The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Open accessAbstract
Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to insulin resistance. We hypothesized that macrophages migrating to adipose tissue upon high-fat feeding may differ from those that reside there under normal diet conditions. To this end, we found a novel F4/80(+)CD11c(+) population of ATMs in adipose tissue of obese mice that was not seen in lean mice. ATMs from lean mice expressed many genes characteristic of M2 or "alternatively activated" macrophages, including Ym1, arginase 1, and Il10. Diet-induced obesity decreased expression of these genes in ATMs while increasing expression of genes such as those encoding TNF-alpha and iNOS that are characteristic of M1 or "classically activated" macrophages. Interestingly, ATMs from obese C-C motif chemokine receptor 2-KO (Ccr2-KO) mice express M2 markers at levels similar to those from lean mice. The antiinflammatory cytokine IL-10, which was overexpressed in ATMs from lean mice, protected adipocytes from TNF-alpha-induced insulin resistance. Thus, diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These cells produce high levels of TNFα, IL-6, and IL-1β, all of which are also observed in increased levels of adipose tissue from insulin resistant individuals.”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [70]
In the citing paper
“While the ATMs present in healthy lean adipose tissue are primarily of an M2 phenotype, those that accumulate in the adipose tissue during obesity have a strongly polarized pro-inflammatory, M1 phenotype [63,69–71].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [70]
In the citing paper
“However, two studies that investigated cellular markers of inflammation both reported an anti-inflammatory effect of vitamin D (747,748) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [747]
In the citing paper
“Using data pooled from thirty-six healthy subjects, twenty-four type 1 diabetics and twenty-six type 1 diabetics with microvascular complications, Devaraj et al. (747) found significant inverse relationships between serum 25(OH)D 3 and CRP concentration, monocyte NF-kB activation and TLR4 expression.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [747]
In the citing paper
“Accordingly, because of their proinflammatory properties, these macrophages are implicated in the pathogenesis of insulin resistance (103, 105, 112, 113).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [103]
In the citing paper
“The combination of microhypoxia and lipid overload triggers the recruitment of immune cells, such as macrophages in the adipose tissue and their activation ([103](#B103), [129](#B129), [171](#B171)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [103]
In the citing paper
“Under stimulation by B cells, effector T cells and Th1cells release cytokines such as interferon-γ to further stimulate activation of macrophages and induce a shift in macrophages from an M2-like phenotype to an M1-like phenotype.”
From The Vasculature in Prediabetes (2018) · cites this paper as [83]
In the citing paper
“In obese mice, a shift in the activation state of WAT macrophages from an M2 'alternatively activated' state to an M1 'pro-inflammatory state' was observed in response to diet-induced obesity [47].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [47]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682
Flagged first, then by citations
Research works printed but not linked: 3
- Barzilai, 1999, Am. J. Physiol., 277, E291
- Juge-Aubry, 2005, Cytokine., 29, 270
- Lumeng, 2006, Diabetes.
Cited by
Sorted by citations
Items 601–700 of 1,050
Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment
Reichel, D., Tripathi, M., & Perez, J. M. (2018) · Nanotheranostics · doi:10.7150/ntno.30052 · Cited by 178
Metabolic influence on macrophage polarization and pathogenesis
Thapa, B., & Lee, K. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.6.140 · Cited by 176
Pejnovic, N. N., Pantic, J. M., Jovanović, I., Radosavljevic, G. D., Milovanović, M., Nikolić, I., Zdravkovic, N. S., Djukić, A., Arsenijević, N., & Lukić, M. L. (2013) · Diabetes · doi:10.2337/db12-0222 · Cited by 172
Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution
Orr, J. S., Kennedy, A. J., Anderson‐Baucum, E. K., Webb, C. D., Fordahl, S. C., Erikson, K. M., Zhang, Y., Etzerodt, A., Moestrup, S. K., & Hasty, A. H. (2013) · Diabetes · doi:10.2337/db13-0213 · Cited by 172
Reduced oxidative capacity in macrophages results in systemic insulin resistance
Jung, S.-B., Choi, M. J., Ryu, D., Yi, H., Lee, S. E., Chang, J. Y., Chung, H. K., Kim, Y. K., Kang, S., Lee, J. H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03998-z · Cited by 174
