Sixteen years and counting: an update on leptin in energy balance

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725

Identification and expression cloning of a leptin receptor, OB-R.

Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243

Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.

Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176

Role of leptin in the neuroendocrine response to fasting

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936

Stearoyl-CoA desaturase-1 and adaptive stress signaling

Koeberle, A., Loeser, K., & Thürmer, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.08.009 · Cited by 47

Effects of arsenic on adipocyte metabolism: Is arsenic an obesogen?

Ceja-Galicia, Z. A., Daniel, A., Salazar, A. M., Pánico, P., Ostrosky‐Wegman, P., & Díaz‐Villaseñor, A. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.05.008 · Cited by 48

Role of arsenic exposure in adipose tissue dysfunction and its possible implication in diabetes pathophysiology

Renu, K., Madhyastha, H., Madhyastha, R., Maruyama, M., Arunachlam, S., & Gopalakrishnan, A. V. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.11.032 · Cited by 47

Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors

Kouidhi, S., & Clerget-Froidevaux, M.-S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072017 · Cited by 48

Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview

Vismara, M. E. M., Girone, N., Cirnigliaro, G., Fasciana, F., Vanzetto, S., Ferrara, L., Priori, A., D’Addario, C., Viganò, C. A., & Dell’Osso, B. M. (2020) · Brain Sciences · doi:10.3390/brainsci10080564 · Cited by 48

WAT is a functional adipocyte?

CHURCH, C. D., Horowitz, M. C., & Rodeheffer, M. S. (2012) · Adipocyte · doi:10.4161/adip.19132 · Cited by 49

IKKε Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity

Weissmann, L., Quaresma, P. G. F., Santos, A. C., de Matos, A. H. B., Pascoal, V., Zanotto, T. M., Castro, G., Guadagnini, D., da Silva, J. M., Velloso, L. A., et al. (2014) · Diabetes · doi:10.2337/db13-1817 · Cited by 44

Appetite, appetite hormone and energy intake responses to two consecutive days of aerobic exercise in healthy young men

Douglas, J. A., King, J. A., McFarlane, E., Baker, L. A., Bradley, C., Crouch, N., Hill, D. W., & Stensel, D. J. (2015) · Appetite · doi:10.1016/j.appet.2015.05.006 · Cited by 45

The Expression of LEP, LEPR, IGF1 and IL10 in Obesity and the Relationship with microRNAs

Collares-Pelizaro, R. V. A., Salgado, W., Tirapelli, D. P. D. C., & dos Santos, J. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093512 · Cited by 44

Locus of Control and Obesity

Neymotin, F., & Nemzer, L. R. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00159 · Cited by 46

Short-Term Effects of Sleeve Gastrectomy and Caloric Restriction on Blood Pressure in Diet-Induced Obese Rats

Rodrı́guez, A., Becerril, S., Valentí, V., Moncada, R., Méndez-Giménez, L., Ramírez, B., Lancha, A., Martín, M., Burrell, M. A., Catalán, V., et al. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0702-4 · Cited by 45

The role of leptin in the sporadic form of Alzheimer's disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin

Folch, J., Patraca, I., Martínez, N., Pedrós, I., Petrov, D., Ettcheto, M., Abad, S., Marin, M., Beas-Zarate, C., & Camins, A. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.05.002 · Cited by 48

The Ventral Premammillary Nucleus Links Metabolic Cues and Reproduction

Donato, J., & Elias, C. F. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00057 · Cited by 46

Do the Interactions between Glucocorticoids and Sex Hormones Regulate the Development of the Metabolic Syndrome?

Alemany, M. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00027 · Cited by 45

Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity

Boughton, C. K., & Murphy, K. G. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12037 · Cited by 45

Hyperleptinemia Exacerbates High‐Fat Diet‐Mediated Atrial Fibrosis and Fibrillation

Fukui, A., Ikebe, Y., Kondo, H., Saito, S., Aoki, K., Fukunaga, N., Shinohara, T., Masaki, T., Teshima, Y., & TAKAHASHI, N. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13200 · Cited by 43

PI3K signaling in the pathogenesis of obesity: The cause and the cure

Beretta, M., Bauer, M. W., & Hirsch, E. (2014) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.11.004 · Cited by 42

Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions

Saito, K., Davis, K., Morgan, D. A., Toth, B. A., Jiang, J., Singh, U., Berglund, E. D., Grobe, J. L., Rahmouni, K., & Cui, H. (2019) · Diabetes · doi:10.2337/db18-1167 · Cited by 42

