Cited by 2,319Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismImmune cells in cancer

The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.

Inflammatory links between obesity and metabolic disease

Open access

Lumeng, Carey N., Saltiel, Alan R.·2011·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Review, we highlight the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation. We also emphasize how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci57132

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition
Ropelle, E. R., Flores, M. B. S., Cintra, D. E., Rocha, G. Z., Pauli, J. R., Morari, J., de Souza, C. T., Moraes, J. C., Prada, P. O., Guadagnini, D., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000465 · Cited by 333
Retracted
Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function
Calegari, V. C., Torsoni, A. S., Vanzela, E. C., ARAUJO, E. P. D., Morari, J., Zoppi, C. C., Sbragia, L., Boschero, A. C., & Velloso, L. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173021 · Cited by 77
Retracted
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Self-citation
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543

Show all 124 references

Sorted by citations

Items 801–900 of 1,009

Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity
Chen, Z., Shen, H., Sun, C., Yin, L., Tang, F., Zheng, P., Liu, Y., Brink, R. A., & Rui, L. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00470.2014 · Cited by 39
Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity
Qian, Y., Zhang, Y., Zhong, P., Peng, K., Xu, Z., Chen, X., Lu, K., Chen, G., Li, X., & Liang, G. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12832 · Cited by 39
MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways
Moore, C. E., Pickford, J., Cagampang, F. R. A., Stead, R., Tian, S., Zhao, X., Tang, X., Byrne, C. D., & Proud, C. G. (2016) · Scientific Reports · doi:10.1038/srep23476 · Cited by 39
Hypothalamic and inflammatory basis of hypertension
Khor, S., & Cai, D. (2017) · Clinical Science · doi:10.1042/cs20160001 · Cited by 40
Rainbow trout (Oncorhynchus mykiss) adipose tissue undergoes major changes in immune gene expression following bacterial infection or stimulation with pro-inflammatory molecules
Veenstra, K. A., Wangkahart, E., Wang, T., Tubbs, L., Arous, J. B., & Secombes, C. J. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.11.001 · Cited by 39
High-fat diet triggers obesity-related early infiltration of macrophages into adipose tissue and transient reduction of blood monocyte count
Liu, Y., Lu, X., Li, X., Du, P., & Qin, G. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.11.002 · Cited by 39
Relation of Reduced Preclinical Left Ventricular Diastolic Function and Cardiac Remodeling in Overweight Youth to Insulin Resistance and Inflammation
Dahiya, R., Shultz, S. P., Dahiya, A., Fu, J., Flatley, C. J., Duncan, D., Cardinal, J. W., Kostner, K., Byrne, N. M., Hills, A. P., et al. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.02.005 · Cited by 38
Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice
Chartoumpekis, D. V., Palliyaguru, D. L., Wakabayashi, N., Khoo, N. K. H., Schoiswohl, G., O'Doherty, R. M., & Kensler, T. W. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.04.004 · Cited by 38
Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin.
