 · see citing works
- Authors
- Masters, R. C., Liese, A. D., Haffner, S. M., Wagenknecht, L. E., & Hanley, A. J.
- Affiliations
- University of South Carolina (US)
- The University of Texas at San Antonio Health Science Center (US)
- Wake Forest University (US)
- University of Toronto (CA)
- Corresponding author
- Hanley, Anthony J.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 140
- Issue
- 3
- Pages
- 587-594
- ISSN
- 0022-3166 (ISSN-L)
- PMC
- PMC2821887
- OpenAlex
- W2129936669
- Cited by
- 121
- References
- 50
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 12 · 2018: 15 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 12 · 2013: 10 · 2012: 9
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u01hl047887-09, 5u01hl047889-09)
- U.S. Public Health Service (R01-58329)
- Canadian Institutes of Health Research
- National Heart, Lung, and Blood Institute (U01HL047902, U01-HL 47889, U01-HL 47887, U01HL047892)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK029867, DK29867)
- National Center for Research Resources (M01RR000043)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- whole grain intake, dietary fiber, inflammation, plasminogen activator inhibitor-1, C-reactive protein, fibrinogen, insulin sensitivity, type 2 diabetes, cardiovascular disease, Insulin Resistance Atherosclerosis Study
- MeSH terms
- Adult, C-Reactive Protein, Edible Grain, Diet, Female, Fibrinogen, Humans, Inflammation, Male, Middle Aged, Obesity, Sex Characteristics, Diet Records, Plasminogen Activator Inhibitor 1, Waist Circumference
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review