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Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Open accessAbstract
Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to insulin resistance. We hypothesized that macrophages migrating to adipose tissue upon high-fat feeding may differ from those that reside there under normal diet conditions. To this end, we found a novel F4/80(+)CD11c(+) population of ATMs in adipose tissue of obese mice that was not seen in lean mice. ATMs from lean mice expressed many genes characteristic of M2 or "alternatively activated" macrophages, including Ym1, arginase 1, and Il10. Diet-induced obesity decreased expression of these genes in ATMs while increasing expression of genes such as those encoding TNF-alpha and iNOS that are characteristic of M1 or "classically activated" macrophages. Interestingly, ATMs from obese C-C motif chemokine receptor 2-KO (Ccr2-KO) mice express M2 markers at levels similar to those from lean mice. The antiinflammatory cytokine IL-10, which was overexpressed in ATMs from lean mice, protected adipocytes from TNF-alpha-induced insulin resistance. Thus, diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance.
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“These cells produce high levels of TNFα, IL-6, and IL-1β, all of which are also observed in increased levels of adipose tissue from insulin resistant individuals.”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [70]
In the citing paper
“While the ATMs present in healthy lean adipose tissue are primarily of an M2 phenotype, those that accumulate in the adipose tissue during obesity have a strongly polarized pro-inflammatory, M1 phenotype [63,69–71].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [70]
In the citing paper
“However, two studies that investigated cellular markers of inflammation both reported an anti-inflammatory effect of vitamin D (747,748) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [747]
In the citing paper
“Using data pooled from thirty-six healthy subjects, twenty-four type 1 diabetics and twenty-six type 1 diabetics with microvascular complications, Devaraj et al. (747) found significant inverse relationships between serum 25(OH)D 3 and CRP concentration, monocyte NF-kB activation and TLR4 expression.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [747]
In the citing paper
“Accordingly, because of their proinflammatory properties, these macrophages are implicated in the pathogenesis of insulin resistance (103, 105, 112, 113).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [103]
In the citing paper
“The combination of microhypoxia and lipid overload triggers the recruitment of immune cells, such as macrophages in the adipose tissue and their activation ([103](#B103), [129](#B129), [171](#B171)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [103]
In the citing paper
“Under stimulation by B cells, effector T cells and Th1cells release cytokines such as interferon-γ to further stimulate activation of macrophages and induce a shift in macrophages from an M2-like phenotype to an M1-like phenotype.”
From The Vasculature in Prediabetes (2018) · cites this paper as [83]
In the citing paper
“In obese mice, a shift in the activation state of WAT macrophages from an M2 'alternatively activated' state to an M1 'pro-inflammatory state' was observed in response to diet-induced obesity [47].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [47]
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Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682
Flagged first, then by citations
Research works printed but not linked: 3
- Barzilai, 1999, Am. J. Physiol., 277, E291
- Juge-Aubry, 2005, Cytokine., 29, 270
- Lumeng, 2006, Diabetes.
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Items 401–500 of 1,050
Macrophage function in adipose tissue homeostasis and metabolic inflammation
Chavakis, T., Alexaki, V. I., & Ferrante, A. W. (2023) · Nature Immunology · doi:10.1038/s41590-023-01479-0 · Cited by 279
Mechanisms of macrophage activation in obesity-induced insulin resistance
Odegaard, J. I., & Chawla, A. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0976 · Cited by 259
Domínguez, P. M., & Ardavín, C. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00876.x · Cited by 273
The Relationship Between Gut Microbiota and Inflammatory Diseases: The Role of Macrophages
Wang, J., Chen, W., & Wang, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01065 · Cited by 269
McGillicuddy, F. C., Chiquoine, E. H., Hinkle, C. C., Kim, R. J., Shah, R. D., Roche, H. M., Smyth, E. M., & Reilly, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.061655 · Cited by 258
Immunity as a link between obesity and insulin resistance
Kalupahana, N. S., Moustaïd‐Moussa, N., & Claycombe, K. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.011 · Cited by 264
Caesar, R., Fåk, F., & Bäckhed, F. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02270.x · Cited by 254
Effects of obesity on depression: A role for inflammation and the gut microbiota
Schachter, J., Martel, J., Lin, C.-S., Chang, C., Wu, T.-R., Lu, C., Ko, Y., Lai, H., Ojcius, D. M., & Young, J. D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.026 · Cited by 263
Adipose tissue inflammation in obesity: A metabolic or immune response?