Cardinali, D. P., Pagano, E. S., Bernasconi, P. A. S., Reynoso, R., & Scacchi, P. A. (2011) · PubMed · Cited by 38
The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome
Traba, J., & Sack, M. N. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2431-7 · Cited by 37
M2-specific reduction of CD1d switches NKT cell-mediated immune responses and triggers metaflammation in adipose tissue
Zhang, H., Xue, R., Zhu, S., Fu, S., Chen, Z., Zhou, R., Zhigang, T., & Bai, L. (2017) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.11 · Cited by 38
Reduced Risk of Acute Exacerbation of COPD After Bariatric Surgery
Goto, T., Tsugawa, Y., Faridi, M. K., Camargo, C. A., & Hasegawa, K. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.07.003 · Cited by 38
Visceral adipose tissue macrophage-targeted TACE silencing to treat obesity-induced type 2 diabetes
Yong, S., Song, Y., & Kim, Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.023 · Cited by 38
Contributions of innate type 2 inflammation to adipose function
Bolus, W. R., & Hasty, A. H. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r085993 · Cited by 42
CD4+ T cells in obesity and obesity-associated diseases
Zhao, Y., Lin, L., Li, J., Xiao, Z., Chen, B., Wan, L., Li, M., Wu, X., Cho, C. H., & Shen, J. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.08.013 · Cited by 38
GM-CSF Administration Improves Defects in Innate Immunity and Sepsis Survival in Obese Diabetic Mice
Frydrych, L. M., Bian, G., Fattahi, F., Morris, S. B., O’Rourke, R. W., Lumeng, C. N.-K., Kunkel, S. L., Ward, P. A., & Delano, M. J. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800713 · Cited by 41
Self-citation
Fibroblast Growth Factor 21 Exerts its Anti‐inflammatory Effects on Multiple Cell Types of Adipose Tissue in Obesity
Wang, N., Zhao, T., Li, S., Sun, X., Li, Z., Li, Y., Li, D., & Wang, W. (2019) · Obesity · doi:10.1002/oby.22376 · Cited by 38
Impact of parental over- and underweight on the health of offspring
Bellver, J., & Mariani, G. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.02.128 · Cited by 38
Autonomic regulation of T-lymphocytes: Implications in cardiovascular disease
Elkhatib, S. K., & Case, A. J. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104293 · Cited by 37
Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors
Lai, B., Wang, J., Fagenson, A. M., Sun, Y., Saredy, J., Lu, Y., Nanayakkara, G., Yang, W. Y., Yu, D., Shao, Y., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02612 · Cited by 37
POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?
Quarta, C., Fioramonti, X., & Cota, D. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.031 · Cited by 41
Safety and Efficacy of Bariatric Surgery in Inflammatory Bowel Disease Patients: a Systematic Review and Meta-analysis
Garg, R., Mohan, B. P., Ponnada, S., Singh, A., Aminian, A., Regueiro, M. D., & Click, B. H. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04729-4 · Cited by 38
Drug Repurposing: An Emerging Tool for Drug Reuse, Recycling and Discovery
Roy, S., Dhaneshwar, S. S., & Bhasin, B. (2021) · Current Drug Research Reviews · doi:10.2174/2589977513666210211163711 · Cited by 38
Tissue Engineering Chamber Promotes Adipose Tissue Regeneration in Adipose Tissue Engineering Models Through Induced Aseptic Inflammation
Peng, Z., Dong, Z., Chang, Q., Zhan, W., Zeng, Z., Zhang, S., & Lu, F. (2014) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0431 · Cited by 38
Role of Peripheral Blood Mononuclear Cells in the Predisposition of Obese Individuals to Inflammation and Infection
Dicker, D., Salook, M. A., Marcoviciu, D., Djaldetti, M., & Bessler, H. (2013) · Obesity Facts · doi:10.1159/000350775 · Cited by 38
Cooperation between HMGA1 and HIF-1 Contributes to Hypoxia-Induced VEGF and Visfatin Gene Expression in 3T3-L1 Adipocytes
Messineo, S., Laria, A. E., Arcidiacono, B., CHIEFARI, E. D., Luque, R. M., FOTI, D. P., & Brunetti, A. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00073 · Cited by 39
Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals
López-Vicario, C., Rius, B., Alcaraz-Quiles, J., González-Périz, A., Martínez-Puchol, A. I., Casulleras, M., Duran-Güell, M., Ibarzabal, A., Corcelles, R., Laguna-Fernández, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15951-z · Cited by 37
SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization
Lee, J., Lee, S. H., Lee, E., Cho, J., Song, D., Lee, Y. J., Kwon, T. K., Oh, B., Cho, K. W., Osborne, T. F., et al. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.05.013 · Cited by 37
A Health Threat to Bystanders Living in the Homes of Smokers: How Smoke Toxins Deposited on Surfaces Can Cause Insulin Resistance
Adhami, N., Starck, S. R., Flores, C., & Martins‐Green, M. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149510 · Cited by 38
Distinguishing features of body mass index and psoriasis in men and women in Japan: A hospital‐based case–control study
Naito, R., & Imafuku, S. (2016) · The Journal of Dermatology · doi:10.1111/1346-8138.13439 · Cited by 37
Diabetes and pre-diabetes in adult Nigerians: Prevalence, and correlations of blood glucose concentrations with measures of obesity
Chukwunonso, E. C. C. E., Nnamdi, K. U., & Stella, O. (2015) · African Journal of Biochemistry Research · doi:10.5897/ajbr2015.0817 · Cited by 39
Intestinal Metagenomes and Metabolomes in Healthy Young Males: Inactivity and Hypoxia Generated Negative Physiological Symptoms Precede Microbial Dysbiosis
Šket, R., Debevec, T., Kublik, S., Schloter, M., Schöler, A., Murovec, B., Vogel‐Mikuš, K., Makuc, D., Pečnik, K., Plavec, J., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00198 · Cited by 37
Cardiometabolic Risk Factors among Healthcare Workers: A Cross-Sectional Study at the Sefwi-Wiawso Municipal Hospital, Ghana
Osei-Yeboah, J., Kye-Amoah, K. K., Owiredu, W. K. B. A., Lokpo, S. Y., Esson, J., Johnson, B. B., Amoah, P., & Aduko, R. A. (2018) · BioMed Research International · doi:10.1155/2018/8904548 · Cited by 37
Anaphylatoxin C5a induces inflammation and reduces insulin sensitivity by activating TLR4/NF-kB/PI3K signaling pathway in 3T3-L1 adipocytes
Zhang, X., Liu, Y., He, T., Yang, T., Wu, J., Cianflone, K., & Lü, H. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.057 · Cited by 37
Modelling Sporadic Alzheimer’s Disease Using Induced Pluripotent Stem Cells
Rowland, H. A., Hooper, N. M., & Kellett, K. A. B. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2663-z · Cited by 38
Homeostatic and pathogenic roles of the GM3 ganglioside
Inokuchi, J., Kanoh, H., Inamori, K., Nagafuku, M., Nitta, T., & Fukase, K. (2021) · FEBS Journal · doi:10.1111/febs.16076 · Cited by 38
Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice
Mulder, P., Morrison, M. C., Verschuren, L., Liang, W., van Bockel, J. H., Kooistra, T., Wielinga, P. Y., & Kleemann, R. (2016) · Scientific Reports · doi:10.1038/srep31542 · Cited by 39
Monocyte Trafficking and Polarization Contribute to Sex Differences in Meta-Inflammation
Varghese, M., Clemente, J., Lerner, A., Abrishami, S., Islam, M., Subbaiah, P., & Singer, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.826320 · Cited by 37
Gut microbiota in obesity and related complications: Unveiling the complex interplay
Islam, M. M., Islam, M. M., Rahman, M. A., Ripon, M. A. R., & Hossain, M. S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122211 · Cited by 37
Metabolic dysfunction and alcohol-associated liver disease (MetALD)
Gao, B., Arab, J. P., Liangpunsakul, S., Ding, W., Szabó, G., Mehal, W. Z., Wang, H., He, Y., Stärkel, P., Llorente, C., et al. (2025) · eGastroenterology · doi:10.1136/egastro-2025-100319 · Cited by 43
Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity
Kawasaki, K., Abe, M., Tada, F., Tokumoto, Y., Chen, S., Miyake, T., Furukawa, S., Matsuura, B., Hiasa, Y., & Onji, M. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2012.176 · Cited by 36
Diabetes and Its Link with Cancer: Providing the Fuel and Spark to Launch an Aggressive Growth Regime
