Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Myocardial Reperfusion Injury

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Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning

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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

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Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion.

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Myocardial reperfusion: a double-edged sword?

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Prognostic Significance of Microvascular Obstruction by Magnetic Resonance Imaging in Patients With Acute Myocardial Infarction

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Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

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Direct measurement of free radical generation following reperfusion of ischemic myocardium.

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Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction.

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Research advances and challenges in tissue-derived extracellular vesicles

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Cardioplegia in Open Heart Surgery: Age Matters

Bradić, J., Andjic, M. M., Novakovic, J. N., Jeremic, N. S., & Jakovljevic, V. L. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041698 · Cited by 26

Cardioprotective effect of curcumin on myocardial ischemia/reperfusion injury: a meta-analysis of preclinical animal studies

Zeng, Y., Guo, Q., Wei, X., Chen, S., Sheng, D., Liu, J., Yin, N., Liu, Y., & Zeng, W. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1184292 · Cited by 26

The Role of P53 in Myocardial Ischemia-Reperfusion Injury

Zhu, X.-Z., Qiu, Z., Lei, S., Leng, Y., Li, W., & Xia, Z. (2023) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-023-07480-x · Cited by 26

Disruption of TAB1/p38α Interaction Using a Cell-permeable Peptide Limits Myocardial Ischemia/Reperfusion Injury

Wang, Q., Feng, J., Wang, J., Zhang, X., Zhang, D., Zhu, T., Wang, W., Wang, X., Jin, J., Cao, J., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.90 · Cited by 26

The Role of Antioxidation and Immunomodulation in Postnatal Multipotent Stem Cell-Mediated Cardiac Repair

Saparov, A., Chen, C.-W., Beckman, S., Wang, Y., & Huard, J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816258 · Cited by 26

BLT1 antagonist LSN2792613 reduces infarct size in a mouse model of myocardial ischaemia–reperfusion injury

de Hoog, V. C., Bovens, S. M., de Jager, S. C. A., van Middelaar, B. J., van Duijvenvoorde, A., Doevendans, P. A., Pasterkamp, G., de Kleijn, D. P. V., & Timmers, L. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv224 · Cited by 26

Troponin I-Interacting Protein Kinase

Lal, H., Ahmad, F., Parikh, S. S., & Force, T. L. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0543 · Cited by 26

Activation of transient receptor potential vanilloid 1 protects the heart against apoptosis in ischemia/reperfusion injury through upregulating the PI3K/Akt signaling pathway

Jiang, X., Liu, G., Lei, H., Li, Z., Feng, Q., & Huang, W. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3338 · Cited by 26

Microglia mediated neuroinflammation - signaling regulation and therapeutic considerations with special reference to some natural compounds.

Yao, Y. Y., Ling, E., & Lü, D. (2020) · PubMed · doi:10.14670/hh-18-239 · Cited by 26

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules

Nagata, T., Yasukawa, H., Kyogoku, S., Oba, T., Takahashi, J., Nohara, S., Minami, T., Mawatari, K., Sugi, Y., Shimozono, K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127942 · Cited by 27

Effect of dapagliflozin on ferroptosis through the gut microbiota metabolite TMAO during myocardial ischemia–reperfusion injury in diabetes mellitus rats

Wang, L., Wang, Y., Xu, H., & Li, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-64909-5 · Cited by 25

Molecular and Cellular Mechanisms of Myocardial Ischemia and Reperfusion Injury: A Narrative Review

Juričić, S., Klac, J., Stojkovic, S. M., Beleslin, B., Tesic, M. B., Jovanović, I., Banovic, M. D., Petrovic, O. M., Aleksandric, S. B., Vasic, N., et al. (2026) · Cells · doi:10.3390/cells15030265 · Cited by 25

Optimising cardioprotection during myocardial ischaemia: targeting potential intracellular pathways with glucagon-like peptide-1

Clarke, S. J., McCormick, L. M., & Dutka, D. P. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-12 · Cited by 25

Over-expression of JAZF1 promotes cardiac microvascular endothelial cell proliferation and angiogenesis via activation of the Akt signaling pathway in rats with myocardial ischemia-reperfusion

Shang, J., Gao, Z., Zhang, L., & Wang, C. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1629774 · Cited by 25

Cooling as an Adjunctive Therapy to Percutaneous Intervention in Acute Myocardial Infarction: COOL-MI InCor Trial

Dallan, L. A. P., Giannetti, N. S., Rochitte, C. E., Polastri, T. F., Martin, C. Y. B. S., Hajjar, L. A., Lima, F. G., Nicolau, J. C., de Oliveira, M. T., Dae, M. W., et al. (2020) · Therapeutic Hypothermia and Temperature Management · doi:10.1089/ther.2020.0018 · Cited by 25

