The DOI matches its Crossref record; 179 of the 181 references it cites were found in a registry or an index.
Senescent cells: a therapeutic target for cardiovascular disease
Open accessAbstract
Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging. In the process, senescent cells have attracted attention as a therapeutic target for age-related diseases, including cardiovascular disease (CVD), the leading cause of morbidity and mortality in the elderly. Given the aging global population and the inadequacy of current medical management, attenuating the health care burden of CVD would be transformative to clinical practice. Here, we review the evidence that cellular senescence drives CVD in a bimodal fashion by both priming the aged cardiovascular system for disease and driving established disease forward. Hence, the growing field of senotherapy (neutralizing senescent cells for therapeutic benefit) is poised to contribute to both prevention and treatment of CVD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Emerging experimental evidence indicates that, in contrast to an acute inflammatory response, the SASP is a protracted and chronic source of inflammatory and other plaque-destabilizing factors,9,10 gradually contributing to atherosclerosis pathogenesis.”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [10]
In the citing paper
“Cellular senescence is defined as an irreversible cell cycle arrest (mechanism outlined in Figure 1)8 and is accompanied by a pro-inflammatory phenotype. The phenotype is referred to as the senescence-associated secretory phenotype (SASP), producing pro-inflammatory cytokines [interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-18, CCL-2, tumour necrosis factor α (TNF-α)], metalloproteinases (MMP-1, -2, -3”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [10]
In the citing paper
“Importantly, a fraction of dysfunctional endothelial cells in atherosclerotic plaques is senescent (Minamino et al, 2002) and secretes vascular cell adhesion molecule 1 (VCAM‐1) to recruit and differentiate monocytes into foam cell macrophages (Davignon & Ganz, 2004; Childs et al, 2018).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Childs et al, 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Myocyte Turnover in the Aging Human Heart
Kajstura, J., Gurusamy, N., Ogórek, B., Goichberg, P., Clavo-Rondon, C., Hosoda, T., D'Amario, D., Bardelli, S., Beltrami, A. P., Cesselli, D., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.231498 · Cited by 287
RetractedThe serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×
“Additionally, aging raises circulating levels of angiotensin II, which activates the Ras signaling cascade, a well-known driver of oncogene-induced senescence (113), to produce VSMC senescence (114, 115) and enhance NADPH oxidase expression and ROS production (108).”
BackgroundBone marrow cells regenerate infarcted myocardium
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J. M., McKay, R. D. G., Nadal‐Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,149
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 2×
“To discriminate between these possibilities, an SNC suicide transgenic mouse (INK-ATTAC mouse), which permits INKlinked apoptosis through targeted activation of caspase, was developed (38).”
BackgroundMethodSelf-citationAdult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Beltrami, A. P., Barlucchi, L., Torella, D., Baker, M., Limana, F., Chimenti, S., Kasahara, H., Rota, M., Musso, E., Urbanek, K., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00687-1 · Cited by 3,528
Flagged first, then by citations
2 of the 181 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- John M. Eisenberg Center for Clinical Decisions and Communications Science. Treatments for open-angle glaucoma: a review of the research for adults. In: Comparative Effectiveness Review Summary Guides for Consumers [Internet]. Rockville, Maryland, USA: Agency for Healthcare Research and Quality; 2005. https://www.ncbi.nlm.nih.gov/books/NBK131775/ Accessed January 29, 2018
- 10.1016/j.cell.2008.06.049 · DOI · Paper page
Cited by
Sorted by citations
Measuring biological aging in humans: a quest
Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781
Mechanisms and consequences of endothelial cell senescence
Bloom, S. I., Islam, M. T., Lesniewski, L. A., & Donato, A. J. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00739-0 · Cited by 521
Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 450
Gut microbiota and cardiovascular disease: opportunities and challenges
