Cited by 184T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Control of inflammation by integration of environmental cues by regulatory T cells

Open access

Chaudhry, Ashutosh, Rudensky, Alexander Y.·2013·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci57175

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Self-citation
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
IL-17 and th17 cells
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
How regulatory T cells work
Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
The regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738

Show all 56 references

Research works printed but not linked: 1

Ma, 2008, J Clin Invest., 118, 597

Sorted by citations

Inflammation and tumor progression: signaling pathways and targeted intervention
Zhao, H., Wu, L., Yan, G., Chen, Y., Zhou, M., Wu, Y., & Li, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00658-5 · Cited by 3,058
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298
Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation
Bernardo, M. E., & Fibbe, W. E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.006 · Cited by 1,423
IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
Munn, D. H., & Mellor, A. L. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.002 · Cited by 1,081
STAT3 signaling in immunity
Hillmer, E. J., Zhang, H., Li, H. S., & Watowich, S. S. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.05.001 · Cited by 740
Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer
Plitas, G., Konopacki, C., Wu, K., Bos, P. D., Morrow, M., Putintseva, E. V., Chudakov, D. M., & Rudensky, A. Y. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.032 · Cited by 695
Self-citation
The spectrum of inflammatory responses
Medzhitov, R. (2021) · Science · doi:10.1126/science.abi5200 · Cited by 718
Immunity, inflammation, and cancer: an eternal fight between good and evil
Shalapour, S., & Karin, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80007 · Cited by 713
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
Wang, H., Franco, F., Tsui, Y.-C., Xie, X., Trefny, M. P., Zappasodi, R., Mohmood, S. R., Fernández-García, J., Tsai, C.-H., Schulze, I., et al. (2020) · Nature Immunology · doi:10.1038/s41590-019-0589-5 · Cited by 694
Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity
Overacre-Delgoffe, A. E., Chikina, M., Dadey, R. E., Yano, H., Brunazzi, E. A., Shayan, G., Horne, W., Moskovitz, J. M., Kolls, J. K., Sander, C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.005 · Cited by 627
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells
Vasanthakumar, A., Moro, K., Xin, A., Liao, Y., Gloury, R., Kawamoto, S., Fagarasan, S., Mielke, L. A., Afshar‐Sterle, S., Masters, S. L., et al. (2015) · Nature Immunology · doi:10.1038/ni.3085 · Cited by 568
Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation
Molofsky, A. B., Gool, F. V., Liang, H.-E., Dyken, S. J. V., Nussbaum, J. C., Lee, J., Bluestone, J. A., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.019 · Cited by 451
Homeostatic control of regulatory T cell diversity
Liston, A., & Gray, D. H. D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3605 · Cited by 437
Human regulatory B cells in health and disease: therapeutic potential
Mauri, C., & Menon, M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci85113 · Cited by 429
Regulatory T cells in cardiovascular diseases
Meng, X., Yang, J., Dong, M., Zhang, K., Tu, E., Gao, Q., Chen, W., Zhang, C., & Zhang, Y. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.169 · Cited by 416
Roles of Porphyromonas gingivalis and its virulence factors in periodontitis
Xu, W., Zhou, W., Wang, H., & Liang, S. (2020) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.12.001 · Cited by 423
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy
Li, X., Shao, C., Shi, Y., & Han, W. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0578-4 · Cited by 389
