Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Myocardial Reperfusion Injury

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Prognostic Significance of Microvascular Obstruction by Magnetic Resonance Imaging in Patients With Acute Myocardial Infarction

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Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

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Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction.

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Knockdown of KLF11 attenuates hypoxia/reoxygenation injury via JAK2/STAT3 signaling in H9c2

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Effect of Sodium Thiosulfate Postconditioning on Ischemia-Reperfusion Injury Induced Mitochondrial Dysfunction in Rat Heart

Ravindran, S., & Kurian, G. A. (2018) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-018-9808-y · Cited by 22

Size-Dependent Ability of Liposomes to Accumulate in the Ischemic Myocardium and Protect the Heart

Mukhamadiyarov, R. А., Сенокосова, Е. А., Сергеевич, К. С., Voevoda, D. V., Pyshnaya, I. A., Ivanov, V. V., Lewis, M., & Халиулин, И. Г. (2018) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000606 · Cited by 22

Gastrodin Protects Cardiomyocytes from Anoxia/Reoxygenation Injury by 14‐3‐3η

Zhu, M., Deng, W., Di, S., Qin, M., Liu, D., & Yi, B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3685391 · Cited by 22

Na/K-ATPase Signaling and Cardiac Pre/Postconditioning with Cardiotonic Steroids

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Ebselen protects rat hearts against myocardial ischemia‑reperfusion injury

Cheng, B., Zhong, J., Fu-xia, W., Li, G., Ruan, Q., Luo, G., & Jiang, H. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.7089 · Cited by 22

Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia–reperfusion injury

Alakoski, T., Ulvila, J., Yrjölä, R., Vainio, L., Magga, J. M., Szabó, Z., Licht, J. D., & Kerkelä, R. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-018-0713-y · Cited by 22

Stromal cell-derived factor-1α signals via the endothelium to protect the heart against ischaemia-reperfusion injury

Bromage, D. I., Taferner, S., He, Z., Ziff, O. J., Yellon, D. M., & Davidson, S. M. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.02.002 · Cited by 22

Evaluation of the antioxidant activities of fatty polyhydroquinolines synthesized by Hantzsch multicomponent reactions

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Evaluating Novel Targets of Ischemia Reperfusion Injury in Pig Models

Baehr, A., Klymiuk, N., & Kupatt, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194749 · Cited by 22

The critical roles of protein quality control systems in the pathogenesis of heart failure

Maejima, Y. (2019) · Journal of Cardiology · doi:10.1016/j.jjcc.2019.09.019 · Cited by 23

MicroRNA-206 Protects against Myocardial Ischaemia-Reperfusion Injury in Rats by Targeting Gadd45β.

Zhai, C., Qian, Q., Tang, G., Han, B., Hu, H., Yin, D., Pan, H., & Zhang, S. (2017) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2017.0164 · Cited by 22

miR‑155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling

Xi, J., Li, Q., Li, B., & Li, N. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.10924 · Cited by 22

Inflammation in myocardial injury- Stem cells as potential immunomodulators for myocardial regeneration and restoration

Vadivel, S., Vincent, P., Sekaran, S., Ambi, S. V., Muralidar, S., Vimalraj, S., Palaniappan, B., & Diraviyam, T. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117582 · Cited by 22

Protective effect of dimethyl fumarate on oxidative damage and signaling in cardiomyocytes

Kuang, Y., Zhang, Y., Xiao, Z., Xu, L., Wang, P., & Ma, Q. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11342 · Cited by 22

MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling

Wan, X., Yao, B.-F., Ma, Y., Liu, Y., Tang, Y., Hu, J., Li, M., Fu, S., Zheng, X., & Yin, D. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.07.009 · Cited by 22

Postpartum haemorrhage requiring transfusion and risk of cardiovascular disease later in life: a retrospective cohort study

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iPLA2β Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury

Jin, T., Lin, J., Gong, Y., Bi, X., Hu, S., Lv, Q., Chen, J., Li, X., Chen, J., Zhang, W., et al. (2021) · Cells · doi:10.3390/cells10061446 · Cited by 22

The Effect of MicroRNA-375 Overexpression, an Inhibitor of Helicobacter pylori-Induced Carcinogenesis, on lncRNA SOX2OT

Shafiee, M., Aleyasin, A., Mowla, S. J., Vasei, M., & Yazdanparast, S. A. (2016) · Jundishapur Journal of Microbiology · doi:10.5812/jjm.23464 · Cited by 22