Joshi, S., Liu, M., & Turner, N. A. (2015) · BioMed Research International · doi:10.1155/2015/390863 · Cited by 36
Possible association of hepatitis C virus infection with late‐onset psoriasis: A hospital‐based observational study
Imafuku, S., Naito, R., & NAKAYAMA, J. (2013) · The Journal of Dermatology · doi:10.1111/1346-8138.12240 · Cited by 36
Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions
Akakabe, Y., Koide, M., Kitamura, Y., Matsuo, K., Ueyama, T., Matoba, S., Yamada, H., Miyata, K., Oike, Y., & Ikeda, K. (2013) · Nature Communications · doi:10.1038/ncomms3389 · Cited by 36
A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue
Dobrian, A. D. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00108 · Cited by 36
Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma
Ather, J. L., Chung, M., Hoyt, L. R., Randall, M. J., Georgsdottir, A., Daphtary, N., Aliyeva, M., Suratt, B. T., Bates, J. H. T., Irvin, C. G., et al. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0070oc · Cited by 36
Obesity Cardiomyopathy: Pathophysiologic Factors and Nosologic Reevaluation
Bhatheja, S., Panchal, H. B., Ventura, H. O., & Paul, T. K. (2016) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2016.05.014 · Cited by 36
Role of the Renal Microcirculation in Progression of Chronic Kidney Injury in Obesity
Chade, A., & Hall, J. E. (2016) · American Journal of Nephrology · doi:10.1159/000452365 · Cited by 36
IL‐10 expression in macrophages from neonates born from obese mothers is suppressed by IL‐4 and LPS/INFγ
Cifuentes‐Zúñiga, F., Arroyo‐Jousse, V., Soto‐Carrasco, G., Casanello, P. C., Uauy, R. D., Krause, B. J., & Castro-Rodríguez, J. A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25845 · Cited by 36
Increased hepatic inflammation in a normal-weight mouse after long-term high-fat diet feeding
Toita, R., Kawano, T., Fujita, S., Murata, M., & Kang, J. (2017) · Journal of Toxicologic Pathology · doi:10.1293/tox.2017-0038 · Cited by 35
Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations
Ferreira, S. R., & Motta, A. B. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867325666171205144119 · Cited by 36
Association Between Obesity and Acute Severity Among Patients Hospitalized for Asthma Exacerbation
Luthe, S. K., Hirayama, A., Goto, T., Faridi, M. K., Camargo, C. A., & Hasegawa, K. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.02.001 · Cited by 36
Colorectal carcinogenesis: an archetype of gut microbiota–host interaction
Alexander, J. L., Scott, A. J., Pouncey, A. L., Marchesi, J. R., Kinross, J. K., & TEARE, J. P. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.865 · Cited by 38
Long-Term Changes in Leptin, Chemerin, and Ghrelin Levels Following Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy
Salman, M. A., El‐ghobary, M., Soliman, A. M., Sherbiny, M. E., Abouelregal, T. E., Albitar, A. R., Abdallah, A., Mikhail, H. M. S., Nafea, M. A., Sultan, A. A. E. A., et al. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04254-z · Cited by 37
Nonrespiratory Comorbidities in Asthma
Cardet, J. C., Bulkhi, A. A., & Lockey, R. F. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.08.027 · Cited by 38
Developmental Origins of Metaflammation; A Bridge to the Future Between the DOHaD Theory and Evolutionary Biology
Itoh, H., Ueda, M., Suzuki, M., & Kohmura‐Kobayashi, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.839436 · Cited by 37
Cooked Adzuki Bean Reduces High-Fat Diet-Induced Body Weight Gain, Ameliorates Inflammation, and Modulates Intestinal Homeostasis in Mice
Zhao, Q., Liu, Z., Zhu, Y., Wang, H., Dai, Z., Yang, X., Ren, X., Xue, Y., & Shen, Q. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.918696 · Cited by 37
Association of high obesity with PAM50 breast cancer intrinsic subtypes and gene expression
Kwan, M. L., Kroenke, C. H., Sweeney, C., Bernard, P. S., Weltzien, E. K., Castillo, A., Factor, R. E., Maxfield, K. S., Stijleman, I. J., Kushi, L. H., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1263-4 · Cited by 36
