The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Sixteen years and counting: an update on leptin in energy balance
Open accessAbstract
Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue. Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, endocrine axes, and glucose fluxes. Leptin deficiency in mice and humans causes morbid obesity, diabetes, and various neuroendocrine anomalies, and replacement leads to decreased food intake, normalized glucose homeostasis, and increased energy expenditure. Here, we provide an update on the most current understanding of leptin-sensitive neural pathways in terms of both anatomical organization and physiological roles.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Leptin is satiety promoting hormone produced and secreted primarily by adipose tissue that helps to regulate energy balance by reducing food intake and increasing energy expenditure via activation of hypothalamic circuits.56,57”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [57]
In the citing paper
“Circulating leptin changes rapidly in response to acute caloric intake or restriction, assisting in the control of short-term feeding via mechanisms such as augmentation of the anorectic effects of cholecystokinin, [57][58][59]”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [57]
In the citing paper
“and is thought to be an important mediator of long-term energy balance regulation.57”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
Flagged first, then by citations
Research works printed but not linked: 8
- 10.1210/jc.87.5.2395 · DOI
- 10.1210/en.141.9.3072 · DOI · Paper page
- Flynn, 1998, Am J Physiol., 275, R174
- Kahler, 1998, Am J Physiol., 275, R180
- 10.1210/en.143.1.239 · DOI · Paper page
- Morton, 2005, J Clin Invest., 115, 703, 10.1172/JCI200522081 · DOI
- Rosenbaum, 2008, J Clin Invest., 118, 2583
- 10.1210/en.138.10.4489 · DOI · Paper page
Cited by
Sorted by citations
Items 201–300 of 366
Leptin as an obesity marker in rheumatoid arthritis
Guimarães, M. F. B. D. R., de Andrade, M. V. M., Machado, C. J., Vieira, É. L. M., Pinto, M. R. D. C., Teixeira, A. L., & Kakehasi, A. M. (2018) · Rheumatology International · doi:10.1007/s00296-018-4082-5 · Cited by 18
Central regulation of glucose metabolism in an insulin‐dependent and ‐independent manner
Fujikawa, T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12941 · Cited by 21
Gregorio, P. D., Trana, A. D., Celi, P., Claps, S., & Rando, A. (2014) · Animal Production Science · doi:10.1071/an14101 · Cited by 19
Sleeve Gastrectomy Reduces Blood Pressure in Obese (fa/fa) Zucker Rats
Rodrı́guez, A., Becerril, S., Valentí, V., Ramírez, B., Martín, M., Méndez-Giménez, L., Lancha, A., Calderón, P. D. S., Catalán, V., Burrell, M. A., et al. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0562-3 · Cited by 17
Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78
Thon, M., Hosoi, T., & Ozawa, K. (2016) · Scientific Reports · doi:10.1038/srep34312 · Cited by 15
Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis
Quaresma, P. G. F., Weissmann, L., Zanotto, T. M., Santos, A. C., de Matos, A. H. B., Furigo, I. C., Simabuco, F. M., Donato, J., Bittencourt, J. C., Lopes‐Cendes, Í., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.174 · Cited by 17
Regulation of leptin receptor-expressing neurons in the brainstem by TRPV1
