Cited by 184T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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Control of inflammation by integration of environmental cues by regulatory T cells

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Chaudhry, Ashutosh, Rudensky, Alexander Y.·2013·Journal of Clinical Investigation

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Abstract

Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.

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Richer, W. (2021) · theses.fr (ABES) · doi:10.70675/97f429e9z2993z4b78z88dezf46fae0d3a30
Overcoming the challenges of Treg therapy in type 1 <?A3B2 pi129?>diabetes: Insights from recent research
Ye, C. H. E. N., Liu, L., & ZHENG, S.-G. (2026) · Shengming kexue · doi:10.3724/cbls.2026076

Authors: Chaudhry, A., & Rudensky, A. Y.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
ORCID: Chaudhry, Ashutosh
Rudensky, Alexander Y.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2013-03-01
Volume: 123
Issue: 3
Pages: 939-944
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci57175
PMC: PMC3582113
OpenAlex: W2053418050
Cited by: 183
References: 56
Citations by year: 2026: 3 · 2025: 10 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 18 · 2020: 16 · 2019: 10 · 2018: 12 · 2017: 21 · 2016: 22 · 2015: 23 · 2014: 17 · 2013: 10
FWCI: 2.09
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Cancer Research Institute
Memorial Sloan-Kettering Cancer Center
National Institutes of Health (10021)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: regulatory T cells, inflammation control, environmental cues, Treg homeostasis, Treg migration, immunosuppression, commensal microorganisms, self-tolerance
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Inflammation, Cytokines, Inflammation Mediators, T-Lymphocytes, Regulatory, STAT Transcription Factors

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Control of inflammation by integration of environmental cues by regulatory T cells

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