Epicardial Adipose Tissue: A Novel Potential Imaging Marker of Comorbidities Caused by Chronic Inflammation
Tarsitano, M. G., Pandozzi, C., Muscogiuri, G., Sironi, S., Pujia, A., Lenzi, A., & Giannetta, E. (2022) · Nutrients · doi:10.3390/nu14142926 · Cited by 30
An Easy, Convenient Cell and Tissue Extraction Protocol for Nuclear Magnetic Resonance Metabolomics
Mathéus, N., Hansen, S., Rozet, E., Peixoto, P., Maquoi, E., Lambert, V., Noël, A., Frédérich, M., Mottet, D., & Tullio, P. D. (2014) · Phytochemical Analysis · doi:10.1002/pca.2498 · Cited by 36
Clinical and biochemical effects of a 3-week program of diet combined with spa therapy in obese and diabetic patients: a pilot open study
Fioravanti, A., Adamczyk, P., Pascarelli, N. A., Giannitti, C., Urso, R., Tołodziecki, M. M., & Ponikowska, I. (2014) · International Journal of Biometeorology · doi:10.1007/s00484-014-0894-5 · Cited by 35
TNF‐α downregulates CIDEC via MEK/ERK pathway in human adipocytes
Tan, X., Cao, Z., Li, M., Xu, E., Wang, J., & Xiao, Y. (2016) · Obesity · doi:10.1002/oby.21436 · Cited by 35
The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice
Soofi, A. A., Wolf, K. I., Emont, M. P., Qi, N., Martinez-Santibañez, G., Grimley, E. C., Ostwani, W., & Dressler, G. R. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.771428 · Cited by 36
Endogenous lipid antigens for invariant natural killer T cells hold the reins in adipose tissue homeostasis
van Eijkeren, R. J., Krabbe, O., Boes, M. L., Schipper, H. S., & Kalkhoven, E. (2017) · Immunology · doi:10.1111/imm.12839 · Cited by 35
Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome
Fructuoso, M., Rachdi, L., Philippe, E., Denis, R., Magnan, C., Stunff, H. L., Janel, N., & Dierssen, M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.09.021 · Cited by 35
The role of DNA ‐ PK in aging and energy metabolism
Chung, J. H. (2018) · FEBS Journal · doi:10.1111/febs.14410 · Cited by 34
Adipose tissue as a possible therapeutic target for polyphenols: A case for Cyclopia extracts as anti-obesity nutraceuticals
Jack, B. U., Malherbe, C. J., Mamushi, M., Muller, C. J. F., Joubert, E., Louw, J., & Pheiffer, C. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109439 · Cited by 36
Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats
Halenova, T., Zlatskiy, I. A., Syroeshkin, A. V., Maksimova, T. V., & Плетенева, Т. В. (2019) · Molecules · doi:10.3390/molecules25010023 · Cited by 35
Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
de Carvalho, F. G., Brandão, C., Muñoz, V. R., Batitucci, G., Tavares, M. E. A., Teixeira, G. R., Pauli, J. R., de Moura, L. P., Ropelle, E. R., Cintra, D. E., et al. (2021) · Amino Acids · doi:10.1007/s00726-021-03041-4 · Cited by 35
Indole-3-acetic acid improves the hepatic mitochondrial respiration defects by PGC1a up-regulation
Zhang, C., Fu, Q., Shao, K., Liu, L., Ma, X., Zhang, F., Zhang, X., Meng, L., Yan, C., & Zhao, X. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110442 · Cited by 36
Hepatocyte TRAF3 promotes insulin resistance and type 2 diabetes in mice with obesity
Chen, Z., Canet, M. J., Sheng, L., Jiang, L., Xiong, Y., Yin, L., & Rui, L. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.013 · Cited by 34
Dietary restriction reverses obesity-induced anhedonia
Grillo, C. A., Mulder, P., Macht, V. A., Kaigler, K. F., Wilson, S. P., Wilson, M. A., & Reagan, L. P. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.026 · Cited by 36
Metabolic consequences of obesity as an “outside in” mechanism of disease severity in asthma
Peters, M. C., & Fahy, J. V. (2016) · European Respiratory Journal · doi:10.1183/13993003.01132-2016 · Cited by 39
Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases
Moroni-González, D., Sarmiento-Ortega, V. E., Díaz, A., Brambila, E., & Treviño, S. (2023) · Toxics · doi:10.3390/toxics11030223 · Cited by 34
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders
Luo, J., Wang, F.-X., Zhao, J., Yang, C.-L., Rong, S.-J., Lu, W.-Y., Chen, Q.-J., Zhou, Q., Xiao, J., Wang, Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.08.009 · Cited by 37