Zsombok, A., Jiang, Y., Gao, H., Anwar, I. J., Rezai-Zadeh, K. P., Enix, C. L., Münzberg, H., & Derbenev, A. V. (2014) · Physiological Reports · doi:10.14814/phy2.12160 · Cited by 16
Li, L., Serre, C. B. D. L., Zhang, N., Yang, L., Li, H., & Bi, S. (2016) · Endocrinology · doi:10.1210/en.2016-1662 · Cited by 15
Gonseth, S., Locatelli, I., Bize, R., Nusslé, S. C., Clair, C., Pralong, F. P., & Cornuz, J. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-911 · Cited by 16
Marcelin, G., Liu, S.-M., Li, X., Schwartz, G. J., & Chua, S. C. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m022467 · Cited by 15
Adipoquinas en el niño sano y con obesidad
Martos‐Moreno, G. Á., Kopchick, J. J., & Argente, J. (2012) · Anales de Pediatría · doi:10.1016/j.anpedi.2012.10.008 · Cited by 17
Schlatzer, C., Schwarz, E. I., & Kohler, M. (2014) · Chronic Respiratory Disease · doi:10.1177/1479972313516882 · Cited by 16
Liu, X. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3838-1 · Cited by 15
Genetic factors and the role of pancreatic amylase in the pathogenesis of type 2 diabetes
Abdulkareem, M. A., Owolabi, B., Saheed, E. S., Aromolaran, R. F., Bashiru, R. M., Jumah, T. A., Chijioke, D. U., Amaechi, O. J., Adeleke, F. C., Charles, O. O., et al. (2024) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-024-00505-6 · Cited by 17
Masdrakis, V. G., Papageorgiou, C., & Markianos, M. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.05.025 · Cited by 14
Tu, X., Liu, M., Tang, J., Zhang, Y., Shi, Y., Yu, L., & Sun, Z. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0365-7 · Cited by 13
The Association between Serum Leptin and Post Stroke Depression: Results from a Cohort Study
Li, Y.-T., Zhao, Y., Zhang, H.-J., & Zhao, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103137 · Cited by 15
PATHOGENETIC MECHANISMS OF LEPTIN RESISTANCE
Chumakova, G. A., Ott, A., Veselovskaya, N. G., Гриценко, О. В., & Shenkova, N. N. (2015) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2015-4-107-110 · Cited by 14
Scott, W. R., Gelegen, Ç., Chandarana, K., Karra, E., Yousseif, A., Amouyal, C., Choudhury, A. I., Andréelli, F., Withers, D. J., & Batterham, R. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059407 · Cited by 14
Influence of Obesity on Neurodegenerative Diseases
Awada, R., Parimisetty, A., & d’Hellencourt, C. L. (2013) · InTech eBooks · doi:10.5772/53671 · Cited by 15
Racial Disparities in Methylation of NRF1, FTO, and LEPR Gene in Childhood Obesity
Patel, P., Selvaraju, V., Babu, J. R., Wang, X., & Geetha, T. (2022) · Genes · doi:10.3390/genes13112030 · Cited by 12
Evaluation of Amylase Activity in Patients with Type 2 Daibetes Mellitus
Ewadh, M. J. (2014) · American Journal of BioScience · doi:10.11648/j.ajbio.20140205.11 · Cited by 12
Zhang, N., Yang, L., Guo, L., & Bi, S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00179 · Cited by 12
Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-expressing Neurons
Ren, H., Vieira‐de‐Abreu, A., Yan, S., Reilly, A. M., Chan, O. T. M., & Accili, D. (2019) · Endocrinology · doi:10.1210/en.2019-00341 · Cited by 12
Nabil, M., Demellawy, M. E., Mahmoud, M. F., & Mahmoud, A. A. A. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173136 · Cited by 12
He, Y., von Deneen, K. M., Li, G., Jing, B., Zhou, Y., Zhang, K., Zhang, Y., & Ren, Y. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-021-00519-3 · Cited by 11
Xu, J., Xu, X., Bi, Z., Shi, L., Cao, J., & Zhao, Z. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.02.010 · Cited by 11
