The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Open accessAbstract
Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to insulin resistance. We hypothesized that macrophages migrating to adipose tissue upon high-fat feeding may differ from those that reside there under normal diet conditions. To this end, we found a novel F4/80(+)CD11c(+) population of ATMs in adipose tissue of obese mice that was not seen in lean mice. ATMs from lean mice expressed many genes characteristic of M2 or "alternatively activated" macrophages, including Ym1, arginase 1, and Il10. Diet-induced obesity decreased expression of these genes in ATMs while increasing expression of genes such as those encoding TNF-alpha and iNOS that are characteristic of M1 or "classically activated" macrophages. Interestingly, ATMs from obese C-C motif chemokine receptor 2-KO (Ccr2-KO) mice express M2 markers at levels similar to those from lean mice. The antiinflammatory cytokine IL-10, which was overexpressed in ATMs from lean mice, protected adipocytes from TNF-alpha-induced insulin resistance. Thus, diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These cells produce high levels of TNFα, IL-6, and IL-1β, all of which are also observed in increased levels of adipose tissue from insulin resistant individuals.”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [70]
In the citing paper
“While the ATMs present in healthy lean adipose tissue are primarily of an M2 phenotype, those that accumulate in the adipose tissue during obesity have a strongly polarized pro-inflammatory, M1 phenotype [63,69–71].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [70]
In the citing paper
“However, two studies that investigated cellular markers of inflammation both reported an anti-inflammatory effect of vitamin D (747,748) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [747]
In the citing paper
“Using data pooled from thirty-six healthy subjects, twenty-four type 1 diabetics and twenty-six type 1 diabetics with microvascular complications, Devaraj et al. (747) found significant inverse relationships between serum 25(OH)D 3 and CRP concentration, monocyte NF-kB activation and TLR4 expression.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [747]
In the citing paper
“Accordingly, because of their proinflammatory properties, these macrophages are implicated in the pathogenesis of insulin resistance (103, 105, 112, 113).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [103]
In the citing paper
“The combination of microhypoxia and lipid overload triggers the recruitment of immune cells, such as macrophages in the adipose tissue and their activation ([103](#B103), [129](#B129), [171](#B171)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [103]
In the citing paper
“Under stimulation by B cells, effector T cells and Th1cells release cytokines such as interferon-γ to further stimulate activation of macrophages and induce a shift in macrophages from an M2-like phenotype to an M1-like phenotype.”
From The Vasculature in Prediabetes (2018) · cites this paper as [83]
In the citing paper
“In obese mice, a shift in the activation state of WAT macrophages from an M2 'alternatively activated' state to an M1 'pro-inflammatory state' was observed in response to diet-induced obesity [47].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [47]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682
Flagged first, then by citations
Research works printed but not linked: 3
- Barzilai, 1999, Am. J. Physiol., 277, E291
- Juge-Aubry, 2005, Cytokine., 29, 270
- Lumeng, 2006, Diabetes.