Qualitative differences in T‐cell activation by dendritic cell‐derived extracellular vesicle subtypes
Tkach, M., Kowal, J., Zucchetti, A. E., Enserink, L. N. F. L., Jouve, M. J., Lankar, D., Saitakis, M., Jaular, L. M., & Théry, C. (2017) · The EMBO Journal · doi:10.15252/embj.201696003 · Cited by 392
Regulation of Adaptive Immunity; The Role of Interleukin-10
Ng, T. H. S., Britton, G. J., Hill, E. V., Verhagen, J., Burton, B. R., & Wraith, D. C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00129 · Cited by 364
IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity
Oft, M. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0214 · Cited by 322
Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314
“…et al., 2011) through histone acetyl transferase-1/FoxP3-mediated epigenetic modification of the IL-10 promoter (Chaudhry et al., 2009, 2011; Chaudhry and Rudensky, 2013), thus maintaining the ability of Foxp31 Tregs to inhibit inflammatory Th17 cells (Chaudhry et al., 2009, 2011; Chaudhry…”
BackgroundInfluential
Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues
Thome, J. J. C., Bickham, K. L., Ohmura, Y., Kubota, M., Matsuoka, N., Gordon, C., Granot, T., Griesemer, A., Lerner, H., Kato, T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4008 · Cited by 305
Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity
Yadav, M., Stephan, S. R., & Bluestone, J. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00232 · Cited by 286
T cell senescence and CAR-T cell exhaustion in hematological malignancies
Kasakovski, D., Xu, L., & Li, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0629-x · Cited by 282
Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy
Roy, S., Bag, A. K., Singh, R. K., Talmadge, J. E., Batra, S. K., & Datta, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01228 · Cited by 248
Regulatory T cells in autoimmune neuroinflammation
Kleinewietfeld, M., & Hafler, D. A. (2014) · Immunological Reviews · doi:10.1111/imr.12169 · Cited by 238
Progress and perspectives of short‐chain fatty acids in aquaculture
Tran, N. T., Li, Z., Wang, S., Zheng, H., Aweya, J. J., Wen, X., & Li, S. (2018) · Reviews in Aquaculture · doi:10.1111/raq.12317 · Cited by 218
Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function
Saxena, A., Dobaczewski, M. P., Rai, V., Haque, Z. K., Chen, W., Li, N., & Frangogiannis, N. G. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00328.2014 · Cited by 220
Treating Atherosclerosis With Regulatory T Cells
Foks, A. C., Lichtman, A. H., & Kuiper, J. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303568 · Cited by 203
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
Gómez‐Rodríguez, J., Wohlfert, E. A., Handon, R., Meylan, F., Wu, J. Z., Anderson, S. M., Kirby, M., Belkaid, Y., & Schwartzberg, P. L. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131459 · Cited by 186
The PTEN pathway in T regs is a critical driver of the suppressive tumor microenvironment
Sharma, M. D., Shinde, R. S., McGaha, T. L., Huang, L., Holmgaard, R., Wolchok, J. D., Mautino, M. R., Celis, E., Sharpe, A. H., Francisco, L., et al. (2015) · Science Advances · doi:10.1126/sciadv.1500845 · Cited by 178
FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration
Castiglioni, A., Corna, G., Rigamonti, E., Basso, V., Vezzoli, M., Monno, A., Almada, A. E., Mondino, A., Wagers, A. J., Manfredi, A. A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128094 · Cited by 176
Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis
Benzon, B., Zhao, S. G., Haffner, M. C., Takhar, M. M., Erho, N., Yousefi, K., Hurley, P. J., Bishop, J. L., Tosoian, J. J., Ghabili, K., et al. (2016) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2016.49 · Cited by 169
Ways to Enhance Lymphocyte Trafficking into Tumors and Fitness of Tumor Infiltrating Lymphocytes
Bellone, M., & Calcinotto, A. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00231 · Cited by 167
The Environment of Regulatory T Cell Biology: Cytokines, Metabolites, and the Microbiome
