Inflammatory links between obesity and metabolic disease

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Inflammation and metabolic disorders

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543

Metabolic inflammation in heart failure with preserved ejection fraction

Schiattarella, G. G., Rodolico, D., & Hill, J. A. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa217 · Cited by 284

Towards an integrative approach to understanding the role of chemerin in human health and disease

Rourke, J. L., Dranse, H. J., & Sinal, C. J. (2012) · Obesity Reviews · doi:10.1111/obr.12009 · Cited by 282

Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration

Lee, Y., Petkova, A. P., & Granneman, J. G. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.003 · Cited by 293

Role of immune cells in obesity induced low grade inflammation and insulin resistance

Asghar, A., & Sheikh, N. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.03.001 · Cited by 278

Transforming Growth Factor Beta Signaling in Hepatocytes Participates in Steatohepatitis Through Regulation of Cell Death and Lipid Metabolism in Mice

Yang, L., Roh, Y. S., Song, J., Zhang, B., Liu, C., Loomba, R., & Seki, E. (2014) · Hepatology · doi:10.1002/hep.26698 · Cited by 275

G protein-coupled receptors for energy metabolites as new therapeutic targets

Blad, C. C., Tang, C., & Offermanns, S. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3777 · Cited by 277

Obesity accelerates T cell senescence in murine visceral adipose tissue

Shirakawa, K., Yan, X., Shinmura, K., Endo, J., Kataoka, M., Katsumata, Y., Yamamoto, T., Anzai, A., Isobe, S., Yoshida, N., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88606 · Cited by 271

Increasing Maternal Body Mass Index Is Associated with Systemic Inflammation in the Mother and the Activation of Distinct Placental Inflammatory Pathways1

Aye, I. L. M. H., Lager, S., Ramirez, V. I., Gaccioli, F., Dudley, D. J., Jansson, T., & Powell, T. L. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.116186 · Cited by 285

Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man

Jaïs, A., Einwallner, E., Sharif, O., Gossens, K., Lu, T. T.-H., Soyal, S. M., Medgyesi, D., Neureiter, D., Paier-Pourani, J., Dalgaard, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.043 · Cited by 270

Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

Cavalera, M., Wang, J., & Frangogiannis, N. G. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.001 · Cited by 269

The nutrition‐gut microbiome‐physiology axis and allergic diseases

McKenzie, C. I., Tan, J., Macia, L., & Mackay, C. R. (2017) · Immunological Reviews · doi:10.1111/imr.12556 · Cited by 281

Macrophages in age-related chronic inflammatory diseases

Oishi, Y., & Manabe, I. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.18 · Cited by 262

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

Clària, J., Dalli, J., Yacoubian, S., Gao, F., & Serhan, C. N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201272 · Cited by 271

The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases

Zhang, S., Gang, X., Yang, S., Cui, M., Sun, L., Li, Z., & Wang, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678355 · Cited by 263

CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors

Nawaz, A., Aminuddin, A., Kado, T., Takikawa, A., Yamamoto, S., Tsuneyama, K., Igarashi, Y., Ikutani, M., Nishida, Y., Nagai, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00231-1 · Cited by 270

Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia population in the gut microbiota of high-fat diet-fed mice

Shang, Q., Song, G., Zhang, M., Shi, J., Xu, C., Hao, J., Li, G., & Yu, G. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2016.11.002 · Cited by 258

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

Gomes, P., Outeiro, T. F., & Cavadas, C. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.001 · Cited by 259

Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure

Wolf, Y., Boura‐Halfon, S., Cortese, N., Haimon, Z., Shalom, H. S., Kuperman, Y., Kalchenko, V., Brandis, A. S., David, E., Segal-Hayoun, Y., et al. (2017) · Nature Immunology · doi:10.1038/ni.3746 · Cited by 264

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

Cai, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.11.003 · Cited by 256

Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives

Sun, L., Ma, L., Ma, Y., Zhang, F., Zhao, C., & Nie, Y. (2018) · Protein & Cell · doi:10.1007/s13238-018-0546-3 · Cited by 263

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y., & Saltiel, A. R. (2018) · Cell · doi:10.1016/j.cell.2018.01.007 · Cited by 250

Prevalence of Prediabetes and Diabetes and Metabolic Profile of Patients With Nonalcoholic Fatty Liver Disease (NAFLD)

Ortiz‐Lopez, C., Lomonaco, R., Orsak, B., Finch, J., Chang, Z., Kochunov, V., Hardies, J., & Cusi, K. J. (2012) · Diabetes Care · doi:10.2337/dc11-1849 · Cited by 258

The PI3K/Akt Pathway in Meta-Inflammation

Acosta‐Martínez, M., & Cabail, M. Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315330 · Cited by 259