Stolarczyk, E. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.08.006 · Cited by 247
The PI3K/Akt Pathway in Meta-Inflammation
Acosta‐Martínez, M., & Cabail, M. Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315330 · Cited by 259
Shirakawa, J., Fujii, H., Ohnuma, K., Sato, K., Ito, Y., Kaji, M., Sakamoto, E., Koganei, M., Sasaki, H., Nagashima, Y., et al. (2011) · Diabetes · doi:10.2337/db10-1338 · Cited by 246
Wang, Y., & Harris, D. C. H. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010030269 · Cited by 248
Frank, N., & Tadros, E. M. (2013) · Equine Veterinary Journal · doi:10.1111/evj.12169 · Cited by 260
Interplay between the immune system and adipose tissue in obesity
Exley, M. A., Hand, L., O'Shea, D., & Lynch, L. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0516 · Cited by 242
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
Kolb, R., Phan, L., Borcherding, N., Liu, Y., Yuan, F., Janowski, A. M., Xie, Q., Markan, K. R., Li, W., Potthoff, M. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13007 · Cited by 239
Mitochondrial fatty acid oxidation in obesity
Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246
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Nichols, A. E. C., Best, K. T., & Loiselle, A. E. (2019) · Translational research · doi:10.1016/j.trsl.2019.02.002 · Cited by 251
Ren, Y., Zhao, H., Yin, C., Lan, X., Wu, L., Du, X., Griffiths, H. R., & Gao, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.873699 · Cited by 276
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Dalmas, É., Clément, K., & Guerre-Millo, M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.008 · Cited by 267
Mansuy‐Aubert, V., Zhou, Q. L., Xie, X., Gong, Z., Huang, J., Khan, A. R., Aubert, G., Candelaria, K., Thomas, S. C., Shin, D.-J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.005 · Cited by 248
MacKenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y. A., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202462 · Cited by 252
DNA methylation markers in obesity, metabolic syndrome, and weight loss
Samblas, M., Milagro, F. I., & Martínez, J. A. (2019) · Epigenetics · doi:10.1080/15592294.2019.1595297 · Cited by 247
Ontogeny and Polarization of Macrophages in Inflammation: Blood Monocytes Versus Tissue Macrophages
Dey, A., Allen, J., & Hankey-Giblin, P. A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00683 · Cited by 254
MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis
Hulsmans, M., Keyzer, D. D., & Holvoet, P. (2011) · The FASEB Journal · doi:10.1096/fj.11-181149 · Cited by 244
Verboven, K., Wouters, K., Gaens, K. H. J., Hansen, D., Bijnen, M., Wetzels, S., Stehouwer, C. D. A., Goossens, G. H., Schalkwijk, C., Blaak, E. E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22962-x · Cited by 265
White adipose tissue dysfunction in obesity and aging
Reyes-Farias, M., Fos-Domenech, J., Serra, D., Herrero, L., & Sánchez-Infantes, D. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114723 · Cited by 250
Patel, T. P., Rawal, K., Bagchi, A. K., Akolkar, G., Bernardes, N., Dias, D. D. S., Gupta, S. S., & Singal, P. K. (2015) · Heart Failure Reviews · doi:10.1007/s10741-015-9515-6 · Cited by 243
Lifestyle and Environmental Factors in Multiple SclerosisPreprint
Alfredsson, L. S., & Olsson, T. P. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028944 · Cited by 244
Inflammasome Priming in Sterile Inflammatory Disease
Patel, M. N., Carroll, R. G., Galván-Peña, S., Mills, E. L., Olden, R., Triantafilou, M., Wolf, A. I., Bryant, C. E., Triantafilou, K., & Masters, S. L. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.12.007 · Cited by 241
Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice
Li, P., Lu, M. M., Nguyen, M. T., Bae, E. J., Chapman, J., Feng, D., Hawkins, M. A., Pessin, J. E., Sears, D. D., Nguyen, A.-K., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100263 · Cited by 249
Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses
Boutens, L., Hooiveld, G. J. E. J., Dhingra, S., Cramer, R. A., Netea, M. G., & Stienstra, R. (2018) · Diabetologia · doi:10.1007/s00125-017-4526-6 · Cited by 254
Obesity decreases B cell responses in young and elderly individuals
Frasca, D., Ferracci, F., Diaz, A., Romero, M., Lechner, S., & Blomberg, B. B. (2016) · Obesity · doi:10.1002/oby.21383 · Cited by 228
Central and Peripheral Inflammation Link Metabolic Syndrome and Major Depressive Disorder
Chan, K. L., Cathomas, F., & Russo, S. J. (2019) · Physiology · doi:10.1152/physiol.00047.2018 · Cited by 227
