Cited by 2,212Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Inflammatory mechanisms linking obesity and metabolic disease

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Saltiel, Alan R., Olefsky, Jerrold M.·2017·Journal of Clinical Investigation

DOI 10.1172/jci92035PMC PMC5199709

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Abstract

There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration. The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome. We now know that an inflammatory program is activated early in adipose expansion and during chronic obesity, permanently skewing the immune system to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of obesity and inflammation. Reviews in this series examine the activation of the innate and adaptive immune system in obesity; inflammation within diabetic islets, brain, liver, gut, and muscle; the role of inflammation in fibrosis and angiogenesis; the factors that contribute to the initiation of inflammation; and therapeutic approaches to modulate inflammation in the context of obesity and metabolic syndrome.

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Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice
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FSTL3 is highly expressed in adipose tissue of individuals with overweight or obesity and is associated with inflammation
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Gross Olfaction Before and After Laparoscopic Gastric Bypass
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Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients
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Prevalence and predictors of thyroid nodules among adults: analyzing the association with metabolic syndrome in a cross-sectional study
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Neutrophils preserve energy storage in sympathetically activated adipocytes
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12-OAHSA is a component of olive oil and mitigates obesity-induced inflammation
Moyo, K. M., Choi, J., Chang, J., Soedono, S., Vo, D. H. N., Song, Y., Park, S. J., Go, G., Lee, D. Y., & Cho, K. W. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109127 · Cited by 14
Bacterial Urinary Tract Infection and Early Asymptomatic Bacteriuria in Kidney Transplantation Still Negatively Affect Kidney Transplant Outcomes in the Era of Modern Immunosuppression and Cotrimoxazole Prophylaxis
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Background

Authors: Saltiel, A. R., & Olefsky, J. M.
Affiliations: University of California San Diego (US)
ORCID: Saltiel, Alan R.
Olefsky, Jerrold M.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2017-01-03
Volume: 127
Issue: 1
Pages: 1-4
ISSN: 0021-9738 (ISSN-L)
1558-8238
DOI: 10.1172/jci92035
PMC: PMC5199709
OpenAlex: W2567264284
Cited by: 2,212
References: 44
Citations by year: 2026: 261 · 2025: 318 · 2024: 265 · 2023: 255 · 2022: 308 · 2021: 280 · 2020: 270 · 2019: 136 · 2018: 80 · 2017: 36
FWCI: 18.93
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: University of California, San Diego (P30DK063491, DK063491)
National Institute of Diabetes and Digestive and Kidney Diseases (DK063491, P30DK063491)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: obesity, metabolic syndrome, low-grade inflammation, insulin resistance, type 2 diabetes, adipose tissue expansion, innate immune system, adaptive immunity, neuroinflammation, liver inflammation, intestinal inflammation, skeletal muscle inflammation, fibrosis, angiogenesis, anti-inflammatory therapy
MeSH terms: Animals, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Inflammation, Neoplasms, Obesity, Organ Specificity, Neurodegenerative Diseases, Metabolic Syndrome

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