The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
Open accessAbstract
Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism. The genes encoding clock proteins are expressed throughout the brain, though it is unknown whether these proteins modulate brain homeostasis. We observed that deletion of circadian clock transcriptional activators aryl hydrocarbon receptor nuclear translocator-like (Bmal1) alone, or circadian locomotor output cycles kaput (Clock) in combination with neuronal PAS domain protein 2 (Npas2), induced severe age-dependent astrogliosis in the cortex and hippocampus. Mice lacking the clock gene repressors period circadian clock 1 (Per1) and period circadian clock 2 (Per2) had no observed astrogliosis. Bmal1 deletion caused the degeneration of synaptic terminals and impaired cortical functional connectivity, as well as neuronal oxidative damage and impaired expression of several redox defense genes. Targeted deletion of Bmal1 in neurons and glia caused similar neuropathology, despite the retention of intact circadian behavioral and sleep-wake rhythms. Reduction of Bmal1 expression promoted neuronal death in primary cultures and in mice treated with a chemical inducer of oxidative injury and striatal neurodegeneration. Our findings indicate that BMAL1 in a complex with CLOCK or NPAS2 regulates cerebral redox homeostasis and connects impaired clock gene function to neurodegeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In vivo BMAL1 deletion was found to induce activation of glial cells and degeneration of presynaptic axonal terminals.122”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [122]
In the citing paper
“Circadian rhythms have been shown to regulate redox homeostasis in the brain, and disruption of circadian genes causes neuronal oxidative damage (Musiek et al., 2013).”
From Clock Genes Control Cortical Critical Period Timing (2015) · cites this paper as Musiek et al., 2013
In the citing paper
“mice with a brain-specific Bmal1 deletion also exhibit increased astrocytosis, despite having mostly normal locomotor circadian rhythms and sleep–wake cycling (that is, relatively normal clock function in the SCN); thus, these neurodegenerative effects are probably due to loss of the local control of cellular metabolism in specific regions of the brain that is normally mediated by BMAL1, indep”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [291]
In the citing paper
“ROS accumulation is considerably higher in Bmal1−/− mice and correlates with increases in astrocytosis and levels of oxidative damage markers in the brain.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [291]
In the citing paper
“Bmal1−/− mice, which lack a functional molecular clock, show premature ageing, neurodegeneration and a reduced lifespan291.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [291]
In the citing paper
“This preclinical investigation demonstrates that components of the molecular clock control redox state and, when disrupted, lead to oxidative stress and cell death related to neurodegeneration.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [291]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., & Weitz, C. J. (1998) · Science · doi:10.1126/science.280.5369.1564 · Cited by 2,035
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R., Klein, R., & Schütz, G. (1999) · Nature Genetics · doi:10.1038/12703 · Cited by 1,841
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621
Self-citationMolecular analysis of mammalian circadian rhythms
Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444
Self-citationKondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188
Hughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087
Self-citationRudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059
Self-citationRegulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 523
Alzheimer's Disease and Sleep–Wake Disturbances: Amyloid, Astrocytes, and Animal Models
Vanderheyden, W. M., Lim, M. M., Musiek, E. S., & Gerstner, J. R. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1135-17.2017 · Cited by 64
Self-citationNi, J., Wu, Z., Meng, J., Saito, T., Saido, T. C., Qing, H., & Nakanishi, H. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1562-9 · Cited by 69
Circadian disturbances and frailty risk in older adults
Cai, R., Gao, L., Gao, C., Yu, L., Zheng, X., Bennett, D. A., Buchman, A. S., Hu, K., & Li, P. (2023) · Nature Communications · doi:10.1038/s41467-023-42727-z · Cited by 73
Licastro, E., Pignataro, G., Iliff, J. J., Xiang, Y., Lo, E. H., Hayakawa, K., & Esposito, E. (2024) · Communications Biology · doi:10.1038/s42003-024-05911-5 · Cited by 70
Fan, R., Peng, X., Xie, L., Dong, K., Ma, D., Xu, W., Shi, X., Zhang, S., Chen, J., Yu, X., et al. (2022) · Aging Cell · doi:10.1111/acel.13704 · Cited by 60
Brancaccio, M., Enoki, R., Mazuski, C. N., Jones, J. R., Evans, J. A., & Azzi, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3233-14.2014 · Cited by 67
The Hepatic Circadian Clock Modulates Xenobiotic Metabolism in Mice
DeBruyne, J. P., Weaver, D. R., & Dallmann, R. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414544740 · Cited by 62
Self-citationMood‐related central and peripheral clocks
Ketchesin, K. D., Becker‐Krail, D. D., & McClung, C. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14253 · Cited by 67
Central and peripheral circadian clocks and their role in Alzheimer's disease
Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58
“The damage to the hippocampus has been likened to accelerated ageing, likely mediated by astrogliosis and increased production of reactive oxygen species (Ali et al., 2015; Musiek et al., 2013).”
