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Control of inflammation by integration of environmental cues by regulatory T cells
Open accessAbstract
Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.
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“STAT3 and Foxp3 appear to coregulate IL10 in T-regs”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Chaudhry and Rudensky, 2013
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Metadata
- Authors
- Chaudhry, A., & Rudensky, A. Y.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2013-03-01
- Volume
- 123
- Issue
- 3
- Pages
- 939-944
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3582113
- OpenAlex
- W2053418050
- Cited by
- 183
- References
- 56
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 18 · 2020: 16 · 2019: 10 · 2018: 12 · 2017: 21 · 2016: 22 · 2015: 23 · 2014: 17 · 2013: 10
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Cancer Research Institute
- Memorial Sloan-Kettering Cancer Center
- National Institutes of Health (10021)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- regulatory T cells, inflammation control, environmental cues, Treg homeostasis, Treg migration, immunosuppression, commensal microorganisms, self-tolerance
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Humans, Inflammation, Cytokines, Inflammation Mediators, T-Lymphocytes, Regulatory, STAT Transcription Factors
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