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Myocardial ischemia-reperfusion injury: a neglected therapeutic target
Open accessAbstract
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI.
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“In cases such as myocardial IR, nano drug delivery vehicles accumulate in the injured tissue due to inflammation-mediated increased vascular permeability.160”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [160]
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Metadata
- Authors
- Hausenloy, D. J., & Yellon, D. M.
- Affiliations
- University College London (GB)
- Corresponding author
- Yellon, Derek M.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-01-02
- Volume
- 123
- Issue
- 1
- Pages
- 92-100
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3533275
- OpenAlex
- W2051395985
- Cited by
- 2,357
- References
- 115
- Citations by year
- 2026: 176 · 2025: 177 · 2024: 226 · 2023: 218 · 2022: 236 · 2021: 231 · 2020: 240 · 2019: 226 · 2018: 172 · 2017: 124 · 2016: 130 · 2015: 101 · 2014: 69 · 2013: 28
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0510-10164)
- British Heart Foundation (RG/03/007, RG/08/015/26411, FS/06/023)
- University College London
- Medical Research Council (MR/K002066/1)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- myocardial ischemia-reperfusion injury, acute myocardial infarction, cardiomyocyte death, primary percutaneous coronary intervention, thrombolysis, therapeutic target, cardioprotection
- MeSH terms
- Animals, Humans, Myocardial Infarction, Myocardial Reperfusion Injury, Thrombolytic Therapy, Cell Death, Myocytes, Cardiac, Percutaneous Coronary Intervention
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