Comparative metabonomics of Wenxin Keli and Verapamil reveals differential roles of gluconeogenesis and fatty acid β-oxidation in myocardial injury protection

Jiang, M., Wang, Q., Chen, J., Wang, Y., Fan, G., & Zhu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-09547-w · Cited by 22

Long noncoding RNA TALNEC2 regulates myocardial ischemic injury in H9c2 cells by regulating miR‐21/PDCD4‐medited activation of Wnt/β‐catenin pathway

Lin, H., Wang, J., & Liu, N. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28562 · Cited by 22

Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole

Martinez, C. S., Zheng, A., & Xiao, Q. (2024) · Antioxidants · doi:10.3390/antiox13111330 · Cited by 26

The main active components of Prunella vulgaris L. alleviate myocardial ischemia-reperfusion injury by inhibiting oxidative stress and ferroptosis via the NRF2/GPX4 pathway

Leng, L., Li, P., Liu, R., Francis, O. B., Song, S., Sui, Y., Yang, Y., Wang, Y., Sun, X., Miao, R., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119630 · Cited by 21

Shenxiong Yixin Decoction polysaccharides exert therapeutic effects against myocardial ischemia-reperfusion injury via intestinal exosomal microRNA-21 regulation

De-sheng, X., Wang, Y., Li, Z.-R., Mo, P., Chen, M., Zhao, R., Fan, Z., Mo, W.-J., Li, Q. Y., Pi, F.-C., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107725 · Cited by 21

Macrophage Polarization in Myocardial Ischemia‒Reperfusion Injury: Pathophysiology and Therapeutic Targets

Liu, G., Dai, Y., Fu, C.-Y., Lv, X., Qin, J., & Xie, J. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s516001 · Cited by 22

Myocardial Ischemia–Reperfusion Injury—Mechanistic Insights and Novel Therapeutics

Han, D.-Y., Ahn, H., & Park, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052106 · Cited by 23

Protection from Reperfusion Injury with Intracoronary N-Acetylcysteine in Patients with STEMI Undergoing Primary Percutaneous Coronary Intervention in a Cardiac Tertiary Center

Nozari, Y., Eshraghi, A., Talasaz, A. H., Bahremand, M., Salamzadeh, J., Salarifar, M., Pourhosseini, H., Jalali, A., & Mortazavi, S. H. (2018) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-017-0258-8 · Cited by 21

Development of a model of ischemic heart disease using cardiomyocytes differentiated from human induced pluripotent stem cells

Wei, H., Wang, C., Guo, R., Takahashi, K., & Naruse, K. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.09.119 · Cited by 21

Effect of sequential nicorandil on myocardial microcirculation and short-term prognosis in acute myocardial infarction patients undergoing coronary intervention

Pi, S., Liu, Y., Li, T., Wang, Y., Zhou, Q., Liu, B.-J., Peng, W., Li, X., Wang, Y., & Huang, L. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.02.23 · Cited by 21

TRIM27 protects against cardiac ischemia-reperfusion injury by suppression of apoptosis and inflammation via negatively regulating p53

Li, Y., Qing Zhuang, M. E. N. G., Wang, L., & Cui, Y. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.03.061 · Cited by 21

A novel Danshensu/tetramethylpyrazine protects against Myocardial Ischemia Reperfusion Injury in rats

Wang, J., Fan, K., He, C., Wang, Q., Zhang, Q., & Huang, W. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.59411 · Cited by 21

Extracorporeal Cardiac Shock Wave-Induced Exosome Derived From Endothelial Colony-Forming Cells Carrying miR-140-3p Alleviate Cardiomyocyte Hypoxia/Reoxygenation Injury via the PTEN/PI3K/AKT Pathway

Yang, D., Wang, M., Zhao, H., Ma, Y., Shi, Y., Cao, X., Guo, T., Cai, H., & Cai, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.779936 · Cited by 21

Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury

Jin, A., Zhang, Q., Cheng, H., Yang, C., & Wang, X. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108740 · Cited by 21

Effects of Dexmedetomidine Administered Through Different Routes on Kidney Tissue in Rats with Spinal Cord Ischaemia–Reperfusion Injury

Şengel, N., Köksal, Z., Dursun, A. D., Kurtipek, Ö., Sezen, Ş. C., Arslan, M., & Kavutçu, M. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s361618 · Cited by 21

Pathways for Cardioprotection in Perspective: Focus on Remote Conditioning and Extracellular Vesicles

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MST1: A future novel target for cardiac diseases

Shao, Y., Wang, Y., Sun, L., Zhou, S., Xu, J., & Xing, D. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124296 · Cited by 21

Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway

Qin, Y., Shi, Y., Yu, Q., Yang, S., Wang, Y., Dai, X., Li, G., & Cheng, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114761 · Cited by 22

CaMKII, ‘jack of all trades’ in inflammation during cardiac ischemia/reperfusion injury

Zhang, W., Dong, E., Zhang, J., & Zhang, Y. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.10.003 · Cited by 21

Effect of traditional Chinese medicine on metabolism disturbance in ischemic heart diseases

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Progress of organoid platform in cardiovascular research

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TGF-β improves myocardial function and prevents apoptosis induced by anoxia–reoxygenation, through the reduction of endoplasmic reticulum stress

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Controlled Reperfusion Strategies Improve Cardiac Hemodynamic Recovery after Warm Global Ischemia in an Isolated, Working Rat Heart Model of Donation after Circulatory Death (DCD)

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Intracoronary hypothermia for acute myocardial infarction in the isolated beating pig heart.

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Umbelliferone Alleviates Myocardial Ischemia: the Role of Inflammation and Apoptosis

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Molecular mechanism and therapy application of necrosis during myocardial injury

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Proteomics Research on the Protective Effect of Mangiferin on H9C2 Cell Injury Induced by H2O2

Guan, W., Liu, Y., Liu, Y., Wang, Q., Ye, H.-L., Cheng, Y., Kuang, H., Jiang, X., & Yang, B. (2019) · Molecules · doi:10.3390/molecules24101911 · Cited by 22

Effect of Telmisartan in the Oxidative Stress Components Induced by Ischemia Reperfusion in Rats

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Cortical bone-derived stem cell therapy reduces apoptosis after myocardial infarction

Hobby, A. R. H., Sharp, T. E., Berretta, R. M., Borghetti, G., Feldsott, E. A., Mohsin, S., & Houser, S. R. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00144.2019 · Cited by 21

Low n-6/n-3 PUFA ratio improves inflammation and myocardial ischemic reperfusion injury

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Synthesis and biological evaluation of panaxatriol derivatives against myocardial ischemia/reperfusion injury in the rat

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Attenuation of the Na/K‑ATPase/Src/ROS amplification signaling pathway by astaxanthin ameliorates myocardial cell oxidative stress injury

Qu, X., Zhang, Z., Hu, W., Lou, M., Zhai, B., Mei, S., Hu, Z.-H., Zhang, L., Liu, D., Liu, Z., et al. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11613 · Cited by 21

CircRbms1 knockdown alleviates hypoxia-induced cardiomyocyte injury via regulating the miR-742-3p/FOXO1 axis

Лю, Б., & Guo, K. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00330-y · Cited by 21

Mesenchymal stromal cells improve cardiac function and left ventricular remodeling in a heart transplantation model

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Oleuropein Protects Cardiomyocyte against Apoptosis via Activating the Reperfusion Injury Salvage Kinase Pathway In Vitro

Zhao, Q., Bai, Y., Li, C., Yang, K., Wei, W., Li, Z., Li, P., Li, X., & Zhang, X. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/2109018 · Cited by 21

Fenofibrate protects against acute myocardial I/R injury in rat by suppressing mitochondrial apoptosis as decreasing cleaved caspase-9 activation

Zhao, Q. C., Cui, Z., Zheng, Y., Li, Q., Xu, C., Sheng, X., Tao, M., & Xu, H. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170572 · Cited by 21

Bisoprolol protects myocardium cells against ischemia/reperfusion injury by attenuating unfolded protein response in rats

Zhang, C., He, S., Li, Y., Li, F., Liu, Z., Liu, J., & Gong, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-12366-8 · Cited by 21

Endoplasmic reticulum stress-induced apoptosis: A possible role in myocardial ischemia–reperfusion injury

Wu, H., Ye, M., Yang, J., & Ding, J. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.01.119 · Cited by 21

Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches

Zhou, X., Wang, H., Yan, B., Nie, X., Chen, Q., Yang, X., Lei, M., Guo, X., Ouyang, C., & Ren, Z. (2024) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-024-07642-5 · Cited by 21

Metabolic Adaptations and Therapies in Cardiac Hypoxia

Li, H., Xiao, F., Zhou, C., Zhu, T., & Wang, S. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.12.008 · Cited by 20

Downregulated microRNA‐330 suppresses left ventricular remodeling via the TGF‐β1/Smad3 signaling pathway by targeting SRY in mice with myocardial ischemia–reperfusion injury