Energy Homeostasis: Paraventricular Nucleus System☆
Timofeeva, E., Caron, A., & Richard, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02753-x · Cited by 11
Anggraeny, O., Dianovita, C., Putri, E. N., Sastrina, M., & Dewi, R. S. (2016) · Indonesian Journal of Human Nutrition · doi:10.21776/ub.ijhn.2016.003.002.6 · Cited by 11
Rimbach, R., Blanc, S., Zahariev, A., Pillay, N., & Carsten Schradin, A. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.12.003 · Cited by 11
Insights into the putative role of leptin in various traversing stages of women: A narrative review
Saranya, G., & Pathy, M. R. (2018) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2018.8722 · Cited by 11
Leptin-dependent neurotoxicity via induction of apoptosis in adult rat neurogenic cells
Segura, S., Efthimiadi, L., Porcher, C., Courtes, S., Coronas, V., Krantic, S. M., & Moyse, E. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00350 · Cited by 12
Breast feeding, obesity, and asthma association: clinical and molecular views
Kian, N., Bagheri, A., Salmanpour, F., Soltani, A., Mohajer, Z., Samieefar, N., Barekatain, B., & Kelishadi, R. (2023) · Clinical and Molecular Allergy · doi:10.1186/s12948-023-00189-0 · Cited by 12
Ahima, R. S., & Flier, J. S. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042324-100259 · Cited by 10
Shi, Q., Wang, J., Shi, Y., Jin, Z. Y., & Li, H. (2013) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12206 · Cited by 28
Effects of a dietary crude fibre concentrate on growth in weaned piglets
Superchi, P., Saleri, R., Borghetti, P., Ferrarini, G., Cavalli, V., Sereni, M., Zavattini, S., & Sabbioni, A. (2017) · animal · doi:10.1017/s175173111700057x · Cited by 9
Obesity, Diabetes and Cancer: A Mechanistic Perspective
Cifarelli, V., & Hursting, S. (2015) · International Journal of Diabetology & Vascular Disease Research · doi:10.19070/2328-353x-si04001 · Cited by 9
Molecular and metabolic mechanisms underlying the obesity-cancer link
O’Flanagan, C. H., Bowers, L. W., Allott, E. H., & Hursting, S. D. (2018) · Research Portal (Queen's University Belfast) · Cited by 9
Kim, B., Lee, S. H., & Koh, J. (2019) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-019-9257-4 · Cited by 8
Tsai, C., Lin, Y., Yu, H., Sheen, J., Lin, I.-C., Lai, Y., Tain, Y., Huang, L., & Tiao, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113565 · Cited by 8
Strategies for Human Adipose Tissue Repair and Regeneration
Monfort, A., & Izeta, A. (2012) · Journal of Cosmetics Dermatological Sciences and Applications · doi:10.4236/jcdsa.2012.222021 · Cited by 7
Taslimi, S., Esteghamati, A., Rashidi, A., Tavakkoli, H. M., Nakhjavani, M., & Kebriaeezadeh, A. (2012) · Peptides · doi:10.1016/j.peptides.2012.12.020 · Cited by 8
Weight Loss: How Does It Fit in With Liposuction?
Davis, W., & Lawrence, N. (2019) · Dermatologic Surgery · doi:10.1097/dss.0000000000002225 · Cited by 7
Ofori, E. K., Adekena, C. N., Boima, V., Asare‐Anane, H., Yorke, E., Nyarko, E. N. Y., Mohammed, B. N., Quansah, E., Jayasinghe, S. U., & Amanquah, S. D. (2023) · Health Science Reports · doi:10.1002/hsr2.1053 · Cited by 7
Stemer, B., Melmer, A., Fuchs, D., Ebenbichler, C. F., Kemmler, G., & Deisenhammer, E. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.068 · Cited by 7
More News About NUCB2/Nesfatin-1: A New Factor in the Hypothalamic Control of Glucose Homeostasis?