A review of nutrition and dietary interventions in oncology

Gray, A., Dang, B. N., Moore, T. B., Clemens, R., & Pressman, P. (2020) · SAGE Open Medicine · doi:10.1177/2050312120926877 · Cited by 49

Effects of chronic leptin infusion on subsequent body weight and composition in mice: Can body weight set point be reset?a

Ravussin, Y., LeDuc, C. A., Watanabe, K., Mueller, B. R., Skowronski, A., ROSENBAUM, M. S., & Leibel, R. L. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.02.003 · Cited by 37

Melanocortin-3 Receptors and Metabolic Homeostasis

Begriche, K., Clemence, G., McDonald, P. H., & Butler, A. A. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386933-3.00004-2 · Cited by 42

Drug targeting of leptin resistance

Santoro, A. N., Raso, G. M., & Meli, R. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.05.012 · Cited by 41

MECHANISMS IN ENDOCRINOLOGY: Hypothalamic inflammation and nutrition

ARAUJO, E. P. D., Moraes, J. C., Cintra, D. E., & Velloso, L. A. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-1207 · Cited by 39

Acutely Decreased Thermoregulatory Energy Expenditure or Decreased Activity Energy Expenditure Both Acutely Reduce Food Intake in Mice

Kaiyala, K. J., Morton, G. J., Thaler, J. P., Meek, T. H., Tylee, T. S., Ogimoto, K., & Wisse, B. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041473 · Cited by 37

Leptin and the central control of feeding behavior

Pénicaud, L., Meillon, S., & Brondel, L. (2012) · Biochimie · doi:10.1016/j.biochi.2012.04.013 · Cited by 49

Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults

Muneyuki, T., Nakajima, K., Aoki, A., Yoshida, M., Fuchigami, H., Munakata, H., Ishikawa, S., Sugawara, H., Kawakami, M., Momomura, S., et al. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-80 · Cited by 40

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

Lim, M. A., Bence, K. K., Sandesara, I., Andreux, P. A., Auwerx, J. H., Ishibashi, J., Seale, P., & Kalb, R. G. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu214 · Cited by 37

Glut4 expression defines an insulin-sensitive hypothalamic neuronal population

Ren, H., Yan, S., Zhang, B., Lu, T. Y., Arancio, O., & Accili, D. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.04.006 · Cited by 41

Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity

Page‐Wilson, G., Meece, K., White, A. E., Rosenbaum, M. S., Leibel, R. L., Smiley, R. M., & Wardlaw, S. L. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00206.2015 · Cited by 36

Obesity, Hypertension, and Bariatric Surgery

Samson, R., Ayinapudi, K., Jemtel, T. H. L., & Oparil, S. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01049-x · Cited by 38

Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors

Thompson, H. J., SEDLACEK, S. M., Wolfe, P., Paul, D., Gilchrist, S. C., Playdon, M. C., McGinley, J. N., & Matthews, S. B. (2015) · Nutrients · doi:10.3390/nu7075156 · Cited by 35

Melatonin in the Regulation of Liver Steatosis following Prenatal Glucocorticoid Exposure

Tiao, M., Huang, L., Chen, C., Sheen, J., Tain, Y., Chen, C., Kuo, H., Huang, Y., Tang, K.-S., Chu, E.-W., et al. (2014) · BioMed Research International · doi:10.1155/2014/942172 · Cited by 35

Children's psychosocial stress and emotional eating: A role for leptin?

Michels, N., Sioen, I., Ruige, J. B., & Henauw, S. D. (2016) · International Journal of Eating Disorders · doi:10.1002/eat.22593 · Cited by 34

Gastric Leptin and Tumorigenesis: Beyond Obesity

Inagaki‐Ohara, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112622 · Cited by 34

Normal Leptin Expression, Lower Adipogenic Ability, Decreased Leptin Receptor and Hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis

Liang, G., Gao, W., Liang, A., Ye, W., Peng, Y., Zhang, L., Sharma, S., Su, P., & Huang, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036648 · Cited by 34

Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism

Hwang, E., Portillo, B., Grose, K. C., Fujikawa, T., & Williams, K. W. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101745 · Cited by 36

Recent advances in the pathophysiology and pharmacological treatment of obesity

Chugh, P. K., & Sharma, S. (2012) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2012.01347.x · Cited by 33