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Lin, N., & Simon, M. C. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84426 · Cited by 170
Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA
Reddy, M. A., Chen, Z., Park, J. T., Wang, M., Lanting, L. L., Zhang, Q., Bhatt, K. S., Leung, A., Wu, X., Putta, S., et al. (2014) · Diabetes · doi:10.2337/db14-0298 · Cited by 172
Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus
Guilherme, A., Henriques, F. D. S., Bedard, A. H., & Czech, M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0165-y · Cited by 179
Smitka, K., & Maresova, D. (2015) · Prague Medical Report · doi:10.14712/23362936.2015.49 · Cited by 178
Xia, S., Sha, H., Liu, Y., Ji, Y., Ostrand‐Rosenberg, S., & Qi, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237123 · Cited by 169
Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
Trim, W. V., Turner, J. E., & Thompson, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00169 · Cited by 178
Badeanlou, L., Furlan-Freguia, C., Yang, G., Ruf, W., & Samad, F. (2011) · Nature Medicine · doi:10.1038/nm.2461 · Cited by 172
Obesity and colorectal cancer: molecular features of adipose tissue
Martínez‐Useros, J., & García‐Foncillas, J. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0772-5 · Cited by 181
Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19
Mauvais‐Jarvis, F. (2020) · Diabetes · doi:10.2337/dbi19-0023 · Cited by 170
Obesity, Metabolic Syndrome, and Osteoarthritis—An Updated Review
Sampath, S. J. P., Venkatesan, V., Ghosh, S., & Kotikalapudi, N. (2023) · Current Obesity Reports · doi:10.1007/s13679-023-00520-5 · Cited by 182
Alisi, A., Carpino, G., de Oliveira, F. L., Panera, N., Nobili, V., & Gaudio, E. (2017) · Mediators of Inflammation · doi:10.1155/2017/8162421 · Cited by 172
Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases
Chehimi, M., Vidal, H., & Eljaafari, A. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6070068 · Cited by 172
The immune system's involvement in obesity-driven type 2 diabetes
Shu, C. J., Benoist, C. O., & Mathis, D. J. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.12.001 · Cited by 170
Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases
Korta, P., Pocheć, E., & Mazur-Biały, A. I. (2019) · Medicina · doi:10.3390/medicina55080485 · Cited by 169
Zeyda, M., Wernly, B., Demyanets, S., Kaun, C., Hämmerle, M., Hantusch, B., Schranz, M., Neuhofer, A., Itariu, B. K., Keck, M. K., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.118 · Cited by 165
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes
Oral, E. A., Reilly, S. M., Gomez, A. V., Meral, R., Butz, L., Ajluni, N., Chenevert, T. L., Korytnaya, E., Neidert, A., HENCH, R. P., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.006 · Cited by 165
Self-citationXiong, X., Geng, Z., Zhou, B. R., Zhang, F., Han, Y., Zhou, Y., Wang, J., Gao, X.-Y., Chen, Q., Li, Y., et al. (2018) · Metabolism · doi:10.1016/j.metabol.2018.01.013 · Cited by 165
Namgaladze, D., & Brüne, B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.002 · Cited by 169
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges
Silva, H. M., Báfica, A. L. B., Rodrigues-Luiz, G. F., Chi, J., Santos, P. D. A., Reis, B. S., van Konijnenburg, D. P. H., Crane, A., Arifa, R. D. D. N., Martin, P. K., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181049 · Cited by 168
Diet-regulated production of PDGFcc by macrophages controls energy storage
Cox, N., Crozet, L., Holtman, I. R., Loyher, P.-L., Lazarov, T., White, J. B., Mass, E., Stanley, E. R., Elemento, O., Glass, C. K., et al. (2021) · Science · doi:10.1126/science.abe9383 · Cited by 172
Fetuin-A: A novel link between obesity and related complications
Trepanowski, J. F., Mey, J., & Varady, K. A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.203 · Cited by 161
PGE2 induced in and released by dying cells functions as an inhibitory DAMP
Hangai, S., Ao, T., Kimura, Y., Matsuki, K., Kawamura, T., Negishi, H., Nishio, J., Kodama, T., Taniguchi, T., & Yanai, H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602023113 · Cited by 168
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue
Goldberg, E. L., Shchukina, I., Asher, J. L., Sidorov, S., Artyomov, M. N., & Dixit, V. D. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0160-6 · Cited by 162
Wueest, S., Rapold, R. A., Schumann, D., Rytka, J. M., Schildknecht, A., Nov, O., Chervonsky, A. V., Rudich, A., Schoenle, E. J., Donath, M. Y., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38388 · Cited by 161