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation

Douglass, J. D., Dorfman, M. D., Fasnacht, R., Shaffer, L. D., & Thaler, J. P. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.01.010 · Cited by 248

Inflammageing and metaflammation: The yin and yang of type 2 diabetes

Prattichizzo, F., Nigris, V. D., Spiga, R., Mancuso, E., Sala, L. L., Antonicelli, R., Testa, R., Procopio, A. D., Olivieri, F., & Ceriello, A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.003 · Cited by 255

Imbalance between Neutrophil Elastase and its Inhibitor α1-Antitrypsin in Obesity Alters Insulin Sensitivity, Inflammation, and Energy Expenditure

Mansuy‐Aubert, V., Zhou, Q. L., Xie, X., Gong, Z., Huang, J., Khan, A. R., Aubert, G., Candelaria, K., Thomas, S. C., Shin, D.-J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.005 · Cited by 248

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism

Bai, J., & Liu, F. (2019) · Diabetes · doi:10.2337/dbi18-0052 · Cited by 253

Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a Diabetes Care Editors’ Expert Forum

Cefalu, W. T., Bray, G. A., Home, P., Garvey, W. T., Klein, S., Pi-Sunyer, X., Hu, F. B., Raz, I., Gaal, L. V., Wolfe, B. M., et al. (2015) · Diabetes Care · doi:10.2337/dc15-1081 · Cited by 251

Nuclear sirtuins and inflammatory signaling pathways

Mendes, K. L., Lelis, D. D. F., & Santos, S. H. S. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.11.001 · Cited by 239

Fibrin(ogen) in human disease: both friend and foe

Vilar, R., Fish, R. J., Casini, A., & Neerman‐Arbez, M. (2020) · Haematologica · doi:10.3324/haematol.2019.236901 · Cited by 251

Metabolic Syndrome and the Lung

Baffi, C. W., Wood, L. G., Winnica, D., Strollo, P. J., Gladwin, M. T., Que, L. G., & Holguín, F. (2016) · CHEST Journal · doi:10.1016/j.chest.2015.12.034 · Cited by 236

Ectopic lipid storage and insulin resistance: a harmful relationship

Borén, J., Taskinen, M., Olofsson, S. ‐., & Levin, M. C. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12071 · Cited by 240

IL-33/ST2 Axis in Organ Fibrosis

Kotsiou, O. S., Gourgoulianis, K. I., & Zarogiannis, S. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02432 · Cited by 234

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

Neuhofer, A., Zeyda, M., Mascher, D. G., Itariu, B. K., Murano, I., Leitner, L., Hochbrugger, E., Fraisl, P., Cinti, S., Serhan, C. N., et al. (2013) · Diabetes · doi:10.2337/db12-0828 · Cited by 239

Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders

Theoharides, T. C., Tsilioni, I., Patel, A., & Doyle, R. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.77 · Cited by 234

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

Yang, L., Calay, E. S., Fan, J., Arduini, A., Kunz, R. C., Gygi, S. P., Yalçın, A., Fu, S., & Hotamışlıgil, G. S. (2015) · Science · doi:10.1126/science.aaa0079 · Cited by 235

Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites

Chen, W., & Pang, Y. (2021) · Metabolites · doi:10.3390/metabo11120869 · Cited by 228

Excess body weight: Novel insights into its roles in obesity comorbidities

Zhang, X., Ha, S., Lau, H. C.-H., & Yu, J. Q. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.03.008 · Cited by 255

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

Perino, A., Pols, T. W. H., Nomura, M., Stein, S., Pellicciari, R., & Schoonjans, K. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76289 · Cited by 233

Fatty Acids and NLRP3 Inflammasome–Mediated Inflammation in Metabolic Tissues

Ralston, J. C., Lyons, C. L., Kennedy, E. B., Kirwan, A. M., & Roche, H. M. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064836 · Cited by 231

Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Shahwan, M. J., Alhumaydhi, F. A., Ashraf, G. M., Hasan, P. M. Z., & Shamsi, A. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.004 · Cited by 232

Obesity as a risk factor for Alzheimer's disease: weighing the evidence

Alford, S., Patel, D. K., Perakakis, N., & Mantzoros, C. S. (2017) · Obesity Reviews · doi:10.1111/obr.12629 · Cited by 232

Adipose tissue plasticity from WAT to BAT and in between

Lee, Y., Mottillo, E. P., & Granneman, J. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.011 · Cited by 236

Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice

Morris, D. L., Cho, K. W., DelProposto, J. L., Oatmen, K. E., Geletka, L. M., Martinez-Santibanez, G., Singer, K., & Lumeng, C. N. (2013) · Diabetes · doi:10.2337/db12-1404 · Cited by 217