Hoeppli, R. E., Wu, D., Cook, L., & Levings, M. K. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00061 · Cited by 162
Lymph node – an organ for T‐cell activation and pathogen defense
Gasteiger, G., Ataide, M. A., & Kastenmüller, W. (2016) · Immunological Reviews · doi:10.1111/imr.12399 · Cited by 155
Amniotic Membrane Mesenchymal Cells-Derived Factors Skew T Cell Polarization Toward Treg and Downregulate Th1 and Th17 Cells Subsets
Pianta, S., Signoroni, P. B., Muradore, I., Rodrigues, M. F., Rossi, D., Silini, A. R., & Parolini, O. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-014-9558-4 · Cited by 138
Paracrine co-delivery of TGF-β and IL-2 using CD4-targeted nanoparticles for induction and maintenance of regulatory T cells
McHugh, M. D., Park, J. Y., Uhrich, R., Gao, W., Horwitz, D. A., & Fahmy, T. M. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.003 · Cited by 124
Organ-Specific and Memory Treg Cells: Specificity, Development, Function, and Maintenance
Gratz, I. K., & Campbell, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00333 · Cited by 123
Tissue regeneration: The crosstalk between mesenchymal stem cells and immune response
Qi, K., Li, N., Zhang, Z., & Melino, G. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.11.010 · Cited by 122
Interleukin-10 in cancer immunotherapy: from bench to bedside
Salkeni, M. A., & Naing, A. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.05.003 · Cited by 123
Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells
Pandiyan, P., & Zhu, J. (2015) · Cytokine · doi:10.1016/j.cyto.2015.07.005 · Cited by 124
Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8
Stockis, J., Liénart, S., Colau, D., Collignon, A., Nishimura, S. L., Sheppard, D., Coulie, P. G., & Lucas, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710680114 · Cited by 111
Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
de, M. M., Kumar, R., Rivera, F. D. L., Amante, F. H., Sheel, M., Faleiro, R. J., Bunn, P. T., Best, S. E., Beattie, L., Ng, S. S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.015 · Cited by 102
Insights into the biology and therapeutic implications of TNF and regulatory T cells
Salomon, B. L. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00639-6 · Cited by 106
Physical exercise modulates the homeostasis of human regulatory T cells
Weinhold, M., Shimabukuro‐Vornhagen, A., Franke, A., Theurich, S., Wahl, P., Hallek, M. J., Schmidt, A., Schinköthe, T., Mester, J., von Bergwelt‐Baildon, M., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.035 · Cited by 102
IL-17A-Producing Foxp3+Regulatory T Cells and Human Diseases
Jung, M. K., Kwak, J.-E., & Shin, E. (2017) · Immune Network · doi:10.4110/in.2017.17.5.276 · Cited by 104
S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3
Priceman, S. J., Shen, S., Wang, L., Deng, J., Yue, C., Kujawski, M., & Yu, H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.016 · Cited by 99
Cytokine-based Cancer Immunotherapy: Challenges and Opportunities for IL-10
Rallis, K. S., Corrigan, A. E., Dadah, H., George, A. M., Keshwara, S. M., Sideris, M. C., & Szabados, B. E. (2021) · Anticancer Research · doi:10.21873/anticanres.15110 · Cited by 91
CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN
Paust, H., Riedel, J.-H., Krebs, C. F., Turner, J., Brix, S. R., Krohn, S., Velden, J., Wiech, T., Kaffke, A., Peters, A., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015020203 · Cited by 91
MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions
Gkountidi, A. O., Garnier, L., Dubrot, J., Angelillo, J., Harlé, G., Brighouse, D., Wrobel, L. J., Pick, R., Scheiermann, C., Swartz, M. A., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0784 · Cited by 90
Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity
Wang, S., Gao, X., Shen, G., Wang, W., Li, J., Zhao, J., Wei, Y.-Q., & Edwards, C. K. (2016) · Scientific Reports · doi:10.1038/srep24249 · Cited by 91
Cytokines: Can Cancer Get the Message?
