Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Myocardial Reperfusion Injury

Yellon, D. M., & Hausenloy, D. J. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071667 · Cited by 3,797

Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning

Zhao, Z., Corvera, J. S., Halkos, M. E., Kerendi, F., Wang, N.-P., Guyton, R. A., & Vinten‐Johansen, J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01064.2002 · Cited by 2,073

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Stefani, D. D., Raffaello, A., Teardo, E., Szabó, I., & Rizzuto, R. (2011) · Nature · doi:10.1038/nature10230 · Cited by 1,957

The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.

Reimer, K. A., Lowe, J. E., Rasmussen, M. M., & Jennings, R. B. (1977) · Circulation · doi:10.1161/01.cir.56.5.786 · Cited by 1,944

Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion.

Przyklenk, K., Bauer, B., Ovize, M., Kloner, R. A., & Whittaker, P. (1993) · Circulation · doi:10.1161/01.cir.87.3.893 · Cited by 1,379

Myocardial reperfusion: a double-edged sword?

D, E. B. M., & Kloner, R. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112160 · Cited by 1,368

Prognostic Significance of Microvascular Obstruction by Magnetic Resonance Imaging in Patients With Acute Myocardial Infarction

Wu, K. C., Zerhouni, E. A., Judd, R. M., Lugo-Olivieri, C. H., Barouch, L. A., Schulman, S. P., Blumenthal, R. S., & Lima, J. A. C. (1998) · Circulation · doi:10.1161/01.cir.97.8.765 · Cited by 1,356

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

Piot, C. A., Croisille, P., Staat, P., Thibault, H., Rioufol, G., Mewton, N., Belghiti, R. E., Cung, T. T., Bonnefoy‐Cudraz, E., Angoulvant, D., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa071142 · Cited by 1,339

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

Zweier, J. L., Flaherty, J. T., & Weisfeldt, M. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1404 · Cited by 1,189

Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction.

Ito, H., Tomooka, T., Sakai, N., Yu, H., Higashino, Y., Fujii, K., Masuyama, T., Kitabatake, A., & Minamino, T. (1992) · Circulation · doi:10.1161/01.cir.85.5.1699 · Cited by 1,052

Irisin attenuates myocardial ischemia/reperfusion‐induced cardiac dysfunction by regulating ER‐mitochondria interaction through a mitochondrial ubiquitin ligase‐dependent mechanism

Lu, L., Ma, J., Tang, J., Yang, L., Zheng, Q., Chen, S., Gao, E., Ren, J. T., Yang, L., & Yang, J. Z. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.166 · Cited by 84

Comprehensive review of ST-segment elevation myocardial infarction: Understanding pathophysiology, diagnostic strategies, and current treatment approaches

Elendu, C., Amaechi, D. C., Elendu, T. C., Omeludike, E., Alakwe-Ojimba, C. E., Obidigbo, B. T., Akpovona, O. L., Sucari, Y. P. O., Saggi, S. K., Dang, K., et al. (2023) · Medicine · doi:10.1097/md.0000000000035687 · Cited by 92

Vitexin attenuates myocardial ischemia/reperfusion injury in rats by regulating mitochondrial dysfunction induced by mitochondrial dynamics imbalance

Wei, X., Wang, X., Tang, H. Y., Sun, F., Zhu, H., Huang, D., & Dong, L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109849 · Cited by 82

miR-429 regulates the transition between hypoxia-inducible factor (HIF)1A and HIF3A expression in human endothelial cells

Janaszak-Jasiecka, A., Bartoszewska, S., Kochan, K., Piotrowski, A., Kalinowski, L., Kamysz, W., Ochocka, R. J., Bartoszewski, R., & Collawn, J. F. (2016) · Scientific Reports · doi:10.1038/srep22775 · Cited by 81

Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive

Kohlhauer, M., Pell, V. R., Burger, N., Spiroski, A., Gruszczyk, A. V., Mulvey, J. F., Mottahedin, A., Costa, A. S. H., Frezza, C., Ghaleh, B., et al. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0727-0 · Cited by 81