Inflammation, Metabolic Dysregulation, and Pulmonary Function among Obese Urban Adolescents with Asthma

Rastogi, D., Fraser, S., Oh, J. G., Huber, A. M., Schulman, Y., Bhagtani, R. H., Khan, Z., Tesfa, L., Hall, C. B., & Macián, F. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201409-1587oc · Cited by 218

Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO)

Hedrich, C. M., Hofmann, S. R., Pablik, J., Morbach, H., & Girschick, H. J. (2013) · Pediatric Rheumatology · doi:10.1186/1546-0096-11-47 · Cited by 215

Regulatory dendritic cells: there is more than just immune activation

Schmidt, S. V., Niño‐Castro, A., & Schultze, J. L. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00274 · Cited by 224

The anti-obesity effect of green tea polysaccharides, polyphenols and caffeine in rats fed with a high-fat diet

Xü, Y., Zhang, M., Wu, T., Dai, S., Xu, J., & Zhou, Z. (2014) · Food & Function · doi:10.1039/c4fo00970c · Cited by 210

Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

Gao, D., Madi, M., Ding, C., Fok, M., Steele, T., Ford, C. T., Hunter, L., & Chen, B. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00430.2013 · Cited by 216

Systems vaccinology: Probing humanity’s diverse immune systems with vaccines

Pulendran, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400476111 · Cited by 218

Estrogen Signaling in Metabolic Inflammation

Monteiro, R., Teixeira, D., & Calhau, C. (2014) · Mediators of Inflammation · doi:10.1155/2014/615917 · Cited by 223

Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?

Zhou, M.-S., Wang, A., & Yu, H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-12 · Cited by 217

Adipokines, diabetes and atherosclerosis: an inflammatory association

Freitas‐Lima, L. C., Braga, V. A., de França-Silva, M. D. S., Cruz, J. C., Santos, S. H. S., Monteiro, M. M. D. O., & Balarini, C. M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00304 · Cited by 218

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

Thaler, J. P., Guyenet, S. J., Dorfman, M. D., Wisse, B. E., & Schwartz, M. W. (2013) · Diabetes · doi:10.2337/db12-1605 · Cited by 215

Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome

Eduardo Fuentes, Q., Fuentes, F., Vilahur, G., Badimón, L., & Palomo, I. F. (2013) · Mediators of Inflammation · doi:10.1155/2013/136584 · Cited by 212

Adipose tissue and adipocyte dysregulation

Lafontan, M. (2013) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.08.002 · Cited by 218

The Many Facets of Erythropoietin Physiologic and Metabolic Response

Suresh, S., Rajvanshi, P. K., & Noguchi, C. T. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01534 · Cited by 217

The activation and regulation of IL-17 receptor mediated signaling

Song, X., & Qian, Y. (2013) · Cytokine · doi:10.1016/j.cyto.2013.03.014 · Cited by 206

Linking Chronic Inflammation with Cardiovascular Disease: From Normal Aging to the Metabolic Syndrome.

López‐Candales, A., Burgos, P. M. H., Hernández-Suárez, D. F., & Harris, D. A. (2017) · PubMed · Cited by 214

Adipose tissue inflammation and ectopic lipid accumulation [Review]

Suganami, T., Tanaka, M., & Ogawa, Y. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0271 · Cited by 207

Inflammation revisited: inflammation versus resolution of inflammation following myocardial infarction

Kain, V., Prabhu, S. D., & Halade, G. V. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0444-7 · Cited by 209

Structural Brain Changes Associated with Overweight and Obesity

Apo, E. G., Mondragón‐Maya, A., Ferrari-Díaz, M., & Silva‐Pereyra, J. (2021) · Journal of Obesity · doi:10.1155/2021/6613385 · Cited by 218

Obesity, Brain Volume, and White Matter Microstructure at MRI: A Cross-sectional UK Biobank Study

Dekkers, I. A., Jansen, P. R., & Lamb, H. J. (2019) · Radiology · doi:10.1148/radiol.2019181012 · Cited by 204

Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms

Fan, W., Huang, Y., Zheng, H., Li, S., Li, Z., Li, Y., Cheng, X., He, C., & Sun, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110915 · Cited by 207

Mechanisms of Obesity-Induced Gastrointestinal Neoplasia

Alemán, J. O., Eusebi, L. H., Ricciardiello, L., Patidar, K. R., Sanyal, A. J., & Holt, P. R. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.051 · Cited by 201

Vascular senescence in cardiovascular and metabolic diseases

Katsuumi, G., Shimizu, I., Yoshida, Y., & Minamino, T. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00018 · Cited by 196