Systemic leptin dose-dependently increases STAT3 phosphorylation within hypothalamic and hindbrain nuclei

Maniscalco, J. W., & Rinaman, L. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00017.2014 · Cited by 34

Postnatal Leptin Promotes Organ Maturation and Development in IUGR Piglets

Attig, L., Brisard, D., Larcher, T., Mickiewicz, M., Guilloteau, P., Boukthir, S., Niamba, C.-N., Gertler, A., Djiane, J., Monniaux, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064616 · Cited by 32

Relationship Between Body Mass Index, ApoE4 Status, and PET-Based Amyloid and Neurodegeneration Markers in Amyloid-Positive Subjects with Normal Cognition or Mild Cognitive Impairment

Blautzik, J., Initiative, A. D. N., Kotz, S., Brendel, M., Sauerbeck, J., Vettermann, F. J., Winter, Y., Bartenstein, P., Ishii, K., & Rominger, A. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170064 · Cited by 32

Translating Mechanism-Based Strategies to Break the Obesity−Cancer Link: A Narrative Review

Smith, L. A., O’Flanagan, C. H., Bowers, L. W., Allott, E. H., & Hursting, S. D. (2017) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2017.08.112 · Cited by 33

Circadian rhythms: a possible new player in non-alcoholic fatty liver disease pathophysiology

Gnocchi, D., Custodero, C., Sabbà, C., & Mazzocca, A. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01780-2 · Cited by 33

Central visfatin potentiates glucose-stimulated insulin secretion and β-cell mass without increasing serum visfatin levels in diabetic rats

Kim, D. S., Kang, S., Moon, N. R., & Park, S. (2013) · Cytokine · doi:10.1016/j.cyto.2013.11.008 · Cited by 30

BMP Receptor 1A Regulates Development of Hypothalamic Circuits Critical for Feeding Behavior

Peng, C., Mukhopadhyay, A., Jarrett, J. C., Yoshikawa, K., & Kessler, J. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2484-12.2012 · Cited by 34

The regulation of circulating ghrelin — with recent updates from cell-based assays [Review]

Iwakura, H., Kangawa, K., & Nakao, K. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej14-0419 · Cited by 33

The gut hormone secretin triggers a gut–brown fat–brain axis in the control of food intake

Schnabl, K., Li, Y., & Klingenspor, M. (2020) · Experimental Physiology · doi:10.1113/ep087878 · Cited by 31

Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lepob/ob Mice

Bolze, F., Morath, V., Bast‐Habersbrunner, A., Rink, N., Schlapschy, M., Mocek, S., Skerra, A., & Klingenspor, M. (2015) · Endocrinology · doi:10.1210/en.2015-1519 · Cited by 31

Maternal protein restriction during pregnancy and lactation alters central leptin signalling, increases food intake, and decreases bone mass in 1 year old rat offspring

Qasem, R. J., Li, J., Tang, H. M., Pontiggia, L., & D’mello, A. P. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12545 · Cited by 29

Infection and Immunometabolism in the Central Nervous System: A Possible Mechanistic Link Between Metabolic Imbalance and Dementia

Shinjyo, N., & Kita, K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.765217 · Cited by 29

Adipokines in Childhood Obesity

Martos‐Moreno, G. Á., Barrios, V., Chowen, J. A., & Argente, J. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-407766-9.00006-7 · Cited by 31

Altered metabolic homeostasis is associated with appetite regulation during and following 48-h of severe energy deprivation in adults

Karl, J. P., Smith, T. J., Wilson, M. A., Bukhari, A. S., Pasiakos, S. M., McClung, H. L., McClung, J. P., & Lieberman, H. R. (2015) · Metabolism · doi:10.1016/j.metabol.2015.11.001 · Cited by 30

Brain STAT5 signaling and behavioral control

Furigo, I. C., Ramos-Lobo, A. M., Frazão, R., & Donato, J. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.04.019 · Cited by 29

Curcuminoids Lower Plasma Leptin Concentrations: A Meta‐analysis

Atkin, S. L., Katsiki, N., Derosa, G., Maffioli, P., & Sahebkar, A. (2017) · Phytotherapy Research · doi:10.1002/ptr.5905 · Cited by 29

Leptin and Aldosterone

Faulkner, J., & de Chantemèle, E. J. B. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.09.003 · Cited by 30

Early weaning is associated with higher neuropeptide Y (NPY) and lower cocaine- and amphetamine-regulated transcript (CART) expressions in the paraventricular nucleus (PVN) in adulthood