Propofol-induced MiR-20b expression initiates endogenous cellular signal changes mitigating hypoxia/re-oxygenation-induced endothelial autophagy in vitro

Lu, Y., Wang, S., Cai, S., Gu, X., Wang, J., Yang, Y., Hu, Z., Zhang, X.-H., Ye, Y., Shen, S., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02828-9 · Cited by 25

Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury

Wang, W., Wang, B., Sun, S., Cao, S., Zhai, X., Zhang, C., Zhang, Q., Yuan, Q., Sun, Y., Xue, M., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16328 · Cited by 25

Effects of Therapeutic Hypothermia on Normal and Ischemic Heart

Yamada, K. P., Kariya, T., Aikawa, T., & Ishikawa, K. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.642843 · Cited by 25

Function and Mechanism of Trimetazidine in Myocardial Infarction-Induced Myocardial Energy Metabolism Disorder Through the SIRT1–AMPK Pathway

Luo, X., Zhong, Z., Chong, A.-G., Zhang, W., & Wu, X.-D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.645041 · Cited by 25

Recent progress of nanomedicine in secreted phospholipase A2 as a potential therapeutic target

Shi, D., Feng, C., Xie, J., Zhang, X., Dai, H., & Yan, L. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00608a · Cited by 25

Heme-induced contractile dysfunction in Human cardiomyocytes caused by oxidant damage to thick filament proteins

Contreras, G. A., Jeney, V., Tóth, A., Csősz, É., Kalló, G., Huynh, A. T., Hajnal, C., Kalász, J., Pásztor, E. T., Edes, I. F., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.158 · Cited by 25

A Food and Drug Administration–Approved Antiviral Agent that Inhibits Adenylyl Cyclase Type 5 Protects the Ischemic Heart Even When Administered after Reperfusion

Bravo, C., Vatner, D. E., Pachon, R. E., Zhang, J., & Vatner, S. F. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.232538 · Cited by 25

PINK1 alleviates myocardial hypoxia-reoxygenation injury by ameliorating mitochondrial dysfunction

Li, Y., Qiu, L., Liu, X., Hou, Z., & Yu, B. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.061 · Cited by 25

The cardioprotective effects of (-)-Epicatechin are mediated through arginase activity inhibition in a murine model of ischemia/reperfusion

Ortiz-Vilchis, P., Ortíz-Flores, M., Pacheco, M., Ramírez‐Sánchez, I., Moreno‐Ulloa, A., Vega, L., Ortiz, A., Villarreal, F. J., Rubio‐Gayosso, I., Nájera, N., et al. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.11.007 · Cited by 25

Protective effect of celastrol on myocardial ischemia–reperfusion injury

Li, X. (2017) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2017.7866 · Cited by 25

Functional regulation of large conductance Ca2+-activated K+ channels in vascular diseases

Zhu, Y., Ye, P., Chen, S., & Zhang, D. (2018) · Metabolism · doi:10.1016/j.metabol.2018.01.008 · Cited by 25

Intermittent hypoxia-generated ROS contributes to intracellular zinc regulation that limits ischemia/reperfusion injury in adult rat cardiomyocyte

Lien, C., Lee, W., Wang, I.-C., Chen, T.-I., Chen, T.-L., & Yang, K. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.03.014 · Cited by 25

Clinical associations of microvascular obstruction and intramyocardial hemorrhage on cardiovascular magnetic resonance in patients with acute ST segment elevation myocardial infarction (STEMI)

Ma, M., Diao, K., Yang, Z.-G., Zhu, Y., Guo, Y., Yang, M., Zhang, Y., & He, Y. (2018) · Medicine · doi:10.1097/md.0000000000011617 · Cited by 25

Inhibition of TRAF3 expression alleviates cardiac ischemia reperfusion (IR) injury: A mechanism involving in apoptosis, inflammation and oxidative stress

Liu, X., Zhang, L., Qin, H., Han, X., Zhang, Z., Zhang, Z., Qin, S., & Niu, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.058 · Cited by 25

Ginkgolide B for Myocardial Ischemia/Reperfusion Injury: A Preclinical Systematic Review and Meta-Analysis

Zhu, P.-C., Tong, Q., Zhuang, Z., Wang, Z.-H., Deng, L.-H., Zheng, G., & Wang, Y. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01292 · Cited by 25

Endothelial Cell Activation in an Embolic Ischemia-Reperfusion Injury Microfluidic Model

Amar, D. N., Epshtein, M., & Korin, N. (2019) · Micromachines · doi:10.3390/mi10120857 · Cited by 25

Protective mechanisms of hydrogen sulfide in myocardial ischemia

Chen, Y., Zhang, F., Yin, J., Wu, S., & Zhou, X. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29761 · Cited by 25

Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury

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The role of lactate metabolism and lactylation in pulmonary arterial hypertension