Hernández‐Aguilera, A., Rull, A., Rodríguez‐Gallego, E., Riera-Borrull, M., Luciano‐Mateo, F., Camps, J., Menéndez, J. A., & Joven, J. (2013) · Mediators of Inflammation · doi:10.1155/2013/135698 · Cited by 167
Louwen, F., Ritter, A., Kreis, N., & Yuan, J. (2018) · Obesity Reviews · doi:10.1111/obr.12679 · Cited by 163
Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee
Xie, J., Huang, Z., Yu, X., Zhou, L., & Pei, F. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.03.004 · Cited by 166
Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction
Gu, P., & Xu, A. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9230-8 · Cited by 160
Inflammation and adipose tissue macrophages in lipodystrophic mice
Herrero, L., Shapiro, H., Nayer, A., Lee, J., & Shoelson, S. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905310107 · Cited by 163
Diabetes and inflammation: Fundamental aspects and clinical implications
Garcia, C., Fève, B., Ferré, P., Halimi, S., Baïzri, H., Bordier, L., Guiu, G., Dupuy, O., Bauduceau, B., & Mayaudon, H. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.07.001 · Cited by 167
Risk factors that may modify the innate and adaptive immune responses in periodontal diseases
Knight, E. T., Liu, J. X., Seymour, G. J., Faggion, C. M., & Cullinan, M. P. (2016) · Periodontology 2000 · doi:10.1111/prd.12110 · Cited by 170
Segovia, S. A., Vickers, M. H., Harrison, C. J., Patel, R., Gray, C. L., & Reynolds, C. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00001 · Cited by 160
TGFβ signalling plays an important role in IL4-induced alternative activation of microglia
Zhou, X., Spittau, B., & Krieglstein, K. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-210 · Cited by 159
Ambarus, C. A., Noordenbos, T., de Hair, M. J. H., Tak, P. P., & Baeten, D. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3796 · Cited by 161
Resistance Training Reduces Subclinical Inflammation in Obese, Postmenopausal Women
Phillips, M. D., Patrizi, R. M., Cheek, D. J., Wooten, J. S., Barbee, J. J., & Mitchell, J. B. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182644984 · Cited by 160
Vitamin D: A new player in non-alcoholic fatty liver disease?
Eliades, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i6.1718 · Cited by 165
Lee, J. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0023-8 · Cited by 161
Veremeyko, T., Siddiqui, S., Sotnikov, I., Yung, A., & Ponomarev, E. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081774 · Cited by 165
Dixit, V. D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108028 · Cited by 163
Immune Regulation in Obesity-Associated Adipose Inflammation
Han, J. M., & Levings, M. K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301035 · Cited by 162
Nutrition, microRNAs, and Human Health
Cui, J., Zhou, B., Ross, S. A., & Zempleni, J. (2017) · Advances in Nutrition · doi:10.3945/an.116.013839 · Cited by 161
Lymphocytes in obesity-related adipose tissue inflammation
Chatzigeorgiou, A., Karalis, K. P., Bornstein, S. R., & Chavakis, T. (2012) · Diabetologia · doi:10.1007/s00125-012-2607-0 · Cited by 163
Adipose-Tissue and Intestinal Inflammation – Visceral Obesity and Creeping Fat
Kredel, L. I., & Siegmund, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00462 · Cited by 166
Lumeng, C. N.-K., Maillard, I. P., & Saltiel, A. R. (2009) · Nature Medicine · doi:10.1038/nm0809-846 · Cited by 162
Self-citationAdipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes
Lü, J., Zhao, J., Meng, H., & Zhang, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01173 · Cited by 164
Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence
Bojková, B., Winklewski, P. J., & Wszędybył-Winklewska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114114 · Cited by 166
Ito, A., Suganami, T., 山内, 明., Degawa‐Yamauchi, M., Tanaka, M., Kouyama, R., Kobayashi, Y., Nitta, N., Yasuda, K., Hirata, Y., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804220200 · Cited by 156
Insulin Inhibits IL-10–Mediated Regulatory T Cell Function: Implications for Obesity
Han, J. M., Patterson, S. J., Speck, M., Ehses, J. A., & Levings, M. K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302181 · Cited by 156
Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes
Kohlgruber, A. C., & Lynch, L. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0670-x · Cited by 163
Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Li, X., Ren, Y., Chang, K.-W., Wu, W., Griffiths, H. R., Lu, S., & Gao, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1153915 · Cited by 181
Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12
Lorenzo, M., Fernández‐Veledo, S., Vila‐Bedmar, R., García‐Guerra, L., de Álvaro, C., & Nieto-Vázquez, I. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0462 · Cited by 161