Morris, R. M., Mortimer, T. O., & O'Neill, K. L. (2022) · Cancers · doi:10.3390/cancers14092178 · Cited by 96
Regulatory T cells in ischemic stroke
Wang, H.-Y., Ye, J.-R., Cui, L.-Y., Chu, S.-F., & Chen, N.-H. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00641-4 · Cited by 17
Peripheral and Thymic Foxp3+ Regulatory T Cells in Search of Origin, Distinction, and Function
Dhamne, C. A., Chung, Y., Alousi, A. M., Cooper, L. J. N., & Tran, D. Q. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00253 · Cited by 81
Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice
Chen, Y., Li, C., Weng, D., Song, L., Tang, W., Dai, W., Yu, Y., Liu, F., Zhao, M., Lu, C., et al. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.11.012 · Cited by 75
Validation of Predictors of Disease Severity and Outcomes in COVID-19 Patients: A Descriptive and Retrospective Study
Tan, L., Kang, X., Ji, X., Li, G., Wang, Q. M., Li, Y., Wang, Q., & Miao, H. (2020) · Med · doi:10.1016/j.medj.2020.05.002 · Cited by 73
Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells
Ogawa, C., Bankoti, R., Nguyen, T., Hassanzadeh‐Kiabi, N., Nadeau, S., Porritt, R. A., Couse, M., Fan, X., Dhall, D., Eberl, G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.016 · Cited by 73
Immune regulation and cytotoxic T cell activation of IL-10 agonists – Preclinical and clinical experience
Oft, M. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101325 · Cited by 71
Harnessing FOXP3+ regulatory T cells for transplantation tolerance
Waldmann, H., Hilbrands, R., Howie, D., & Cobbold, S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67226 · Cited by 69
Regulatory T cells are expanded by Teriparatide treatment in humans and mediate intermittent PTH‐induced bone anabolism in mice
Yu, M., D’Amelio, P., Tyagi, A. M., Vaccaro, C., Li, J., Hsu, E., Buondonno, I., Sassi, F., Adams, J., Weitzmann, M. N., et al. (2017) · EMBO Reports · doi:10.15252/embr.201744421 · Cited by 70
Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease
Wang, L., Hu, Y. W., Song, B., Xiong, Y., Wang, J., & Chen, D. (2021) · Inflammation Research · doi:10.1007/s00011-021-01482-x · Cited by 68
Regulation of regulatory T cells in cancer
Stockis, J., Roychoudhuri, R., & Halim, T. Y. F. (2019) · Immunology · doi:10.1111/imm.13064 · Cited by 68
Inflammation indices in association with periodontitis and cancer
Walther, K., Gröger, S., Vogler, J. A. H., Wöstmann, B., & Meyle, J. (2024) · Periodontology 2000 · doi:10.1111/prd.12612 · Cited by 65
Regulatory T Cells: From Discovery to AutoimmunityPreprint
Kitz, A., Singer, E. R., & Hafler, D. A. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029041 · Cited by 71
Specificity of regulatory T cells that modulate vascular inflammation
Franco, A., Touma, R., Song, Y., Shimizu, C., Tremoulet, A. H., Kanegaye, J. T., & Burns, J. C. (2014) · Autoimmunity · doi:10.3109/08916934.2013.860524 · Cited by 62
Prenatal Acetaminophen Affects Maternal Immune and Endocrine Adaptation to Pregnancy, Induces Placental Damage, and Impairs Fetal Development in Mice
Thiele, K., Solano, M. E., Huber, S., Flavell, R. A., Keßler, T., Barikbin, R., Jung, R., Karimi, K., Tiegs, G., & Arck, P. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.06.019 · Cited by 59
Characterization of Blimp-1 function in effector regulatory T cells
Cretney, E., Leung, P. S., Trezise, S., Newman, D. M., Rankin, L. C., Teh, C. E., Putoczki, T. L., Gray, D. H. D., Belz, G. T., Mielke, L. A., et al. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.04.003 · Cited by 55
Re‐wiring regulatory cell networks in immunity by galectin–glycan interactions
Blidner, A. G., Méndez‐Huergo, S. P., Cagnoni, A. J., & Rabinovich, G. A. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.08.037 · Cited by 57
The pleiotropic role of interleukin-17 in atherosclerosis
Allam, G. A., Abdel‐Moneim, A., & Gaber, A. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.110 · Cited by 57