Peng, T.-Y., Lu, J., Zheng, X.-L., Zeng, C. C., & He, Y. (2025) · Respiratory Research · doi:10.1186/s12931-025-03163-3 · Cited by 24

JAK/STAT pathway in myocardial infarction: Crossroads of immune signaling and cardiac remodeling

Yang, Q., Ji, H., & Chahardehi, A. M. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.08.018 · Cited by 24

Sappanone A alleviates hypoxia/reoxygenation-induced cardiomyocytes injury through inhibition of mitochondrial apoptosis and activation of PI3K–Akt–Gsk-3β pathway

Shi, X., Tao, G., Ji, L., & Tian, G. (2020) · Bioscience Reports · doi:10.1042/bsr20192442 · Cited by 24

Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties

Li, X., Zheng, S., Tan, W., Chen, H., Li, X., Wu, J., Luo, T., Ren, X., Pyle, W. G., Wang, L., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00228 · Cited by 24

Rno-microRNA-30c-5p promotes myocardial ischemia reperfusion injury in rats through activating NF-κB pathway and targeting SIRT1

Chen, J., Zhang, M., Zhang, S., Wu, J., & Xue, S. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01520-2 · Cited by 24

The Antioxidant Selenoprotein T Mimetic, PSELT, Induces Preconditioning-like Myocardial Protection by Relieving Endoplasmic-Reticulum Stress

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Preventing ischemia-reperfusion injury by acousto-mechanical local oxygen delivery

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Energy substrate metabolism, mitochondrial structure and oxidative stress after cardiac ischemia-reperfusion in mice lacking UCP3

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Pharmaceutical Therapies for Necroptosis in Myocardial Ischemia–Reperfusion Injury

Zhang, Y., Zhang, Y., Zang, J., Li, Y., & Wu, X. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10070303 · Cited by 24

Effects of apocynin, an NADPH oxidase inhibitor, on levels of ADMA, MPO, iNOS and TLR4 induced by myocardial ischemia reperfusion

Uysal, A., Şahna, E., Ozguler, I., Burma, O., & İlhan, N. (2014) · Perfusion · doi:10.1177/0267659114559260 · Cited by 24

Relaxin’ the Heart

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Modeling oxygen requirements in ischemic cardiomyocytes

McDougal, A. D., & Dewey, C. F. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.751826 · Cited by 24

Platelets activation is associated with elevated plasma mitochondrial DNA during cardiopulmonary bypass

Qin, C., Gu, J., Hu, J., Qian, H., Xu, F., Li, Y., Liu, R., & Meng, W. (2016) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-016-0481-4 · Cited by 24

Metabolic profiling of hypoxia/reoxygenation injury in H9c2 cells reveals the accumulation of phytosphingosine and the vital role of Dan-Shen in Xin-Ke-Shu

Sun, L., Jia, H., Ma, L.-Y., Yu, M., Yang, Y., Liu, Y., Zhang, H., & Zou, Z. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.06.026 · Cited by 24

Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection

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Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury

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The Guizhi Gancao Decoction Attenuates Myocardial Ischemia-Reperfusion Injury by Suppressing Inflammation and Cardiomyocyte Apoptosis

Gao, Y., Song, G., Cao, Y., Yan, K., Li, B., Zhu, X.-F., Wang, Y., Xing, Z., Cui, L., Wang, X., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/1947465 · Cited by 25

MiR‐183‐5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1

Lin, D., Cui, B., Ma, J., & Ren, J. (2019) · BioFactors · doi:10.1002/biof.1571 · Cited by 24

Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury

Olmedo, I., Pino, G., Riquelme, J. A., Aránguiz, P., Díaz‐Vesga, M. C., López‐Crisosto, C., Lavandero, S., Donoso, P., Pedrozo, Z., & Sánchez, G. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165659 · Cited by 24

Isovaleroylbinankadsurin A Ameliorates Cardiac Ischemia/Reperfusion Injury Through Activating GR Dependent RISK Signaling

Zuo, Y.-H., Liu, Y., Cheng, C., Yang, Y., Xie, Y., Luo, P., Wang, W., & Zhou, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104897 · Cited by 24

Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133

Zhu, Y., Zou, C., Jia, Y., Zhang, H., Ma, X., & Zhang, J. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1814025 · Cited by 24

Donor heart preservation with hypoxic-conditioned medium-derived from bone marrow mesenchymal stem cells improves cardiac function in a heart transplantation model

Zhou, P., Liu, H., Liu, X., Ling, X., Xiao, Z., Zhu, P., Zhu, Y., Lu, J., & Zheng, S. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02114-7 · Cited by 24

Dexmedetomidine alleviates myocardial ischemia/reperfusion-induced injury and Ca2+ overload via the microRNA-346-3p/CaMKIId axis