Cited by
Sorted by citations
Items 301–400 of 1,050
Aging and adipose tissue: potential interventions for diabetes and regenerative medicine
Palmer, A. K., & Kirkland, J. L. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.013 · Cited by 324
Elias, I., Franckhauser, S., Ferré, T., Vilà, L., Tafuro, S., MUÑOZ, S. A., Roca, C., Ramos, D., Pujol, A., Riu, E., et al. (2012) · Diabetes · doi:10.2337/db11-0832 · Cited by 332
Mikita, J., Dubourdieu-Cassagno, N., Deloire, M. S., Vekris, A., Biran, M., Raffard, G., Brochet, B., Canron, M.-H., Franconi, J.-M., Boiziau, C., et al. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458510379243 · Cited by 358
Xia, W. G., Hilgenbrink, A. R., Matteson, E. L., Lockwood, M. B., Cheng, J., & Low, P. S. (2008) · Blood · doi:10.1182/blood-2008-04-150789 · Cited by 325
Pinto, A. R., Paolicelli, R., Salimova, E., Gospocic, J., Slonimsky, E., Bilbao-Cortes, D., Godwin, J. W., & Rosenthal, N. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036814 · Cited by 318
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 327
Macrophage functions in lean and obese adipose tissue
Thomas, D. D., & Apovian, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.04.005 · Cited by 333
A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease
Chen, Z., Yu, R., Xiong, Y., Du, F.-T., & Zhu, S. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0572-9 · Cited by 325
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs
Virtue, A. T., McCright, S. J., Wright, J. M., Jimenez, M. T., Mowel, W. K., Kotzin, J. J., Joannas, L., Basavappa, M. G., Spencer, S. P., Clark, M. L., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav1892 · Cited by 317
Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity
Geeraerts, X., Bolli, E., Fendt, S., & Ginderachter, J. A. V. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00289 · Cited by 326
Regulatory Effects of Quercetin on M1/M2 Macrophage Polarization and Oxidative/Antioxidative Balance
Tsai, C., Chen, G., Chen, Y.-C., Shen, C., Lu, D., Yang, L., Chen, J.-H., & Yeh, W. (2021) · Nutrients · doi:10.3390/nu14010067 · Cited by 324
Deiuliis, J. A., Shah, Z., Shah, N., NEEDLEMAN, B. J., Mikami, D. J., Narula, V. K., Perry, K. A., Hazey, J. W., Kampfrath, T., Kollengode, M. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016376 · Cited by 325
Self-citationObstfeld, A. E., Sugaru, E., Thearle, M. S., Francisco, A.-M., Gayet, C., Ginsberg, H. N., Ables, E., & Ferrante, A. W. (2010) · Diabetes · doi:10.2337/db09-1403 · Cited by 321
DeFuria, J., Bennett, G., Strissel, K. J., James, W. P., Milbury, P. E., Greenberg, A. S., & Obin, M. S. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.105155 · Cited by 313
Feig, J. E., Rong, J. X., Shamir, R., Sanson, M., Vengrenyuk, Y., Liu, J., Rayner, K. J., Moore, K. J., Garabedian, M. J., & Fisher, E. A. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016086108 · Cited by 313
Inflammation of brown/beige adipose tissues in obesity and metabolic disease
Villarroya, F., Cereijo, R., Gavaldà‐Navarro, A., Villarroya, J., & Giralt, M. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12803 · Cited by 328
Karczewski, J., Śledzińska, E., Baturo, A., Jończyk, I., Maleszko, A., Maleszko, A., Samborski, P., Krasińska, B., & Dobrowolska, A. (2018) · European Cytokine Network · doi:10.1684/ecn.2018.0415 · Cited by 321
The pancreas anatomy conditions the origin and properties of resident macrophages
Calderon, B., Carrero, J. A., Ferris, S. T., Sojka, D. K., Moore, L., Epelman, S., Murphy, K. M., Yokoyama, W. M., Randolph, G. J., & Unanue, E. R. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150496 · Cited by 321
Visceral obesity, metabolic syndrome, insulin resistance and cancer
Doyle, S. L., Donohoe, C. L., Lysaght, J., & Reynolds, J. V. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s002966511100320x · Cited by 318
Zeyda, M., & Stulnig, T. M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.003 · Cited by 316
Al‐Aly, Z., Shao, J.-S., Lai, C., Huang, E., Cai, J., Behrmann, A., Cheng, S., & Towler, D. A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.153668 · Cited by 308