Butler, A. A. (2012) · Diabetes · doi:10.2337/db12-0576 · Cited by 7
Valros, A., Pedersen, L. J., Pöytäkangas, M., & Jensen, M. B. (2017) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2017.05.017 · Cited by 7
Nambu, Y., Ohira, K., Morita, M., Yasumoto, H., Kurganov, E., & Miyata, S. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.05.012 · Cited by 7
The Anti-Obesity Potential of Green Tea: The Effect on Leptin and Adiponectin
Essex, K., & Mosawy, S. (2017) · Clinical Immunology Endocrine & Metabolic Drugs · doi:10.2174/2212707004666161228142812 · Cited by 7
Correction: Postnatal Leptin Promotes Organ Maturation and Development in IUGR Piglets
Attig, L., Brisard, D., Larcher, T., Mickiewicz, M., Guilloteau, P., Boukthir, S., Niamba, C.-N., Gertler, A., Djiane, J., Monniaux, D., et al. (2013) · PLoS ONE · doi:10.1371/annotation/14e40c23-6fa2-4892-b843-419eb47e4db4 · Cited by 7
Unamuno, X., Frühbeck, G., & Catalán, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65163-2 · Cited by 7
Circadian systems biology in Metazoa
Lin, L., Huang, H., Juan, H., & for the 2014 Taida Cancer Systems Biology Study Group (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv006 · Cited by 6
Brown adipose tissue thermogenesis precedes food intake in genetically obese Zucker (fa/fa) rats
Kontos, A., de Menezes, R. C. A., Ootsuka, Y., & Blessing, W. W. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.05.021 · Cited by 6
Evaluation of Serum Leptin Levels and Growth in Patients withβ-Thalassaemia Major
Al-Naama, L. M., Hassan, M. K., & Karim, M. M. A. (2016) · Anemia · doi:10.1155/2016/8454286 · Cited by 7
Genetic Factors That Act As An Effect Modifier for Environmental Risk Factors of Obesity
Al-Domi, H. A. (2014) · Cited by 5
Onset of leptin resistance shows temporal differences related to dose or pulsed treatment
Strehler, K. Y. E., Matheny, M. E., Kirichenko, N., Sakarya, Y., Bruce, E. B., Toklu, H. Z., Carter, C. S., Morgan, D., Tümer, N., & Scarpace, P. J. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.026 · Cited by 5
Neuroendocrinology of the Hypothalamus and Pituitary Axes
Tran, T. N., Sosa-Pagan, M., & Uwaifo, G. I. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-030-62187-2_5 · Cited by 5
Weise, C. M., Chen, K., Chen, Y., Devadas, V., Su, Y., & Reiman, E. M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1031189 · Cited by 5
Calorie Restriction and Cancer Prevention: Established and Emerging Mechanisms
Hursting, S. D., Ford, N. A., Dunlap, S. M., Hursting, M. J., & Lashinger, L. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6819-6_14 · Cited by 5
Gut Hormones Restrict Neurodegeneration in Parkinson’s Disease
Bayliss, J. A., Stark, R., Reichenbach, A., & Zane, B. (2011) · InTech eBooks · doi:10.5772/28028 · Cited by 6
Adipokines and central control in adenosine A1 receptor dependent glucose metabolism
Faulhaber‐Walter, R. (2012) · Adipocyte · doi:10.4161/adip.19285 · Cited by 5
A brown fat-enriched adipokine, ASRA, is a leptin receptor antagonist that stimulates appetitePreprint
Huang, L., Liu, P., Du, Y., Bazán, J. F., Pan, D., Chen, Q., Lee, A., Kola, V. S. R., Wolfe, S. A., & Wang, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.12.557454 · Cited by 5
The role of hypothalamus in the pathophysiological process of MASLD and advances in drug discovery
Wei, S., Dong, Y., Wang, Y., Li, G., Zhao, Y., & Zheng, R. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107972 · Cited by 4
Role of Microneedles for Improved Treatment of Obesity: Progress and Challenges
Chilamakuri, S. N., Manasa, N., Thalla, M., Ravichandiran, V., Lee, Y., Cho, S. M., Jung, H., & Natesan, S. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c01115 · Cited by 4
Animal Models for Manipulation of Thermogenesis
Fuller‐Jackson, J., Clarke, I. J., & Henry, B. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00012-7 · Cited by 4
Warrilow, A., Pumpa, K. L., Somerset, S. M., & Naumovski, N. (2023) · Diabetology · doi:10.3390/diabetology4010008 · Cited by 4
Mapping leptin's link to reproduction
Könner, A. C., & Brüning, J. C. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.08.001 · Cited by 4
Metabolic Syndrome as a Risk Factor for Alzheimer Disease
Farooqui, A. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7318-3_8 · Cited by 5
Endocrine Responses to Acute and Chronic Exercise in the Developing Child
Rubin, D., Tufano, J., & McMurray, R. (2020) · Endocrinology of Physical Activity and Sport · doi:10.1007/978-1-62703-314-5_22 · Cited by 2
The between-day reproducibility of fasting, satiety-related analytes, in 8 to 11 year-old boys
Allsop, S., Rumbold, P. L. S., & Green, B. P. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.06.002 · Cited by 4
Leptin, Sonic Hedgehogs, and Neurogenesis- A Primary Cilium’s Taleon
Armato, U., Chakravarthy, B., Chiarini, A., Chioffi, F., Prà, I. D., & Whitfield, J. F. (2012) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000e105 · Cited by 4
Editorial: Molecular Obesity Research: Lessons Learned?