Role of Platelet Activation and Oxidative Stress in the Evolution of Myocardial Infarction

Eduardo Fuentes, Q., Moore‐Carrasco, R., Paes, A. M. D. A., & Trostchansky, A. (2019) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248419861437 · Cited by 81

Current state and future perspective of cardiovascular medicines derived from natural products

Zhao, C., Li, S., Zhang, J., Huang, Y., Zhang, L., Zhao, F., Du, X., Hou, J., Zhang, T., Shi, C.-J., et al. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107698 · Cited by 80

Microengineered platforms for characterizing the contractile function of in vitro cardiac models

Dou, W., Malhi, M., Zhao, Q., Wang, L., Huang, Z., Law, J., Liu, N., Simmons, C. A., Maynes, J. T., & Sun, Y. (2022) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00344-0 · Cited by 83

The cardioprotective effect of dihydromyricetin prevents ischemia–reperfusion-induced apoptosis in vivo and in vitro via the PI3K/Akt and HIF-1α signaling pathways

Liu, S., Ai, Q., Feng, K., Li, Y., & Liu, X. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1306-6 · Cited by 79

The lncRNA H19/miR-675 axis regulates myocardial ischemic and reperfusion injury by targeting PPARα

Luo, H., Wang, J., Liu, D., Zang, S., Ma, N., Zhao, L., Zhang, L., Zhang, X., & Qiao, C. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.11.011 · Cited by 79

Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review

Xin, L., Gao, J., Lin, H., Qu, Y., Shang, C., Wang, Y., Lu, Y., & Cui, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.583200 · Cited by 80

CIRKIL Exacerbates Cardiac Ischemia/Reperfusion Injury by Interacting With Ku70

Xiao, H., Zhang, M., Wu, H., Wu, J., Hu, X., Pei, X., Li, D., Zhao, L., Hua, Q., Meng, B., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.318992 · Cited by 79

TBC1D15-Drp1 interaction-mediated mitochondrial homeostasis confers cardioprotection against myocardial ischemia/reperfusion injury

Sun, S., Yu, W., Xu, H., Li, C., Zou, R., Wu, N. N., Wang, L., Ge, J., Ren, J. T., & Zhang, Y. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155239 · Cited by 80

Novel Therapeutic Strategies to Reduce Reperfusion Injury After Acute Myocardial Infarction

Schäfer, A., König, T., Bauersachs, J. K., & Akin, M. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101398 · Cited by 80

Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction

Redgrave, R. E., Dookun, E., Booth, L. K., Camacho-Encina, M., Folaranmi, O., Tual‐Chalot, S., Gill, J. H., Owens, W. A., Spyridopoulos, I., Passos, J. F., et al. (2023) · npj Aging · doi:10.1038/s41514-023-00113-5 · Cited by 79

The unfolded protein response in ischemic heart disease

Wang, X., Xu, L., Gillette, T. G., Jiang, X., & Wang, Z. V. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.02.013 · Cited by 79

In Vitro Models of Ischemia-Reperfusion Injury

Chen, T. F., & Vunjak‐Novakovic, G. (2018) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-018-0056-0 · Cited by 82

Liraglutide directly protects cardiomyocytes against reperfusion injury possibly via modulation of intracellular calcium homeostasis.