Zheng, X., Li, J., Fan, Q., Zhao, X., & Chen, K. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.03.016 · Cited by 24

Cardiac Response to Oxidative Stress Induced by Mitochondrial Dysfunction

Kim, H. K., Nilius, B., Kim, N., Ko, K. S., Rhee, B. D., & Han, J. (2016) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2015_5004 · Cited by 26

circMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis

Yin, L., Li, L., Gao, M., Qi, Y., Xu, L., & Peng, J. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103175 · Cited by 23

Left Ventricular Unloading in Anterior ST-Segment Elevation Myocardial Infarction Without Shock

Kapur, N. K., Mangner, N., Aghili, N., Faraz, H. A., McElwee, S., Nazir, R. A., Chieffo, A., Jolly, S. S., Bieniarz, M. C., Cuculi, F., et al. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2026.03.071 · Cited by 23

Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia–reperfusion injury by 3′,4′-dihydroxyflavonol

Thomas, C. J., Lim, N. R., Kedikaetswe, A., Yeap, Y. Y. C., Woodman, O. L., Ng, D. C. H., & May, C. N. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.054 · Cited by 23

The Potential for Nanotechnology to Improve Delivery of Therapy to the Acute Ischemic Heart

Evans, C. W., Iyer, K. S., & Hool, L. C. (2016) · Nanomedicine · doi:10.2217/nnm.16.7 · Cited by 23

Exogenous ubiquitin reduces inflammatory response and preserves myocardial function 3 days post-ischemia-reperfusion injury

Scofield, S. L. C., Dalal, S., Lim, K. A., Thrasher, P. R., Daniels, C. R., Peterson, J. M., Singh, M., & Singh, K. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00654.2018 · Cited by 23

Effects of metformin on the heart with ischaemia-reperfusion injury: Evidence of its benefits from in vitro, in vivo and clinical reports

Higgins, L., Palee, S., Chattipakorn, S. C., & Chattipakorn, N. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172489 · Cited by 24

Clinical Applicability of Conditioning Techniques in Ischemia-Reperfusion Injury: A Review of the Literature

Kumar, K., Singh, N., Jaggi, A. S., & Маслов, Л. Н. (2020) · Current Cardiology Reviews · doi:10.2174/1573403x16999200817170619 · Cited by 23

Brazilin prevents against myocardial ischemia-reperfusion injury through the modulation of Nrf2 via the PKC signaling pathway

Qi, B., Zhang, X., Yu, H., Bao, Y., Wu, N., & Jia, D. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-4414 · Cited by 23

Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia–Reperfusion Injury by Enhancing Mitophagy

Hong, T., Zhou, Y., Li, P., Wu, X., Li, Y., Li, Y., & Zhao, Y. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.043 · Cited by 23

Anthracycline-induced cardiotoxicity and senescence

Booth, L. K., Redgrave, R. E., Folaranmi, O., Gill, J. H., & Richardson, G. D. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.1058435 · Cited by 25

Effect of tanshinone IIA for myocardial ischemia/reperfusion injury in animal model: preclinical evidence and possible mechanisms

Zhu, P.-C., Shen, J., Qian, R.-Y., Xu, J., Liu, C., Hu, W., Zhang, Y., & Lv, L.-C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1165212 · Cited by 23

Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans

Tian, Y., Li, H., Liu, P., Xu, J., Irwin, M. G., Xia, Z., & Guogang, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/819232 · Cited by 23

Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation

Su, H.-H., Chu, Y., Liao, J.-M., Wang, Y.-H., Jan, M., Lin, C.-W., Wu, C.-Y., Tseng, C., Yen, J., & Huang, S.-S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00175 · Cited by 23

Survival kinase-dependent pathways contribute to gender difference in the response to myocardial ischemia–reperfusion and ischemic post-conditioning

Pardo, A. C., Scuri, S. R., Arbeláez, L. F. G., Caldiz, C. I., Fantinelli, J. C., & Mosca, S. M. (2017) · Cardiovascular Pathology · doi:10.1016/j.carpath.2017.12.003 · Cited by 23

Preconditioning the rat heart with sodium thiosulfate preserved the mitochondria in response to ischemia-reperfusion injury

Ravindran, S., & Kurian, G. A. (2019) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-019-09794-8 · Cited by 23

Pre‑treatment with a combination of Shenmai and Danshen injection protects cardiomyocytes against hypoxia/reoxygenation‑ and H2O2‑induced injury by inhibiting mitochondrial permeability transition pore opening

Li, L., Sha, Z., Wang, Y., Yang, D., Li, J., Duan, Z., Wang, H., & Li, Y. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7462 · Cited by 23

Exogenous supplemental NAD+ protect myocardium against myocardial ischemic/reperfusion injury in swine model.

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The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion

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