Liu, C., Xu, X., Bai, Y., Wang, T.-Y., Rao, X., Wang, A., Sun, L., Ying, Z., Gushchina, L. V., Maiseyeu, A., et al. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306841 · Cited by 237
Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b
Yang, X., Wang, X., Liu, D., Yu, L., Xue, B., & Shi, H. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1293 · Cited by 243
Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells
Singer, K., DelProposto, J. L., Morris, D. L., Zamarron, B. F., Mergian, T. A., Maley, N., Cho, K. W., Geletka, L. M., Subbaiah, P., Muir, L. A., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.06.005 · Cited by 243
Self-citationRole of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation
Xia, C. Q., Rao, X., & Zhong, J. (2017) · Journal of Diabetes Research · doi:10.1155/2017/6494795 · Cited by 240
Hirata, A., Maeda, N., Hiuge, A., Hibuse, T., Fujita, K., Okada, T., Kihara, S., Funahashi, T., & Shimomura, I. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp191 · Cited by 241
Convertible visceral fat as a therapeutic target to curb obesity
Giordano, A., Frontini, A., & Cinti, S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.31 · Cited by 241
Wu, H., Wang, Y., Li, W., Chen, H., Du, L., Liu, D., Wang, X., Xu, T., Liu, L., & Chen, Q. (2019) · Autophagy · doi:10.1080/15548627.2019.1596482 · Cited by 235
The Mechanism behind Influenza Virus Cytokine Storm
Gu, Y., Zuo, X., Zhang, S., Ouyang, Z., Jiang, S., Wang, F., & Wang, G. (2021) · Viruses · doi:10.3390/v13071362 · Cited by 241
The autocrine and paracrine roles of adipokines
Karastergiou, K., & Mohamed-Ali, V. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.11.011 · Cited by 233
Koliwad, S. K., Streeper, R. S., Monetti, M., Cornelissen, I., Chan, L. C., Terayama, K., Naylor, S. G., Rao, M., Hubbard, B. K., & Farese, R. V. (2010) · Journal of Clinical Investigation · doi:10.1172/jci36066 · Cited by 236
Liu, C., Lǐ, Y., Yu, J., Ling, F., Hou, S., Liu, Y., Guo, M., Xie, Y., Meng, J., Zhang, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054841 · Cited by 233
Interplay Between Human Adipocytes and T Lymphocytes in Obesity
Duffaut, C., Zakaroff‐Girard, A., Bourlier, V., Decaunes, P., Maumus, M., Chiotasso, P., Sengenès, C., Lafontan, M., Galitzky, J., & Bouloumié, A. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.192583 · Cited by 242
Hams, E., Locksley, R. M., McKenzie, A. N. J., & Fallon, P. G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301176 · Cited by 232
Adipose extracellular matrix remodelling in obesity and insulin resistance
Lin, D., Chun, T., & Kang, L. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.05.005 · Cited by 243
Truax, A. D., Chen, L., Tam, J. W., Cheng, N., Guo, H., Koblansky, A. A., Chou, W.-C., Wilson, J. E., Brickey, W. J., Petrucelli, A., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.08.009 · Cited by 228
Neuhofer, A., Zeyda, M., Mascher, D. G., Itariu, B. K., Murano, I., Leitner, L., Hochbrugger, E., Fraisl, P., Cinti, S., Serhan, C. N., et al. (2013) · Diabetes · doi:10.2337/db12-0828 · Cited by 239
Garg, S. S., Kushwaha, K., Dubey, R., & Gupta, J. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110691 · Cited by 253
Varma, V., Yao-Borengasser, A., Rasouli, N., Nolen, G. T., Phanavanh, B., Starks, T., Gurley, C., Simpson, P., McGehee, R. E., Kern, P. A., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90885.2008 · Cited by 229
Oxidative Stress, Inflammaging, and Immunosenescence
Bauer, M. E., & la Fuente, M. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00004-6 · Cited by 229
Stefanović-Račić, M., Yang, X., Turner, M. S., Mantell, B. S., Stolz, D. B., Sumpter, T. L., SIPULA, I. J., Dedousis, N. L., Scott, D. K., Morel, P. A., et al. (2012) · Diabetes · doi:10.2337/db11-1523 · Cited by 229
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Zhang, X., Ha, S., Lau, H. C.-H., & Yu, J. Q. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.03.008 · Cited by 255
Korakas, E., Ikonomidis, I., Kousathana, F., Balampanis, K., Kountouri, A., Raptis, A. E., Palaiodimou, L., Kokkinos, A. D., & Lambadiari, V. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00198.2020 · Cited by 226
HIV and antiretroviral therapy-related fat alterations
Koethe, J. R., Lagathu, C., Lake, J. E., Domingo, P., Calmy, A., Falutz, J., Brown, T. T., & Capeau, J. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0181-1 · Cited by 234
Overview of Adipose Tissue and Its Role in Obesity and Metabolic Disorders
Frühbeck, G. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-245-8_1 · Cited by 233
