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Inflammatory mechanisms linking obesity and metabolic disease
Open accessAbstract
There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration. The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome. We now know that an inflammatory program is activated early in adipose expansion and during chronic obesity, permanently skewing the immune system to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of obesity and inflammation. Reviews in this series examine the activation of the innate and adaptive immune system in obesity; inflammation within diabetic islets, brain, liver, gut, and muscle; the role of inflammation in fibrosis and angiogenesis; the factors that contribute to the initiation of inflammation; and therapeutic approaches to modulate inflammation in the context of obesity and metabolic syndrome.
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Citations
Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
The global obesity pandemic: shaped by global drivers and local environments
Swinburn, B. A., Sacks, G., Hall, K. D., McPherson, K., Finegood, D. T., Moodie, M. L., & Gortmaker, S. L. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60813-1 · Cited by 4,888
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Self-citationMutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655
Inflammatory links between obesity and metabolic disease
Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319
Self-citation
Cited by
Sorted by citations
Items 501–600 of 1,002
Fang, R., Yang, S., Gu, X., Li, C., Bi, N., & Wang, H.-L. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119201 · Cited by 32
Ding, Y., & Xu, X. (2021) · Journal of Sports Sciences · doi:10.1080/02640414.2021.1932279 · Cited by 30
“This antiinflammatory effect was thought to be mediated by reductions in the size of adipose tissue, which acts as an endocrine and paracrine organ to stimulate the secretion of inflammatory mediators (Saltiel & Olefsky, 2017).”
BackgroundVolqvartz, T., Andersen, H. H., Pedersen, L. H., & Larsen, A. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16184 · Cited by 31
“It is well-established that, at least in non-pregnant subjects, obesity induces chronic low-grade inflammation (Saltiel & Olefsky, 2017), hyperactivity of the HPA (hypo-thalamic – pituitary – adrenal) axis and changes in cortisol metabolism (Incollingo Rodriguez et al., 2015; Johns et al., 2020;…”
BackgroundDavies, M. J., Lim, S. K., Slater, T., Goldney, J., Philis‐Tsimikas, A., Franco, D. R., Lamptey, R., Yates, T. E., Tankova, T. I., & Lingvay, I. (2026) · Nature Reviews Disease Primers · doi:10.1038/s41572-026-00687-w · Cited by 45
Lu, Y., Wang, C.-P., Yu, T., Tsai, I., Hung, W., Lu, I.-C., Hsu, C., Tang, W.-H., Houng, J., Chung, F., et al. (2017) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-017-0283-4 · Cited by 31
Kim, C. Y., Kang, B., Suh, H. J., & Choi, H. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.169 · Cited by 31
Watts, E. L., Perez‐Cornago, A., Appleby, P. N., Albanes, D., Ardanáz, E., Black, A., Bueno-de-Mesquita, H. B., Chan, J. M., Chen, C., Chubb, S. A. P., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32276 · Cited by 30
Sereysky, J., Parsikia, A., Stone, M. E., Castaldi, M. T., & McNelis, J. (2019) · Hernia · doi:10.1007/s10029-019-02050-3 · Cited by 32
Rajan, M. R., Soták, M., Barrenäs, F., Shen, T., Borkowski, K., Ashton, N. J., Biörserud, C., Lindahl, T. L., Ramström, S., Schöll, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51673-0 · Cited by 31
Thomas, S. S., Cha, Y., & Kim, K. (2020) · Nutrition Research and Practice · doi:10.4162/nrp.2020.14.5.425 · Cited by 31
“Activation of the inflammatory nuclear factor kappa B (NF-κB) pathway by endotoxins such as lipopolysaccharide (LPS) via membrane receptor Toll-like receptor 4 (TLR4) in fat cells is among the suggested mechanisms that trigger obesity-associated inflammation [5].”
BackgroundMetabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome
Moin, A. S. M., Sathyapalan, T., Diboun, I., Elrayess, M. A., Butler, A. E., & Atkin, S. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-84586-y · Cited by 31
Lin, C., Adhikary, P., & Cheng, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.008 · Cited by 31
Selle, J., Dinger, K., Jentgen, V., Zanetti, D., Will, J., Georgomanolis, T., Vohlen, C., Wilke, R., Kojonazarov, B. K., Klymenko, O., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31655-z · Cited by 33
Sánchez-Medina, A., Redondo-Puente, M., Dupák, R., Bravo, L., Goya, L., & Sarriá, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021440 · Cited by 32
“Low-grade inflammation is also associated with obesity and is primarily localized in metabolic tissues, such as white adipose tissue [3,4] and other organs including liver, pancreas, heart, brain, and skeletal muscle [5].”
BackgroundPyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression
Ishak, N. S. M., & Ikemoto, K. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1200025 · Cited by 25
Lu, L., He, X., Song, Y., Zhuang, M., Wu, X., & Chen, N. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1034542 · Cited by 30
“Obesity, as a prevalent disease among older population, is related to a variety of adverse outcomes, such as chronic low-grade inflammation state, metabolic diseases, cardiovascular disorders, and mortality (Calle et al., 2005; Ghoorah et al., 2016; Saltiel and Olefsky, 2017; Kawai et al., 2021).”
BackgroundLab-on-chip technologies for exploring the gut–immune axis in metabolic disease
Wheeler, A., Stoeger, V., & Owens, R. M. (2024) · Lab on a Chip · doi:10.1039/d3lc00877k · Cited by 30
Lam, T. F., Lyu, Z., Wu, X., Wong, Y., Cao, P., Wong, E. Y., Hung, H. B., Zhang, S., Bian, Z., & Zhong, L. L. D. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04340-5 · Cited by 31
“On the other hand, inflammation was a well-known risk factor for the initiation and perpetuation of obesity [29].”
BackgroundRios, F. J. O., Ciuceis, C. D., Georgiopoulos, G. A., Lazaridis, A. A., Nosalski, R., Pavlidis, G., Tual‐Chalot, S., Rosei, C. A., Camargo, L. L., Dąbrowska, E., et al. (2024) · Hypertension · doi:10.1161/hypertensionaha.123.22483 · Cited by 34
Wang, T., Zhang, M., Shi, W., Li, Y., Zhang, T., & Shi, W. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02653-4 · Cited by 30
“In turn, atherogenic dyslipidemia complex, mostly from obesity, could elevate a low-grade inflammatory condition via the lipotoxic effects [46].”
Clayton, Z. S., & McCurdy, C. E. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00364.2017 · Cited by 30
“Obesity-induced insulin resistance is thought to occur secondary to the release of proinflammatory cytokines and chemokines, which may be secreted as an adaptive response to maintain adipose tissue function in the presence of expanding or hypoxic adipocytes (32).”
BackgroundObesity as an immune-modifying factor in cancer immunotherapy
Canter, R. J., Le, C. T., Beerthuijzen, J. M. T., & Murphy, W. J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.5ri1017-401rr · Cited by 30
Cinti, S., Graciotti, L., Giordano, A., Valerio, A., & Nisoli, E. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0624-5 · Cited by 29
“Obesity is associated with increased expression of inflammatory mediators in adipose tissue and this inflammation interferes with glucose metabolism (also named metaflammation) in both animals and humans, mainly due to macrophage infiltration [8, 9].”
BackgroundHigh Glucose‐Aggravated Hepatic Insulin Resistance: Role of the NLRP3 Inflammasome in Kupffer Cells
Zheng, T., Wang, Q., Dong, Y., Ma, W., Zhang, Y., Zhao, Y., Bian, F., & Chen, L. (2020) · Obesity · doi:10.1002/oby.22821 · Cited by 30
“Accumulating evidence has suggested that chronic metaflammation mediates insulin-resistance pathogenesis (1,4-6).”