Kang, Y. E., Kim, J. M., Joung, K. H., Lee, J. H., You, B. R., Choi, M. J., Ryu, M. J., Ko, Y. B., Lee, M. A., Lee, J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154003 · Cited by 306
The immune cells in adipose tissue
Ferrante, A. W. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12154 · Cited by 318
Mechanisms of Inflammatory Responses in Obese Adipose Tissue
Sun, S., Ji, Y., Kersten, S., & Qi, L. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150623 · Cited by 322
(n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights
Kalupahana, N. S., Claycombe, K. J., & Moustaid-Moussa, N. (2011) · Advances in Nutrition · doi:10.3945/an.111.000505 · Cited by 305
Hellmann, J. L., Tang, Y., Kosuri, M., Bhatnagar, A., & Spite, M. R. (2011) · The FASEB Journal · doi:10.1096/fj.10-178657 · Cited by 316
Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
Liu, R., & Nikolajczyk, B. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01587 · Cited by 318
Pietiläinen, K. H., Naukkarinen, J., Rissanen, A., Saharinen, J., Ellonen, P., Keränen, H., Suomalainen, A., Götz, A., Suortti, T., Yki‐Järvinen, H., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050051 · Cited by 303
Ying, W., Gao, H., Reis, F. C. G., Bandyopadhyay, G. K., Ofrecio, J. M., Luo, Z., Ji, Y., Jin, Z., Ly, C., & Olefsky, J. M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.019 · Cited by 311
Frydrych, L. M., Bian, G., O’Lone, D. E., Ward, P. A., & Delano, M. J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.5vmr0118-021rr · Cited by 311
The role of low-grade inflammation in the polycystic ovary syndrome
Repaci, A., Gambineri, A., & Pasquali, R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.08.002 · Cited by 310
The Role of Lipocalin 2 in the Regulation of Inflammation in Adipocytes and Macrophages
Zhang, J., Wu, Y., Zhang, Y., LeRoith, D., Bernlohr, D., & Chen, X. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0420 · Cited by 302
Gilbert, C. A., & Slingerland, J. M. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-121211-091527 · Cited by 311
Oxidative stress, inflamm-aging and immunosenescence
Cannizzo, E. S., Clement, C. C., Sahu, R. K., Follo, C., & Santambrogio, L. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.005 · Cited by 315
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages
Satoh, T., Kidoya, H., Naito, H., Yamamoto, M., Takemura, N., Nakagawa, K., Yoshioka, Y., Morii, E., Takakura, N., Takeuchi, O., et al. (2013) · Nature · doi:10.1038/nature11930 · Cited by 311
Macrophage infiltration into adipose tissue: initiation, propagation and remodeling
Surmi, B. K., & Hasty, A. H. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.545 · Cited by 307
Harford, K. A., Reynolds, C. M., McGillicuddy, F. C., & Roche, H. M. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111000565 · Cited by 309
Yang, G., Badeanlou, L., Bielawski, J., Roberts, A. J., Hannun, Y. A., & Samad, F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91014.2008 · Cited by 295
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Khodabandehloo, H., Gorgani‐Firuzjaee, S., Panahi, G., & Meshkani, R. (2015) · Translational research · doi:10.1016/j.trsl.2015.08.011 · Cited by 307
Intradermal adipocytes mediate fibroblast recruitment during skin wound healing
Schmidt, B. A., & Horsley, V. (2013) · Development · doi:10.1242/dev.087593 · Cited by 318
SirT1 regulates adipose tissue inflammation
Gillum, M. P., Kotas, M. E., Erion, D. M., Kursawe, R., Chatterjee, P., Nead, K. T., Muise, E. S., Hsiao, J. J., Frederick, D. W., Yonemitsu, S., et al. (2011) · Diabetes · doi:10.2337/db11-0616 · Cited by 260
Filippo, K. D., Henderson, R. B., Laschinger, M., & Hogg, N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.4308 · Cited by 305
Activins and Inhibins: Roles in Development, Physiology, and Disease
Namwanje, M., & Brown, C. W. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021881 · Cited by 294
