The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Inflammatory links between obesity and metabolic disease
Open accessAbstract
The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that they are inextricably linked. The reframing of obesity as an inflammatory condition has had a wide impact on our conceptualization of obesity-associated diseases. In this Review, we highlight the cellular and molecular mechanisms at play in the generation of obesity-induced inflammation. We also emphasize how defining the immune regulation in metabolic tissues has broadened the understanding of the diversity of inflammatory responses.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Increased circulating concentrations of these pro-inflammatory markers are reported in adolescents with T2DM 30 .”
From Type 2 diabetes in adolescents and young adults (2018) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Aged WAT is characterized by a proinflammatory microenvironment with elevated expression of inflammatory genes associated with metabolic disease (39).”
From Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan (2025) · cites this paper as [39]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Perturbations in immune function have been demonstrated to exacerbate neurodegeneration and metabolic diseases (Lumeng and Saltiel, 2011; Ransohoff, 2016; Reilly and Saltiel, 2017).”
From Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice (2022) · cites this paper as Lumeng and Saltiel, 2011
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Ropelle, E. R., Flores, M. B. S., Cintra, D. E., Rocha, G. Z., Pauli, J. R., Morari, J., de Souza, C. T., Moraes, J. C., Prada, P. O., Guadagnini, D., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000465 · Cited by 333
RetractedInflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function
Calegari, V. C., Torsoni, A. S., Vanzela, E. C., ARAUJO, E. P. D., Morari, J., Zoppi, C. C., Sbragia, L., Boschero, A. C., & Velloso, L. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173021 · Cited by 77
RetractedObesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Self-citationEndoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 1,009
Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation
Mitsuya, K., Parker, A. N., Liu, L., Ruan, J., Vissers, M. C. M., & Myatt, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186115 · Cited by 113
Microbiota associated with type 2 diabetes and its related complications
Zhang, Y., & Zhang, H. (2013) · Food Science and Human Wellness · doi:10.1016/j.fshw.2013.09.002 · Cited by 115
Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders
Wani, K., AlHarthi, H., Alghamdi, A. A., Sabico, S., & Al‐Daghri, N. M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020511 · Cited by 118
Pickens, C. A., Sordillo, L. M., Zhang, C., & Fenton, J. I. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.034 · Cited by 109
Cressman, A. M., Petrović, V., & Piquette‐Miller, M. (2011) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.11.66 · Cited by 112
γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice
Mehta, P., Nuotio-Antar, A. M., & Smith, C. W. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0414-211rr · Cited by 111
Malaisé, Y., Menard, S., Cartier, C., Gaultier, E., Lasserre, F., Lencina, C., Harkat, C., Geoffre, N., Lakhal, L., Castan, I., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15196-w · Cited by 107
Morelli, A., Sarchielli, E., Comeglio, P., Filippi, S., Vignozzi, L., Marini, M., Rastrelli, G., Maneschi, E., Cellai, I., Persani, L., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.017 · Cited by 107
Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases
Molla, M. D., Akalu, Y., Geto, Z., Dagnew, B., Ayelign, B., & Shibabaw, T. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s277457 · Cited by 119
Décarie-Spain, L., Sharma, S., Hryhorczuk, C., Issa-Garcia, V., Barker, P. A., Arbour, N., Alquier, T., & Fulton, S. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.018 · Cited by 107
Misu, H., Ishikura, K., Kurita, S., Takeshita, Y., Ota, T., Saito, Y., Takahashi, K., Kaneko, S., & Takamura, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034952 · Cited by 105
Morrison, M. C., & Kleemann, R. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00308 · Cited by 105
Lee, C. H., Kim, H. J., Lee, Y. S., Kang, G. M., Lim, H. S., Lee, S.-H., Song, D. K., Kwon, O., Hwang, I., Son, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.070 · Cited by 111
Cancer-associated adipocytes as immunomodulators in cancer
Wu, Q., Li, B., Li, J., Sun, S., Yuan, J., & Sun, S. (2021) · Biomarker Research · doi:10.1186/s40364-020-00257-6 · Cited by 105
Wu, Y., Yu, Y., Szabo, A., Han, M., & Huang, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092618 · Cited by 105
Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages
Im, D. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.094 · Cited by 104
Kondo, H., Abe, I., Gotoh, K., Fukui, A., Takanari, H., Ishii, Y., Ikebe, Y., Kira, S., Oniki, T., Saito, S., et al. (2018) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.006040 · Cited by 103
Is There a Link Between Obesity and Asthma?