Late Engagement of CD86 after Influenza Virus Clearance Promotes Recovery in a FoxP3+ Regulatory T Cell Dependent Manner
Moser, E. K., Hufford, M. M., & Braciale, T. J. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004315 · Cited by 60
Association between Porphyromonas Gingivalis and systemic diseases: Focus on T cells-mediated adaptive immunity
Li, C., Yu, R., & Ding, Y. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1026457 · Cited by 55
Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4
Glatigny, S., Duhen, R., Arbelaez, C. A., Kumari, S., & Bettelli, E. (2015) · Scientific Reports · doi:10.1038/srep07834 · Cited by 54
Dendritic cells and adipose tissue
Rajan, S. S., & Longhi, M. P. (2016) · Immunology · doi:10.1111/imm.12653 · Cited by 53
Tregitope: Immunomodulation Powerhouse
Cousens, L. P., Najafian, N., Martin, W. D., & Groot, A. S. D. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.10.012 · Cited by 49
TLR-2 Signaling Promotes IL-17A Production in CD4+CD25+Foxp3+ Regulatory Cells during Oropharyngeal Candidiasis
Bhaskaran, N., Cohen, S., Zhang, Y., Weinberg, A., & Pandiyan, P. (2015) · Pathogens · doi:10.3390/pathogens4010090 · Cited by 49
Mesenchymal Stem Cells Modulate the Immune System in Developing Therapeutic Interventions
Rawat, S. J., Gupta, S., & Mohanty, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80772 · Cited by 50
Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation
Pandiyan, P., Younes, S., Ribeiro, S. P., Talla, A., McDonald, D. J., Bhaskaran, N., Levine, A. D., Weinberg, A., & Sékaly, R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00228 · Cited by 47
Mechanism and potential predictive biomarkers of immune checkpoint inhibitors in NSCLC
Qu, J., Jiang, M., Wang, L., Zhao, D., Qin, K., Wang, Y., Tao, J., & Zhang, X. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109996 · Cited by 46
Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs
Wienke, J., Brouwers, L., van der Burg, L. M., Mokrý, M., Scholman, R. C., Nikkels, P. G. J., van Rijn, B. B., & van Wijk, F. (2020) · JCI Insight · doi:10.1172/jci.insight.137926 · Cited by 43
Development and Function of Effector Regulatory T Cells
Teh, P. P., Vasanthakumar, A., & Kallies, A. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.08.005 · Cited by 42
TCR tuning of T cell subsets
Cho, J., & Sprent, J. (2018) · Immunological Reviews · doi:10.1111/imr.12646 · Cited by 48
ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice
Deng, T., Suo, C., Chang, J., Yang, R., Li, J., Cai, T., & Qiu, J. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0200-x · Cited by 44
Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function
Akimova, T., Levine, M. H., Beier, U. H., & Hancock, W. W. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3139-2_4 · Cited by 43
Immune Response Activation and Immunomodulation
Tyagi, R. K., & Bisen, P. S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.73708 · Cited by 44
IDO, PTEN-expressing Tregs and control of antigen-presentation in the murine tumor microenvironment
Munn, D. H., Sharma, M. D., Johnson, T. S., & Rodrı́guez, P. C. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-2010-2 · Cited by 45
Restoring Host-Microbe Homeostasis via Selective Chemoattraction of Tregs
Garlet, G. P., Sfeir, C. S., & Little, S. R. (2014) · Journal of Dental Research · doi:10.1177/0022034514544300 · Cited by 42
Stat3 Is Important for Follicular Regulatory T Cell Differentiation
Wu, H., Xie, M. M., Liu, H., & Dent, A. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155040 · Cited by 45
Estrogen regulates sex-specific localization of regulatory T cells in adipose tissue of obese female mice
Ishikawa, A., Wada, T., Nishimura, S., Ito, T., Okekawa, A., Onogi, Y., Watanabe, E., Sameshima, A., Tanaka, T., Tsuneki, H., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230885 · Cited by 41
Regulatory T cells (Tregs) in lymphoid malignancies and the impact of novel therapies