Kitade, H., Sawamoto, K., Nagashimada, M., Inoue, H., Yamamoto, Y., Sai, Y., Takamura, T., Yamamoto, H., Miyamoto, K., Ginsberg, H. N., et al. (2012) · Diabetes · doi:10.2337/db11-1506 · Cited by 298
Oxidative stress and metabolic pathologies: from an adipocentric point of view
Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/908539 · Cited by 291
Adipose Tissue Extracellular Matrix and Vascular Abnormalities in Obesity and Insulin Resistance
Spencer, M. L., Ünal, R., Zhu, B., Rasouli, N., McGehee, R. E., Peterson, C. A., & Kern, P. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1567 · Cited by 309
The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_9 · Cited by 299
Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis
Rensen, S. S., Slaats, Y., Nijhuis, J., Jans, A., Bieghs, V., Driessen, A., Malle, E., Greve, J. W., & Buurman, W. A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080999 · Cited by 290
Itoh, M., Suganami, T., Satoh, N., Tanimoto-Koyama, K., Yuan, X., Tanaka, M., Kawano, H., Yano, T., Aoe, S., Takeya, M., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.136853 · Cited by 292
Dong, J., Zhang, X., Zhang, L., Bian, H., Xu, N., Bao, B., & Liu, J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m038786 · Cited by 299
Moraes‐Vieira, P. M., Yore, M. M., Dwyer, P., Syed, I., Aryal, P., & Kahn, B. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.018 · Cited by 292
White, G. E., Iqbal, A. J., & Greaves, D. R. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005074 · Cited by 295
Styskal, J., Remmen, H. V., Richardson, A. G., & Salmon, A. B. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.441 · Cited by 289
Flachs, P., Rossmeisl, M., Bryhn, M., & Kopecký, J. (2008) · Clinical Science · doi:10.1042/cs20070456 · Cited by 293
Luo, W., Xu, Q., Wang, Q., Wu, H., & Hua, J. (2017) · Scientific Reports · doi:10.1038/srep44612 · Cited by 293
Rodríguez, A., Ezquerro, S., Méndez-Giménez, L., Becerril, S., & Frühbeck, G. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2015 · Cited by 287
Macrophages in obesity and non-alcoholic fatty liver disease: crosstalk with metabolism
Lefere, S., & Tacke, F. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.02.004 · Cited by 278
High salt reduces the activation of IL-4– and IL-13–stimulated macrophages
Binger, K. J., Gebhardt, M., Heinig, M., Rintisch, C., Schroeder, A., Neuhofer, W., Hilgers, K. F., Manzel, A., Schwartz, C., Kleinewietfeld, M., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80919 · Cited by 283
Standard of care for lipedema in the United States
Herbst, K. L., Kahn, L. A., Iker, E., Ehrlich, C., Wright, T. F., McHutchison, L., Schwartz, J. S., Sleigh, M., Donahue, P. M. C., Lisson, K. H., et al. (2021) · Phlebology The Journal of Venous Disease · doi:10.1177/02683555211015887 · Cited by 282
Macrophage recruitment in obese adipose tissue
Bai, Y., & Sun, Q. (2015) · Obesity Reviews · doi:10.1111/obr.12242 · Cited by 287
Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration
Lee, Y., Petkova, A. P., & Granneman, J. G. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.003 · Cited by 293
Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism
Greer, R. L., Dong, X., de Moraes, A. C. F., Zielke, R. A., Fernandes, G. D. R., Peremyslova, E., Vasquez‐Perez, S., Schoenborn, A. A., Gomes, E. P., Pereira, A. C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13329 · Cited by 282
IL-10/TGF-β–Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis
Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V. W., Zheng, G., Tan, T. K., Ince, J., Alexander, S. I., et al. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060592 · Cited by 287
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue
Nishimura, S., Manabe, I., Nagasaki, M., Seo, K., Yamashita, H., Hosoya, Y., Ohsugi, M., Tobe, K., Kadowaki, T., Nagai, R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33328 · Cited by 277
Kraakman, M. J., Murphy, A. J., Jandeleit-Dahm, K. A. M., & Kammoun, H. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00470 · Cited by 278
