Last observation carried forward versus mixed models in the analysis of psychiatric clinical trials.
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Pattern-mixture models were used to test whether key slope estimates depended on missing data patterns or cohort effects.
“We also implemented pattern-mixture models (Hedeker & Gibbons, 1997) to assess whether important slope estimates were dependent on missing data patterns (Hamer & Simpson, 2009) or cohort effects.”
From Impact of dialectical behavior therapy versus community treatment by experts on emotional experience, expression, and acceptance in borderline personality disorder (2014) · cites this paper as Hamer & Simpson, 2009
The study applied intention-to-treat analysis with last observation carried forward for missing data.
“The study applied the intention-to-treat (ITT) analysis method.34 In the case of missing data, we applied the last observation carried forward (LOCF) method.35”
From Effects of Immersive Virtual Therapy as a Method Supporting Recovery of Depressive Symptoms in Post-Stroke Rehabilitation: Randomized Controlled Trial (2022) · cites this paper as [35]
Mixed modelling allows the use of all available data for each participant to yield unbiased estimates of effects under the assumption that missingness is either completely at random or at random conditional on observed data.
“Mixed modelling allows the use of all available data for each participant to yield unbiased estimates of effects under the assumption that missingness is either completely at random (MCAR) or at random conditional on observed data (MAR) [30].”
From Internet-Based CBT for Depression with and without Telephone Tracking in a National Helpline: Randomised Controlled Trial (2011) · cites this paper as [30]
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Recommendations for the Primary Analysis of Continuous Endpoints in Longitudinal Clinical Trials
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MMRM vs. LOCF: A Comprehensive Comparison Based on Simulation Study and 25 NDA Datasets
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The prevention and handling of the missing data
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Likelihood Analysis of Imperfect Data
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- Authors
- Hamer, R. M., & Simpson, P. M.
- ORCID
- Simpson, Pippa M.
- Venue
- American Journal of Psychiatry
- Published
- 2009-06
- Volume
- 166
- Issue
- 6
- Pages
- 639-641
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2153647448
- Cited by
- 233
- References
- 6
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 8 · 2023: 12 · 2022: 15 · 2021: 16 · 2020: 21 · 2019: 12 · 2018: 14 · 2017: 6 · 2016: 12 · 2015: 17 · 2014: 15 · 2013: 22 · 2012: 17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Bayesian Inference
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Keywords
- last observation carried forward, mixed models, missing data, psychiatric clinical trials, longitudinal analysis, imputation methods
- MeSH terms
- Mental Disorders, Humans, Mathematical Computing, Patient Dropouts, Statistics as Topic, Randomized Controlled Trials as Topic
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