Ahima, R. S. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1140 · Cited by 4
Assessment of Serum Leptin Levels in Pediatric Patients of Beta Thalassemia
Fatah, M. F. A., Shaffi, M. M. E., Eldin, Z. M. E., & Youssef, A. M. M. (2022) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2022.232825 · Cited by 3
López-Acosta, O., Cristóbal-García, M., Cardoso-Saldaña, G. C., Carvajal, K., & El‐Hafidi, M. (2023) · Antioxidants · doi:10.3390/antiox12030728 · Cited by 3
Arsenic and adipose tissue: an unexplored pathway for toxicity and metabolic dysfunction
Khandayataray, P., Samal, D., & Murthy, M. K. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-31683-2 · Cited by 3
Rodrı́guez, A., Catalán, V., & Frühbeck, G. (2013) · Elsevier eBooks · doi:10.1533/9780857098719.2.75 · Cited by 3
Obesity, adipose tissue types and adipocytokines
Shareef, N. A., & Abduljalal, M. H. (2020) · Annals of the College of Medicine Mosul/Annals of the College of Medecine · doi:10.33899/mmed.2020.128256.1045 · Cited by 3
Mechanisms Linking Obesity and Leukemia Prognosis
Mittelman, S. D., & Butturini, A. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-2403-1_3 · Cited by 3
A case for new therapy for diabetes, is it leptin?
Kalra, S. P. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105566 · Cited by 3
Pancréatites aiguës et grossesse : cas cliniques et revue de la littérature
Charlet, P., Lambert, V., & Carles, G. (2014) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2014.08.002 · Cited by 3
Las adipocinas como mediadoras en la inflamación y el sistema inmune
Nava-Santana, C. A., Guerra-Soto, A. D. J., Mendoza-Vázquez, G., Flores-Chávez, A., & Nava, A. (2013) · Cited by 3
Sayán, O. C., & Woolcott, O. O. (2017) · Anales de la Facultad de Medicina · doi:10.15381/anales.v78i2.13215 · Cited by 3
Trends in obesity and type 2 diabetes : ethnic aspects and links to adipokines
Lilja, M. (2011) · DiVA at Umeå University (Umeå University) · Cited by 3
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou, M., Dereki, I., Sgourou, A., & Lagoumintzis, G. (2026) · Future Science OA · doi:10.1080/20565623.2026.2641015 · Cited by 5
Evolutionary Aspects of Obesity, Insulin Resistance, and Cardiovascular Risk
Spreadbury, I., & Samis, A. J. W. (2013) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-013-0293-1 · Cited by 2
Leptin/Melanocortin Pathway in Cholelithiasis Patients: A Diagnostic Perspective
Ağbektaş, T., Güçlü, G. B., Taş, A., Özmen, E., Topçu, Ö., Aydın, S., & Siliğ, Y. (2024) · Protein and Peptide Letters · doi:10.2174/0109298665343979241025114114 · Cited by 2
Isoleucine, PPAR and Uncoupling Proteins
Masaki, T. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1923-9_4 · Cited by 2
The role of the central nervous system in glucose homeostasis
Muntean, C., Moța, M., Popa, S. G., & Mitrea, A. (2012) · Romanian Journal of Diabetes Nutrition and Metabolic Diseases · doi:10.2478/v10255-012-0025-1 · Cited by 2
Pancreatitis In Pregnancy: What has Remained The Same and What has Changed?