TNF Counterbalances the Emergence of M2 Tumor Macrophages
Kratochvill, F., Neale, G. A. M., Haverkamp, J. M., de Velde, L.-A. V., Smith, A. M., Kawauchi, D., McEvoy, J. D., Roussel, M. F., Dyer, M. A., Qualls, J. E., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.033 · Cited by 291
Resident and Monocyte-Derived Macrophages in Cardiovascular Disease
Honold, L., & Nahrendorf, M. (2018) · Circulation Research · doi:10.1161/circresaha.117.311071 · Cited by 283
Leal, V. D. O., & Mafra, D. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.02.003 · Cited by 287
Insulin signalling mechanisms for triacylglycerol storage
Czech, M., Tencerová, M., Pedersen, D. J., & Aouadi, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2869-1 · Cited by 289
Strissel, K. J., DeFuria, J., Shaul, M. E., Bennett, G., Greenberg, A. S., & Obin, M. S. (2010) · Obesity · doi:10.1038/oby.2010.1 · Cited by 276
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Saxton, S. N., Clark, B., Withers, S., Eringa, E. C., & Heagerty, A. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00034.2018 · Cited by 290
Russo, S. L. M. L., Kwiatkowski, M., Govorukhina, N. I., Bischoff, R., & Melgert, B. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.746151 · Cited by 286
The adipocyte as an endocrine organ in the regulation of metabolic homeostasis
Harwood, H. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.010 · Cited by 282
Myocardial, Perivascular, and Epicardial Fat
Iozzo, P. (2011) · Diabetes Care · doi:10.2337/dc11-s250 · Cited by 279
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty
Stout, M. B., Justice, J. N., Nicklas, B. J., & Kirkland, J. L. (2017) · Physiology · doi:10.1152/physiol.00012.2016 · Cited by 272
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274
“In adipose tissue, the majority of NOS2 is derived from infiltrating bone marrow-derived macrophages that display a proinflammatory phenotype [151–153].”
BackgroundHeme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man
Jaïs, A., Einwallner, E., Sharif, O., Gossens, K., Lu, T. T.-H., Soyal, S. M., Medgyesi, D., Neureiter, D., Paier-Pourani, J., Dalgaard, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.043 · Cited by 270
Self-citationMacrophage polarization: the link between inflammation and related diseases
Bashir, S., Sharma, Y., Elahi, A., & Khan, F. (2015) · Inflammation Research · doi:10.1007/s00011-015-0874-1 · Cited by 279
Targeting the gut microbiome to treat the osteoarthritis of obesity
Schott, E. M., Farnsworth, C. W., Grier, A., Lillis, J. A., Soniwala, S., Dadourian, G. H., Bell, R. D., Doolittle, M. L., Villani, D. A., Awad, H. A., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.95997 · Cited by 277
Macrophages, Chronic Inflammation, and Insulin Resistance
He, L., Meng, Y., He, S., Tan, X., Zhang, Y., Zhang, X., Wang, L., & Zheng, W. (2022) · Cells · doi:10.3390/cells11193001 · Cited by 286
Obesity-induced Insulin Resistance and Hyperglycemia
Martyn, J. A. J., Kaneki, M., Yasuhara, S., Warner, D. S., & Warner, M. A. A. (2008) · Anesthesiology · doi:10.1097/aln.0b013e3181799d45 · Cited by 278
Adipocyte-Macrophage Cross-Talk in Obesity
Engin, A. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_14 · Cited by 275
Li, P., Fan, W., Xu, J., Lu, M. M., Yamamoto, H., Auwerx, J. H., Sears, D. D., Talukdar, S., Oh, D., Chen, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.050 · Cited by 264
Macrophages in age-related chronic inflammatory diseases
Oishi, Y., & Manabe, I. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.18 · Cited by 262
Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Arendt, L. M., McCready, J., Keller, P. J., Baker, D. D., Naber, S. P., Seewaldt, V. L., & Kuperwasser, C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0926 · Cited by 273
Macrophages regulate corpus luteum development during embryo implantation in mice
Care, A. S., Diener, K. R., Jasper, M. J., Brown, H. M., Ingman, W. V., & Robertson, S. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci60561 · Cited by 261
Creatine metabolism: energy homeostasis, immunity and cancer biology