Hu, S.-Y., Zhang, Y., Zhu, P., Zhou, H., & Chen, Y.-D. (2017) · PubMed · doi:10.11909/j.issn.1671-5411.2017.01.008 · Cited by 79

Low Density Lipoprotein Receptor-Related Protein-1 in Cardiac Inflammation and Infarct Healing

Potere, N., Buono, M. G. D., Mauro, A. G., Abbate, A., & Toldo, S. A. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00051 · Cited by 86

Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway

Bibli, S., Andreadou, I., Chatzianastasiou, A., Tzimas, C., Sanoudou, D., Kranias, E. G., Brouckaert, P., Coletta, C., Szabó, C., Kremastinos, D. T., et al. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv129 · Cited by 77

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α

Siraj, M. A., Mundil, D., Beca, S., Momen, A., Shikatani, E. A., Afroze, T., Sun, X., Liu, Y., Ghaffari, S., Lee, W. L., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci99934 · Cited by 79

Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress

Farías, J. G., Herrera, E. A., Carrasco‐Pozo, C., Sotomayor‐Zárate, R., Cruz, G., Morales, P., & Castillo, R. L. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.006 · Cited by 77

Mitochondrial Quality Control: Role in Cardiac Models of Lethal Ischemia-Reperfusion Injury

Kulek, A. R., Anzell, A. R., Wider, J. M., Sanderson, T. H., & Przyklenk, K. (2020) · Cells · doi:10.3390/cells9010214 · Cited by 78

C-Reactive Protein and Its Structural Isoforms: An Evolutionary Conserved Marker and Central Player in Inflammatory Diseases and Beyond

McFadyen, J. D., Zeller, J., Potempa, L. A., Pietersz, G. A., Eisenhardt, S. U., & Peter, K. (2020) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-41769-7_20 · Cited by 79

Myocardial‐Targeting Tannic Cerium Nanocatalyst Attenuates Ischemia/Reperfusion Injury

Wang, L., Qiu, S., Li, X., Zhang, Y., Huo, M., & Shi, J. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202305576 · Cited by 76

Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes

Huang, Z., Ye, B., Dai, Z., Wu, X., Lu, Z., Shan, P., & Huang, W. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3322 · Cited by 76

Atrial natriuretic peptide: An old hormone or a new cytokine?

Vito, P. D. (2014) · Peptides · doi:10.1016/j.peptides.2014.06.011 · Cited by 76

MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics

Tilstam, P. V., Qi, D., Leng, L., Young, L. H., & Bucala, R. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1336227 · Cited by 76

Cell-Specific Roles of NLRP3 Inflammasome in Myocardial Infarction

Takahashi, M. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000709 · Cited by 77

Melatonin and Nicotinamide Mononucleotide Attenuate Myocardial Ischemia/Reperfusion Injury via Modulation of Mitochondrial Function and Hemodynamic Parameters in Aged Rats

Hosseini, L., Vafaee, M. S., & Badalzadeh, R. (2019) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248419882002 · Cited by 76

Pharmacologic Therapy That Simulates Conditioning for Cardiac Ischemic/Reperfusion Injury

Sivaraman, V., & Yellon, D. M. (2013) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248413499973 · Cited by 75

Coronary No-Reflow after Primary Percutaneous Coronary Intervention—Current Knowledge on Pathophysiology, Diagnosis, Clinical Impact and Therapy

Ndrepepa, G., & Kastrati, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12175592 · Cited by 77

Astragaloside IV Protects Heart from Ischemia and Reperfusion Injury via Energy Regulation Mechanisms

Tu, L., Pan, C., Wei, X., Yan, L., Liu, Y., Fan, J., Mu, H., Li, Q., Li, L., Zhang, Y., et al. (2013) · Microcirculation · doi:10.1111/micc.12074 · Cited by 75

Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration

Natarajan, N., Abbas, Y., Bryant, D. M., González‐Rosa, J. M., Sharpe, M., Uygur, A., Cocco-Delgado, L. H., Ho, N., Gerard, N. P., Gerard, C. J., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.030801 · Cited by 76

Targeted pharmacotherapy for ischemia reperfusion injury in acute myocardial infarction

Rout, A., Tantry, U. S., Novaković, M., Sukhi, A., & Gurbel, P. A. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1787987 · Cited by 74

Traditional Chinese medicine and mitophagy: A novel approach for cardiovascular disease management