Liu, Z., Pan, H., Cao, Y., Zheng, J., Zhang, Y., Tang, Y., He, J., Hu, Y., Wang, C., Zou, Q., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27800 · Cited by 20

Identification of lncRNA and mRNA expression profiles in rat spinal cords at various time‑points following cardiac ischemia/reperfusion

Wang, Q., Li, Z., Li, Y., He, Z., Chen, Y., Feng, M., Li, S., Wu, D., & Xiang, H. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4151 · Cited by 20

Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1

Li, W., Jin, S., Hao, J., Shi, Y., Li, W., & Jiang, L. (2021) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0180 · Cited by 20

Therapeutic hypothermia for acute myocardial infarction: a narrative review of evidence from animal and clinical studies

Jung, K. T., Bapat, A. C., Kim, Y., Hucker, W. J., & Lee, K. (2022) · Korean Journal of Anesthesiology · doi:10.4097/kja.22156 · Cited by 20

The mechanism by which miR-494-3p regulates PGC1-α-mediated inhibition of mitophagy in cardiomyocytes and alleviation of myocardial ischemia—reperfusion injury

Mu, N., Zhang, T., Zhu, Y., Lu, B., Zheng, Q., & Duan, J. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03226-7 · Cited by 20

Heart Disease and Ageing: The Roles of Senescence, Mitochondria, and Telomerase in Cardiovascular Disease

Booth, L. K., Redgrave, R. E., Tual‐Chalot, S., Spyridopoulos, I., Phillips, H. M., & Richardson, G. D. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_4 · Cited by 20

Early long-term low-dosage colchicine and major adverse cardiovascular events in patients with acute myocardial infarction: a systematic review and meta-analysis

Zhou, Y., Liu, Y., Zeng, R., Qiu, W., Zhao, Y., & Zhou, Y. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1194605 · Cited by 20

Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

Yang, S., Chen, H., Su, W. C., Luo, Y., Liao, J., Wang, Y., Xiong, L., Zhang, C., Li, F., Chen, Z., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1297124 · Cited by 20

Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice

Khang, A. R., Kim, D. H., Kim, M., Oh, C. J., Jeon, J., Choi, S. H., & Lee, I. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0196 · Cited by 20

Puerarin-Loaded Liposomes Co-Modified by Ischemic Myocardium-Targeting Peptide and Triphenylphosphonium Cations Ameliorate Myocardial Ischemia-Reperfusion Injury

Wang, Y., Li, F., Wei, S., Li, W., Wu, J., Li, S., Hu, X.-B., Tang, T., & Liu, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s468394 · Cited by 20

Ginsenoside Rb1 prevents hypoxia-reoxygenation-induced apoptosis in H9c2 cardiomyocytes via an estrogen receptor-dependent crosstalk among the Akt, JNK, and ERK 1/2 pathways using a label-free quantitative proteomics analysis

Ai, Q., Sun, G., Luo, Y., Dong, X., Hu, R., Meng, X., & Sun, X. (2015) · RSC Advances · doi:10.1039/c5ra02432c · Cited by 20

Cardiomyocyte Ca2+dynamics: clinical perspectives

Aronsen, J. M., Louch, W. E., & Sjaastad, I. (2016) · Scandinavian Cardiovascular Journal · doi:10.3109/14017431.2015.1136079 · Cited by 20

Modulating endoplasmic reticulum stress to alleviate myocardial ischemia and reperfusion injury from basic research to clinical practice: A long way to go

Wu, H., Ye, M., Yang, J., & Ding, J. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.08.266 · Cited by 20

Dang Gui Bu Xue Tang ameliorates coronary artery ligation-induced myocardial ischemia in rats

Ma, C., Hongyan, L., Weina, Z., He, X., Zhang, Y., & Jie, R. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.079 · Cited by 20

MicroRNA-15a inhibition protects against hypoxia/reoxygenation-induced apoptosis of cardiomyocytes by targeting mothers against decapentaplegic homolog 7

Yang, Y., Ding, S., Xu, G., Chen, F., & Ding, F. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6466 · Cited by 20

Effects of microRNA-292-5p on myocardial ischemia–reperfusion injury through the peroxisome proliferator-activated receptor-α/-γ signaling pathway

Zhu, Z., Ye, J., Niu, H., Ma, Y., Fu, X., Xia, Z., & Zhang, X. (2018) · Gene Therapy · doi:10.1038/s41434-018-0014-y · Cited by 20

The role of sphingosine 1 phosphate in coronary artery disease and ischemia reperfusion injury

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