Kazemian, N., Mahmoudi, M., Halperin, F. A., Wu, J. C., & Pakpour, S. (2020) · Microbiome · doi:10.1186/s40168-020-00821-0 · Cited by 404
Ferrucci, L., Levine, M. E., Kuo, P.-L., & Simonsick, E. M. (2018) · Circulation Research · doi:10.1161/circresaha.118.312816 · Cited by 303
Aged-senescent cells contribute to impaired heart regeneration
Lewis‐McDougall, F. C., Ruchaya, P. J., Domenjo‐Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., et al. (2019) · Aging Cell · doi:10.1111/acel.12931 · Cited by 317
Targeting Age-Related Pathways in Heart Failure
Li, H., Hastings, M. H., Rhee, J., Trager, L. E., Roh, J. D., & Rosenzweig, A. (2020) · Circulation Research · doi:10.1161/circresaha.119.315889 · Cited by 276
Self-citationAging, Cellular Senescence, and Alzheimer’s Disease
Liu, R.-M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041989 · Cited by 267
NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates
Yang, D., Sun, B., Li, S., Wei, W., Liu, X., Cui, X., Zhang, X., Liu, N., Yan, L., Deng, Y., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add1951 · Cited by 217
Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz919 · Cited by 188
Cellular Senescence in Cardiovascular Diseases: A Systematic Review
Hu, C., Zhang, X., Teng, T., Ma, Z., & Tang, Q. (2022) · Aging and Disease · doi:10.14336/ad.2021.0927 · Cited by 184
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges
Xueke, Z., Hong, Y., Zhang, H., & Li, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00364 · Cited by 170
Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases
de Almeida, A. J. P. O., Rezende, M. S. D. A., Dantas, S. H., Silva, S. D. L., de Oliveira, J. C. P. L., de Azevedo, F. D. L. A. A., Alves, R. M. F. R., de Menezes, G. M. S., dos Santos, P. F., Gonçalves, T. A. F., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1954398 · Cited by 173
Muñoz, D. P., Yannone, S. M., Daemen, A., Sun, Y., Vakar-Lopez, F., Kawahara, M., Freund, A. M., Rodier, F., Wu, J. D., Desprez, P.-Y., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.124716 · Cited by 162
Relationship Between Sarcopenia and Cardiovascular Diseases in the Elderly: An Overview
He, N., Zhang, Y., Zhang, L., Zhang, S., & Ye, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.743710 · Cited by 165
Barreto, J., Karathanasis, S. K., Remaley, A. T., & Sposito, A. C. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315421 · Cited by 160
Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration
Wan, M., Gray-Gaillard, E. F., & Elisseeff, J. H. (2021) · Bone Research · doi:10.1038/s41413-021-00164-y · Cited by 155
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
Sun, Y., Wang, X., Liu, T., Zhu, X., & Pan, X. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00815-5 · Cited by 156
Sirtuins and Insulin Resistance
Zhou, S., Tang, X., & Chen, H. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00748 · Cited by 155
Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem
Evangelou, K., Vasileiou, P. V. S., Papaspyropoulos, A., Hazapis, O. G., Petty, R., Demaria, M., & Gorgoulis, V. G. (2022) · Physiological Reviews · doi:10.1152/physrev.00007.2022 · Cited by 127
Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain
Graves, S. I., & Baker, D. J. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13403 · Cited by 118
Romero, A., Hipólito‐Luengo, Á. S., Villalobos, L. A., Vallejo, S., Valencia, I., Michalska, P., Pajuelo‐Lozano, N., Sánchez‐Pérez, I., Leon, R. M., Bartha, J. L., et al. (2019) · Aging Cell · doi:10.1111/acel.12913 · Cited by 119
Cell senescence and fibrotic lung diseases
Liu, R.-M., & Liu, G. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110836 · Cited by 117
Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research
Yessenkyzy, A., Saliev, T. M., Zhanaliyeva, M., Masoud, A., Umbayev, B. A., Sergazy, S., Кривых, Е. А., Gulyayev, A., & Nurgozhin, T. S. (2020) · Nutrients · doi:10.3390/nu12051344 · Cited by 119
Cellular senescence in the lung across the age spectrum
Parikh, P., Wicher, S., Khandalavala, K., Pabelick, C. M., Britt, R. D., & Prakash, Y. S. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00424.2018 · Cited by 112
Cellular senescence as a potential mediator of COVID‐19 severity in the elderly
Nehme, J., Borghesan, M., Mackedenski, S., Bird, T. G., & Demaria, M. (2020) · Aging Cell · doi:10.1111/acel.13237 · Cited by 94
The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
Samarakoon, R., Higgins, S. P., Higgins, C. E., & Higgins, P. J. (2019) · Biomolecules · doi:10.3390/biom9080341 · Cited by 104
Hepatic senescence, the good and the bad