Wang, J., Zou, J., Shi, Y., Zeng, N., Guo, D., Wang, H., Zhao, C., Luan, F., Zhang, X., & Sun, J. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155472 · Cited by 75

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury

Zhu, L., Xu, C., Huo, X., Hao, H., Wan, Q., Chen, H., Zhang, X., BREYER, R. M., Huang, Y., Cao, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09492-4 · Cited by 74

Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study

Ong, S., Kwek, X.-Y., Katwadi, K., Hernández‐Reséndiz, S., Crespo-Avilan, G. E., Ismail, N. I., Lin, Y., Yap, E. P., Lim, S.-Y., Ja, K. P. M. M., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163972 · Cited by 74

Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat

Tang, C., Hu, Y., Gao, J., Jiang, J., Shi, S., Wang, J., Geng, Q., Liang, X., & Chai, X. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118004 · Cited by 73

Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury

Beach, T. E., Prag, H. A., Pala, L., Logan, A., Huang, M. M., Gruszczyk, A. V., Martin, J. L., Mahbubani, K. T. A., Hamed, M. O., Hosgood, S. A., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101640 · Cited by 73

Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I

Zeng, H., Wang, L., Zhang, J., Pan, T. S., Yu, Y., Lu, J., Zhou, P., Yang, H. Q., & Li, P. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.09.006 · Cited by 73

Discovery of new therapeutic redox targets for cardioprotection against ischemia/reperfusion injury and heart failure

Daiber, A., Andreadou, I., Oelze, M. W., Davidson, S. M., & Hausenloy, D. J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.026 · Cited by 75

Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases

Li, X., Liu, S., Qu, L., Chen, Y., Yuan, C., Qin, A., Liang, J., Huang, Q., Jiang, M., & Zou, W. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114018 · Cited by 73

Protective effects of crocetin pretreatment on myocardial injury in an ischemia/reperfusion rat model

Wang, Y., Sun, J., Liu, C., & Fang, C. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.052 · Cited by 73

Immune responsive resolvin D1 programs myocardial infarction‐induced cardiorenal syndrome in heart failure

Halade, G. V., Kain, V., & Serhan, C. N. (2018) · The FASEB Journal · doi:10.1096/fj.201701173rr · Cited by 73

MCUb Induction Protects the Heart From Postischemic Remodeling

Huo, J., Lü, S., Kwong, J. Q., Bround, M. J., Grimes, K. M., Sargent, M. A., Brown, M. E., Davis, M. E., Bers, D. M., & Molkentin, J. D. (2020) · Circulation Research · doi:10.1161/circresaha.119.316369 · Cited by 72

Large Animal Models of Heart Failure

Silva, K. A. S., & Emter, C. A. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.04.011 · Cited by 73

A New Therapeutic Candidate for Cardiovascular Diseases: Berberine

Cai, Y., Xin, Q., Lu, J., Yu, M., Lin, Q., Cong, W., & Chen, K. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.631100 · Cited by 74

Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation

Lei, I., Tian, S., Gao, W., Liu, L., Guo, Y., Tang, P., Chen, E., & Wang, Z. (2021) · eLife · doi:10.7554/elife.60311 · Cited by 72

Ferroptosis and its role in cardiomyopathy

Li, D., Pi, W., Sun, Z., Liu, X., & Jiang, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113279 · Cited by 72

MicroRNA-92a Inhibition Attenuates Hypoxia/Reoxygenation-Induced Myocardiocyte Apoptosis by Targeting Smad7

Zhang, B., Zhou, M., Li, C., Zhou, J., Li, H., Zhu, D., Wang, Z., Chen, A., & Zhao, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100298 · Cited by 72

Resveratrol attenuates myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B

Yang, L., Zhang, Y., Zhu, M., Zhang, Q., Wang, X., Wang, Y., Zhang, J., Li, J., Yang, L., Liu, J., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.016 · Cited by 72

Regulation of the JAK/STAT signaling pathway: The promising targets for cardiovascular disease