Kim, S., Sutherland, E. R., & Gelfand, E. W. (2014) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2014.6.3.189 · Cited by 107
New therapeutic approaches for the treatment of obesity
Saltiel, A. R. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad1811 · Cited by 102
Self-citationGe, Q., Brichard, S. M., Yi, X., & Li, Q. (2014) · Journal of Immunology Research · doi:10.1155/2014/987285 · Cited by 105
Schmidt, S., Monk, J. M., Robinson, L. E., & Mourtzakis, M. (2015) · Obesity Reviews · doi:10.1111/obr.12281 · Cited by 104
Insulin Resistance in the Defense against Obesity
Saltiel, A. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.001 · Cited by 105
Self-citationNLRP3 Inflammasome Activation in Adipose Tissues and Its Implications on Metabolic Diseases
Wu, K. K.-L., Cheung, S. W. M., & Cheng, K. K. Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114184 · Cited by 105
Liver-spleen axis in nonalcoholic fatty liver disease
Tarantino, G., Citro, V., & Balsano, C. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1914587 · Cited by 107
Lade, A. G., Noon, L. A., & Friedman, S. L. (2013) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000042 · Cited by 103
Geovanini, G. R., Wang, R., Weng, J. F., Jenny, N. S., Shea, S. A., Allison, M., Libby, P., & Redline, S. S. (2018) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201802-121oc · Cited by 100
Obese-Inflammatory Phenotypes in Heart Failure With Preserved Ejection Fraction
Sabbah, M. S., Fayyaz, A. U., de Denus, S., Felker, G. M., Borlaug, B. A., Dasari, S., Carter, R. E., & Redfield, M. M. (2020) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006414 · Cited by 100
Exploring the Impact of Obesity on Skeletal Muscle Function in Older Age
Morgan, P. T., Smeuninx, B., & Breen, L. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.569904 · Cited by 108
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Setayesh, T., Nersesyan, A., Mišík, M., Ferk, F., Langie, S., Andrade, V. M., Haslberger, A., & Knasmüller, S. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.07.001 · Cited by 98
Strong, A. L., Burow, M. E., Gimble, J. M., & Bunnell, B. A. (2014) · Stem Cells · doi:10.1002/stem.1857 · Cited by 102
In vivo Manipulation of Stem Cells for Adipose Tissue Repair/Reconstruction
Yoshimura, K., Eto, H., D, H. K. M., Doi, K., & Aoi, N. (2011) · Regenerative Medicine · doi:10.2217/rme.11.62 · Cited by 97
Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis
Chen, W., Balland, É., & Cowley, M. A. (2017) · Neuroendocrinology · doi:10.1159/000455865 · Cited by 101
Chang, E. H., Chavan, S. S., & Pavlov, V. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00263 · Cited by 98
Children With Metabolically Healthy Obesity: A Review
Vuković, R., Santos, T. J. D., Ybarra, M., & Atar, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00865 · Cited by 102
Fontes-Cal, T. C. M., Mattos, R. T., Medeiros, N. I., Pinto, B. F., Belchior-Bezerra, M., Roque-Souza, B., Dutra, W. O., Ferrari, T. C. A., Vidigal, P. V. T., Faria, L. C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708959 · Cited by 97
“LDL, mg/dL 120,5 (66,2-175,7) 117,9 (35,0-165,5) 105 (89-122) HDL, mg/dL 43 (32-65)* 42 (25-105)* 57 (42-75)”
BackgroundInfluentialRisk of an asthma exacerbation after bariatric surgery in adults
Hasegawa, K., Tsugawa, Y., Chang, Y., & Camargo, C. A. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1931 · Cited by 97
Jamka, M., Woźniewicz, M., Walkowiak, J., Bogdański, P., Jeszka, J., & Stelmach-Mardas, M. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1089-5 · Cited by 96
Non-alcoholic fatty liver disease and associated dietary and lifestyle risk factors
Al-Dayyat, H. M., Rayyan, Y. M., & Tayyem, R. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.03.016 · Cited by 103
Krajewska, M., Witkowska–Sędek, E., Rumińska, M., Stelmaszczyk‐Emmel, A., Sobol, M., Majcher, A., & Pyrżak, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.920340 · Cited by 109
Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging
Ghosh, A. K., Garg, S. K., Mau, T., O’Brien, M., Liu, J., & Yung, R. L. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu186 · Cited by 96
Plasma Clusterin (ApoJ) Levels Are Associated with Adiposity and Systemic Inflammation
Won, J. C., Park, C., Oh, S. W., Lee, E. S., Youn, B., & Kim, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103351 · Cited by 98
Tuulari, J. J., Karlsson, H. K., Antikainen, O., Hirvonen, J., Pham, T. T., Salminen, P. T. P., Helmiö, M., Parkkola, R. K., Nuutila, P., & Nummenmaa, L. (2016) · Human Brain Mapping · doi:10.1002/hbm.23272 · Cited by 94
Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids
May, K. S., & den Hartigh, L. J. (2021) · Nutrients · doi:10.3390/nu13103666 · Cited by 105
Zhang, Z., Yuan, Y., Hu, L., Tang, J., Meng, Z., Dai, L., Gao, Y., Ma, S., Wang, X., Yuan, Y., et al. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.08.006 · Cited by 96
Inflammation and atherosclerosis: direct versus indirect mechanisms
Rosenfeld, M. E. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.01.003 · Cited by 96
Kanda, T., Goto, T., Hirotsu, Y., Masuzaki, R., Moriyama, M., & Omata, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041525 · Cited by 97
Fazolini, N. P. B., Cruz, A. L. S., Werneck, M. B. F., Viola, J. P. B., Maya‐Monteiro, C. M., & Bozza, P. T. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1041684 · Cited by 99
Endoplasmic Reticulum Stress, the Hypothalamus, and Energy Balance
Çakır, I., & Nillni, E. A. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.01.002 · Cited by 94
Diet‐induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow
van den Berg, S. M., Seijkens, T. T. P., Kusters, P. J. H., Beckers, L., den Toom, M., Smeets, E., Levels, J. H. M., de Winther, M. P. J., & Lutgens, E. (2016) · The FASEB Journal · doi:10.1096/fj.201500175 · Cited by 96
Mesri Alamdari, N., Mahdavi, R., Roshanravan, N., Lotfi Yaghin, N., Ostadrahimi, A., & Faramarzi, E. (2014) · Hormone and Metabolic Research · doi:10.1055/s-0034-1384587 · Cited by 93
Sattler, F. R., He, J., Letendre, S. L., Wilson, C. C., Sanders, C., Heaton, R. K., Ellis, R. J., Franklin, D., Aldrovandi, G. M., Marra, C. M., et al. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000458 · Cited by 92
Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis
Chun, T. (2012) · Adipocyte · doi:10.4161/adip.19752 · Cited by 96
Erythropoietin, a Novel Versatile Player Regulating Energy Metabolism beyond the Erythroid System
Wang, L., Di, L., & Noguchi, C. T. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.9518 · Cited by 91
An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling
Jun, H., Yu, H. M., Gong, J., Jiang, J., Qiao, X., Perkey, E., Kim, D., Emont, M. P., Zestos, A. G., Cho, J.-S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0032-8 · Cited by 92
The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy
Assumpção, J. A. F., Pasquarelli-do-Nascimento, G., Viegas, M. S., Bonamino, M., & Magalhães, K. G. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00796-0 · Cited by 97
Zhang, A. M. Y., Xia, Y. H., Lin, J. S. H., Chu, K., Wang, W. C. K., Ruiter, T. J. J., Yang, J. C. C., Chen, N., Chhuor, J., Patil, S., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.10.003 · Cited by 91
Sex Differences in White Matter Alterations Accompanying Obstructive Sleep Apnea
Macey, P. M., Kumar, R., Yan‐Go, F. L., Woo, M. A., & Harper, R. M. (2012) · SLEEP · doi:10.5665/sleep.2228 · Cited by 93
Sena, C. M., Pereira, A. M., Fernandes, R., Letra, L., & Seiça, R. M. F. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13756 · Cited by 91
Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)
Eduardo Fuentes, Q., Guzmán, L., Moore‐Carrasco, R., & Palomo, I. F. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1714 · Cited by 89
Watanabe, Y., Nagai, Y., & Takatsu, K. (2013) · Nutrients · doi:10.3390/nu5093757 · Cited by 92
DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity
Soussi, H., Reggio, S., Alili, R., Prado, C., Mutel, S., Pini, M., Rouault, C., Clément, K., & Dugail, I. (2015) · Diabetes · doi:10.2337/db14-1933 · Cited by 93
Jha, M. K., Lee, I., & Suk, K. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.006 · Cited by 94
Nutrient Deficiencies Are Common Prior to Bariatric Surgery
Frame, L. A., Megill, R. D., Carobrese, S., & Schweitzer, M. (2017) · Nutrition in Clinical Practice · doi:10.1177/0884533617712701 · Cited by 89
Quarta, C., Clemmensen, C., Zhu, Z., Yang, B. S., Joseph, S. S., Lutter, D., Yi, C., Graf, E., García‐Cáceres, C., Legutko, B., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.023 · Cited by 89
Terzo, S., Mulè, F., Caldara, G., Baldassano, S., Puleio, R., Vitale, M., Cassata, G., Ferrantelli, V., & Amato, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010365 · Cited by 89
Arcidiacono, B., CHIEFARI, E. D., Foryst‐Ludwig, A., Currò, G., Navarra, G., Brunetti, F. S., Mirabelli, M., Corigliano, D. M., Kintscher, U., Britti, D., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102912 · Cited by 95
Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
Nguyen, H. N., Ullevig, S. L., Short, J. D., Wang, L., Ahn, Y. J., & Asmis, R. (2021) · Antioxidants · doi:10.3390/antiox10081161 · Cited by 89
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 89
Self-citationGuria, S., Hoory, A., Das, S., Chattopadhyay, D., & Mukherjee, S. (2023) · Bioscience Reports · doi:10.1042/bsr20220200 · Cited by 105
Tanaka, N., Takahashi, S., Matsubara, T., Jiang, C., Sakamoto, W., Chanturiya, T., Teng, R., Gavrilova, O., & Gonzalez, F. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.605980 · Cited by 89
Xu, E., Pereira, M. M. A., Karakasilioti, I., Theurich, S., Al-Maarri, M., Rappl, G., Waisman, A., Wunderlich, F. T., & Brüning, J. C. (2017) · Nature Communications · doi:10.1038/ncomms14803 · Cited by 95
Jeftic, I. D., Jovicic, N. U., Pantic, J. M., Arsenijević, N., Lukić, M. L., & Pejnovic, N. N. (2015) · Molecular Medicine · doi:10.2119/molmed.2014.00178 · Cited by 89
Hanly, J., Mitchell, M. J., Barnes, D. C., & MacMillan, L. (1994) · PubMed · Cited by 88
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 92
Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance
Aouadi, M., Vangala, P., Yawe, J. C., Tencerová, M., Nicoloro, S. M. C., Cohen, J. L., Shen, Y., & Czech, M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00187.2014 · Cited by 99
Kong, L. C., Wuillemin, P.-H., Bastard, J., Sokolovska, N., Gougis, S., Fellahi, S., Darakhshan, F., Bonnefont‐Rousselot, D., Bittar, R., Dore, J. M., et al. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058099 · Cited by 92
Thoudam, T., Jeon, J., Ha, C., & Lee, I. (2016) · Mediators of Inflammation · doi:10.1155/2016/1851420 · Cited by 91
Hypothalamic lipid‐laden astrocytes induce microglia migration and activation
Kwon, Y., Kim, J., Kim, C., Tu, T. H., Kim, M., Suk, K., Kim, D. H., Lee, B. J., Choi, H., Park, T., et al. (2017) · FEBS Letters · doi:10.1002/1873-3468.12691 · Cited by 87
Kang, H. S., Liao, G., DeGraff, L. M., Gerrish, K., Bortner, C. D., Garantziotis, S., & Jetten, A. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058417 · Cited by 85
Ghaderi, A., Banafshe, H. R., Motmaen, M., Rasouli‐Azad, M., Bahmani, F., & Asemi, Z. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.016 · Cited by 86
Dionysopoulou, S., Charmandari, E., Bargiota, Α., Vlahos, N., Mastorakos, G. P., & Valsamakis, G. (2021) · Nutrients · doi:10.3390/nu13020498 · Cited by 91
Wan, M., Pan, S., Shan, B., Diao, H., Jin, H., Wang, Z., Wang, W., Han, S., Liu, W., He, J., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02258-1 · Cited by 102
Microglia activation due to obesity programs metabolic failure leading to type two diabetes
Maldonado‐Ruiz, R., Montalvo-Martínez, L., Fuentes‐Mera, L., & Camacho‐Morales, A. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.10 · Cited by 87