Huda, N., Liu, G., Hong, H., Yan, S., Khambu, B., & Yin, X.-M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i34.5069 · Cited by 100
Nakao, T., Bick, A. G., Taub, M. A., Zekavat, S. M., Uddin, M. M., Niroula, A., Carty, C. L., Lane, J., Honigberg, M. C., Weinstock, J. S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl6579 · Cited by 91
Senescence-associated secretory phenotype and its impact on oral immune homeostasis
Yue, Z., Nie, L., Zhao, P., Ji, N., Liao, G., & Wang, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1019313 · Cited by 101
Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair
Witjas, F. M. R., van den Berg, B. M., van den Berg, C. W., Engelse, M. A., & Rabelink, T. J. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0155 · Cited by 88
de Carvalho, F. G., Justice, J. N., de Freitas, E. C., Kershaw, E. E., & Sparks, L. M. (2019) · Nutrients · doi:10.3390/nu11112553 · Cited by 93
Is exercise a senolytic medicine? A systematic review
Chen, X., Yi, Z., Wong, G. T., Hasan, K. M. M., Kwan, J. S., Ma, A. C., & Chang, R. C. (2021) · Aging Cell · doi:10.1111/acel.13294 · Cited by 88
Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments
Morris, G., Puri, B. K., OLIVE, L. S., Carvalho, A. F., Berk, M., Walder, K. R., Gustad, L. T., & Maes, M. H. J. (2020) · BMC Medicine · doi:10.1186/s12916-020-01749-w · Cited by 88
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
Culley, M. K., Zhao, J., Tai, Y., Tang, Y., Perk, D., Negi, V., Yu, Q., Woodcock, C.-. C., Handen, A. L., Speyer, G., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci136459 · Cited by 81
Lérida‐Viso, A., Estepa‐Fernández, A., Morellá‐Aucejo, Á., Lozano‐Torres, B., Alfonso, M., Blandez, J. F., Bisbal, V., Sepúlveda, P., García‐Fernández, A., Orzáez, M., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106356 · Cited by 84
Salminen, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101280 · Cited by 77
The aging venous system: from varicosities to vascular cognitive impairment
Molnár, A., Nádasy, G. L., Dörnyei, G., Patai, B. B., DelFavero, J., Fülöp, G., Kirkpatrick, A. C., Ungvari, Z. I., & Merkely, B. P. (2021) · GeroScience · doi:10.1007/s11357-021-00475-2 · Cited by 74
Endothelial Senescence: A New Age in Pulmonary Hypertension
Culley, M. K., & Chan, S. Y. (2022) · Circulation Research · doi:10.1161/circresaha.121.319815 · Cited by 71
Cherry, C., Andorko, J. I., Krishnan, K., Mejías, J. C., Nguyen, H. H., Stivers, K. B., Gray-Gaillard, E. F., Ruta, A., Han, J., Hamada, N., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00785-7 · Cited by 66
DNA methylation processes in atherosclerotic plaque
Aavik, E., Babu, M., & Ylä‐Herttuala, S. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.006 · Cited by 72
Hadri, K. E., Smith, R., Duplus, E., & Amri, C. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010077 · Cited by 71
- Retracted
Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
Machado-Oliveira, G., Ramos, C., Marques, A. R. A., & Vieira, O. V. (2020) · Cells · doi:10.3390/cells9102146 · Cited by 70
Senescence in tissue samples of humans with age-related diseases: A systematic review
Tuttle, C. S. L., Luesken, S. W. M., Waaijer, M. E. C., & Maier, A. B. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101334 · Cited by 68
Relationships Between Ion Channels, Mitochondrial Functions and Inflammation in Human Aging
Strickland, M., Yacoubi‐Loueslati, B., Bouhaouala‐Zahar, B., Pender, S. L. F., & Larbi, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00158 · Cited by 64
Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease
Yan, C., Xu, Z.-M., & Huang, W. (2021) · Aging and Disease · doi:10.14336/ad.2020.0811 · Cited by 61
Sasaki, N., Itakura, Y., & Toyoda, M. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00533-w · Cited by 63
Targeting Immune Senescence in Atherosclerosis
Vellasamy, D. M., Lee, S.-J., Goh, K. W., Goh, B. H., Tang, Y.-Q., Ming, L. C., & Yap, W. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113059 · Cited by 63
Nagane, M., Yasui, H., Kuppusamy, P., Yamashita, T., & Inanami, O. (2021) · Journal of Radiation Research · doi:10.1093/jrr/rrab032 · Cited by 59
Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer
Banerjee, P., Kotla, S., Velatooru, L. R., Abe, R. J., Olmsted‐Davis, E. A., Cooke, J. P., Schadler, K., Deswal, A. M., Herrmann, J., Lin, S. H., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.763930 · Cited by 55
The struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52
Long-term cardiovascular complications following sepsis: is senescence the missing link?