BackgroundAn Integrative Review of Brain-Derived Neurotrophic Factor and Serious Cardiovascular Conditions
Halloway, S., Jung, M., Yeh, A.-Y., Liu, J., McAdams, E., Barley, M., Dorsey, S. G., & Pressler, S. J. (2020) · Nursing Research · doi:10.1097/nnr.0000000000000454 · Cited by 30
“In clinical populations, chronic inflammation that can occur inobesity is potentially associatedwith thedevelopment of metabolic syndrome and cardiovascular disease (Park et al., 2017; Saltiel & Olefsky, 2017).”
Depression and obesity among females, are sex specificities considered?
Baldini, I., Casagrande, B. P., & Estadella, D. (2021) · Archives of Women s Mental Health · doi:10.1007/s00737-021-01123-6 · Cited by 33
“Symbols: → indicates direct relationship, indicates a negative modulatory effect, indicates impairment of the negative modulatory effect 1 3 People with depression present several physiological changes, the neuroinflammation hypothesis is based on patients with MDD having higher brain inflammatory cytokine levels (IL-…”
BackgroundInfluentialPrediction of Metabolic Disorders Using NMR-Based Metabolomics: The Shanghai Changfeng Study
Wu, Q., Huang, Q., Zeng, H., Ma, S., Lin, H., Xia, M., Tang, H., & Gao, X. (2021) · Phenomics · doi:10.1007/s43657-021-00021-2 · Cited by 30
The importance of inflammation markers in polycystic ovary syndrome
Özay, A. C., & Özay, Ö. E. (2021) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.20200860 · Cited by 30
Li, J., Lv, J.-L., Cao, X.-Y., Zhang, H., Tan, Y., Chu, T., Zhao, L., Liu, Z., & Ren, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1040846 · Cited by 30
“A few decades ago, the hypothesis that obesity affects the immune system, which subsequently contributes to the development of T2DM, was proposed, and this hypothesis was confirmed by subsequent research (Saltiel and Olefsky, 2017).”
BackgroundResultRamon‐Krauel, M., Pentinat, T., Bloks, V. W., Cebrià, J., Ribó, S., Pérez-Wienese, R., Vilà, M., Palacios‐Marin, I., Fernández-Pérez, A., Vallejo, M., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700717rr · Cited by 33
“This last one is especially relevant in humans, were it appears closely linked to obesity (40).”
BackgroundUDP-glucose sensing P2Y14R: A novel target for inflammation
Zhang, J.-Z., Shi, N.-R., Wu, J., Wang, X., Illés, P., & Tang, Y. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109655 · Cited by 29
“It has been widely recognized that inflammation is directly associated with insulin resistance, and by inhibiting inflammation via NF-κB and JNK pathways or by cytokines, such as IL-1, alleviates the inflammation-related insulin resistance (Shi et al., 2006; Saltiel and Olefsky, 2017).”
BackgroundDiagnosis and Treatment Options for T2-Low Asthma
Thomas, D., Hamada, Y., Gibson, P. G., Brightling, C. E., Castro, M., & Heaney, L. G. (2025) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2025.04.055 · Cited by 33
Shimizu, H., Hatao, F., Imamura, K., Takanishi, K., & Tsujino, M. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2756-9 · Cited by 31
“Obesity is related to chronic low-grade inflammation caused by pro-inflammatory cytokines produced by adipose tissue [31, 32].”
BackgroundPérez‐Bey, A., Segura‐Jiménez, V., Fernández‐Santos, J. R., Esteban‐Cornejo, I., Gómez‐Martínez, S., Veiga, Ó. L., Marcos, A., Ortega, F. B., & Castro‐Piñero, J. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12800 · Cited by 29
“On the other hand, adipose tissue produces several adipokines involved in inflammation.(40) Obesity-induced inflammation is well known for being responsible of several cardiometabolic disorders, including insulin resistance; however, it is also responsible of fibrosis and necrosis which may produce important damages i…”
BackgroundKorduner, J., Bachus, E., Jujić, A., Magnusson, M., & Nilsson, P. M. (2019) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2019.10.002 · Cited by 29
Skurski, J., Penniman, C. M., Geesala, R., Dixit, G., Pulipati, P., Bhardwaj, G., Meyerholz, D. K., Issuree, P. D. A., O'Neill, B. T., & Maretzky, T. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154194 · Cited by 29
Hossain, M. M., Park, D., Rahman, M. S., Ki, S. J., Lee, Y. R., Imran, K. M., Yoon, D., Heo, J.-Y., Lee, T.-J., & Kim, Y. S. (2020) · Beneficial Microbes · doi:10.3920/bm2019.0179 · Cited by 29
Beneficial Flavonoid in Foods and Anti-obesity Effect
Liu, J., Cao, J., Li, Y., & Guo, F. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1923730 · Cited by 29
“Inflammatory infiltration caused by hepatic macrophages also releases proinflammatory cytokines, which result in insulin resistance in the liver.([189]) Flavonoids mainly by suppressing proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), interferon-γ (I…”
BackgroundFrudd, K., Sivaprasad, S., Raman, R., Krishnakumar, S., Revathy, Y. R., & Turowski, P. (2021) · Acta Ophthalmologica · doi:10.1111/aos.14954 · Cited by 29
Adipoclast: a multinucleated fat-eating macrophage
Olona, A., Mukhopadhyay, S., Hateley, C., Martínez, F. O., Gordon, S., & Behmoaras, J. V. (2021) · BMC Biology · doi:10.1186/s12915-021-01181-3 · Cited by 32
“To date, it is well-accepted that obesity triggers the recruitment of monocytes into adipose tissue to promote inflammation, which itself may cause ectopic fat deposition in the liver and insulin resistance [99, 100].”
BackgroundOkrzeja, J., Karwowska, A., & Błachnio-Zabielska, A. U. (2022) · Nutrients · doi:10.3390/nu14122438 · Cited by 29
“Moreover, other research showed that the deletion of CerK suppresses obesity-related inflammatory cytokines IL-6 and TNFα and reduced macrophage infiltration in adipose tissue, resulting in reduced inflammatory responses in animals fed a high-fat diet [88,89].”
BackgroundMengozzi, A., Ciuceis, C. D., Dell’Oro, R., Georgiopoulos, G. A., Lazaridis, A. A., Nosalski, R., Pavlidis, G., Tual‐Chalot, S., Rosei, C. A., Anyfanti, P., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003503 · Cited by 32
“However, this neoangiogenetic process [76] ultimately proves detrimental and further promotes an overt dysfunctional phenotype for both the PVAT and the ECs.”
BackgroundRandell, E. W., Twells, L., Gregory, D. M., Lester, K. K., Daneshtalab, N., Dillon, C. M., Pace, D., Smith, C., & Boone, D. C. (2017) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2017.10.010 · Cited by 29
Association of light at night with cardiometabolic disease: A systematic review and meta-analysis
Xu, Y.-X., Zhang, J., & Ding, W.-Q. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.123130 · Cited by 27
Mohaghegh, N., Iyer, A., Wang, E., Balajam, N. Z., Kang, H., Akbari, M., Barnhill, M. S., Khademhosseini, A., Pearson, R. M., & Najafabadi, A. H. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113670 · Cited by 28
Obesity is Associated with an Increased Prevalence of Glenohumeral Osteoarthritis and Arthroplasty
Wall, K. C., Politzer, C. S., Chahla, J. A., & Garrigues, G. E. (2020) · Orthopedic Clinics of North America · doi:10.1016/j.ocl.2019.12.001 · Cited by 28
C-reactive protein and ART outcomes: a systematic review
Brouillet, S., Boursier, G., Anav, M., Boissière, B. D. B. D. L., Gala, A., Ferrières-Hoa, A., Touitou, I., & Hamamah, S. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa012 · Cited by 29
Ioannou, M., Foiselle, M., Mallet, J., Stam, E. L., Godin, O., Dubertret, C., Terro, E., Sommer, I. E., Haarman, B. C. M., Leboyer, M., et al. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.001 · Cited by 28
Kurgan, N., McKee, K. T., Calleja, M., Josse, A. R., & Klentrou, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.531926 · Cited by 31
The Important Role of Leptin in Modulating the Risk of Dermatological Diseases
Su, X., Cheng, Y., & Chang, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.593564 · Cited by 28
“org 2 disturbed secretion of multiple cytokines, such as leptin, adiponectin, and chemokines, that play a modulatory role in inflammatory response (10).”
BackgroundDaneshmoghadam, J., Omidifar, A., Dilmaghani, N. A., Karimi, Z., Emamgholipour, S., & Shanaki, M. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23741 · Cited by 28
He, L., & Sun, Y. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00762-z · Cited by 30
Associations of weight loss with obesity‐related comorbidities in a large integrated health system
Mariam, A., Miller-Atkins, G. A., Pantalone, K. M., Iyer, N. N., Misra‐Hebert, A. D., Milinovich, A., Bauman, J. M., Mocarski, M., Ramasamy, A., Smolarz, B. G., et al. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14538 · Cited by 27
“Weight loss for individuals with obesity results in health benefits due to lowering of risk factors (eg, hyperglycaemia, cholesterol, blood pressure inflammatory markers).(6,27,28) However, the concept of the “obesity paradox” has arisen due to observations of reduced risk of cardiometabolic outcomes and mortality in…”
BackgroundLiu, Y., Hong, F., Lebaka, V. R., Mohammed, A., Ji, L., Zhang, Y., & Korivi, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.754731 · Cited by 31
Mundula, T., Russo, E., Curini, L., Giudici, F., Piccioni, A., Franceschi, F., & Amedei, A. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220430131018 · Cited by 29
Yang, C., Lü, Y., Xia, H., Liu, H., Pan, D., Yang, X., & Sun, G. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2019.1664602 · Cited by 26
“resistance, type 2 diabetes and hepatic steatosis (9).”
BackgroundResistin Regulates Inflammation and Insulin Resistance in Humans via the Endocannabinoid System
Yang, H., Kim, J., Kim, B.-K., Seo, H., Kim, J.-Y., Lee, J., Lee, J., You, J., Jin, S., Kwon, Y., et al. (2024) · Research · doi:10.34133/research.0326 · Cited by 28
“There have been many studies demonstrating the underlying mechanism of insulin resistance [2,23–25].”
BackgroundMetabolic Disorders and Inflammatory Bowel Diseases
Hyun, H. K., & Cheon, J. H. (2025) · Gut and Liver · doi:10.5009/gnl240316 · Cited by 27
“6,7 Epidemiological studies have consistently demonstrated a correlation between metabolic syndrome and IBD, indicating shared pathogenic mechanisms.”
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity
Liu, D., Zhou, C., Wang, X., Luo, Z., Xu, R., Huo, S., Guo, L., Luo, X., Yang, S., Click, A., et al. (2026) · Science · doi:10.1126/science.adq9006 · Cited by 32
Schwartsburd, P. M. (2017) · Future Science OA · doi:10.4155/fsoa-2017-0015 · Cited by 30
Liu, L., He, Y., Wang, K., Miao, J., & Zheng, Z. (2020) · Food & Function · doi:10.1039/d0fo02112a · Cited by 27
Molecular and Cellular Mechanisms of Electronegative Lipoproteins in Cardiovascular Diseases
Ke, L., Law, S. H., Mishra, V. K., Parveen, F., Chan, H., Lu, Y., & Chu, C. (2020) · Biomedicines · doi:10.3390/biomedicines8120550 · Cited by 28
“9 billion people are obese or overweight worldwide [1].”
BackgroundPathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity
Mondanelli, G., Albini, E., Orecchini, E., Pallotta, M. T., Belladonna, M. L., Ricci, G., Grohmann, U., & Orabona, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.713989 · Cited by 27
“Obesity is a metabolic disorder characterized by a chronic, low-grade inflammatory state and associated with the development of numerous comorbid conditions, including insulin resistance and type 2 diabetes (10).”
BackgroundLabadie, B. W., Balar, A. V., & Luke, J. J. (2021) · Cancers · doi:10.3390/cancers13215415 · Cited by 30
Chronic Inflammation in Obesity and Cancer Cachexia
Divella, R., Gadaleta‐Caldarola, G., & Mazzocca, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11082191 · Cited by 31
Zhao, Y., Wang, Q., Zhou, P., Li, Z., Zhong, W., Zhuo, Y., Che, L., Xu, S., Fang, Z., Jiang, X., et al. (2022) · animal · doi:10.1016/j.animal.2022.100526 · Cited by 27
Akter, R., Ling, L., Rupa, E. J., KyuPark, J., Mathiyalagan, R., Nahar, J., Won, L. J., Hyun, K. D., Murugesan, M., Yang, D., et al. (2022) · Molecules · doi:10.3390/molecules27092795 · Cited by 29
“Multiple organs, including the pancreas, adipose, liver, skeletal muscle, brain, and heart, are involved in obesity-induced inflammation [11].”
BackgroundClemente‐Suárez, V. J., Bustamante-Sánchez, Á., Tornero-Aguilera, J. F., Ruisoto, P., & Mielgo‐Ayuso, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415584 · Cited by 27
“Chronic inflammation, condition accompanying obesity, and metabolic syndrome produces an abnormal proinflammatory cytokine production of TNFα, IL-1, and IL-6 and increased acute phase reactants [31].”
BackgroundSalivary fingerprint of simple obesity
Kalata, A. P. L. , Miechowicz, I., Korybalska, K., Swora-Cwynar, E., Czepulis, N., Łuczak, J., Orzechowska, Z., Grzymislawski, M. B., Surdacka, A., & Witowski, J. (2018) · Cytokine · doi:10.1016/j.cyto.2018.05.006 · Cited by 27
Liu, R., Wang, M., Li, E., Yang, Y., Li, J., Chen, S., Shen, W., Azhar, S., Guo, Z., & Hu, Z. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158640 · Cited by 27
Su, Y., Wang, W., Xiao, Q., Tang, L., Wang, T., Xie, M., & Su, Y. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.08.055 · Cited by 27
Bao, Y., Lu, P., Wang, M., Zhang, X., Song, A., Gu, X., Ma, T., Su, S., Wang, L., Shang, X., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-03204-y · Cited by 26
“This dietary pattern may contribute to overweight and obesity, resulting in abnormal adipocytokine secretion and elevated risk of related comorbidities [36, 37].”
BackgroundLong-term ambient air pollution and the risk of musculoskeletal diseases: A prospective cohort study
Cheng, B., Pan, C., Cai, Q., Liu, L., Cheng, S., Yang, X., Meng, P., Wei, W., He, D., Liu, H., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133658 · Cited by 26
Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang, P., Yang, X., Zhang, L., Sha, S., Huang, J., Peng, J., Gu, J., Pearson, J. A., Hu, Y., Zhao, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48611-8 · Cited by 28
Monocyte Subpopulation Recovery as Predictors of Hematopoietic Cell Transplantation Outcomes
Turcotte, L. M., Cao, Q., Cooley, S., Curtsinger, J., Holtan, S. G., Luo, X., Yingst, A., Weisdorf, D. J., Blazar, B. R., Miller, J. S., et al. (2019) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2019.01.003 · Cited by 26
Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors
Perpetuini, A. C., Giuliani, G., Reggio, A., Cerretani, M., Santoriello, M., Stefanelli, R., Palma, A., Vumbaca, S., Harper, S., Castagnoli, L., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62194-6 · Cited by 26
Austvoll, C. T., Gallo, V., & Montag, D. (2020) · Global Health · doi:10.1017/gheg.2020.2 · Cited by 25
Wu, Y., Yang, J., Liu, X., Zhang, Y., Lei, A., Yi, R., Tan, F., & Zhao, X. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1758 · Cited by 24
“…Number: 2013BSRC001 K E Y W O R D S anti-inflammation, anti-obesity, high-fat diet, Ligustrum robustum, lipid metabolism, smallleaved Kuding tea (Saltiel & Olefsky, 2017), and oxidative stress (Savini, Gasperi, & Catani, 2016) are all possible mechanisms by which obesity occurs and develops.”
BackgroundYuan, Y., Zhou, J., Hu, R., Zou, L., Ji, L., & Jiang, G. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119312 · Cited by 26
Wu, Q., Wang, J., Qin, M., Yang, H., Liang, Z., & Tang, G. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01470-4 · Cited by 26
“Studies have shown that patients who are obese have higher levels of circulating neutrophils [27] and blood cytokines [28], and have lowgrade chronic inflammation triggered by obesity [29].”
BackgroundHuang, J., Peng, X., Dong, K., Jing, T., & Yang, Y. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s305054 · Cited by 32
Wei, D., Hou, J., Liu, X., Zhang, L., Wang, L., Liu, P., Fan, K., Zhang, L., Nie, L., Xu, Q., et al. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.06.906 · Cited by 26
KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
Ruberto, A. A., Gréchez‐Cassiau, A., Guérin, S., Martin, L., Revel, J. S., Mehiri, M., Subramaniam, M., Delaunay, F., & Teboul, M. (2021) · eLife · doi:10.7554/elife.65574 · Cited by 27
Ding, F., Luo, X., Tu, Y., Duan, X., Liu, J., Jia, L., & Zheng, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705751 · Cited by 26
“A series of studies have demonstrated that a chronic and low-grade inflammation, characterized by the elevated pro-inflammatory cytokines such as TNF-a and IL-6, exists in obese and type 2 diabetic patients (40, 41).”
BackgroundChiou, W.-C., Chang, B.-H., Tien, H.-H., Cai, Y.-L., Fan, Y.-C., Chen, W. J., Chu, H.-F., Chen, Y.-H., & Huang, C. (2021) · Nutrients · doi:10.3390/nu13093161 · Cited by 27
“Obesity-related metabolic disorders elicit systemic low-grade inflammation by increasing the levels of proinflammatory factors, such as monocyte chemoattractant protein1 (MCP-1), CD11c, tumor necrosis factor-α (TNF-α), leptin, lipopolysaccharide binding protein (LBP), and interleukin-6 (IL-6) [26,28,29].”
Backgroundβ-Arrestins as Important Regulators of Glucose and Energy Homeostasis
Pydi, S. P., Barella, L. F., Zhu, L., Meister, J., Rossi, M., & Wess, J. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-092948 · Cited by 25
Anaeigoudari, A., Safari, H., & Khazdair, M. R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762182 · Cited by 31
“It has been also revealed that obesity caused by inflammation affects various organs such as the liver, heart, and brain and disturbs hemostatic mechanisms in the body (Saltiel and Olefsky, 2017).”
BackgroundAssociation between metabolic syndrome and clinicopathological features of papillary thyroid cancer
Song, J., Li, L., Yu, X., Zhan, L., Zhi-liang, X., Li, J., Sun, S., & Chen, C. (2021) · Endocrine · doi:10.1007/s12020-021-02940-6 · Cited by 26
Lauria, F., Iacomino, G., Russo, P., Venezia, A., Marena, P., Ahrens, W., Henauw, S. D., Eiben, G., Foraita, R., Hebestreit, A., et al. (2022) · Genes · doi:10.3390/genes13040632 · Cited by 26
“The resulting persistent chronic low-grade inflammation represents a hallmark of obesity that leads to and perpetuates the state of metabolic alterations and insulin resistance in target organs, including the adipose tissue, liver, muscles, and vascular system [14].”