BackgroundCircadian rhythm of ischaemic core progression in human stroke
Reidler, P., Brehm, A., Sporns, P. B., Burbano, V. G., Stueckelschweiger, L., Broocks, G., Liebig, T., Psychogios, M., Ricke, J., Dimitriadis, K. A., et al. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-326072 · Cited by 60
Neural function of Bmal1: an overview
Zheng, Y., Pan, L., Wang, F., Yan, J., Wang, T., Xia, Y., Yao, L., Deng, K., Zheng, Y., Xia, X., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-022-00947-8 · Cited by 65
Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice
Barca‐Mayo, O., Boender, A. J., Armirotti, A., & Tonelli, D. D. P. (2019) · Glia · doi:10.1002/glia.23764 · Cited by 66
Premature aging of the hippocampal neurogenic niche in adult Bmal1‐ deficient mice
Ali, A. A. H., Schwarz‐Herzke, B., Stahr, A., Prozorovski, T., Aktaş, O., & von Gall, C. (2015) · Aging · doi:10.18632/aging.100764 · Cited by 59
Weissová, K., Škrabalová, J., Skálová, K., Červená, K., Bendová, Z., Miletínová, E., Kopřivová, J., Šonka, K., Dudysová, D., Bartoš, A., et al. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.07.019 · Cited by 58
Liu, D., Nanclares, C., Simbriger, K., Fang, K., Lorsung, E., Le, N., Amorim, I. S., Chalkiadaki, K., Pathak, S. S., Li, J., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01499-6 · Cited by 56
Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence
Zhang, W., Xiong, Y., Tao, R., Panayi, A. C., Mi, B., & Liu, G. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.915139 · Cited by 61
Zhao, Y., Zhang, R., Wang, Z., Chen, Z., Wang, G., Guan, S., & Lu, J. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04337 · Cited by 58
Reciprocal interactions between circadian clocks and aging
Banks, G. T., Nolan, P. M., & Peirson, S. N. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9639-6 · Cited by 60
The Glial Perspective on Sleep and Circadian Rhythms
Artiushin, G., & Sehgal, A. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-091819-094557 · Cited by 57
Aging, circadian disruption and neurodegeneration: Interesting interplay
Verma, A. K., Singh, S., & Rizvi, S. I. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2022.112076 · Cited by 55
Interacting influences of aging and Alzheimer's disease on circadian rhythms
Duncan, M. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14358 · Cited by 55
Implications of Circadian Rhythm in Stroke Occurrence: Certainties and Possibilities
Fodor, D. M., Marta, M. M., & Perju‐Dumbravă, L. (2021) · Brain Sciences · doi:10.3390/brainsci11070865 · Cited by 55
The hidden link between circadian entropy and mental health disorders
Alachkar, A., Lee, J., Asthana, K., Monfared, R. V., Chen, J., Alhassen, S., Samad, M., Wood, M. A., Mayer, E. A., & Baldi, P. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02028-3 · Cited by 54
Fung, C. H., Vitiello, M. V., Alessi, C., & Kuchel, G. A. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14493 · Cited by 52
Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson’s Disease
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2020) · Cells · doi:10.3390/cells9020314 · Cited by 55
Qi, G., Mi, Y., Fan, R., Zhao, B., Ren, B., & Liu, X. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.031 · Cited by 55
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8486-x · Cited by 54
The Mammalian Circadian Time-Keeping System
Patton, A. P., & Hastings, M. H. (2023) · Journal of Huntington s Disease · doi:10.3233/jhd-230571 · Cited by 50
Sengupta, S., Yang, G., O’Donnell, J. C., Hinson, M. D., McCormack, S. E., Falk, M. J., La, P., Robinson, M. B., Williams, M., Yohannes, M. T., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.004 · Cited by 50
Self-citationBmal1 Is Required for Normal Reproductive Behaviors in Male Mice
Schoeller, E. L., Clark, D. D., Dey, S., Cao, N. V., Semaan, S. J., Chao, L. W., Kauffman, A. S., Stowers, L., & Mellon, P. L. (2016) · Endocrinology · doi:10.1210/en.2016-1620 · Cited by 47