PTP1B: A simple enzyme for a complex world

Feldhammer, M., Uetani, N., Miranda‐Saavedra, D., & Tremblay, M. L. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.819830 · Cited by 201

Innate sensors of pathogen and stress: Linking inflammation to obesity

Jin, C., & Flavell, R. A. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.06.022 · Cited by 197

The nexus between nutrient metabolism, oxidative stress and inflammation in transition cows

Sordillo, L. M., & Mavangira, V. (2014) · Animal Production Science · doi:10.1071/an14503 · Cited by 195

Long Noncoding RNAs: A New Regulatory Code in Metabolic Control

Zhao, X.-Y., & Lin, J. D. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.08.002 · Cited by 196

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

Han, J. M., Wu, D., Denroche, H. C., Yao, Y. F., Verchere, C. B., & Levings, M. K. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500020 · Cited by 193

Inflammation links excess fat to insulin resistance: the role of the interleukin‐1 family

Tack, C. J., Stienstra, R., Joosten, L. A. B., & Netea, M. G. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01145.x · Cited by 199

Intestinal Microbiome Shifts, Dysbiosis, Inflammation, and Non-alcoholic Fatty Liver Disease

Saltzman, E., Palacios, T., Thomsen, M., & Vitetta, L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00061 · Cited by 197

Metabolic inflammation: Connecting obesity and insulin resistance

Dali‐Youcef, N., Mecili, M., Ricci, R., & Andrès, E. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.705015 · Cited by 201

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

Cai, D., & Liu, T. (2012) · Aging · doi:10.18632/aging.100431 · Cited by 192

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

Rajbhandari, P., Thomas, B. J., Feng, A., Hong, C., Wang, J., Vergnes, L., Sallam, T., Wang, B., Sandhu, J., Seldin, M. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.019 · Cited by 190

Immune and inflammatory pathways in NASH

Ganz, M., & Szabó, G. (2013) · Hepatology International · doi:10.1007/s12072-013-9468-6 · Cited by 195

Connecting Type 1 and Type 2 Diabetes through Innate ImmunityPreprint

Odegaard, J. I., & Chawla, A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007724 · Cited by 188

Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: systematic review and meta-analysis

Rocha, A. L. L., Faria, L. C., Guimarães, T. C. M., Moreira, G. V., Cândido, A. L., Couto, C. A., & dos Reis, F. M. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0708-9 · Cited by 190

Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

Jayaraman, A., & Pike, C. J. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0476-2 · Cited by 185

Melatonin alleviates adipose inflammation through elevating α‐ketoglutarate and diverting adipose‐derived exosomes to macrophages in mice

Liu, Z., Gan, L., Zhang, T., Ren, Q., & Sun, C. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12455 · Cited by 186

Metaflammation in obesity and its therapeutic targeting

Schleh, M. W., Caslin, H. L., Garcia, J. N., Mashayekhi, M., Srivastava, G., Bradley, A. B., & Hasty, A. H. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf9382 · Cited by 200

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

Traba, J., Kwarteng-Siaw, M., Okoli, T. C., Li, J., Huffstutler, R. D., Bray, A., Waclawiw, M. A., Han, K., Pelletier, M., Sauve, A. A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83260 · Cited by 180

Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions

Hirabara, S. M., Gorjão, R., Vinolo, M. A. R., Rodrigues, A. C., Nachbar, R. T., & Curi, R. (2012) · BioMed Research International · doi:10.1155/2012/379024 · Cited by 180

MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling

Yi, J.-S., Park, J. S., Ham, Y., Nguyen, N. T. B., Lee, N.-R., Hong, J. H., Kim, B.-W., Lee, H., Lee, C. S., Jeong, B., et al. (2013) · Nature Communications · doi:10.1038/ncomms3354 · Cited by 179

Kaempferol reduces obesity, prevents intestinal inflammation, and modulates gut microbiota in high-fat diet mice

Bian, Y., Lei, J., Zhong, J., Wang, B., Wan, Y., Li, J., Liao, C., He, Y., Liu, Z., Ito, K., et al. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108840 · Cited by 175

Chronic disease risk among adults with cerebral palsy: the role of premature sarcopoenia, obesity and sedentary behaviour

Peterson, M. D., Gordon, P. M., & Hurvitz, E. A. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01052.x · Cited by 185

Digging deeper into obesity

Ahima, R. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58719 · Cited by 180

The innate immune response during liver inflammation and metabolic disease

Bieghs, V., & Trautwein, C. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.04.005 · Cited by 176

Galectin-3 Deficiency Accelerates High-Fat Diet–Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic Islets

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Role of taurine in the pathogenesis of obesity

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