Kazak, L., & Cohen, P. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0365-5 · Cited by 267
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Xourafa, G., Korbmacher, M., & Roden, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00898-1 · Cited by 274
Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases
Manabe, I. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-1184 · Cited by 272
Ni, Y., Nagashimada, M., Zhuge, F., Zhan, L., Nagata, N., Tsutsui, A., Nakanuma, Y., Kaneko, S., & Ota, T. (2015) · Scientific Reports · doi:10.1038/srep17192 · Cited by 262
Inflammation as a Therapeutic Target for Diabetic Neuropathies
Pop‐Busui, R., Ang, L. P., Holmes, C., Gallagher, K. A., & Feldman, E. L. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0727-5 · Cited by 278
Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states
Morris, D. L., Singer, K., & Lumeng, C. N.-K. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328347970b · Cited by 262
Self-citationNetrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity
Ramkhelawon, B., Hennessy, E. J., Ménager, M. M., Ray, T. D., Sheedy, F. J., Hutchison, S. B., Wanschel, A. C. B. A., Oldebeken, S. R., Geoffrion, M., Spiro, W., et al. (2014) · Nature Medicine · doi:10.1038/nm.3467 · Cited by 280
Nawaz, A., Aminuddin, A., Kado, T., Takikawa, A., Yamamoto, S., Tsuneyama, K., Igarashi, Y., Ikutani, M., Nishida, Y., Nagai, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00231-1 · Cited by 270
Metabolically Healthy Obesity: Criteria, Epidemiology, Controversies, and Consequences
Tsatsoulis, A. A., & Paschou, S. Α. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00375-0 · Cited by 272
Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders
Singh, R., Zogg, H., Wei, L., Bartlett, A., Ghoshal, U. C., Rajender, S., & Ro, S. (2020) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20149 · Cited by 274
Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species
Wei, Y., Chen, K., Whaley‐Connell, A. T., Stump, C. S., Ibdah, J. A., & Sowers, J. R. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00561.2007 · Cited by 270
Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation
Kim, J. I., Huh, J. Y., Sohn, J. H., Choe, S. S., Lee, Y. S., Lim, C. Y., Jo, A., Park, S. B., Han, W., & Kim, J. B. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01321-14 · Cited by 272
Role of lipids in the metabolism and activation of immune cells
Hubler, M. J., & Kennedy, A. J. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.11.002 · Cited by 264
Molecular Mechanism for Adiponectin-dependent M2 Macrophage Polarization
Mandal, P., Pratt, B. T., Barnes, M. A., McMullen, M. R., & Nagy, L. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204644 · Cited by 260
Metadata
- Authors
- Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Saltiel, Alan R.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-01-02
- Volume
- 117
- Issue
- 1
- Pages
- 175-184
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1716210
- OpenAlex
- W2145697808
- Cited by
- 4,664
- References
- 54
- Citations by year
- 2026: 157 · 2025: 214 · 2024: 227 · 2023: 224 · 2022: 256 · 2021: 324 · 2020: 320 · 2019: 304 · 2018: 290 · 2017: 322 · 2016: 296 · 2015: 290 · 2014: 286 · 2013: 319 · 2012: 226
- FWCI
- 92.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan
- National Institutes of Health (HD028820)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK60591, R01DK060591)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007513, K12HD028820)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- obesity, adipose tissue macrophages, macrophage polarization, M1/M2 macrophages, insulin resistance, diet-induced obesity, CCR2, IL-10, TNF-α, adipocyte inflammation, high-fat diet, M2 macrophages
- MeSH terms
- Adipose Tissue, Animals, Base Sequence, Biological Transport, Energy Intake, Deoxyglucose, Dietary Fats, Disease Models, Animal, Macrophages, Male, Mice, Inbred C57BL, Mice, Obese, Obesity, 3T3 Cells, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