Racing the clock: The role of circadian rhythmicity in addiction across the lifespan
Gulick, D., & Gamsby, J. J. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.03.003 · Cited by 53
Aging and the clock: Perspective from flies to humans
Nobrega, A. K. D., & Lyons, L. C. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14176 · Cited by 50
Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease
Rigat, L., Ouk, K., Kramer, A., & Priller, J. (2023) · Acta Physiologica · doi:10.1111/apha.13970 · Cited by 50
Epigenetic Basis of Neuronal and Synaptic Plasticity
Karpova, N. N., Sales, A. J., & Joca, S. R. L. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666160414124628 · Cited by 51
Park, J., Cederroth, C. R., Basinou, V., Meltser, I., Lundkvist, G. B. S., & Canlon, B. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3616-15.2016 · Cited by 50
González, M. M. C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00609 · Cited by 53
Circadian regulation of astrocyte function: implications for Alzheimer’s disease
McKee, C. A., Lananna, B. V., & Musiek, E. S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03314-y · Cited by 49
Self-citationNakanishi, H., Ni, J., Nonaka, S., & Hayashi, Y. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104905 · Cited by 49
Means, J. C., Venkatesan, A., Gerdes, B. C., Fan, J.-Y., Bjes, E. S., & Price, J. L. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005171 · Cited by 48
Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice
Day, S. M., Gironda, S. C., Clarke, C. W., Snipes, J. A., Nicol, N. I., Kamran, H., Vaughan, W., Weiner, J. L., & Macauley, S. L. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105967 · Cited by 48
Molecular-genetic Manipulation of the Suprachiasmatic Nucleus Circadian Clock
Hastings, M. H., Smyllie, N. J., & Patton, A. P. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.019 · Cited by 52
Titova, O. E., Lindberg, E., Elmståhl, S., Lind, L., Schiöth, H. B., & Benedict, C. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.05.007 · Cited by 49
Melatonin Entrains PER2::LUC Bioluminescence Circadian Rhythm in the Mouse Cornea
Baba, K., Davidson, A. J., & Tosini, G. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17124 · Cited by 46
Xu, F., Kula-Eversole, E., Iwanaszko, M., Hutchison, A. L., Dinner, A. R., & Allada, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.015 · Cited by 44
Gong, C., Li, C., Qi, X., Song, Z., Wu, J., Hughes, M. E., & Li, X. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1085388 · Cited by 43
Circadian control of tissue homeostasis and adult stem cells
Janich, P., Meng, Q., & Benitah, S. A. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.06.010 · Cited by 45
Wirianto, M., Wang, C., Kim, E., Koike, N., Gomez‐Gutierrez, R., Nohara, K., Escobedo, G., Choi, J. M., Han, C., Yagita, K., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101633r · Cited by 47
Knitting Up the Raveled Sleave of Care
Yang, G., Paschos, G. K., Curtis, A. M., Musiek, E. S., McLoughlin, S. C., & FitzGerald, G. A. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007225 · Cited by 45
Self-citationYalçın, M., Mundorf, A., Thiel, F., Amatriain‐Fernández, S., Kalthoff, I. S., Beucke, J., Budde, H., Garthus‐Niegel, S., Peterburs, J., & Relógio, A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.873237 · Cited by 47
Wu, J., Xu, J., Du, Q., Sun, X., Holgersson, K., Gao, J., He, X., Hosaka, K., Zhao, C., Tao, W., et al. (2023) · Advanced Science · doi:10.1002/advs.202301505 · Cited by 43
Self-citationDopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium
Baba, K., DeBruyne, J. P., & Tosini, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-05394-x · Cited by 44
Effects of BMAL1 Manipulation on the Brain's Master Circadian Clock and Behavior.