Younes-Rapozo, V., de Moura, E. G., Lima, N. D. S., Barradas, P. C., Manhães, A. C., OLIVEIRA, E. B. D., & Lisboa, P. C. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000487 · Cited by 29

Knockdown of neuropeptide Y in the dorsomedial hypothalamus reverses high-fat diet-induced obesity and impaired glucose tolerance in rats

Kim, Y. J., & Bi, S. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00174.2015 · Cited by 28

Sweet taste receptor in the hypothalamus: a potential new player in glucose sensing in the hypothalamus

Kohno, D. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0535-y · Cited by 31

The Impact ofLEPG-2548A andLEPRGln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a Mexican Mestizo Population

Chavarría-Ávila, E., Mercado, M. V.-D., Gómez-Bañuelos, E., Ruíz-Quezada, S. L., Castro-Albarrán, J., Sánchez-López, L., Martín-Márquez, B. T., & Navarro-Hernández, R. E. (2015) · BioMed Research International · doi:10.1155/2015/539408 · Cited by 27

TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons

Xie, D., Stutz, B., Li, F., Chen, F., Lv, H., Šestan-Peša, M., Catarino, J. D. S., Gu, J., Zhao, H., Stoddard, C. E., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci162365 · Cited by 27

Blunted Refeeding Response and Increased Locomotor Activity in Mice Lacking FoxO1 in Synapsin-Cre–Expressing Neurons

Ren, H., Plum‐Mörschel, L., Juárez, R. G., Lu, T. Y., Kim-Muller, J. Y., Heinrich, G., Wardlaw, S. L., Silver, R., & Accili, D. (2013) · Diabetes · doi:10.2337/db13-0597 · Cited by 25

Actividad física, ejercicio y deporte en la lucha contra la obesidad infantil y juvenil

y Salud, E. R. E. D. I. E. E. F., Vicente‐Rodríguez, G., Benito, P. J., Casajús, J. A., Ara, I., Aznar, S., Castillo, M. J., Dorado, C., González‐Agüero, A., González‐Gallego, J., et al. (2016) · Nutrición Hospitalaria · doi:10.20960/nh.828 · Cited by 37

Nutritional support for low birth weight infants: insights from animal studies

Li, N., Wang, W., Wu, G., & Wang, J. (2017) · British Journal Of Nutrition · doi:10.1017/s000711451700126x · Cited by 25

Leptin Is Required for Glucose Homeostasis after Roux-en-Y Gastric Bypass in Mice

Mokadem, M., Zechner, J. F., Uchida, A., & Aguirre, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139960 · Cited by 25

Significant Weight Loss and Rapid Resolution of Diabetes and Dyslipidemia During Short-Term Follow-Up After Laparoscopic Sleeve Gastrectomy

Perathoner, A., Weißenbacher, A., Sucher, R., Laimer, E., Pratschke, J., & Mittermair, R. P. (2013) · Obesity Surgery · doi:10.1007/s11695-013-1038-4 · Cited by 26

Age‐related changes of leptin and leptin receptor variants in healthy elderly and long‐lived adults

Roszkowska-Gancarz, M., Jonas, M. I., Owczarz, M., Kuryłowicz, A., Połosak, J., Franek, E., Ślusarczyk, P., Mossakowska, M., & Puzianowska‐Kuźnicka, M. (2014) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12267 · Cited by 26

Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia

Hambly, C., Duncan, J. S., Archer, Z. A., Moar, K. M., Mercer, J. G., & Speakman, J. R. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007781 · Cited by 25

Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7

Lanfray, D., & Richard, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00328 · Cited by 25

Neuroanatomical Characterisation of the Expression of the Lipodystrophy and Motor-Neuropathy Gene Bscl2 in Adult Mouse Brain

Garfield, A. S., Chan, W. S., Dennis, R. J., Ito, D., Heisler, L. K., & Rochford, J. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045790 · Cited by 24

Living without insulin: the role of leptin signaling in the hypothalamus

Fujikawa, T., & Coppari, R. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00108 · Cited by 24

Mechanistic Targets and Phytochemical Strategies for Breaking the Obesity-Cancer Link

Ford, N. A., Lashinger, L., Allott, E., & Hursting, S. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00209 · Cited by 21

Subfornical organ neurons integrate cardiovascular and metabolic signals

Cancelliere, N. M., & Ferguson, A. V. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00423.2016 · Cited by 24