Pang, Q., You, L., Meng, X., Li, Y., Deng, T., Li, D., & Zhu, B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115587 · Cited by 75

Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection

Mukherjee, U., Ong, S., Ong, S., & Hausenloy, D. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.10.005 · Cited by 72

Future treatment strategies in ST-segment elevation myocardial infarction

Windecker, S., Bax, J. J., Myat, A., Stone, G. W., & Marber, M. S. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61452-x · Cited by 72

Lymphocyte Communication in Myocardial Ischemia/Reperfusion Injury

Boag, S. E., Andreano, E., & Spyridopoulos, I. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6940 · Cited by 71

Treatment with D-β-hydroxybutyrate protects heart from ischemia/reperfusion injury in mice

Yu, Y., Yu, Y., Zhang, Y., Zhang, Z., An, W., & Zhao, X. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.04.019 · Cited by 71

Intermittent Hypoxia Prevents Myocardial Mitochondrial Ca2+ Overload and Cell Death during Ischemia/Reperfusion: The Role of Reactive Oxygen Species

Chang, J.-C., Lien, C., Lee, W., Chang, H.-R., Hsu, Y., Luo, Y., Jeng, J., Hsieh, J., & Yang, K. (2019) · Cells · doi:10.3390/cells8060564 · Cited by 70

Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases

Zhang, W., Wang, T., Xue, Y., Zhan, B., Lai, Z., Huang, W., Peng, X., & Zhou, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1238789 · Cited by 70

Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H)

Boslett, J., Hemann, C., Zhao, Y. J., Lee, H.-C., & Zweier, J. L. (2017) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.239459 · Cited by 69

TAT‐dextran–mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes

Maeda, H., Kami, D., Maeda, R., Murata, Y., Jo, J., Kitani, T., Tabata, Y., Matoba, S., & Gojo, S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15120 · Cited by 70

The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury

Mata, A., & Cadenas, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111939 · Cited by 70

Ferroptosis in cardiovascular disease

Liu, G., Xie, X., Liao, W., Chen, S., Zhong, R., Qin, J., He, P., & Xie, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116057 · Cited by 69

Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization

Martindale, J. J., & Metzger, J. M. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.12.008 · Cited by 69

Modulation of signaling mechanisms in the heart by thioredoxin 1

Nagarajan, N., Oka, S., & Sadoshima, J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.020 · Cited by 69

Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages

Heimerl, M., Sieve, I., Ricke‐Hoch, M., Erschow, S., Battmer, K., Scherr, M., & Hilfiker‐Kleiner, D. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-020-00821-z · Cited by 69

PCSK9 inhibitor improves cardiac function and reduces infarct size in rats with ischaemia/reperfusion injury: Benefits beyond lipid‐lowering effects

Palee, S., McSweeney, C. M., Maneechote, C., Moisescu, D. M., Jaiwongkam, T., Kerdphoo, S., Chattipakorn, S. C., & Chattipakorn, N. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14586 · Cited by 71

From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease

Fan, X., Li, A., Yan, Z., Geng, X., Lian, L., Lv, H., Gao, D., & Zhang, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6291889 · Cited by 68

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Kell, D. B., & Pretorius, E. (2022) · Biochemical Journal · doi:10.1042/bcj20220154 · Cited by 74

The therapeutic value of bifidobacteria in cardiovascular disease

Tang, J., Wei, Y., Pi, C., Zheng, W., Zuo, Y., Shi, P., Chen, J., Xiong, L., Chen, T., Liu, H., et al. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00448-7 · Cited by 70

ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury

He, K., Yan, L., Pan, C., Liu, Y., Cui, Y., Hu, B., Chang, X., Li, Q., Sun, K., Mao, X.-W., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00259.2014 · Cited by 68

Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction

Rodrigo, R., Libuy, M., Feliú, F., & Hasson, D. (2013) · BioMed Research International · doi:10.1155/2013/437613 · Cited by 68