Haque, S., Booreddy, S., & Welsh, D. K. (2019) · PubMed · Cited by 40
Hunt, L. C., Jiao, J., Wang, Y., Finkelstein, D., Rao, D., Curley, M., Robles‐Murguia, M., Shirinifard, A., Pagala, V., Peng, J., et al. (2019) · Genome Research · doi:10.1101/gr.246884.118 · Cited by 42
The Retinal Circadian Clock and Photoreceptor Viability
Baba, K., Ribelayga, C., Iuvone, P. M., & Tosini, G. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-75402-4_42 · Cited by 43
Circadian Rhythm Abnormalities in Parkinson’s Disease from Humans to Flies and Back
Lazzari, F. D., Bisaglia, M., Zordan, M. A., & Sandrelli, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123911 · Cited by 46
Stroke in the Time of Circadian Medicine
Mergenthaler, P., Balami, J. S., Neuhaus, A. A., Mottahedin, A., Albers, G. W., Rothwell, P. M., Saver, J. L., Young, M. E., & Buchan, A. M. (2024) · Circulation Research · doi:10.1161/circresaha.124.323508 · Cited by 43
Morioka, N., Saeki, M., Sugimoto, T., Higuchi, T., Zhang, F. F., Nakamura, Y., Hisaoka‐Nakashima, K., & Nakata, Y. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.01.007 · Cited by 41
Non-transcriptional processes in circadian rhythm generation
Wong, D., & O'Neill, J. S. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.10.003 · Cited by 40
Mosser, E. A., Chiu, C. N., Tamai, K., Hirota, T., Li, S., Hui, M., Wang, A., Singh, C., Giovanni, A., Kay, S. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48914-7 · Cited by 42
The Molecular Clock and Neurodegenerative Disease: A Stressful Time
Carter, B., Justin, H. S., Gulick, D., & Gamsby, J. J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.644747 · Cited by 42
Amidfar, M., Garcez, M. L., & Kim, Y. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110721 · Cited by 43
Spiers, J. G., Breda, C., Robinson, S., Giorgini, F., & Steinert, J. R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00086 · Cited by 40
Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease
Pulver, R. L., Kronberg, E., Medenblik, L. M., Kheyfets, V. O., Ramos, A. R., Holtzman, D. M., Morris, J. C., Toedebusch, C. D., Sillau, S., Bettcher, B. M., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13420 · Cited by 47
Self-citationAgorastos, A., & Linthorst, A. C. E. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12330 · Cited by 41
A multi‐level assessment of the bidirectional relationship between aging and the circadian clock
Buijink, M. R., & Michel, S. H. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15286 · Cited by 43
Circadian control of β ‐cell function and stress responses
Lee, J., Liu, R., de Jesus, D. S., Kim, B. S., Ma, K., Moulik, M., & Yechoor, V. K. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12524 · Cited by 42
Qi, G., Wu, W., Mi, Y., Shi, R., Sun, K., Li, R., Liu, X., & Liu, X. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.10.031 · Cited by 40
Circadian rhythms and glial cells of the central nervous system
Brécier, A., Li, V. W., Smith, C. S., Halievski, K., & Ghasemlou, N. (2022) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12917 · Cited by 40
Relationships between the Circadian System and Alzheimer's Disease-Like Symptoms in Drosophila
Long, D. M., Blake, M. R., Dutta, S., Holbrook, S. D., Kotwica‐Rolinska, J., Kretzschmar, D., & Giebultowicz, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106068 · Cited by 44
G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes
Leysen, H., van Gastel, J., Hendrickx, J. O., Santos‐Otte, P., Martin, B., & Maudsley, S. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102919 · Cited by 37
Duncan, M. J., Guerriero, L. E., Köhler, K., Beechem, L., Gillis, B. D., Salisbury, F., Wessel, C. R., Wang, J., Sunderam, S., Bachstetter, A. D., et al. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.042 · Cited by 44
