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Cited by 144Child and Adolescent Psychosocial and Emotional DevelopmentNeural and Behavioral Psychology StudiesPsychology and Mental Health

Pubertal neuromaturation, stress sensitivity, and psychopathology

WALKER, ELAINE F., SABUWALLA, ZAINAB, HUOT, REBECCA·2004·Development and Psychopathology
DOI 10.1017/s0954579404040027
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Abstract

Normal adolescent development is often accompanied by transient emotional and behavioral problems. For most individuals with postpubertal-onset adjustment problems, there is a resolution by early adulthood and relative stability through the adult life span. But for a minority, adjustment problems escalate during adolescence and portend the development of serious mental illness in adulthood. In this article, we explore adolescent behavioral changes and neurodevelopmental processes that might contribute to stress sensitivity and vulnerability for the emergence of the mental disorders. Of particular interest is the role that hormonal changes might play in the expression of genetic vulnerabilities for psychopathology. Drawing on recent findings from clinical research and behavioral neuroscience, we describe the ways in which postpubertal hormones might alter brain function and, thereby, behavior. It is concluded that there are both activational and organization effects of hormones on the adolescent brain, and these contribute to developmental discontinuities in behavioral adjustment. Implications for adult psychopathology and preventive intervention are discussed.

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Crossref · 10.1017/s0954579404040027

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119 of 119 references verified0 citation errors · 0 not checkable

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  • Heightened brain plasticity in adolescence may increase vulnerability to certain forms of psychopathology, many of which begin or worsen during adolescence.

    “heightened brain plasticity in adolescence may contribute to increased vulnerability to certain forms of psychopathology, many of which begin or intensify during adolescence.”

    From A behavioral scientist looks at the science of adolescent brain development (2010) · cites this paper as Walker et al., 2004

  • The pubertal/adolescent transition in humans and laboratory animals is generally associated with increased ANS and stress hormone reactivity to stressors, and slower post-stress hormonal recovery relative to adults.

    “the pubertal/adolescent transition in humans and laboratory animals has generally been reported to be associated with increased ANS and stress hormone reactivity to stressors (e.g., Vázquez, 1998; Walker et al, 2004; Gunnar et al, 2009; Stroud et al, 2009), along with slower post-stress hormonal recovery relative to adults (Romeo & McEwen, 2006).”

    From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Walker et al, 2004

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Authors
WALKER, E. F., SABUWALLA, Z., & HUOT, R.
Affiliations
Emory University (US)
ORCID
WALKER, ELAINE F.
Venue
Development and Psychopathology
Publisher
Cambridge University Press (CUP)
Published
2004-12
Volume
16
Issue
4
Pages
807-824
ISSN
  • 0954-5794 (ISSN-L)
  • 1469-2198
DOI
10.1017/s0954579404040027
OpenAlex
W2098615840
Cited by
144
References
119
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 9 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 16 · 2014: 4 · 2013: 10 · 2012: 10
FWCI
5.67
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Development and Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Psychology and Mental Health
Keywords
stress sensitivity, adolescent psychopathology, activational effects, organizational effects, genetic susceptibility, behavioral adjustment, developmental discontinuity, prevention of mental disorders
MeSH terms
Adolescent, Mental Disorders, Brain, Child, Female, Humans, Male, Psychosexual Development, Puberty, Gonadal Steroid Hormones, Social Adjustment, Stress, Psychological

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