Machado, N. O. (2015) · Pancreatic Disorders and Therapy · doi:10.4172/2165-7092.1000e140 · Cited by 2
Hypothalamic Control of Appetite and Energy Metabolism
Reichenbach, A., Stark, R., & Andrews, Z. B. (2013) · Cited by 2
Animal Models for Manipulation of Thermogenesis
Henry, B. A., & Clarke, I. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415894-8.00014-2 · Cited by 2
Perkembangan Terkini Investigasi Gen Leptin pada Ayam: Ulasan
Mahardhika, I. W. S., & Daryono, B. S. (2021) · Buletin Veteriner Udayana · doi:10.24843/bulvet.2021.v13.i01.p13 · Cited by 2
Role of adipokines in regulation of colonic motor activity in overweight and obese individuals
Fedorin, M. M., Livzan, M. A., & Gaus, O. V. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-35-48-51 · Cited by 2
Li, W., Qu, J., Li, W., Cao, Y., Xu, R., & Xu, L. (2026) · Nanoscale · doi:10.1039/d5nr05009j · Cited by 2
The Central Control of Bone Mass
Takeda, S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-415784-2.00003-8 · Cited by 1
Morales, J. S., Lucía, A., & Pareja-Galeano, H. (2016) · ABACUS. Repositorio de Producción Científica (Universidad Europea) · Cited by 1
Obesity Brain Gut Adipocyte Interaction
Iqbal, A., & Rehman, A. U. (2019) · StatPearls · Cited by 1
Hypothalamic Obesity and Wasting Syndromes
Uwaifo, G. I. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-030-62187-2_12 · Cited by 1
Some Biochemical Parameters Secreted from the Adipose Tissues
Abduljalal, M. H., AL-Talib, N. A., & Mohialdeen, S. K. (2023) · Mağallaẗ al-tarbiyaẗ wa-al-ʻilm · doi:10.33899/edusj.2023.136498.1361 · Cited by 1
Carsten Schradin, A., Pillay, N., & Rimbach, R. (2025) · Journal of Zoology · doi:10.1111/jzo.70084 · Cited by 1
Metadata
- Authors
- Gautron, L., & Elmquist, J. K.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Elmquist, Joel K.
- ORCID
- Elmquist, Joel K.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-06-01
- Volume
- 121
- Issue
- 6
- Pages
- 2087-2093
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3104762
- OpenAlex
- W2068769790
- Cited by
- 367
- References
- 128
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 4 · 2023: 11 · 2022: 8 · 2021: 10 · 2020: 18 · 2019: 17 · 2018: 17 · 2017: 26 · 2016: 28 · 2015: 33 · 2014: 52 · 2013: 52 · 2012: 66
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, ob gene, energy balance, white adipose tissue, leptin deficiency, morbid obesity, diabetes mellitus, glucose homeostasis, dietary intake, energy expenditure, neuroendocrine regulation, metabolic rate
- MeSH terms
- Adaptation, Physiological, Animals, Body Weight, Brain, Disease Models, Animal, Energy Metabolism, Feeding Behavior, Glucose, Humans, Hypothalamus, Mice, Obese, Models, Biological, Pro-Opiomelanocortin, Starvation, Sympathetic Nervous System, Leptin, Receptor, Melanocortin, Type 4, Overnutrition, Mice, Adipose Tissue, White, Receptors, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review