Central Administration of 1‐Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High‐Fat Diet‐Induced Obesity

Kim, J., Yun, E., Quan, F., Park, S.-W., & Goo, T. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/3607089 · Cited by 24

Inflammatory and Metabolic Biomarker Assessment in a Randomized Presurgical Trial of Curcumin and Anthocyanin Supplements in Patients with Colorectal Adenomas

Macis, D., Briata, I. M., D’Ecclesiis, O., Johansson, H. A., Aristarco, V., Webber, T. B., Oppezzi, M., Gandini, S., Bonanni, B., & DeCensi, A. (2023) · Nutrients · doi:10.3390/nu15183894 · Cited by 23

AMPK regulates KATP channel trafficking via PTEN inhibition in leptin-treated pancreatic β-cells

Park, S.-H., Ho, W., & Jeon, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.09.099 · Cited by 23

Maternal–fetal metabolic gene–gene interactions and risk of neural tube defects

Lupo, P. J., Mitchell, L. E., Canfield, M. A., Shaw, G. M., Olshan, A. F., Finnell, R. H., & Zhu, H. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.11.004 · Cited by 23

Deconvoluting the Obesity and Breast Cancer Link: Secretome, Soil and Seed Interactions

Ford, N. A., Devlin, K. L., Lashinger, L. M., & Hursting, S. D. (2013) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-013-9301-9 · Cited by 22

Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention

Yao, Y., Jia, X., & Li, B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1044923 · Cited by 25

Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction

Gatford, K. L., Kaur, G., Falcão‐Tebas, F., Wadley, G. D., Wlodek, M. E., Laker, R. C., Ebeling, P. R., & McConell, G. K. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00456.2013 · Cited by 22

The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer

Gunter, J. H., Lubik, A. A., McKenzie, I., Pollak, M., & Nelson, C. C. (2012) · Advances in Urology · doi:10.1155/2012/248607 · Cited by 23

Continuous 24-Hour Leptin, Proopiomelanocortin, and Amino Acid Measurements in Human Cerebrospinal Fluid: Correlations With Plasma Leptin, Soluble Leptin Receptor, and Amino Acid Levels

Wardlaw, S. L., Burant, C., Klein, S., Meece, K., White, A. E., Kasten, T. P., Lucey, B. P., & Bateman, R. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4087 · Cited by 21

Independent association between low serum amylase and non-alcoholic fatty liver disease in asymptomatic adults: a cross-sectional observational study

Nakajima, K., Oshida, H., Muneyuki, T., Saito, M., Hori, Y., Fuchigami, H., Kakei, M., & Munakata, H. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002235 · Cited by 22

Mouse Models of Lipodystrophy and Their Significance in Understanding Fat Regulation

Rochford, J. J. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-397920-9.00005-6 · Cited by 23

Obesity and Breast Cancer: A Complex Relationship

Gershuni, V. M., Ahima, R. S., & Tchou, J. C. (2016) · Current Surgery Reports · doi:10.1007/s40137-016-0134-5 · Cited by 23

Central Neuronal Control of Bone Remodeling

Ochi, H., Baldock, P. A. J., & Takeda, S. (2018) · Wiley eBooks · doi:10.1002/9781119266594.ch131 · Cited by 22

Rapid development of systemic insulin resistance with overeating is not accompanied by robust changes in skeletal muscle glucose and lipid metabolism

Cornford, A. S., Hinko, A., Nelson, R. K., Barkan, A. L., & Horowitz, J. F. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0266 · Cited by 21

Potential Role of Leptin Signaling in DMBA induced Mammary Tumors by Non-Responsive C57BL/6J Mice Fed a High-Fat Diet

Gillespie, C. (2012) · Journal of Carcinogenesis & Mutagenesis · doi:10.4172/2157-2518.1000132 · Cited by 20

Central transthyretin acts to decrease food intake and body weight

Zheng, F., Kim, Y. J., Moran, T. H., Li, H., & Bi, S. (2016) · Scientific Reports · doi:10.1038/srep24238 · Cited by 21

Diabetes and Tryptophan Metabolism

Ünlütürk, U., & Erbas, T. A. (2015) · Molecular and integrative toxicology · doi:10.1007/978-3-319-15630-9_7 · Cited by 20