Induction of Autophagy by Tongxinluo Through the MEK/ERK Pathway Protects Human Cardiac Microvascular Endothelial Cells From Hypoxia/Reoxygenation Injury

Cui, H., Li, X., Li, N., Qi, K., Li, Q., Chen, J., Zhang, Q., Jiang, L., & Yang, Y. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000104 · Cited by 68

Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury

Ansari, J., Kaur, G., & Gavins, F. N. E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041211 · Cited by 68

MicroRNA-495 Ameliorates Cardiac Microvascular Endothelial Cell Injury and Inflammatory Reaction by Suppressing the NLRP3 Inflammasome Signaling Pathway

Zhou, T., Xiang, D., Li, S., Yang, L., Gao, L., & Feng, C. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493042 · Cited by 68

Cardioprotective effects of curcumin against myocardial I/R injury: A systematic review and meta-analysis of preclinical and clinical studies

Li, T., Jin, J., Pu, F., Bai, Y., Chen, Y., Li, Y., & Wang, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1111459 · Cited by 67

Inhibition of the Cardiomyocyte-Specific Kinase TNNI3K Limits Oxidative Stress, Injury, and Adverse Remodeling in the Ischemic Heart

Vagnozzi, R. J., Gatto, G. J. J., Kallander, L. S., Hoffman, N. E., Mallilankaraman, K. B., Ballard, V. L. T., Lawhorn, B. G., Stoy, P., Philp, J., Graves, A. P., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006479 · Cited by 68

Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications

Kim, S. Y., & Yang, E. (2015) · Molecules · doi:10.3390/molecules201119717 · Cited by 67

The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway

Song, Y.-F., Zhao, L., Wang, B., Sun, J., Hu, J., Zhu, X., Zhao, J., Zheng, D.-K., & Ge, Z. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.05.013 · Cited by 66

Interplay of Oxidative Stress and Necrosis-like Cell Death in Cardiac Ischemia/Reperfusion Injury: A Focus on Necroptosis

Adameová, A., Horvath, C., Abdul-Ghani, S., Varga, Z. V., Suleiman, M. S., & Dhalla, N. S. (2022) · Biomedicines · doi:10.3390/biomedicines10010127 · Cited by 67

Pretreatment with Panaxatriol Saponin Attenuates Mitochondrial Apoptosis and Oxidative Stress to Facilitate Treatment of Myocardial Ischemia‐Reperfusion Injury via the Regulation of Keap1/Nrf2 Activity

Yao, H., Xie, Q., He, Q., Zeng, L., Long, J., Gong, Y., Li, X., Li, X., Liu, W., Xu, Z., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9626703 · Cited by 66

Novel therapeutics in myocardial infarction: targeting microvascular dysfunction and reperfusion injury

Fordyce, C. B., Gersh, B. J., Stone, G. W., & Granger, C. B. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.06.004 · Cited by 66

Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI

Du, X., You, H., Li, Y., Wang, Y., Peng, H., Qiao, B., Lu, J., Zhang, W., Zhou, S., Zheng, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34245-6 · Cited by 66

Diversity and Composition of Rumen Bacteria, Fungi, and Protozoa in Goats and Sheep Living in the Same High-Altitude Pasture

Suo, L., Zhang, C., Zhang, K., Ba, G., De, J., Ciren, D., Cuoji, A., Wang, X., & Wu, Y. (2020) · Animals · doi:10.3390/ani10020186 · Cited by 67

The role of RIPK3‐regulated cell death pathways and necroptosis in the pathogenesis of cardiac ischaemia‐reperfusion injury

Luo, Y., Benjanuwattra, J., Chattipakorn, S. C., & Chattipakorn, N. (2020) · Acta Physiologica · doi:10.1111/apha.13541 · Cited by 65

Mechanisms of postischemic cardiac death and protection following myocardial injury

Mastoor, Y., Murphy, E., & Román, B. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184134 · Cited by 68