Merdji, H., Schini‐Kerth, V. B., Meziani, F., & Toti, F. (2021) · Annals of Intensive Care · doi:10.1186/s13613-021-00937-y · Cited by 57
Arauna, D., Furrianca, M. C., Espinosa‐Parrilla, Y., Eduardo Fuentes, Q., Alarcón, M. A., & Palomo, I. F. (2019) · Molecules · doi:10.3390/molecules24234259 · Cited by 50
A tale of the good and bad: Cell senescence in bone homeostasis and disease
Liu, X., & Wan, M. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.03.005 · Cited by 45
Marino, J., Wigdahl, B. L., & Nonnemacher, M. R. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00168 · Cited by 43
Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women
Schuermans, A., Nakao, T., Uddin, M. M., Hornsby, W., Ganesh, S., Shadyab, A. H., Liu, S., Haring, B., SHUFELT, C. L., Taub, M. A., et al. (2023) · Circulation Research · doi:10.1161/circresaha.123.322984 · Cited by 43
Bilanda, D. C., Goufani, R. B. A., Dzeufiet, P. D. D., Fouda, Y. B., Fifen, R. N., Tcheutchoua, Y. C., Owona, P. E., Wouamba, S. C. N., Tatchou, L. T., Dimo, T., et al. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112200 · Cited by 41
Focus on senescence: Clinical significance and practical applications
Boccardi, V., Orr, M. E., Polidori, M. C., Ruggiero, C., & Mecocci, P. (2024) · Journal of Internal Medicine · doi:10.1111/joim.13775 · Cited by 40
Chemical activation of SAT1 corrects diet-induced metabolic syndrome
Castoldi, F., Hyvönen, M. T., Durand, S., Aprahamian, F., Sauvat, A., Malik, S. A., Baracco, E. E., Vacchelli, E., Opolon, P., Signolle, N., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0550-z · Cited by 39
Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium
Moreno‐Gómez‐Toledano, R., Sánchez, S. G., Cook‐Calvete, A., Mínguez-Moratinos, M., Ramírez-Carracedo, R., Reventún, P., Delgado-Marín, M., Bosch, R. J., & Saura, M. (2021) · Biomolecules · doi:10.3390/biom11101429 · Cited by 39
PAI-1: A Major Player in the Vascular Dysfunction in Obstructive Sleep Apnea?
Badran, M., & Gozal, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105516 · Cited by 38
Diwan, B., & Sharma, R. (2022) · Food Science and Biotechnology · doi:10.1007/s10068-022-01114-y · Cited by 37
Xia, Y., Li, J., Wang, L., Xie, Y., Zhang, L., Han, X., Tan, W., & Liu, Y. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202214169 · Cited by 34
Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
Ahmed, R., Nakahata, Y., Shinohara, K., & Bessho, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.638122 · Cited by 32
Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells
Belcastro, E., Rehman, A. U., Remila, L., Park, S., Gong, D., Anton, N., Auger, C., Lefèbvre, O., Goetz, J. G., Collot, M., et al. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102379 · Cited by 33
Wang, G., Han, B., Zhang, R., Liu, Q., Wang, X., Huang, X., Liu, D., Qiao, W., Yang, M., Luo, X., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.758792 · Cited by 33
Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders
Bortoletto, P. E., Lucas, E. S., Melo, P., Gallos, I. D., Devall, A., Bourne, T., Quenby, S. M., Bennett, P. R., Coomarasamy, A., & Brosens, J. J. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104134 · Cited by 33
Ma, Y., Liu, Y., Han, F., Qiu, H., Shi, J., Huang, N., Hou, N., & Sun, X. (2021) · Aging · doi:10.18632/aging.202881 · Cited by 33
Epigenetic Clock and Circadian Rhythms in Stem Cell Aging and Rejuvenation
Samoilova, E. M., Викторович, Б. В., Ekusheva, E. V., Zhang, C., Troitskiy, A. V., & Baklaushev, V. P. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111050 · Cited by 32
Gao, L., Slack, M. A., McDavid, A., Anolik, J. H., & Looney, R. J. (2019) · Current Rheumatology Reports · doi:10.1007/s11926-019-0800-6 · Cited by 29
Calderón‐Larrañaga, A., Saadeh, M., Hooshmand, B., Refsum, H., Smith, A. D., Marengoni, A., & Vetrano, D. L. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.5316 · Cited by 29
Anaya-Isaza, A., & Zequera-Diaz, M. (2022) · IEEE Access · doi:10.1109/access.2022.3180036 · Cited by 33
Promoting healthy cardiovascular aging: emerging topics
Clayton, Z. S., Craighead, D. H., Darvish, S., Coppock, M. E., Ludwig, K. R., Brunt, V. E., Seals, D. R., & Rossman, M. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.27 · Cited by 29
Pulakat, L., & Chen, H. H. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00774 · Cited by 30
Cai, X., Hu, J., Wang, M., Wen, W., Wang, J., Yang, W., Dang, Y., Luo, Q., Hong, J., & Li, N. (2023) · Aging · doi:10.18632/aging.204587 · Cited by 29
The role of cellular senescence in cardiovascular disease
Xu, C., Qiu, Z., Guo, Q., Huang, Y., Zhao, Y., & Zhao, R. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02720-5 · Cited by 34
Okuno, K., Cicalese, S. M., Elliott, K. J., Kawai, T., Hashimoto, T. N., & Eguchi, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186579 · Cited by 28
Thorin‐Trescases, N., Labbé, P., Mury, P., Lambert, M., & Thorin, É. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212232 · Cited by 31
Cell senescence: basic mechanisms and the need for computational networks in vascular ageing
Regnault, V., Challande, P., Pinet, F., Li, Z., & Lacolley, P. J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa318 · Cited by 27
Senolytic agents lessen the severity of abdominal aortic aneurysm in aged mice
Parvizi, M., Franchi, F., Arendt, B. K., Ebtehaj, S., Rodriguez-Porcel, M. G., & Lanza, I. R. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111416 · Cited by 27
An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging
Kaur, A., Macip, S., & Stover, C. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00218 · Cited by 25
Endothelial cell senescence: A machine learning-based meta-analysis of transcriptomic studies
Park, H. S., & Kim, S. Y. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101213 · Cited by 26
Mapping cellular senescence networks in human diabetic foot ulcers
Yu, G., Monie, D. D., Khosla, S., Tchkonia, T., Kirkland, J. L., & Wyles, S. P. (2023) · GeroScience · doi:10.1007/s11357-023-00854-x · Cited by 26
