Depressive mood, suicide ideation and anxiety in smokers who do and smokers who do not manage to stop smoking after a target quit day
Abstract
Aims The effect of successful and unsuccessful smoking cessation on depressive mood, anxiety‐ and suicide‐related outcomes is unclear. The aim of this secondary analysis was to explore the relationship between abstinence status and these outcomes. Design Cohort of adult smokers attempting to stop smoking. Smoking status was assessed by a daily diary; depressed mood, anxiety and suicidal tendencies by the Hamilton Depression Rating Scale (HDRS). The association of complete and point‐prevalence abstinence with the HDRS variables was assessed using multi‐level linear regression models. Setting Randomized trial of sertraline versus placebo for smoking cessation with weekly behavioural support provided in a clinic. Participants A total of 133 adult smokers with past major depression. Findings Pre‐quit mood scores did not predict smoking status post‐quit day. Both continuous and point‐prevalence abstainers had significantly lower total HDRS, suicide and anxiety scores, adjusted for all potential confounders, during the period following quit day than did non‐abstainers who experienced a significant mood deterioration. There was a significant effect of sertraline on post‐quit HDRS scores but not on abstinence. Conclusions Contrary to expectation, smoking abstinence among smokers with a history of major depression did not lead to increase in depression, anxiety or suicide ideation; however, failed quit attempts did. Persisting with a quit attempt while unable to achieve abstinence may be associated with mood deterioration.
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Previous data from small cessation trials and recent data from population surveys suggested that relapse in a quit attempt may predict an increase in depressive symptoms.
“Previous data from small cessation trials [34, 35] and recent data from population surveys suggested that relapse in a quit attempt may predict an increase in depressive symptoms [36].”
From Depression and smoking cessation: evidence from a smoking cessation clinic with 1-year follow-up (2017) · cites this paper as [35]
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- Authors
- Berlin, I., Chen, H., & Covey, L. S.
- Affiliations
- Inserm (FR)
- Winthrop-University Hospital (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Berlin, Ivan
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2010-09-15
- Volume
- 105
- Issue
- 12
- Pages
- 2209-2216
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- OpenAlex
- W1585571950
- Cited by
- 56
- References
- 43
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Addiction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- smoking cessation, smoking abstinence, depressive mood, suicidal ideation, anxiety, major depressive disorder, sertraline, behavioral support
- MeSH terms
- Adolescent, Adult, Aged, Anxiety, Depression, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Medical Records, Middle Aged, Patient Acceptance of Health Care, Placebos, Psychiatric Status Rating Scales, Recurrence, Smoking, Linear Models, Smoking Cessation, Selective Serotonin Reuptake Inhibitors, Sertraline, Young Adult, Suicidal Ideation
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