Cited by 2,357Cardiac Ischemia and ReperfusionAcute Myocardial Infarction ResearchCardiac Fibrosis and Remodeling

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Myocardial ischemia-reperfusion injury: a neglected therapeutic target

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Hausenloy, Derek J., Yellon, Derek M.·2013·Journal of Clinical Investigation

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Abstract

Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI.

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Myocardial Reperfusion Injury
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Authors: Hausenloy, D. J., & Yellon, D. M.
Affiliations: University College London (GB)
Corresponding author: Yellon, Derek M.
ORCID: Hausenloy, Derek J.
Yellon, Derek M.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2013-01-02
Volume: 123
Issue: 1
Pages: 92-100
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci62874
PMC: PMC3533275
OpenAlex: W2051395985
Cited by: 2,357
References: 115
Citations by year: 2026: 176 · 2025: 177 · 2024: 226 · 2023: 218 · 2022: 236 · 2021: 231 · 2020: 240 · 2019: 226 · 2018: 172 · 2017: 124 · 2016: 130 · 2015: 101 · 2014: 69 · 2013: 28
FWCI: 16.07
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institute for Health and Care Research (NF-SI-0510-10164)
British Heart Foundation (RG/03/007, RG/08/015/26411, FS/06/023)
University College London
Medical Research Council (MR/K002066/1)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: myocardial ischemia-reperfusion injury, acute myocardial infarction, cardiomyocyte death, primary percutaneous coronary intervention, thrombolysis, therapeutic target, cardioprotection
MeSH terms: Animals, Humans, Myocardial Infarction, Myocardial Reperfusion Injury, Thrombolytic Therapy, Cell Death, Myocytes, Cardiac, Percutaneous Coronary Intervention

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Myocardial ischemia-reperfusion injury: a neglected therapeutic target

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