Maharaj, K. K., Uriepero, A., Sahakian, E., & Pinilla-Ibarz, J. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943354 · Cited by 41
Insights into the tumor microenvironment of B cell lymphoma
Ng, W. L., Ansell, S. M., & Mondello, P. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02579-9 · Cited by 41
Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma
Pinheiro, D., Chang, Y., Bryant, H., Szladovits, B., Dalessandri, T., Davison, L. J., Yallop, E., Mills, E., Leo, C., Lara‐Garcia, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105027 · Cited by 35
CD4+T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes
Krebs, C. F., & Steinmetz, O. M. (2016) · Mediators of Inflammation · doi:10.1155/2016/5393894 · Cited by 35
Generation of Human Breg-Like Phenotype with Regulatory Function In Vitro with Bacteria-Derived Oligodeoxynucleotides
Gallego-Valle, J., Pérez-Fernández, V. A., Correa‐Rocha, R., & Pion, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061737 · Cited by 34
Synergistic Interaction of Low Salinity Stress With Vibrio Infection Causes Mass Mortalities in the Oyster by Inducing Host Microflora Imbalance and Immune Dysregulation
Li, X., Yang, B., Shi, C., Wang, H., Yu, R., Li, Q., & Liu, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.859975 · Cited by 37
Th17 and regulatory T cells in patients with different time of progression of type 2 diabetes mellitus
Guzmán‐Flores, J. M., Ramı́rez-Emiliano, J., Pérez‐Vázquez, V., & López-Briones, S. (2020) · Central European Journal of Immunology · doi:10.5114/ceji.2020.94670 · Cited by 32
Chemo-Immunotherapy: Role of Indoleamine 2,3-Dioxygenase in Defining Immunogenic Versus Tolerogenic Cell Death in the Tumor Microenvironment
Johnson, T. S., McGaha, T. L., & Munn, D. H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-67577-0_7 · Cited by 32
CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion
Correa‐Rocha, R., López‐Abente, J., Gutiérrez, C., Pérez-Fernández, V. A., Prieto-Sánchez, A., Moreno, S., Muñoz‐Fernández, M. Á., & Pion, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203419 · Cited by 31
Identification and functional analysis of heterogeneous FOXP3+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma
Yi, G., Guo, S., Liu, W., Wang, H., Liu, R., Tsun, A., Jin, G. Y., & Li, B. (2018) · 中国科学通报：英文版 · doi:10.1016/j.scib.2018.05.028 · Cited by 29
IFNγ Signaling Endows DCs with the Capacity to Control Type I Inflammation during Parasitic Infection through Promoting T-bet+ Regulatory T Cells
Lee, H., Fleige, A., Forman, R. A., Cho, S., Khan, A. A., Lin, L.-L., Nguyen, D. T., Hall, A. O., Yin, Z., Hunter, C. A., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004635 · Cited by 30

Authors: Chaudhry, A., & Rudensky, A. Y.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
ORCID: Chaudhry, Ashutosh
Rudensky, Alexander Y.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2013-03-01
Volume: 123
Issue: 3
Pages: 939-944
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci57175
PMC: PMC3582113
OpenAlex: W2053418050
Cited by: 183
References: 56
Citations by year: 2026: 3 · 2025: 10 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 18 · 2020: 16 · 2019: 10 · 2018: 12 · 2017: 21 · 2016: 22 · 2015: 23 · 2014: 17 · 2013: 10
FWCI: 2.09
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Cancer Research Institute
Memorial Sloan-Kettering Cancer Center
National Institutes of Health (10021)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: regulatory T cells, inflammation control, environmental cues, Treg homeostasis, Treg migration, immunosuppression, commensal microorganisms, self-tolerance
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Inflammation, Cytokines, Inflammation Mediators, T-Lymphocytes, Regulatory, STAT Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Control of inflammation by integration of environmental cues by regulatory T cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks