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Cited by 32Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsSleep and Wakefulness Research

The Interaction Between Sleep and Metabolism in Alzheimer’s Disease: Cause or Consequence of Disease?

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Carroll, Caitlin M., Macauley, Shannon L.·2019·Frontiers in Aging Neuroscience
DOI 10.3389/fnagi.2019.00258PMC PMC6764218
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Abstract

Alzheimer's disease (AD) is the most common form of dementia and affects over 45 million people worldwide. Both type-2-diabetes (T2D), a metabolic condition associated with aging, and disrupted sleep are implicated in the pathogenesis of AD, but how sleep and metabolism interact to affect AD progression remains unclear. In the healthy brain, sleep/wake cycles are a well-coordinated interaction between metabolic and neuronal activity, but when disrupted, are associated with a myriad of health-related issues, including metabolic syndrome, cardiovascular disease, T2D, and AD. Therefore, this review will explore our current understanding of the relationship between metabolism, sleep, and AD-related pathology to identify the causes and consequences of disease progression in AD. Moreover, sleep disturbances and metabolic dysfunction could serve as potential therapeutic targets to mitigate the increased risk of AD in individuals with T2D or offer a novel approach for treating AD.

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  • Lactate levels in the interstitial fluid were higher in patients than in unaffected individuals.

    “Lactate levels in the interstitial fluid were higher in patients than those in unaffected individuals.29”

    From ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes (2023) · cites this paper as [29]

    The “Glucose Metabolism and Neuronal Activity in AD” section (page unavailable) reports increased interstitial-fluid lactate after induced hyperglycemia in rodents, with a greater effect in mice with substantial amyloid pathology. It does not report higher interstitial-fluid lactate in patients than in unaffected people; the cited comparison changes both the population and condition. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Carroll, C. M., & Macauley, S. L.
Affiliations
Wake Forest University Health Sciences (US)
Corresponding author
Macauley, Shannon L.
ORCID
Venue
Frontiers in Aging Neuroscience
Publisher
Frontiers Media SA
Published
2019-09-20
Volume
11
Pages
258-258
ISSN
1663-4365 (ISSN-L)
DOI
10.3389/fnagi.2019.00258
PMC
PMC6764218
OpenAlex
W2970438846
Cited by
32
References
21
Citations by year
2026: 4 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 3 · 2020: 3
FWCI
0.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Aging Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Wake Forest University
  • National Institute on Aging (R01AG061805, P30AG049638, K01AG050719)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
Alzheimer's disease, sleep, metabolism, type 2 diabetes, sleep disruption, metabolic dysfunction, metabolic syndrome, disease progression, therapeutic target, aging

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