BackgroundShaikh, S. R., MacIver, N. J., & Beck, M. A. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062320-115937 · Cited by 28
Schmitz, T., Harmel, E. K., Heier, M., Peters, A., Linseisen, J., & Meisinger, C. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03644-9 · Cited by 26
Liu, C., Liu, T., Ruan, G., Ge, Y., Song, M., Xie, H., Lin, S., Li, D., Zhang, H., Zhang, Q., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1114963 · Cited by 26
Dai, Z., Zhang, Y., Meng, Y., Li, S., Suonan, Z., Sun, Y., Ji, J., Shen, Q., Zheng, H., & Xue, Y. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.135980 · Cited by 27
Pomegranate (Punica granatum L.) phytochemicals target the components of metabolic syndrome
Laurindo, L. F., Rodrigues, V. D., Minniti, G., de Carvalho, A. C. A., Zutin, T. L. M., DeLiberto, L. K., Bishayee, A., & Barbalho, S. M. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109670 · Cited by 27
Angiogenesis in metabolic-vascular disease
Breier, G., Chavakis, T., & Hirsch, E. (2017) · Thrombosis and Haemostasis · doi:10.1160/th17-05-0325 · Cited by 26
“Experimental evidence accumulated over the last two decades point to a major role of inflammation in the AT for the pathogenesis of obesity-related metabolic dysfunction (9, 10, 20, 21).”
BackgroundAltered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
Sohrabi, Y., Reinecke, H., & Godfrey, R. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.01.001 · Cited by 26
Roles of ubiquitin-specific proteases in inflammatory diseases
Chen, R., Zhang, H., Li, L., Li, J., Xie, J., Weng, J., Tan, H., Liu, Y., Guo, T., & Wang, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1258740 · Cited by 25
Bakhshimoghaddam, F., Chaharlang, R., Mansoori, A., & Dehghanseresht, N. (2024) · Journal of Health Population and Nutrition · doi:10.1186/s41043-024-00580-w · Cited by 28
Córdova, R., Kim, J., Thompson, A. S., Noh, H., Shah, S., Dahm, C. C., Jensen, C. F., Mellemkjær, L., Tjønneland, A. M., Katzke, V. A., et al. (2025) · The Lancet Healthy Longevity · doi:10.1016/j.lanhl.2025.100742 · Cited by 31
Bypassing TBI: Metabolic Surgery and the Link between Obesity and Traumatic Brain Injury—a Review
McGlennon, T. W., Buchwald, J. N., Pories, W. J., Yu, F., Roberts, A. J., Ahnfeldt, E. P., Menon, R., & Buchwald, H. (2020) · Obesity Surgery · doi:10.1007/s11695-020-05065-3 · Cited by 25
Metadata
- Authors
- Saltiel, A. R., & Olefsky, J. M.
- Affiliations
- University of California San Diego (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2017-01-03
- Volume
- 127
- Issue
- 1
- Pages
- 1-4
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC5199709
- OpenAlex
- W2567264284
- Cited by
- 2,212
- References
- 44
- Citations by year
- 2026: 261 · 2025: 318 · 2024: 265 · 2023: 255 · 2022: 308 · 2021: 280 · 2020: 270 · 2019: 136 · 2018: 80 · 2017: 36
- FWCI
- 18.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of California, San Diego (P30DK063491, DK063491)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK063491, P30DK063491)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, metabolic syndrome, low-grade inflammation, insulin resistance, type 2 diabetes, adipose tissue expansion, innate immune system, adaptive immunity, neuroinflammation, liver inflammation, intestinal inflammation, skeletal muscle inflammation, fibrosis, angiogenesis, anti-inflammatory therapy
- MeSH terms
- Animals, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Inflammation, Neoplasms, Obesity, Organ Specificity, Neurodegenerative Diseases, Metabolic Syndrome
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