An intracrine view of sex steroids, immunity, and metabolic regulation
Rubinow, K. B. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.03.001 · Cited by 82
Kodama, K., Toda, K., Morinaga, S., Yamada, S., & Butte, A. J. (2015) · Diabetes · doi:10.2337/db14-0149 · Cited by 85
Vezza, T., Rodríguez‐Nogales, A., Algieri, F., Garrido‐Mesa, J., Romero, M., Sánchez, M., Toral, M., Martín-García, B., Gómez‐Caravaca, A. M., Arraéz-Román, D., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104487 · Cited by 89
Role of adipose tissue macrophages in obesity-related disorders
Chakarov, S., Blériot, C., & Ginhoux, F. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211948 · Cited by 91
Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity
Guerbette, T., Boudry, G., & Lan, A. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101546 · Cited by 100
Ozanne, J., Prescott, A. R., & Clark, K. (2014) · Biochemical Journal · doi:10.1042/bj20141165 · Cited by 88
Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation
Vijayakanthi, N., Greally, J. M., & Rastogi, D. (2016) · PEDIATRICS · doi:10.1542/peds.2015-0812 · Cited by 87
Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults
Yu, J.-Y., Choi, W., Lee, H. S., & Lee, J. (2019) · Medicine · doi:10.1097/md.0000000000014740 · Cited by 89
Kwon, Y. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900824 · Cited by 93
Aryal, P., Syed, I., Lee, J., Patel, R., Nelson, A. T., Siegel, D. R., Saghatelian, A., & Kahn, B. B. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100108 · Cited by 84
Shang, Q., Bai, Y., Wang, G., Song, Q., Guo, C. H., Zhang, L., & Wang, Q. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0557 · Cited by 84
Cai, Z., Li, F., Gong, W., Liu, W., Duan, Q., Chen, C., Ni, L., Xia, Y., Cianflone, K., Dong, N., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300226 · Cited by 83
Toita, R., Kawano, T., Murata, M., & Kang, J. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.018 · Cited by 89
Body Composition and Physical Function in Older Adults with Various Comorbidities
Kim, S., Leng, X., & Kritchevsky, S. B. (2017) · Innovation in Aging · doi:10.1093/geroni/igx008 · Cited by 86
Hamjane, N., Benyahya, F., Nourouti, N. G., Mechita, M. B., & Barakat, A. (2020) · Microvascular Research · doi:10.1016/j.mvr.2020.104023 · Cited by 84
Influenza Vaccines: Successes and Continuing Challenges
Becker, T., Elbahesh, H., Reperant, L. A., Rimmelzwaan, G. F., & Osterhaus, A. D. M. E. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab269 · Cited by 83
Namgaladze, D., Lips, S., Leiker, T. J., Murphy, R. C., Ekroos, K., Ferreirós, N., Geißlinger, G., & Brüne, B. (2014) · Diabetologia · doi:10.1007/s00125-014-3173-4 · Cited by 85
Metadata
- Authors
- Lumeng, C. N., & Saltiel, A. R.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Lumeng, Carey N.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-06-01
- Volume
- 121
- Issue
- 6
- Pages
- 2111-2117
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3104776
- OpenAlex
- W2165604976
- Cited by
- 2,319
- References
- 124
- Citations by year
- 2026: 109 · 2025: 111 · 2024: 105 · 2023: 111 · 2022: 154 · 2021: 187 · 2020: 173 · 2019: 177 · 2018: 186 · 2017: 211 · 2016: 176 · 2015: 163 · 2014: 165 · 2013: 155 · 2012: 108
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090262, R01DK060591, K08DK078851)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- obesity, inflammation, metabolic disorders, obesity-related comorbidities, immune regulation, metabolic tissues
- MeSH terms
- Acute-Phase Proteins, Adipose Tissue, Animals, Anti-Inflammatory Agents, Energy Metabolism, Fibrosis, Humans, Hypothalamus, Inflammation, Leukocytes, Liver, Macrophages, Metabolic Diseases, Models, Biological, Obesity, Organ Specificity, Cytokines, Disease Progression, Muscle, Skeletal, Peroxisome Proliferator-Activated Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