Inhibition of the nucleotide-binding domain, leucine-rich containing family, pyrin-domain containing 3 inflammasome reduces the severity of experimentally induced acute pancreatitis in obese mice
York, J. M., Castellanos, K. J., Cabay, R. J., & Fantuzzi, G. (2014) · Translational research · doi:10.1016/j.trsl.2014.06.012 · Cited by 34
Downregulation of STRA6 in Adipocytes and Adipose Stromovascular Fraction in Obesity and Effects of Adipocyte-Specific STRA6 Knockdown In Vivo
Zemany, L., Kraus, B. J., Norseen, J., Saito, T., Peroni, O. D., Johnson, R. L., & Kahn, B. B. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01106-13 · Cited by 34
ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction
Hao, W., Tarling, E. J., McMillen, T. S., Tang, C., & LeBoeuf, R. C. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m063354 · Cited by 35
Administration of Lactobacillus gasseri SBT2055 suppresses macrophage infiltration into adipose tissue in diet-induced obese mice
Ukibe, K., Miyoshi, M., & Kadooka, Y. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002627 · Cited by 34
Host phenotype is associated with reduced survival independent of tumour biology in patients with colorectal liver metastases
van Dijk, D. P. J., Krill, M., Farshidfar, F., Li, T., Rensen, S. S., Damink, S. W. M. O., Dixon, E., Sutherland, F. R., Ball, C. G., Mazurak, V. C., et al. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12358 · Cited by 34
Short-Term Outcomes of Inflammatory Bowel Disease after Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy
Heshmati, K., Lo, T., Tavakkoli, A., & Sheu, E. G. (2019) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2019.01.021 · Cited by 34
Phosphorylation status of fetuin-A is critical for inhibition of insulin action and is correlated with obesity and insulin resistance
Ren, G., Kim, T., Papizan, J. B., Okerberg, C. K., Kothari, V. M., Zaid, H., Bilan, P. J., Araya-Ramírez, F., Littlefield, L. A., Bowers, R. L., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00089.2018 · Cited by 34
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis
Badenes, M., Amin, A., González‐García, I., Félix, I., Burbridge, E., Cavadas, M. A. S., Ortega, F. J., de Carvalho, É., Faísca, P., Carobbio, S., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.10.006 · Cited by 31
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice
Yu, Y., Cui, S., Zheng, T.-N., Ma, H., Xie, Z., Jiang, H., Li, Y., Zhu, K., Huang, C., Li, J. X., et al. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0427-1 · Cited by 34
Chronic inflammation in psoriasis promotes visceral adiposity associated with noncalcified coronary burden over time
Sajja, A. P., Abdelrahman, K. M., Reddy, A. S., Dey, A. K., Uceda, D. E., Lateef, S. S., Sorokin, A. V., Teague, H., Chung, J., Rivers, J. P., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.142534 · Cited by 38
Resveratrol attenuates inflammation and oxidative stress in epididymal white adipose tissue: Implications for its involvement in improving steroidogenesis in diet‐induced obese mice
Lv, Z., Wang, Q., Chen, Y., Wang, S., & Huang, D. (2015) · Molecular Reproduction and Development · doi:10.1002/mrd.22478 · Cited by 34
Perinatal Iron Deficiency Combined with a High-Fat Diet Causes Obesity and Cardiovascular Dysregulation
Bourque, S. L., Komolova, M., McCabe, K. M., Adams, M. A., & Nakatsu, K. (2011) · Endocrinology · doi:10.1210/en.2011-1700 · Cited by 34
Lack of mature lymphocytes results in obese but metabolically healthy mice when fed a high-fat diet
Liu, X., Huh, J. Y., Gong, H., Chamberland, J. P., Brinkoetter, M. T., Hamnvik, O. R., & Mantzoros, C. S. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.93 · Cited by 34
Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial
Gram, A. S., Bladbjerg, E., Quist, J. S., Blond, M. B., Rosenkilde, M., & Stallknecht, B. M. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.06.923 · Cited by 34