Understanding neuron-glia crosstalk and biological clocks in insomnia
Carvalhas-Almeida, C., Serra, J., Moita, J. J., Cavadas, C., & Álvaro, A. R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105100 · Cited by 41
Circadian Rhythms in AD Pathogenesis: a Critical Appraisal
Musiek, E. S. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0072-5 · Cited by 37
Self-citationUntimely oxidative stress in β-cells leads to diabetes – Role of circadian clock in β-cell function
Lee, J. M., Ma, K., Moulik, M., & Yechoor, V. K. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.022 · Cited by 40
Circadian Rhythm Disruption and Alzheimer's Disease: The Dynamics of a Vicious Cycle
Sharma, A., Sethi, G., Tambuwala, M. M., Aljabali, A. A. A., Chellappan, D. K., Dua, K., & Goyal, R. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200429013041 · Cited by 50
Liu, Y., Niu, L., Liu, X., Cheng, C., & Le, W. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00711-x · Cited by 39
Adult Neurogenesis under Control of the Circadian System
Ali, A. A. H., & von Gall, C. (2022) · Cells · doi:10.3390/cells11050764 · Cited by 40
Jiang, W., Jin, L., Ju, D., Lu, Z., Wang, C., Guo, X., Zhao, H., Shen, S., Cheng, Z., Shen, J., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn3586 · Cited by 38
Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock
Colombini, B., Dinu, M., Murgo, E., Lotti, S., Tarquini, R., Sofi, F., & Mazzoccoli, G. (2022) · Antioxidants · doi:10.3390/antiox11112228 · Cited by 39
Reprogramming energetic metabolism in Alzheimer's disease
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.10.033 · Cited by 38
Bidirectional relationships between sleep and amyloid-beta in the hippocampus
Dufort‐Gervais, J., Mongrain, V., & Brouillette, J. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.06.009 · Cited by 41
Interplay of central and peripheral circadian clocks in energy metabolism regulation
Kolbe, I., Brehm, N., & Oster, H. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12659 · Cited by 38
Cha, H. K., Chung, S., Lim, H. Y., Jung, J., & Son, G. H. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00496 · Cited by 40
Circadian control of stress granules by oscillating EIF2α
Wang, R., Jiang, X., Bao, P., Qin, M., & Xu, J. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1471-y · Cited by 37
Xiao, Q., Shadyab, A. H., Rapp, S. R., Stone, K. L., Yaffe, K., Sampson, J. N., Chen, J., Hayden, K. M., Henderson, V. W., & LaCroix, A. Z. (2022) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17926 · Cited by 37
Redox regulation of circadian molecular clock in chronic airway diseases
Sundar, I. K., Sellix, M. T., & Rahman, I. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.383 · Cited by 37
Goljanek‐Whysall, K., Iwanejko, L., Vasilaki, A., Pekovic‐Vaughan, V., & McDonagh, B. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9643-x · Cited by 34
Song, P., Li, Z., Li, X., Yang, L., Zhang, L., Li, N., Guo, C., Lu, S., & Wei, Y. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14010090 · Cited by 34
Crosstalk Between Aging, Circadian Rhythm, and Melatonin
Verma, A. K., Khan, M. I., Ashfaq, F., & Rizvi, S. I. (2023) · Rejuvenation Research · doi:10.1089/rej.2023.0047 · Cited by 35
Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
Barone, I., Gilette, N. M., Hawks-Mayer, H., Handy, J., Zhang, K. J., Chifamba, F. F., Mostafa, E., Johnson‐Venkatesh, E., Sun, Y., Gibson, J. M., et al. (2023) · Science Advances · doi:10.1126/sciadv.adj1010 · Cited by 33
Kanan, M. F., Sheehan, P. W., Haines, J. N., Gómez, P., Dhuler, A., Nadarajah, C. J., Wargel, Z. M., Freeberg, B. M., Nelvagal, H. R., Izumo, M., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.162771 · Cited by 39
