Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, Carey N., Bodzin, Jennifer L., Saltiel, Alan R.·2007·Journal of Clinical Investigation

DOI 10.1172/jci29881

Cited by (1,048)

Items 501–600 of 1,048

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Kavitha Yaddanapudi, Kalyani Putty, Beatriz E. Rendon, Gwyneth J. Lamont, Jonathan Faughn, Abhay R. Satoskar, Amanda B. Lasnik, John W. Eaton, Robert A. Mitchell · 2013 · The Journal of Immunology
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I M Khan, X-YD Perrard, Gerd Brunner, Hayman Lui, Lauren Marie Sparks, Steven R. Smith, Xuewen Wang, Z-Z Shi, Dorothy E. Lewis, Huaizhu Wu et al. · 2015 · International Journal of Obesity
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Manju Kumari, Xun Wang, Louise Lantier, Anna Lyubetskaya, Jun Eguchi, Sona Kang, Danielle E. Tenen, Hyun Cheol Roh, Xingxing Kong, Lawrence Kazak et al. · 2016 · Journal of Clinical Investigation
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Christoph Hess, Claudia Kemper · 2016 · Immunity
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Rosaria Scandiffio, Federica Geddo, Erika Cottone, Giulia Querio, Susanna Antoniotti, Maria Pia Gallo, Massimo Emilio Maffei, Patrizia Bovolin · 2020 · Nutrients
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Sex differences during the course of diet-induced obesity in mice: adipose tissue expandability and glycemic control
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Tadashi Takeuchi, Keishi Kameyama, Eiji Miyauchi, Yumiko Nakanishi, Takashi Kanaya, Takayoshi Fujii, Tamotsu Kato, Takaharu Sasaki, Naoko Tachibana, Hiroki Negishi et al. · 2023 · Cell Metabolism
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Li, Huating, Wu, Guangyu, Fang, Qichen, Zhang, Mingliang, Hui, Xiaoyan, Sheng, Bin, Wu, Liang, Bao, Yuqian, Li, Peng, Xu, Aimin et al. · 2018 · Nature Communications
Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization
Zhang, Weijuan, Xu, Wei, Xiong, Sidong · 2010 · The Journal of Immunology
Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity
Matthew R. Spite, Jason L. Hellmann, Yunan Tang, Steven Mathis, Madhavi Kosuri, Aruni Bhatnagar, Venkatakrishna Rao Jala, Bodduluri Haribabu · 2011 · The Journal of Immunology
Resistant starch can improve insulin sensitivity independently of the gut microbiota
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Metabolic adaptations of tissue-resident immune cells
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Chung, Kyoung-Jin, Chatzigeorgiou, Antonios, Economopoulou, Matina, Garcia-Martin, Ruben, Alexaki, Vasileia I, Mitroulis, Ioannis, Nati, Marina, Gebler, Janine, Ziemssen, Tjalf, Goelz, Susan E et al. · 2017 · Nature Immunology
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Anita C. Thomas, Joshua T. Mattila · 2014 · Frontiers in Immunology
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Tsatsoulis, Agathocles, Mantzaris, Michalis D., Bellou, Sofia, Andrikoula, Maria · 2013 · Metabolism
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