Adipose tissue-derived autotaxin causes cardiomyopathy in obese mice

Xu, Y., Wang, Y., Liu, J., Cao, W., Li, L., Du, H., Zhan, E., Zhang, R., Liu, H., Xu, M., et al. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0242 · Cited by 20

Central Effects of Leptin on Glucose Homeostasis are Modified during Pregnancy in the Rat

Ladyman, S. R., & Grattan, D. R. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12431 · Cited by 20

Loss of Coiled-Coil Domain Containing 80 Negatively Modulates Glucose Homeostasis in Diet-Induced Obese Mice

Tremblay, F., Huard, C., Dow, J., Gareski, T., Will, S., Richard, A.-M. T., Syed, J., Bailey, S. A., Brenneman, K. A., Martinez, R. V. P., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1242 · Cited by 23

Effects of physical exercise on food intake and body weight: Role of dorsomedial hypothalamic signaling

Zhang, N., & Bi, S. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.03.018 · Cited by 19

Postnatal High-Fat Diet Increases Liver Steatosis and Apoptosis Threatened by Prenatal Dexamethasone through the Oxidative Effect

Huang, Y., Chen, C., Tang, K.-S., Sheen, J., Tiao, M., Tain, Y., Chen, C., Chu, E.-W., Li, S.-W., Yu, H., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030369 · Cited by 19

Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain

Morabito, M. V., Ravussin, Y., Mueller, B. R., Skowronski, A. A., Watanabe, K., Foo, K. S., Lee, S. X., Lehmann, A., Hjorth, S., Zeltser, L. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168226 · Cited by 19

Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice

Shimada, T., Shindo, A., Matsuyama, H., Yata, K., Niwa, A., Sasaki, R., Ayaki, T., Maki, T., Wakita, H., & Tomimoto, H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.009 · Cited by 19

Time-specific changes in DNA methyltransferases associated with the leptin promoter during the development of obesity.

Xia, L., Wang, C., Lu, Y., Fan, C., Ding, X., Fu, H., & Qi, K. (2014) · PubMed · doi:10.3305/nh.2014.30.6.7843 · Cited by 18

Liquid fructose supplementation in LDL-R−/− mice fed a western-type diet enhances lipid burden and atherosclerosis despite identical calorie consumption

Hutter, N., Baena, M., Sangüesa, G., Dávalos, A., Latasa, M. J., Escolá‐Gil, J. C., Sánchez, R. M., Roglans, N., Alegret, M., & Escolá‐Gil, J. C. (2015) · IJC Metabolic & Endocrine · doi:10.1016/j.ijcme.2015.10.002 · Cited by 18

Leptin levels in free ranging striped mice (Rhabdomys pumilio) increase when food decreases: the ecological leptin hypothesis

Carsten Schradin, A., Raynaud, J., Arrivé, M., & Blanc, S. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.06.024 · Cited by 18

Comprehensive Biomarker Testing of Glycemia, Insulin Resistance, and Beta Cell Function Has Greater Sensitivity to Detect Diabetes Risk Than Fasting Glucose and HbA1c and Is Associated with Improved Glycemic Control in Clinical Practice

Varvel, S. A., Vörös, S., Thiselton, D. L., Pottala, J. V., Dall, T., Warnick, G. R., McConnell, J. P., Ghaedi, L., Sasinowski, M., & Graham, T. E. (2014) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-014-9577-1 · Cited by 18

Leptin and its receptors: Modulation of the neuroendocrine axis

Houseknecht, K. L. (2002) · Proceedings of the British Society of Animal Science · doi:10.1017/s1752756200008851

The biology of leptin: a review.

Houseknecht, K. L., Baile, C. A., Matteri, R. L., & Spurlock, M. E. (1998) · Journal of Animal Science · doi:10.2527/1998.7651405x · Cited by 777

Leptin as a Metabolic and Energy Homeostatic Hormone in Dairy Animals: A Review

Singh, S. V., Upadhyay, R. C., Kundu, S., Vaidya, M. M., & Singh, A. K. (2012) · Indian Journal of Animal Nutrition · Cited by 2

[The ob gene product (leptin)--a new hormone of adipose tissue].

Robaczyk, M. G., Śmiarowska, M., & Krzyzanowska-Swiniarska, B. (1997) · PubMed · Cited by 6

Application of Leptin in Enhancing Immunity and Maintaining Obesity

Bereda, G. (2023) · Journal of Clinical Case Studies Reviews & Reports · doi:10.47363/jccsr/2023(5)239 · Cited by 1