Cited by 2,319Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismImmune cells in cancer

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Inflammatory links between obesity and metabolic disease

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Lumeng, Carey N., Saltiel, Alan R.·2011·Journal of Clinical Investigation

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Abstract

The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Review, we highlight the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation. We also emphasize how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses.

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Retracted
Obesity is associated with macrophage accumulation in adipose tissue
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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
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Self-citation
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Authors: Lumeng, C. N., & Saltiel, A. R.
Affiliations: University of Michigan (US)
Corresponding author: Lumeng, Carey N.
ORCID: Lumeng, Carey N.
Saltiel, Alan R.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2011-06-01
Volume: 121
Issue: 6
Pages: 2111-2117
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci57132
PMC: PMC3104776
OpenAlex: W2165604976
Cited by: 2,319
References: 124
Citations by year: 2026: 109 · 2025: 111 · 2024: 105 · 2023: 111 · 2022: 154 · 2021: 187 · 2020: 173 · 2019: 177 · 2018: 186 · 2017: 211 · 2016: 176 · 2015: 163 · 2014: 165 · 2013: 155 · 2012: 108
FWCI: 16.91
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090262, R01DK060591, K08DK078851)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: obesity, inflammation, metabolic disorders, obesity-related comorbidities, immune regulation, metabolic tissues
MeSH terms: Acute-Phase Proteins, Adipose Tissue, Animals, Anti-Inflammatory Agents, Energy Metabolism, Fibrosis, Humans, Hypothalamus, Inflammation, Leukocytes, Liver, Macrophages, Metabolic Diseases, Models, Biological, Obesity, Organ Specificity, Cytokines, Disease Progression, Muscle, Skeletal, Peroxisome Proliferator-Activated Receptors

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