Insomnia improvement during antidepressant treatment andCLOCK gene polymorphism
Abstract
Sleep disturbances are commonly observed in mood disorders, and sleep manipulations can influence the clinical status. In the present study, we investigated the possible effect of the 3111 T/C circadian locomotor output cycles kaput (CLOCK) gene polymorphism on insomnia symptomatology during antidepressant treatment. One hundred seventy-eight inpatients were treated with fluvoxamine 300 mg/day (n = 147) or paroxetine 20-40 mg/day (n = 31), and either placebo or pindolol in a double blind design for 6 weeks. The severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression (HAM-D). We observed a significantly higher presence of insomnia throughout the trial in homozygotes for the C variant (P = 0.026). Other demographic and clinical features were found not to be related with CLOCK polymorphisms. Overall, our findings may suggest that CLOCK genotype influences the time course of insomnia during antidepressant treatment. This, together with previous findings on this polymorphism could lead to a further dissection of the complexity of mood disorders.
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The CLOCK 3111 T to C SNP is associated with greater insomnia in individuals undergoing antidepressant treatment.
“This SNP is also associated with greater insomnia and decreased need for sleep in bipolar patients, as well as greater insomnia in individuals undergoing antidepressant treatment (Serretti et al., 2003; Serretti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Serretti et al., 2005
The CLOCK 3111 T to C SNP is associated with greater insomnia in bipolar patients.
“This SNP is also associated with greater insomnia and decreased need for sleep in bipolar patients, as well as greater insomnia in individuals undergoing antidepressant treatment (Serretti et al., 2003; Serretti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Serretti et al., 2005
The CLOCK 3111 T to C SNP is associated with decreased need for sleep in bipolar patients.
“This SNP is also associated with greater insomnia and decreased need for sleep in bipolar patients, as well as greater insomnia in individuals undergoing antidepressant treatment (Serretti et al., 2003; Serretti et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Serretti et al., 2005
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- Authors
- Serretti, A., Cusin, C., Benedetti, F., Mandelli, L., Pirovano, A., Zanardi, R., Colombo, C., & Smeraldi, E.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- IRCCS Ospedale San Raffaele (IT)
- Corresponding author
- Serretti, Alessandro
- ORCID
- Venue
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2005-08-05
- Volume
- 137B
- Issue
- 1
- Pages
- 36-39
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2090455592
- Cited by
- 164
- References
- 28
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 26 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 11 · 2015: 10 · 2014: 6 · 2013: 6 · 2012: 6
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- insomnia, clock gene polymorphisms, circadian rhythm, antidepressant treatment, fluvoxamine, paroxetine, pindolol, depression, mood disorders, genetic susceptibility, sleep disorders
- MeSH terms
- Adult, Aged, Antidepressive Agents, Double-Blind Method, Drug Therapy, Combination, Female, Gene Frequency, Genotype, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Pindolol, Polymorphism, Genetic, Serotonin Antagonists, Time Factors, Trans-Activators, Multivariate Analysis, Fluvoxamine, Treatment Outcome, Paroxetine, Mood Disorders, CLOCK Proteins
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