Targeting danger-associated molecular patterns after myocardial infarction

van Hout, G. P. J., Arslan, F., Pasterkamp, G., & Hoefer, I. E. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1088005 · Cited by 67

Hydrogen sulfide and cardioprotection — Mechanistic insights and clinical translatability

Salloum, F. N. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.04.004 · Cited by 65

Down‐regulation of GAS5 ameliorates myocardial ischaemia/reperfusion injury via the miR‐335/ROCK1/AKT/GSK‐3β axis

Wu, N., Zhang, X., Bao, Y., Yu, H., Jia, D., & Ma, C. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14724 · Cited by 64

Primidone blocks RIPK1-driven cell death and inflammation

Riebeling, T., Jamal, K., Wilson, R., Kolbrink, B., von Samson‐Himmelstjerna, F. A., Moerke, C., Garcia, L. R., Dahlke, E., Michels, F., Lühder, F., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00690-y · Cited by 65

Exosomal microRNA-98-5p from hypoxic bone marrow mesenchymal stem cells inhibits myocardial ischemia–reperfusion injury by reducing TLR4 and activating the PI3K/Akt signaling pathway

Zhang, L., Wei, Q., Liu, X., Zhang, T., Wang, S., Zhou, L., Zou, L., Fan, F., Chi, H., Sun, J., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107592 · Cited by 64

Empagliflozin alleviates myocardial I/R injury and cardiomyocyte apoptosis via inhibiting ER stress-induced autophagy and the PERK/ATF4/Beclin1 pathway

Wang, C.-C., Li, Y., Qian, X.-Q., Zhao, H., Wang, D., Zuo, G.-X., & Wang, K. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2064479 · Cited by 67

Exercise Alleviates Cardiovascular Diseases by Improving Mitochondrial Homeostasis

Zhang, H., Zhang, Y., Zhang, J., & Jia, D. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.124.036555 · Cited by 69

Interferon regulatory factor 9 is an essential mediator of heart dysfunction and cell death following myocardial ischemia/reperfusion injury

Zhang, Y., Liu, X., She, Z., Jiang, D.-S., Wan, N., Xia, H., Zhu, X., Xiang, W., Zhang, X., & Li, H. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0434-9 · Cited by 64

Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats

Xuan, F., Jian, J., Qin, F., & Huang, R. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s92549 · Cited by 64

Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research

Shin, H. S., Shin, H., & Shudo, Y. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.673683 · Cited by 63

Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia

Schütte, J. P., Manke, M.-C., Hemmen, K., Münzer, P., Schörg, B. F., Ramos, G. C., Pogoda, M., Dicenta, V., Hoffmann, S. H. L., Pinnecker, J., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.322459 · Cited by 66

Elatoside C protects against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on STAT3 activation

Wang, M., Meng, X., Yu, Y., Sun, G., Xu, X., Zhang, X.-P., Dong, X., Ye, J., Xu, H., Sun, Y.-F., et al. (2014) · APOPTOSIS · doi:10.1007/s10495-014-1039-3 · Cited by 63

Myocardial Reperfusion Injury as a New Frontier for Clinical Therapy

Hausenloy, D. J., Kaski, J. C., Gersh, B. J., & Yellon, D. M. (2012) · Springer eBooks · doi:10.1007/978-1-84996-019-9_1 · Cited by 3

Clinical perspectives on reperfusion injury in acute myocardial infarction.

Bainey, K., & Armstrong, P. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.01.015 · Cited by 89

Magnitude and relevance of reperfusion injury

Hausenloy, D. J. (2012) · UCL Discovery (University College London) · Cited by 8

Myocardial reperfusion injury: looking beyond primary PCI

Fröhlich, G., Meier, P., White, S. K., Yellon, D. M., & Hausenloy, D. J. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht090 · Cited by 416

Advances in Therapy for Myocardial Ischemia Reperfusion Injury

Yining, Y. (2011) · Advances in Cardiovascular Diseases