Anti-inflammatory and anti-atherogenic properties of adiponectin
Ohashi, K., Ouchi, N., & Matsuzawa, Y. (2012) · Biochimie · doi:10.1016/j.biochi.2012.06.008 · Cited by 232
Westwell-Roper, C. Y., Ehses, J. A., & Verchere, C. B. (2013) · Diabetes · doi:10.2337/db13-0863 · Cited by 232
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Attie, A., & Scherer, P. E. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800057-jlr200 · Cited by 228
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McMahan, R. H., Wang, X. X., Cheng, L. L., Krisko, T., Smith, M., El Kasmi, K., Pruzanski, M., Adorini, L., Golden-Mason, L., Levi, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.446575 · Cited by 225
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Jing, Y., Wu, F., Li, D., Yang, L., Li, Q., & Li, R. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.025 · Cited by 227
Phenotypic and functional switch of macrophages induced by regulatory CD4 + CD25 + T cells in mice
Liu, G., Ma, H., Qiu, L., Li, L., Cao, Y., Ma, J., & Zhao, Y. X. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.70 · Cited by 223
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Hill, A. A., Bolus, W. R., & Hasty, A. H. (2014) · Immunological Reviews · doi:10.1111/imr.12216 · Cited by 227
Ehses, J. A., Meier, D. T., Wueest, S., Rytka, J. M., Boller, S., Wielinga, P. Y., Schraenen, A., Lemaire, K., Debray, S., Lommel, L. V., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1747-3 · Cited by 243
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German, A. J., Ryan, V. H., German, A. C., Wood, I. S., & Trayhurn, P. (2010) · The Veterinary Journal · doi:10.1016/j.tvjl.2010.04.004 · Cited by 234
Ji, Y., Sun, S., Xu, A., Bhargava, P., Yang, L., Lam, K. S. L., Gao, B., Lee, C., Kersten, S., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.350066 · Cited by 221
Lipid signaling in adipose tissue: Connecting inflammation & metabolism
Masoodi, M., Kuda, O., Rossmeisl, M., Flachs, P., & Kopecký, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.023 · Cited by 229
Obesity, pregnancy, inflammation, and vascular function
Denison, F. C., Roberts, K. A., Barr, S. M., & Norman, J. E. (2010) · Reproduction · doi:10.1530/rep-10-0074 · Cited by 221
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Lovren, F., Pan, Y., Quan, A., Szmitko, P. E., Singh, K. K., Shukla, P. C., Gupta, M., Chan, L., Al-Omran, M. A., Teoh, H., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00115.2010 · Cited by 220
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Segovia, S. A., Vickers, M. H., Gray, C. L., & Reynolds, C. M. (2014) · BioMed Research International · doi:10.1155/2014/418975 · Cited by 233
Damouche, A., Lazure, T., Avettand-Fènoël, V., Huot, N., Dejucq‐Rainsford, N., Satié, A.-P., Mélard, A., David, L., Gommet, C., Ghosn, J., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005153 · Cited by 228
The role of declining adaptive homeostasis in ageing
Pomatto, L. C. D., & Davies, K. J. A. (2017) · The Journal of Physiology · doi:10.1113/jp275072 · Cited by 231
Patel, V. B., Shah, S., Verma, S., & Oudit, G. Y. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9644-1 · Cited by 218
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Metadata
- Authors
- Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Saltiel, Alan R.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-01-02
- Volume
- 117
- Issue
- 1
- Pages
- 175-184
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1716210
- OpenAlex
- W2145697808
- Cited by
- 4,664
- References
- 54
- Citations by year
- 2026: 157 · 2025: 214 · 2024: 227 · 2023: 224 · 2022: 256 · 2021: 324 · 2020: 320 · 2019: 304 · 2018: 290 · 2017: 322 · 2016: 296 · 2015: 290 · 2014: 286 · 2013: 319 · 2012: 226
- FWCI
- 92.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan
- National Institutes of Health (HD028820)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK60591, R01DK060591)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007513, K12HD028820)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- obesity, adipose tissue macrophages, macrophage polarization, M1/M2 macrophages, insulin resistance, diet-induced obesity, CCR2, IL-10, TNF-α, adipocyte inflammation, high-fat diet, M2 macrophages
- MeSH terms
- Adipose Tissue, Animals, Base Sequence, Biological Transport, Energy Intake, Deoxyglucose, Dietary Fats, Disease Models, Animal, Macrophages, Male, Mice, Inbred C57BL, Mice, Obese, Obesity, 3T3 Cells, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Mice
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