Sansbury, B. E., Cummins, T. D., Tang, Y., Hellmann, J., Holden, C. R., Harbeson, M. A., Chen, Y., Patel, R. P., Spite, M., Bhatnagar, A., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.266395 · Cited by 156
TGR5 and Immunometabolism: Insights from Physiology and Pharmacology
Perino, A., & Schoonjans, K. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.002 · Cited by 157
Mojumdar, K., Liang, F., Giordano, C., Lemaire, C. F., Danialou, G., Okazaki, T., Bourdon, J., Rafei, M., Galipeau, J., Divangahi, M., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201403967 · Cited by 156
Cucak, H., Grunnet, L. G., & Rosendahl, A. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0213075 · Cited by 162
Burke, S. J., Batdorf, H. M., Burk, D. H., Noland, R. C., Eder, A. E., Boulos, M. S., Karlstad, M. D., & Collier, J. J. (2017) · Journal of Diabetes Research · doi:10.1155/2017/8503754 · Cited by 164
Estrogen as a key regulator of energy homeostasis and metabolic health
Mahboobifard, F., Pourgholami, M. H., Jorjani, M., Dargahi, L., Amiri, M., Sadeghi, S., & Tehrani, F. R. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113808 · Cited by 154
Organotins: A review of their reproductive toxicity, biochemistry, and environmental fate
Graceli, J. B., Sena, G. C., Lopes, P. F. I., Zamprogno, G. C., da Costa, M. B., Godoi, A. F. L., dos Santos, D. M., de Marchi, M. R. R., & Fernandez, M. A. D. S. (2012) · Reproductive Toxicology · doi:10.1016/j.reprotox.2012.11.008 · Cited by 160
Cross-talk between macrophages and atrial myocytes in atrial fibrillation
Sun, Z., Zhou, D., Xie, X., Wang, S., Wang, Z., Zhao, W., Xu, H., & Zheng, L. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0584-z · Cited by 153
Adipocytokines and liver disease
Kamada, Y., Takehara, T., & Hayashi, N. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2213-6 · Cited by 155
PPARγ in the endothelium regulates metabolic responses to high-fat diet in mice
Kanda, T., Brown, J. D., Orasanu, G., Vogel, S., Gonzalez, F. J., Sartoretto, J. L., Michel, T. M., & Plutzky, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36233 · Cited by 160
Anderson‐Baucum, E. K., Gutierrez, D. A., Kennedy, A. J., & Hasty, A. H. (2013) · Diabetes · doi:10.2337/db12-1076 · Cited by 153
Role of Epicardial Adipose Tissue in Health and Disease: A Matter of Fat?
Gaborit, B., Sengenès, C., Ancel, P., Jacquier, A., & Dutour, A. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160034 · Cited by 183
Tian, X. Y., Ganeshan, K., Hong, C., Nguyen, K. D., Qiu, Y., Kim, J., Tangirala, R. K., Tontonoz, P., & Chawla, A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.003 · Cited by 155
Cross-talk between adipose tissue and vasculature: role of adiponectin
Li, F. Y. L., Cheng, K. K. Y., Lam, K. S. L., Vanhoutte, P. M., & Xu, A. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02216.x · Cited by 155
Virus Infections and Host Metabolism—Can We Manage the Interactions?
Sumbria, D., Berber, E., Mathayan, M., & Rouse, B. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594963 · Cited by 147
Ji, Y., Sun, S., Xia, S., Yang, L., Li, X., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371807 · Cited by 150
Leptin-Induced JAK/STAT Signaling and Cancer Growth
Mullen, M., & Gonzalez-Perez, R. R. (2016) · Vaccines · doi:10.3390/vaccines4030026 · Cited by 154
Microglia and Monocyte-Derived Macrophages in Stroke
Kim, E., & Cho, S. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0463-1 · Cited by 159
Cho, K. W., Zamarron, B. F., Muir, L. A., Singer, K., Porsche, C. E., DelProposto, J. B., Geletka, L. M., Meyer, K. A., O’Rourke, R. W., & Lumeng, C. N.-K. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600820 · Cited by 149
Self-citationAsthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation
Bantulà, M., Roca‐Ferrer, J., Arismendi, E., & Picado, C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10020169 · Cited by 160
Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders
Maioli, T. U., Nogués, E. B., Torres, L., Barbosa, S. C., Martins, V. D., Langella, P., Azevedo, V., & Chatel, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.740636 · Cited by 159
Kirk, E. A., Sagawa, Z. K., McDonald, T. O., O'Brien, K. D., & Heinecke, J. W. (2008) · Diabetes · doi:10.2337/db07-1061 · Cited by 149
He, H., Zhang, S., Tighe, S. P., Son, J., & Tseng, S. C. G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.479584 · Cited by 152
Adipose tissue recruitment of leukocytes
Anderson‐Baucum, E. K., Gutierrez, D. A., & Hasty, A. H. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283393867 · Cited by 156
