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Clinical characteristics and family history in DSM-III obsessive- compulsive disorder
Abstract
The authors present the clinical characteristics, demographic features, and family history of a clinical sample of 44 patients who met DSM-III criteria for obsessive-compulsive disorder. Their findings are consistent with those of previous epidemiologic studies completed before the introduction of DSM-III with regard to phenomenology, course, and demographic characteristics. Most of the 44 patients had concomitant or lifetime histories of a major depressive disorder or another anxiety disorder. A number of first-degree relatives of these patients had probable obsessive-compulsive disorder or obsessive traits. The findings of this study should prove useful in further epidemiologic, biologic, and behavioral studies.
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“The mean duration between onset of first OCD symptoms and presentation for treatment is around seven years [19, 20].”
From Study protocol for a randomised controlled trial of internet-based cognitive-behavioural therapy for obsessive-compulsive disorder (2014) · cites this paper as [20]
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Obsessive-Compulsive Disorders
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Summary of research prepared by Steven Moldin, NIMH
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“A range of obsessions and compulsions may be present in any one patient (Table 1), and these symptoms may also evolve over time, with one set of obsessions and compulsions replacing another (2, 3).”
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“Interestingly, most OCD patients wait as long as seven years before seeking help (Rasmussen and Tsuang, 1986).”
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“…numerous family (Black, Noyes, Goldstein, & Blum, 1992; Nicolini, Weissbecker, Mejia, & Sanchez de Carmona, 1993; Pauls et al., 1995) and twin studies (Andrews, Stewart, Allen, & Henderson, 1990; Rasmussen & Tsuang, 1986; Rosario-Campos et al., 2001) suggest that OCD has a strong genetic component.”
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“Rasmussen and Tsuang [1], in a summary of twin studies, reported MZ concordance rates in the range of 53% to 87%, and DZ rates from 22% to 47% for OCD, with variability arising with different diagnostic criteria.”
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“Although some patients experience a single thought obsessionally, a majority experience more than one obsession or compulsion either simultaneously or over the course of illness (Rasmussen & Tsuang, 1986).”
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“…thoughts, perfectionism, responsibility, religious themes in obsessive thoughts and compulsive rituals, overvaluation of thoughts, maladaptive beliefs, etc.) (Abramowitz et al., 2004; Rachman, 1997, 2006; Rasmussen and Tsuang, 1986; Sica et al., 2002; Steketee et al., 1991; Yorulmaz et al., 2009).”
BackgroundThe role of clinical phenotypes in understanding the genetics of obsessive–compulsive disorder
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“compared to 10% in DZ twins [6,7].”
Obsessive-compulsive disorder and schizophrenia in three identical twin pairs
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Siev, J., Huppert, J. D., & Zuckerman, S. E. (2017) · doi:10.1002/9781118890233.ch29 · Cited by 14
Is disgust in obsessive-compulsive disorder mediated by fear of pathogens?
Eyal, T., Dar, R., & Liberman, N. (2020) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2020.102340 · Cited by 13
Obsessions of child murder: underrecognized manifestations of obsessive-compulsive disorder.
Booth, B. D., Friedman, S. H., Curry, S., Ward, H., & Stewart, S. E. (2014) · PubMed · Cited by 13
The Relationship Between Trait Guilt, Disgust Propensity, and Contamination Fear
Melli, G., Gremigni, P., Elwood, L. S., Stopani, E., Bulli, F., & Carraresi, C. (2015) · International Journal of Cognitive Therapy · doi:10.1521/ijct_2015_8_01 · Cited by 13
Miguita, K., Cordeiro, Q., Siqueira-Roberto, J., Shavitt, R. G., Castillo, J. C. R., Castillo, A. R. G. L., Miguel, E. C., & Vallada, H. (2007) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2007000600002 · Cited by 12
Pichichero, M. E. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-79838-7_17 · Cited by 13
Kyrios, M., Nedeljkovic, M., Moulding, R., Klein, B., Austin, D., Meyer, D., & Ahern, C. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-209 · Cited by 12
“The mean duration between onset of first OCD symptoms and presentation for treatment is around seven years [19,20].”
BackgroundThe Role of Religiosity and Guilt in Symptomatology and Outcome of Obsessive Compulsive Disorder
Kumar, R., Arvind, S., Bansal, P. D., Bahetra, M., Saini, B., Moria, K., Kaur, N., Shrutika, G., Priyanka, B., Arun, K., et al. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4408 · Cited by 12
Obsessive-Compulsive Disorder in Late Life
Calamari, J. E., Pontarelli, N. K., Armstrong, K. M., & Salstrom, S. A. (2011) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2010.10.004 · Cited by 12
Moshier, S. J., Molokotos, E. K., Stein, A. T., & Otto, M. W. (2015) · International Journal of Cognitive Therapy · doi:10.1521/ijct_2015_8_02 · Cited by 12
An integrative approach to the treatment of obsessive-compulsive disorder
Foster, P. S., & Eisler, R. M. (2001) · Comprehensive Psychiatry · doi:10.1053/comp.2001.19757 · Cited by 12
Altın, M., & Gençöz, T. (2007) · Behaviour Change · doi:10.1375/bech.24.3.146 · Cited by 12
“Behaviour Change Several researchers and clinicians have recognised that there are strong relationships between obsessions, compulsions, and mood disorders, particularly depression (e.g., Rasmussen & Eisen, 1991, Fireman, Koran, Leventhal, & Jacabson, 2001; Rasmussen & Tsuang, 1986).”
Background
Metadata
- Authors
- Rasmussen, S. A., & Tsuang, M. T.
- Affiliations
- Butler Hospital (US)
- Venue
- American Journal of Psychiatry
- Published
- 1986-03-01
- Volume
- 143
- Issue
- 3
- Pages
- 317-322
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1679486966
- Cited by
- 668
- References
- 22
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 4 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 15 · 2016: 14 · 2015: 17 · 2014: 19 · 2013: 15 · 2012: 51
- FWCI
- 17.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH38096, MH38079)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, DSM-III criteria, clinical features, family history (medicine), first-degree relatives, comorbid depression, anxiety disorders, demographic factors, clinical course
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Depressive Disorder, Female, Humans, Male, Manuals as Topic, Obsessive-Compulsive Disorder, Risk, Schizophrenia
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