Luo, X., Zhou, J., Wang, Z., He, Y., Yu, L., Ma, S., Wang, S., Wang, X., Yuan, Y., Li, D., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118199 · Cited by 24
Mesenchymal Stem Cell Senescence and Osteogenesis
Tjempakasari, A., Suroto, H., & Santoso, D. (2021) · Medicina · doi:10.3390/medicina58010061 · Cited by 25
A Unified Model of Age-Related Cardiovascular Disease
Fossel, M., Bean, J., Khera, N., & Kolonin, M. G. (2022) · Biology · doi:10.3390/biology11121768 · Cited by 24
Pettinato, A. M., Yoo, D., VanOudenhove, J., Chen, Y., Cohn, R. L., Ladha, F. A., Yang, X., Thakar, K., Romano, R., Legere, N., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.109088 · Cited by 22
Siddharthan, D. V. M., Livia, C., Peterson, T. E., Stalboerger, P. G., Attia, Z. I., Clavell, A. L., Friedman, P. A., Kapa, S., Noseworthy, P. A., Schafer, M. J., et al. (2023) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2022.10.026 · Cited by 21
Target and Cell Therapy for Atherosclerosis and CVD
Markina, Y. V., Kirichenko, T. V., Tolstik, T. V., Bogatyreva, A. I., Zotova, U., Cherednichenko, V. R., Postnov, A. Y., & Markin, A. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210308 · Cited by 21
Immunosenescence: A new direction in anti-aging research
Li, H., Lin, S., Wang, Y., Shi, Y., Fang, X., Wang, J., Cui, H., Bian, Y., & Qi, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112900 · Cited by 21
Self-citationCellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges
Li, D., Li, Y., Ding, H., Wang, Y., Xie, Y., & Zhang, X. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10100439 · Cited by 21
Cellular senescence in vivo: From cells to tissues to pathologies
Kumar, A., Bano, D., & Ehninger, D. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111308 · Cited by 19
Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging
Yang, D., Wang, Q., Wei, G., Wu, J., Zhu, Y. C., Zhu, Q., Ni, T., Liu, X., & Zhu, Y. Z. (2020) · Aging · doi:10.18632/aging.103895 · Cited by 19
Senolytic therapies for cardiovascular aging: tackling fibrosis and metabolic dysfunction
Atlante, S., Zamperla, M. G., Cis, L., Farsetti, A., & Gaetano, C. (2025) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2025.07.009 · Cited by 21
The Immune System and Cellular Senescence: A Complex Interplay in Aging and Disease
Ayoub, M., Jaoude, C. A., Ayoub, M., Hamadé, A., & Rima, M. (2025) · Immunology · doi:10.1111/imm.70036 · Cited by 25
Senescence in RASopathies, a possible novel contributor to a complex pathophenoype
Engler, M., Fidan, M., Nandi, S., & Cirstea, I. C. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111411 · Cited by 15
Herrmann, J., Xia, M., Gummi, M. R., Greco, A., Schacke, A., van der Giet, M., Tölle, M., & Schuchardt, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.752305 · Cited by 18
Xu, H., Yu, M., Yu, Y., Li, Y., Yang, F., Liu, Y., Han, L., Xu, Z., & Wang, G. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13804 · Cited by 20
Tokuyama, T., Uosaki, H., Sugiura, A., Nishitai, G., Takeda, K., Nagashima, S., Shiiba, I., Ito, N., Amo, T., Mohri, S., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104582 · Cited by 19
Metadata
- Authors
- Childs, B. G., Li, H., & van Deursen, J. M.
- Affiliations
- Mayo Clinic (US)
- Venue
- Journal of Clinical Investigation
- Published
- 2018-04-02
- Volume
- 128
- Issue
- 4
- Pages
- 1217-1228
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC5873883
- OpenAlex
- W2795134170
- Cited by
- 192
- References
- 181
- Citations by year
- 2026: 17 · 2025: 21 · 2024: 13 · 2023: 24 · 2022: 32 · 2021: 35 · 2020: 27 · 2019: 16 · 2018: 7
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Glenn Foundation for Medical Research
- Fondation pour la Recherche Médicale
- National Institutes of Health
- National Institute on Aging (R01AG057493, T32AG049672)
- National Cancer Institute (R01CA126828, R01CA096985)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- cellular senescence, senolytics, senotherapy, cardiovascular disease, aging, age-related diseases, senolytic therapy, cardiovascular aging
- MeSH terms
- Aged, Aging, Animals, Cardiovascular Diseases, Cardiovascular System, Humans, Cellular Senescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
