Cited by 668Obsessive-Compulsive Spectrum DisordersPsychoanalysis and Psychopathology ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Clinical characteristics and family history in DSM-III obsessive- compulsive disorder

Steven A. Rasmussen, Ming T. Tsuang·1986·American Journal of Psychiatry

DOI 10.1176/ajp.143.3.317

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Abstract

The authors present the clinical characteristics, demographic features, and family history of a clinical sample of 44 patients who met DSM-III criteria for obsessive-compulsive disorder. Their findings are consistent with those of previous epidemiologic studies completed before the introduction of DSM-III with regard to phenomenology, course, and demographic characteristics. Most of the 44 patients had concomitant or lifetime histories of a major depressive disorder or another anxiety disorder. A number of first-degree relatives of these patients had probable obsessive-compulsive disorder or obsessive traits. The findings of this study should prove useful in further epidemiologic, biologic, and behavioral studies.

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“…M. Lohr c, Tom Armstrong a a Vanderbilt University, United States b University of Texas-Austin, United States c University of Arkansas, United States Contamination fear is a commonly observed phenomenon in obsessive-compulsive disorder (OCD; Rachman & Hodgson, 1980; Rasmussen & Tsuang, 1986).”
Background
Childhood-onset obsessive-compulsive disorder
Eichstedt, J. A., & Arnold, S. L. (2001) · Clinical Psychology Review · doi:10.1016/s0272-7358(99)00044-6 · Cited by 152
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Risk factors prospectively associated with adult obsessive–compulsive symptom dimensions and obsessive–compulsive disorder
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“Several studies have found that stressful life events were linked to the onset of OCD (McKeon et al. 1984 ; Khanna et al. 1988 ; Toro et al. 1992), although Rasmussen & Tsuang (1986) found that most OCD participants were unable to identify an environmental precipitant.”
Background
Gender-Divergent Aetiological Factors in Obsessive-Compulsive Disorder
Noshirvani, H., Kasvikis, Y., Marks, I. M., Tsakiris, F. E., & Monteiro, W. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.158.2.260 · Cited by 145
“Some literature suggeststhat early onset is a bad prognostic factor (Strauss, 1948; Ingram, 1961; Rasmussen & Tsuang, 1986) and associated with greater severity of the disorder (de Silva et a!, 1977).”
Background
The genetics of obsessive compulsive disorder: a review of the evidence
Pauls, D. L. (2008) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.30168 · Cited by 142
Are obsessional thoughts and worry different cognitive phenomena?
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Standardized Assessment of Personality Disorders in Obsessive-Compulsive Disorder
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The interaction between anxiety and sexual functioning: A controlled study of sexual functioning in women with anxiety disorders
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“In a descriptive study of 44 OCD patients (Rasmussen & Tsuang, 1986), 14 (32”
Background
Personality traits in subclinical and non-obsessive-compulsive volunteers and their parents
Frost, R. O., Steketee, G. S., Cohn, L. G., & Griess, K. (1994) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)90083-3 · Cited by 146
Depressive comorbidity of panic, social phobic, and obsessive–compulsive disorders re-examined: is there a bipolar ii connection?
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Obsessive compulsive disorder
Jenike, M. A. (1983) · Comprehensive Psychiatry · doi:10.1016/0010-440x(83)90098-6 · Cited by 143
Gender in obsessive–compulsive disorder: clinical and genetic findings
Lochner, C., Hemmings, S. M. J., Kinnear, C. J., Moolman-Smook, J. C., Corfield, V. A., Knowles, J. A., Niehaus, D. J. H., & Stein, D. J. (2004) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(03)00063-4 · Cited by 141
“, 1999), symmetry and exactness (Lensi et al., 1996; Rasmussen and Tsuang, 1986), concern with numbers (Skoog, 1965; Swedo and Rapoport, 1989), touching rituals (Fischer et al.”
Background
The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Adams, T. G., Kelmendi, B., Brake, C. A., Gruner, P., Badour, C. L., & Pittenger, C. (2018) · Chronic Stress · doi:10.1177/2470547018758043 · Cited by 154
Barriers to treatment among African Americans with obsessive-compulsive disorder
Williams, M. T., Domanico, J., Marques, L. M., LeBlanc, N. J., & Turkheimer, E. N. (2012) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2012.02.009 · Cited by 139
“…of these barriers, specifically stigma and shame, most OCD sufferers wait 8–10 years before seeking treatment (Marques et al., 2010; Pallanti, 2008; Rasmussen & Tsuang, 1986), and as few as 29% of the afflicted population obtain treatment specifically for their OCD (NCS-R; Ruscio et al., 2010).”
Developmental psychopathology of children and adolescents with Tourette syndrome – impact of ADHD
Roessner, V., Becker, A., Banaschewski, T., Freeman, R. D., Rothenberger, A., & Tourette Syndrome International Database Consortium (2007) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-007-1004-6 · Cited by 138
Genetics of personality disorders: Perspectives from personality and psychopathology research.
Nigg, J. T., & Goldsmith, H. H. (1994) · Psychological Bulletin · doi:10.1037/0033-2909.115.3.346 · Cited by 141
Comorbidity of obsessive compulsive disorder in bipolar disorder
Krüger, S. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00008-b · Cited by 137
Obsessive–compulsive disorder (OCD) with schizotypy vs. schizophrenia with OCD: diagnostic dilemmas and therapeutic implications
Poyurovsky, M., & Koran, L. M. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.09.004 · Cited by 139
The role of central oxytocin in obsessive compulsive disorder and related normal behavior
Leckman, J. F., Goodman, W. K., North, W. G., Chappell, P. B., Price, L. H., Pauls, D. L., Anderson, G. M., Riddle, M. A., McDougle, C. J., Barr, L. C., et al. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90021-3 · Cited by 133

Authors: Rasmussen, S. A., & Tsuang, M. T.
Affiliations: Butler Hospital (US)
ORCID: Steven A. Rasmussen
Ming T. Tsuang
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1986-03-01
Volume: 143
Issue: 3
Pages: 317-322
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.143.3.317
OpenAlex: W1679486966
Cited by: 668
References: 22
Citations by year: 2026: 5 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 4 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 15 · 2016: 14 · 2015: 17 · 2014: 19 · 2013: 15 · 2012: 51
FWCI: 17.14
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH38096, MH38079)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: obsessive-compulsive disorder, DSM-III criteria, clinical features, family history (medicine), first-degree relatives, comorbid depression, anxiety disorders, demographic factors, clinical course
MeSH terms: Adolescent, Adult, Anxiety Disorders, Depressive Disorder, Female, Humans, Male, Manuals as Topic, Obsessive-Compulsive Disorder, Risk, Schizophrenia

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Clinical characteristics and family history in DSM-III obsessive- compulsive disorder

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