Flachs, P., Rossmeisl, M., Kuda, O., & Kopecký, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.003 · Cited by 154
Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice
Sakamoto, T., Nitta, T., Maruno, K., Yeh, Y., Kuwata, H., Tomita, K., Goto, T., Takahashi, N., & Kawada, T. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00028.2015 · Cited by 153
Rocca, B., Fox, K. A. A., Ajjan, R., Andreotti, F., Baigent, C., Collet, J., Grove, E. L., Halvorsen, S., Huber, K., Morais, J., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy066 · Cited by 154
Obesity, Inflammation, and Prostate Cancer
Fujita, K., Hayashi, T., Matsushita, M., Uemura, M., & Nonomura, N. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020201 · Cited by 158
Microbiota, Inflammation and Obesity
Sanz, Y., & Moya-Pérez, Á. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_14 · Cited by 151
Toll-like receptors, inflammation, metabolism and obesity
Fresno, M., Álvarez, R., & Cuesta, N. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2011.562514 · Cited by 150
Metformin Down-regulates TNF-α Secretion via Suppression of Scavenger Receptors in Macrophages
Hyun, B., Shin, S., Lee, A., Lee, S., Song, Y., Ha, N., Cho, K., & Kim, K. (2013) · Immune Network · doi:10.4110/in.2013.13.4.123 · Cited by 151
Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice
Wang, M., You, Q., Lor, K., Chen, F., Gao, B., & Ju, C. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.6a0114-004rr · Cited by 151
Gambino, R., Musso, G., & Cassader, M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3058 · Cited by 147
Wu, C., McNeill, J. N., Goon, K. C., Little, D., Kimmerling, K. A., Huebner, J. L., Kraus, V. B., & Guilak, F. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40161 · Cited by 147
Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes
Appari, M., Channon, K. M., & McNeill, E. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7060 · Cited by 154
Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease
Huang, S., Xing, Y., & Liu, Y. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007036 · Cited by 152
Ли, Б., Leung, J. C. K., Chan, L. Y. Y., Yiu, W. H., & Tang, S. C. W. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.101020 · Cited by 149
Adipose Tissue Fibrosis: Mechanisms, Models, and Importance
DeBari, M. K., & Abbott, R. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176030 · Cited by 153
T Cells in Adipose Tissue: Critical Players in Immunometabolism
Wang, Q., & Wu, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02509 · Cited by 154
Macrophages, Meta-Inflammation, and Immuno-Metabolism
Shapiro, H., Lutaty, A., & Ariel, A. (2011) · The Scientific World JOURNAL · doi:10.1100/2011/397971 · Cited by 153
Miyoshi, M., Ogawa, A., Higurashi, S., & Kadooka, Y. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0568-9 · Cited by 144
Scope and mechanisms of obesity-related renal disease
Hunley, T. E., Ma, L., & Kon, V. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283374c09 · Cited by 147
Exercise Attenuates M1 Macrophages and CD8+ T Cells in the Adipose Tissue of Obese Mice
Kawanishi, N., Mizokami, T., Yano, H., & Suzuki, K. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31828ff9c6 · Cited by 146
Role of T Cells in Malnutrition and Obesity
Gerriets, V. A., & MacIver, N. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00379 · Cited by 154
Metadata
- Authors
- Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Saltiel, Alan R.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-01-02
- Volume
- 117
- Issue
- 1
- Pages
- 175-184
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1716210
- OpenAlex
- W2145697808
- Cited by
- 4,664
- References
- 54
- Citations by year
- 2026: 157 · 2025: 214 · 2024: 227 · 2023: 224 · 2022: 256 · 2021: 324 · 2020: 320 · 2019: 304 · 2018: 290 · 2017: 322 · 2016: 296 · 2015: 290 · 2014: 286 · 2013: 319 · 2012: 226
- FWCI
- 92.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan
- National Institutes of Health (HD028820)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK60591, R01DK060591)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007513, K12HD028820)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- obesity, adipose tissue macrophages, macrophage polarization, M1/M2 macrophages, insulin resistance, diet-induced obesity, CCR2, IL-10, TNF-α, adipocyte inflammation, high-fat diet, M2 macrophages
- MeSH terms
- Adipose Tissue, Animals, Base Sequence, Biological Transport, Energy Intake, Deoxyglucose, Dietary Fats, Disease Models, Animal, Macrophages, Male, Mice, Inbred C57BL, Mice, Obese, Obesity, 3T3 Cells, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