Self-citationXin, M., Bi, F., Wang, C., Huang, Y., Xu, Y., Liang, S., Cai, T., Xu, X., Dong, L., Li, T., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.005 · Cited by 35
Lembach, A., Stahr, A., Ali, A. A. H., Ingenwerth, M., & von Gall, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103124 · Cited by 33
Carroll, C. M., & Macauley, S. L. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00258 · Cited by 32
GIT2—A keystone in ageing and age-related disease
van Gastel, J., Boddaert, J., Jushaj, A., Premont, R. T., Luttrell, L. M., Janssens, J., Martin, B., & Maudsley, S. R. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.02.002 · Cited by 32
Ali, A. A. H., Schwarz‐Herzke, B., Rollenhagen, A., Anstötz, M., Holub, M., Lübke, J. H. R., Rose, C. R., Schnittler, H., & von Gall, C. (2019) · Glia · doi:10.1002/glia.23754 · Cited by 34
Słomnicki, Ł. P., Myers, S. A., Ohri, S. S., Parsh, M. V., Andres, K. R., Chariker, J. H., Rouchka, E. C., Whittemore, S. R., & Hetman, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-71131-6 · Cited by 31
The intertwined roles of circadian rhythmsand neuronal metabolism fueling drug reward and addiction
Freyberg, Z., & Logan, R. W. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.08.004 · Cited by 31
Potential Circadian Rhythms in Oligodendrocytes? Working Together Through Time
Colwell, C. S., & Ghiani, C. A. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02778-5 · Cited by 33
Khyati, Malik, I., Agrawal, N., & Kumar, V. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1842752 · Cited by 30
Metadata
- Authors
- Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., Herzog, E. D., Hogenesch, J. B., Wozniak, D. F., Dikranian, K., Giasson, B. I., Weaver, D. R., Holtzman, D. M., & FitzGerald, G. A.
- Affiliations
- Washington University in St. Louis (US)
- University of Pennsylvania (US)
- University of Florida (US)
- University of Massachusetts Chan Medical School (US)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2013-11-25
- Volume
- 123
- Issue
- 12
- Pages
- 5389-5400
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3859381
- OpenAlex
- W2003062381
- Cited by
- 524
- References
- 59
- Citations by year
- 2026: 35 · 2025: 54 · 2024: 46 · 2023: 58 · 2022: 53 · 2021: 48 · 2020: 47 · 2019: 34 · 2018: 42 · 2017: 29 · 2016: 30 · 2015: 23 · 2014: 23 · 2013: 2
- FWCI
- 14.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- eScholarship@UMassChan (submittedVersion, other-oa)
- Funders
- Ellison Medical Foundation
- Cure Alzheimer's Fund (P01NS074969)
- Hope Center for Neurological Disorders (P30 NS057105)
- National Institutes of Health (HL097800, NS057105)
- National Institute on Aging (P50AG005681)
- National Heart, Lung, and Blood Institute (HL 097800, R01HL097800)
- National Institute of Neurological Disorders and Stroke (NS-056125, P30NS057105, R01NS078223, K08NS079405, R25NS065745, R01NS056125, P01NS074969)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- circadian clock proteins, Bmal1, clocks, NPAS2, Per1, Per2, redox homeostasis, oxidative stress, neurodegeneration, brain aging, astrocyte activation, synaptic degeneration, cortical functional connectivity, neuronal cell death, striatal degeneration
- MeSH terms
- Aging, Animals, Brain, Cerebral Cortex, Circadian Rhythm, Corpus Striatum, Gene Expression Regulation, Gliosis, Hippocampus, Homeostasis, Locomotion, Mice, Inbred C57BL, Mice, Neurologic Mutants, Nerve Degeneration, Nerve Tissue Proteins, Neuroglia, Neurons, Oxidation-Reduction, Mice, Knockout, Oxidative Stress, Sleep Disorders, Circadian Rhythm, RNA Interference, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, CLOCK Proteins, ARNTL Transcription Factors, Period Circadian Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