A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome
Galmés, S., Cifre, M., Palou, A., Oliver, P., & Serra, F. A. (2019) · Nutrients · doi:10.3390/nu11020298 · Cited by 35
Heparanase Accelerates Obesity-Associated Breast Cancer Progression
Hermano, E., Goldberg, R., Rubinstein, A. M., Sonnenblick, A., Maly, B., Nahmias, D., Li, J., Bakker, M. A. H., van der Vlag, J., Vlodavsky, I., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-4058 · Cited by 35
C-Reactive Protein Levels in African Americans
Hébert, J. R., Wirth, M. D., Davis, L., Davis, B., Harmon, B. E., Hurley, T. G., Drayton, R., Murphy, E. A., Shivappa, N., Wilcox, S., et al. (2013) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.05.011 · Cited by 35
Body mass index and its effect on outcome in children after lung transplantation
Benden, C., Ridout, D. A., Edwards, L. B., Boehler, A., Christie, J. D., & Sweet, S. C. (2012) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2012.11.002 · Cited by 33
Plac8 is required for White Adipocyte Differentiation in vitro and Cell Number Control in vivo
Jimenez-Preitner, M., Berney, X. P., & Thorens, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048767 · Cited by 33
Preweaning Growth Hormone Treatment Ameliorates Adipose Tissue Insulin Resistance and Inflammation in Adult Male Offspring Following Maternal Undernutrition
Reynolds, C. M., Li, M., Gray, C. L., & Vickers, M. H. (2013) · Endocrinology · doi:10.1210/en.2013-1146 · Cited by 32
Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet‐induced obesity
Kim, J. H., Lee, E., Friedline, R. H., Suk, S., Jung, D. Y., Dağdeviren, S., Hu, X., Inashima, K., Noh, H. L., Kwon, J. Y., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201701017r · Cited by 33
Associations among inflammation, mental health, and quality of life in adults with metabolic syndrome
Kim, J.-R., Kim, H.-N., & Song, S.-W. (2018) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0367-9 · Cited by 33
(−)-Epicatechin mitigates high fat diet-induced neuroinflammation and altered behavior in mice
Kang, J., Wang, Z., & Oteiza, P. I. (2020) · Food & Function · doi:10.1039/d0fo00486c · Cited by 35
Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages
Hu, X., Dong, X., Guo, L., Chen, Y., Chen, J., He, X., Sun, H., Kim, D.-H., Kemper, J. K., & Chen, L. (2021) · JCI Insight · doi:10.1172/jci.insight.143379 · Cited by 34
High Density Lipoprotein Cholesterol / C Reactive Protein Ratio in Heart Failure with Preserved Ejection Fraction
Yano, M., Nishino, M., Ukita, K., Kawamura, A., Nakamura, H., Matsuhiro, Y., Yasumoto, K., Tsuda, M., Okamoto, N., Tanaka, A., et al. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13350 · Cited by 32

Authors: Lumeng, C. N., & Saltiel, A. R.
Affiliations: University of Michigan (US)
Corresponding author: Lumeng, Carey N.
ORCID: Lumeng, Carey N.
Saltiel, Alan R.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2011-06-01
Volume: 121
Issue: 6
Pages: 2111-2117
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci57132
PMC: PMC3104776
OpenAlex: W2165604976
Cited by: 2,319
References: 124
Citations by year: 2026: 109 · 2025: 111 · 2024: 105 · 2023: 111 · 2022: 154 · 2021: 187 · 2020: 173 · 2019: 177 · 2018: 186 · 2017: 211 · 2016: 176 · 2015: 163 · 2014: 165 · 2013: 155 · 2012: 108
FWCI: 16.91
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090262, R01DK060591, K08DK078851)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: obesity, inflammation, metabolic disorders, obesity-related comorbidities, immune regulation, metabolic tissues
MeSH terms: Acute-Phase Proteins, Adipose Tissue, Animals, Anti-Inflammatory Agents, Energy Metabolism, Fibrosis, Humans, Hypothalamus, Inflammation, Leukocytes, Liver, Macrophages, Metabolic Diseases, Models, Biological, Obesity, Organ Specificity, Cytokines, Disease Progression, Muscle, Skeletal, Peroxisome Proliferator-Activated Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammatory links between obesity and metabolic disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks